☆ 4.7 Review

Advancements in gelatin-based hydrogel systems for biomedical applications: A state-of-the-art review

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2023)

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Article Nanoscience & Nanotechnology

Three-Dimensional-Printable Thermo/Photo-Cross-Linked Methacrylated Chitosan-Gelatin Hydrogel Composites for Tissue Engineering

Amarachi Rosemary Osi et al.

Summary: A printable hydrogel ink based on ChMA and GelMA embedding nano-Hap is proposed for constructing complex 3D scaffolds. Tuning the GelMA content can adjust the properties of the hydrogels while maintaining shape retention after printing. In vitro culture experiments show that the formulated biomaterial inks can support the spreading and proliferation of stem cells.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Formulation of pH-sensitive aminated chitosan-gelatin crosslinked hydrogel for oral drug delivery

Ahmed Mohamed Omer et al.

Summary: This study aimed to develop efficient pH-sensitive hydrogel based on aminated chitosan (AmCs) and gelatin (Gel) biopolymers for oral drug delivery. The developed AmCs-Gel crosslinked hydrogel displayed variable pH-sensitive swelling profiles and showed acceptable biodegradability with no cellular toxicity, suggesting their applicability as pH-sensitive oral drug carriers. Adjusting the ratios of AmCs and Gel can achieve variable drug release and loading efficiency.

JOURNAL OF SAUDI CHEMICAL SOCIETY (2021)

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Article Chemistry, Applied

Gelatin/carboxymethyl cellulose based stimuli-responsive hydrogels for controlled delivery of 5-fluorouracil, development, in vitro characterization, in vivo safety and bioavailability evaluation

Samiullah Khan et al.

Summary: The focus of the current work is on the synthesis and characterization of novel pH-sensitive biocompatible gelatin/carboxymethyl cellulose based hydrogels using free radical polymerization technique cross-linked with glutaraldehyde. Various factors affecting the structure and properties of the hydrogels were investigated, and results showed the maximum swelling and highest drug release occurred at pH 1.2, indicating good biocompatibility and controlled release properties of the hydrogels.

CARBOHYDRATE POLYMERS (2021)

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Article Materials Science, Multidisciplinary

Physico-chemical modification of gelatine for the improvement of 3D printability of oxidized alginate-gelatine hydrogels towards cartilage tissue engineering

T. Kreller et al.

Summary: This study utilized 3D printing to fabricate hierarchical scaffold structures mimicking the natural articular cartilage, demonstrating the possibility to enhance the printability of ADA-GEL hydrogels for cartilage tissue engineering. The modified formulation featuring increased gelatine amounts and heat pre-treatment showed tailorable printability characteristics and modifiable mechanical properties, providing a valuable approach for designing scaffolds without the need for additives or crosslinkers.

MATERIALS & DESIGN (2021)

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Article Ophthalmology

Effects of Gelatin Methacrylate Hydrogel on Corneal Repair and Regeneration in Rats

Yun Chen et al.

Summary: The study investigated the repairing process of rat cornea after lamellar keratoplasty and evaluated the effects of Gelatin Methacrylate (GelMA) hydrogel. Results showed significant differences between the LKP group and the GelMA group in inflammatory cell infiltration, corneal thickness, and the expression of alpha-SMA and TGF-)51, indicating the potential of GelMA hydrogel in supporting corneal stroma fibrosis alleviation.

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2021)

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Article Engineering, Biomedical

Utilization of GelMA with phosphate glass fibers for glial cell alignment

Zalike Keskin-Erdogan et al.

Summary: Incorporating phosphate glass fibers into GelMA hydrogel can enhance glial cell alignment and provide physical cues necessary for achieving cell alignment. This approach has the potential to promote neural recovery and could be further utilized in bioengineered constructs designed to repair damaged nerve tissue.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Nanoscience & Nanotechnology

Development of Gelatin-Silk Sericin Incorporated with Poly(vinyl alcohol) Hydrogel-Based Nanocomposite for Articular Cartilage Defects in Rat Knee Joint Repair

Ji-Jun Zhao et al.

Summary: Sericin and poly(vinyl alcohol) hydrogel nanocomposite scaffolds were studied for cartilage repair, with a focus on their microstructure and performance. The presence of PVA in the scaffold was found to impact pore size and uniformity, while the GEL-SS-PVA scaffold showed significant effectiveness in repairing cartilage defects in rats.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Engineering, Chemical

Application of Green Technology in Gelatin Extraction: A Review

Nor Qhairul Izzreen Mohd Noor et al.

