Journal
ELIFE
Volume 5, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.15251
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Funding
- Fundacion Alfonso Martin Escudero
- European Research Council [ERC-2011-AdG294340-GENTRIS]
- National Institutes of Health [RO1 AR068383]
- Ministerio de Economia y Competitividad Espana [SAF2011-25834, SAF 2014-55579-R, SAF2011-27330]
- Comunidad de Madrid [INDISNET-S2011/BMD-2332]
- Institute Salud Carlos III Red Cardiovascular RD [12-0042-0056]
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Heterogeneity and functional specialization among skin-resident macrophages are incompletely understood. In this study, we describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules. Unlike other skin-resident macrophages that are reconstituted by bone marrow-derived progenitors after a genotoxic insult, these cells are replenished by an extramedullary radio-resistant and UV-sensitive Bmi1(+) progenitor. Furthermore, they possess a distinctive anti-inflammatory transcriptional profile, which cannot be polarized under inflammatory conditions, and are involved in repair and remodeling functions for which other skin-resident macrophages appear dispensable. Based on all their properties, we define these macrophages as Skin Transendothelial Radio-resistant Anti-inflammatory Macrophages (STREAM) and postulate that their preservation is important for skin homeostasis.
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