Summary: Growing demand for green and sustainable processing has led to the application of novel extraction technologies for gelatin in the food industry. This review discusses the principles and potential applications of green technologies, as well as factors affecting gelatin quality and various extraction methods. Technologies such as UAE, subcritical water extraction, high-pressure processing, and MAE have shown promise in improving gelatin extraction efficiency and reducing environmental impact.

PROCESSES (2021)

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Article Biotechnology & Applied Microbiology

Hybrid Hydrogel Composed of Hyaluronic Acid, Gelatin, and Extracellular Cartilage Matrix for Perforated TM Repair

Yili Wang et al.

Summary: A novel series of composite hydrogels, composed of HAMA, GelMA, and ECM, were prepared and characterized for potential utility in repairing damaged tympanic membrane. The absence of alpha-1,3-galactosyl glycoprotein in the ECM component from alpha-1,3 GalT-KO pigs could prevent rejection. The results are promising but further development is needed for surgical application.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Biomimetic Methacrylated Gelatin Hydrogel Loaded With Bone Marrow Mesenchymal Stem Cells for Bone Tissue Regeneration

Jun Li et al.

Summary: This study developed a photocrosslinked biomimetic methacrylated gelatin (Bio-GelMA) hydrogel scaffold to simulate the natural bone extracellular matrix, providing a 3D template and extracellular matrix microenvironment. Bone marrow mesenchymal stem cells (BMSCS) encapsulated in Bio-GelMA scaffolds showed therapeutic effects in a 3D environment for segmental bone defects, with good biocompatibility and mechanical properties. In vivo rat model experiments demonstrated that BMSC-loaded Bio-GelMA promoted robust new bone formation, indicating its potential for future clinical applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Chemistry, Physical

The impact of zirconium oxide nanoparticles content on alginate dialdehyde-gelatin scaffolds in cartilage tissue engineering

Mojgan Ghanbari et al.

Summary: This study investigated the preparation method of adding ZrO2 nanoparticles to hydrogels and the properties of the resulting nanocomposite hydrogels. The results showed that hydrogels containing ZrO2 NPs exhibited improved mechanical properties and better biodegradability, suggesting potential applications for cartilage tissue regeneration.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Article Cell & Tissue Engineering

A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy

Pierre C. Dromel et al.

Summary: The biomaterial-based cell replacement approach using gelatin-hyaluronic acid IPN shows promising potential in enhancing intravitreal retinal cell therapy. It improves cell viability, promotes regeneration, and reduces immune cell response, making it a viable treatment option worth further exploration and application in the future.

NPJ REGENERATIVE MEDICINE (2021)

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Article Materials Science, Biomaterials

Synthesis and characterization of site selective photo-crosslinkable glycidyl methacrylate functionalized gelatin-based 3D hydrogel scaffold for liver tissue engineering

Md Moniruzzaman Sk et al.

Summary: The development of a new biocompatible hydrogel material, Gelatin-GMA, showed potential applications in soft tissue engineering, especially in providing a conducive environment for cellular growth and functional development. The synthesis of Gelatin-GMA biopolymers at different pH values, preparation of 3D hydrogel scaffolds, and characterization of mechanical properties confirmed the successful preparation of polymer derivatives. In vitro studies demonstrated enhanced cellular functions and favorable cell response in Gelatin-GMA based hydrogels compared to control samples.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Medicine, Research & Experimental

Gelatin Hydrogels Loaded with Lactoferrin-Functionalized Bio-Nanosilver as a Potential Antibacterial and Anti-Biofilm Dressing for Infected Wounds: Synthesis, Characterization, and Deciphering of Cytotoxicity

Sundos Suleman Ismail Abdalla et al.

Summary: A novel gelatin hydrogel incorporated with bio-nanosilver and lactoferrin was successfully developed, showing promising antimicrobial effects against S. aureus and P. aeruginosa without interfering with normal cellular functions. This new approach may accelerate healing of chronic wounds by targeting biofilms in infected wounds.

MOLECULAR PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle

Xiomara Fernandez-Garibay et al.

Summary: The article describes the development of the first in vitro 3D model of DM1 human skeletal muscle, which shows highly aligned myotubes from both healthy and DM1 cells. The 3D micropatterning significantly improved DM1 cell differentiation into multinucleated myotubes, suitable for drug testing. AntagomiR-23b treatment in bioengineered DM1 skeletal muscle microtissues demonstrates significant therapeutic effects in rescuing molecular DM1 hallmarks and structural phenotypes.

BIOFABRICATION (2021)

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Article Multidisciplinary Sciences

Structure-function engineering of novel fish gelatin-derived multifunctional peptides using high-resolution peptidomics and bioinformatics

Armin Mirzapour-Kouhdasht et al.

Summary: Fish gelatin hydrolysates exhibit multifunctional properties with antibacterial and ACE/DPP-IV enzyme inhibitory activities. The synthesized PEP1, PEP2, and PEP3 peptides demonstrate this multifunctionality, confirmed through in vitro and in silico experiments. The binding energies of these peptides are sufficient to inhibit both ACE and DPP-IV enzymes with excellent three-dimensional conformation in all six docking mechanisms.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering

Jing Ye et al.

Summary: This study aimed to construct composite hydrogels based on natural polymers for tissue engineering. Results showed that these composite hydrogels have good cell viability and mechanical properties, promoting cell proliferation and adhesion of ADSCs.

PEERJ (2021)

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Article Chemistry, Multidisciplinary

Effect of Different Additives on the Mechanical Properties of Gelatin Methacryloyl Hydrogel: A Meta-analysis

Yuzhuo Zhang et al.

Summary: The study used meta-analysis to investigate the influence of additives on the mechanical properties of GelMA composites, revealing heterogeneity among the 23 literatures on composites with different concentrations of GelMA. It was found that additives can improve the mechanical properties at each concentration.

ACS OMEGA (2021)

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Article Engineering, Biomedical

Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing

Manhui Zheng et al.

Summary: The study introduces a mechanically-flexible, electroactive, and self-healable hydrogel (MESGel) with outstanding biocompatibility and multifunctional therapeutic properties. Experimental results demonstrate that MESGel can effectively promote cell proliferation, accelerate skin wound healing, and has the potential to be a novel flexible electronic skin sensor.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Surfactin-reinforced gelatin methacrylate hydrogel accelerates diabetic wound healing by regulating the macrophage polarization and promoting angiogenesis

Lu Yan et al.

Summary: The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Injectable biomimetic hydrogels encapsulating Gold/metal-organic frameworks nanocomposites for enhanced antibacterial and wound healing activity under visible light actuation

Zhiwen Deng et al.

Summary: This study introduced a biomimetic injectable double-network hydrogel using semiconductor nanomaterials to enhance ROS generation for antibacterial properties and wound healing acceleration.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Gelatin-based adhesive hydrogel with self-healing, hemostasis, and electrical conductivity

Kai Han et al.

Summary: A novel gelatin-based adhesive hydrogel was successfully prepared using mussel-inspired chemistry, showing hemostatic properties in a rat hepatic hemorrhage model. The incorporation of graphene oxide enhanced the conductivity and mechanical properties of the hydrogels, enabling successful monitoring of EMG signals and demonstrating good cytocompatibility in L929 cell experiments. These results suggest the potential application of GelDA/GO hydrogels in tissue adhesives, wound dressings, and wearable devices.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

6-deoxy-aminocellulose derivatives embedded soft gelatin methacryloyl (GelMA) hydrogels for improved wound healing applications: In vitro and in vivo studies

Farzana Nazir et al.

Summary: Hydrogels were prepared by mixing protein and carbohydrate-based biopolymers to enhance mechanical properties and promote efficient cell adhesion and proliferation for wound healing applications. The use of GelMA embedded amine MCC derivatives hydrogels showed accelerated wound healing potential based on in vitro and in vivo studies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Berberine carried gelatin/sodium alginate hydrogels with antibacterial and EDTA-induced detachment performances

Xiumei Zhang et al.

Summary: Novel hydrogels with anti-bacterial and induced detachment properties were prepared in this study by dual cross-linking, with the addition of SA significantly improving mechanical properties. These hydrogels have the potential to be used as wound dressing materials in the future.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

An injectable, dual crosslinkable hybrid pectin methacrylate (PECMA)/ gelatin methacryloyl (GelMA) hydrogel for skin hemostasis applications

Jing-Han Wang et al.

Summary: The newly developed PECMA/GelMA hybrid hydrogel has tunable properties, good cytocompatibility, and can synergize to achieve rapid hemostatic effects.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Dual-enzymatically cross-linked gelatin hydrogel promotes neural differentiation and neurotrophin secretion of bone marrow-derived mesenchymal stem cells for treatment of moderate traumatic brain injury

Jinrui Li et al.

Summary: A novel injectable gelatin hydrogel scaffold enhances neural regeneration for TBI treatment. Low-crosslinked gelatin hydrogel promotes cell survival and neural differentiation, enhances neurotrophins secretion from BMSC. BMSC-laden gelatin hydrogel implants significantly reduce damaged area, improve inflammation, attenuate neuronal apoptosis, promote endogenous neural cell survival and proliferation, and enhance neurological function recovery in TBI mice.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Development of dual crosslinked mumio-based hydrogel dressing for wound healing application: Physico-chemistry and antimicrobial activity

Oyunchimeg Zandraa et al.

Summary: An antimicrobial mumio-based hydrogel dressing was developed for wound healing, utilizing a double crosslink network between gelatin and polyvinyl alcohol for enhanced mechanical integrity. By adjusting PVA and BC ratios, the swelling and mechanical strength of the gel dressing can be controlled. Cell cytotoxicity testing confirmed the non-toxicity of the gel dressing on human cells.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Preparation and characterization of injectable self-antibacterial gelatin/ carrageenan/bacterial cellulose hydrogel scaffolds for wound healing application

Fahanwi Asabuwa Ngwabebhoh et al.

Summary: The study prepared injectable self-crosslinked Schiff base gels by blending gelatin and oxidized carrageenan gum with bacterial cellulose, loaded with bovine serum albumin. The gel scaffolds showed improved mechanical integrity and drug release properties, with potential applications in wound dressing and tissue regeneration. Additionally, the gel scaffolds exhibited antibacterial properties and cytocompatibility, making them promising candidates for biomedical applications.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Polymer Science

Shape memory polyacrylamide/gelatin hydrogel with controllable mechanical and drug release properties potential for wound dressing application

Weiwei Fan et al.

Summary: The study synthesized various shape memory PAM-Gels hydrogels with interpenetrating double networks, showing that the PAM-Gel5 hydrogel exhibited the most effective enhancements in physicochemical properties. It displayed well balanced mechanical properties and sustained drug release characteristics, making it a promising option for bio-compatible shape memory hydrogels in wound dressing applications.

POLYMER (2021)

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Article Chemistry, Applied

Borax mediated synthesis of a biocompatible self-healing hydrogel using dialdehyde carboxymethyl cellulose-dextrin and gelatin

Amit Kumar Sharma et al.

Summary: Self-healing hydrogels have high potential applications in the biomedical field. The use of imine bonds and hydrogen bonding in the prepared hydrogels provides self-healing ability and additional strength, with characteristics such as injectability and blood compatibility highlighting their biomedical importance.

REACTIVE & FUNCTIONAL POLYMERS (2021)

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Article Chemistry, Analytical

Liver-lobule-mimicking patterning via dielectrophoresis and hydrogel photopolymerization

Yu-Shih Chen et al.

Summary: A liver-lobule-mimicking labchip was developed to pattern and culture NIH/3T3 and C3A cells, maintaining high cell viability and biomimicking liver-lobule pattern under different GelMA culturing-microenvironments. Urea assays showed that cells cultured in 5% GelMA chamber had high activity and urea secretion levels, preserving the liver-lobule pattern effectively.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Polymer Science

Characterization of Gelatin and Hydrolysates from Valorization of Farmed Salmon Skin By-Products

Jose Antonio Vazquez et al.

Summary: The study proposes the extraction of gelatin from farmed salmon and further valorization of the remaining residue through hydrolysis. Different chemical treatments prior to thermal extraction yield a consistent 5% yield, but with considerable differences in rheological properties. These results indicate the potential for tuning salmon gelatin properties through changes in chemical treatment conditions.

POLYMERS (2021)

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Review Biotechnology & Applied Microbiology

Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

Caiping Yan et al.

Summary: Intervertebral disc degeneration (IDD) is a major cause of low back pain, with genetics, aging, and environmental factors playing a role. Hydrogels, with properties similar to the natural extracellular matrix, have shown promise in regenerative medicine for repairing and regenerating diseased intervertebral discs. Challenges and future developments in the use of hydrogels for IDD treatment are discussed for potential clinical translation.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Biotechnology & Applied Microbiology

Injectable stress relaxation gelatin-based hydrogels with positive surface charge for adsorption of aggrecan and facile cartilage tissue regeneration

Kai-Yang Wang et al.

Summary: The injectable modified gelatin hydrogel developed in this study effectively adsorbed proteoglycans secreted by chondrocytes and introduced dynamic covalent bonds, promoting chondrocyte survival and cartilage differentiation of stem cells. The modified hydrogel showed efficient biocompatibility and enhanced tissue repair of cartilage defects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Materials Science, Multidisciplinary

A multilayer biomimetic chitosan-gelatin-fluorohydroxyapatite cartilage scaffold using for regenerative medicine application

Yuan Cheng et al.

Summary: In this study, pure chitosan and gelatin solutions were blended with Fluorohydroxyapatite (FHA) at various ratios to produce porous scaffolds, which were analyzed using XRD and SEM. The specimen containing 70% chitosan and 30% gelatin showed the best morphological uniformity and in-vitro biocompatibility properties. Additionally, the mechanical properties were enhanced with the addition of 30 wt% FHA nanoparticles.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Article Biotechnology & Applied Microbiology

Fabrication and Characterization of Collagen/PVA Dual-Layer Membranes for Periodontal Bone Regeneration

Tian Zhou et al.

Summary: The developed Col/PVA dual-layer membrane shows promising mechanical and bioactive properties for promoting bone tissue regeneration, making it a potential solution for periodontal defect repair in clinical applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

A Radiation-Crosslinked Gelatin Hydrogel That Promotes Tissue Incorporation of an Expanded Polytetrafluoroethylene Vascular Graft in Rats

Sohei Matsuura et al.

Summary: The use of RXgel-coated vascular grafts can effectively promote tissue integration and healing, which is beneficial for preventing serious sequelae.

BIOMOLECULES (2021)

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Article Oncology

The effects of GelMA hydrogel on nerve repair and regeneration in mice with spinal cord injury

Hongcheng Zhang et al.

Summary: The use of GelMA hydrogel in treating spinal cord injury in mice resulted in enhanced nerve regeneration and recovery of movement function. Injection of GelMA hydrogel reduced the area of syringomyelia and inhibited scar formation, while also promoting axon growth through the regulation of specific proteins.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Materials Science, Biomaterials

3D bioprinting of conductive hydrogel for enhanced myogenic differentiation

Ying Wang et al.

Summary: The study demonstrates the fabrication of a conductive hydrogel scaffold using 3D bioprinting, incorporating PEDOT nanoparticles to enhance electrical conductivity and facilitate myogenic differentiation of C2C12 cells. The GelMA/PEDOT composite scaffolds showed favorable outcomes in terms of cell proliferation, migration, and differentiation, as confirmed by various in vitro investigations. Moreover, the effects of electrical signals on myogenic differentiation and myotube formation in vitro were also explored, showcasing the potential of conductive hydrogels for cell encapsulation and muscle tissue regeneration.

REGENERATIVE BIOMATERIALS (2021)

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Article Materials Science, Biomaterials

Gelatin methacrylate hydrogel scaffold carrying resveratrol-loaded solid lipid nanoparticles for enhancement of osteogenic differentiation of BMSCs and effective bone regeneration

Bangguo Wei et al.

Summary: This study developed an innovative bone engineering scaffold based on GelMA hydrogel loaded with Res-SLNs, which demonstrated improved osteogenic differentiation of BMSCs, particularly with the optimal 0.02 Res-SLNs/GelMA scaffold. The slow and steady release of Res from the scaffold showed potential for application in bone tissue engineering.

REGENERATIVE BIOMATERIALS (2021)

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Article Cell & Tissue Engineering

Matrilin3/TGFβ3 gelatin microparticles promote chondrogenesis, prevent hypertrophy, and induce paracrine release in MSC spheroid for disc regeneration

Alvin Bacero Bello et al.

Summary: Research findings suggest that injecting composite spheroids containing gelatin microparticles loaded with transforming growth factor beta 3 and matrilin 3 can promote chondrogenic differentiation of adipose-derived mesenchymal stem cell spheroids while preventing hypertrophy and terminal differentiation of cells. These composite spheroids induce the release of chondrogenic cytokines that promote regeneration of degenerative chondrocytes in vitro. Injection of these composite spheroids in a rat model of intervertebral disc disease restores chondrogenic properties of the cells and allows for regeneration of chondrogenic tissue in vivo.

NPJ REGENERATIVE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates

Divya Gupta et al.

Summary: The study compared the mechanical properties of gelatin-MTG hydrogels fabricated under different culture conditions, demonstrating their advantages as culture substrates for engineering relatively mature and stable muscle tissues.

BIOENGINEERING-BASEL (2021)

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Review Biotechnology & Applied Microbiology

Recent Advances in Natural Materials for Corneal Tissue Engineering

Julie F. Jameson et al.

Summary: Researchers are developing engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers due to the limited availability of healthy donors. The main goals are to optimize corneal graft properties, reduce complications, and improve outcomes in engineered tissue structures in the eye.

BIOENGINEERING-BASEL (2021)

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Article Biotechnology & Applied Microbiology

Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering

Darlin Lantigua et al.

Summary: This study investigated the osteoinductive capacity of GelMA hydrogels containing bone meal powder particles, showing promising potential for enhancing bone formation. The scaffold displayed enhanced mechanical performance and promoted the differentiation of pre-osteoblast cells in vitro, while also demonstrating promising biocompatibility and biodegradation properties in vivo. The physical and biological properties of this biomaterial can be tuned based on the concentration of bone meal powder in GelMA scaffolds, offering a new composite scaffold for bone tissue engineering.

BIOENGINEERING-BASEL (2021)

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Article Materials Science, Biomaterials

Mechanically robust hybrid hydrogels of photo-crosslinkable gelatin and laminin-mimetic peptide amphiphiles for neural induction

Melis Isik et al.

Summary: This study developed a hybrid neuro-instructive hydrogel with tunable stiffness and hierarchically ordered microstructures, capable of inducing stem cell differentiation and supporting neural cell repair. Metabolomics analysis revealed the hydrogel's influence on cellular metabolic pathways. This research advances a novel approach for nerve tissue regeneration.

BIOMATERIALS SCIENCE (2021)

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Article Pharmacology & Pharmacy

Gelatin hydrogel/contact lens composites as rutin delivery systems for promoting corneal wound healing

Lianghui Zhao et al.

Summary: A study developed a safe and effective method for treating corneal injury using rutin-encapsulated gelatin hydrogel/contact lens composites, showing potential therapeutic effects in vitro. In rabbit experiments, the use of these composites effectively promoted corneal wound healing, suggesting a potential intervention strategy for humans.

DRUG DELIVERY (2021)

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Article Nanoscience & Nanotechnology

Functionalization of an Electroactive Self-Healing Polypyrrole-Grafted Gelatin-Based Hydrogel by Incorporating a Polydopamine@AgNP Nanocomposite

Shen Wang et al.

Summary: This paper presents a gelatin-based hydrogel with self-healing ability, conductivity, and antibacterial and antioxidant activities, which has high water absorption and slightly higher conductivity than skin tissue for effectively transmitting bioelectric signals for skin regeneration. The hydrogel possesses self-healing ability and good blood compatibility and cytocompatibility, showing potential applications as wound dressings.

ACS APPLIED BIO MATERIALS (2021)

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Article Anatomy & Morphology

Fabrication and Characterization of Silk Fibroin-Based Nanofibrous Scaffolds Supplemented with Gelatin for Corneal Tissue Engineering

Ajay Kumar Sahi et al.

Summary: The study developed a silk-gelatin composite scaffold with properties similar to the cornea, demonstrating good transparency, stability, and cellular compatibility after treatment.

CELLS TISSUES ORGANS (2021)

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Article Engineering, Biomedical

A novel gelatin/chitooligosaccharide/demineralized bone matrix composite scaffold and periosteum-derived mesenchymal stem cells for bone tissue engineering

Thakoon Thitiset et al.

Summary: The novel biodegradable scaffold comprising gelatin (G), chitooligosaccharide (COS), and demineralized bone matrix (DBM) showed promising biological characteristics for bone tissue engineering both in vitro cell culture and in vivo animal bioassays.

BIOMATERIALS RESEARCH (2021)

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Article Engineering, Multidisciplinary

Preparation, Mechanical and Biological Properties of Inkjet Printed Alginate/Gelatin Hydrogel

Tian Jiao et al.

Summary: This study successfully developed a double crosslinked ink for printing mechanically reinforced biocompatible hydrogels, achieving optimal printability and mechanical properties by optimizing the components. The compressive modulus of the printed hydrogels could be adjusted by increasing the gelatin content, promoting cell proliferation.

JOURNAL OF BIONIC ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

3D Bioprinting of Reinforced Vessels by Dual-Cross-linked Biocompatible Hydrogels

Ke Peng et al.

Summary: The combination of photo-cross-linking and enzymatic cross-linking enables the fabrication of tubular structures in 3D bioprinting, showing great potential for biomedical applications, especially for artificial blood vessels.

ACS APPLIED BIO MATERIALS (2021)

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Proceedings Paper Materials Science, Multidisciplinary

A review of gelatin: Properties, sources, process, applications, and commercialisation

J. Alipal et al.

Summary: This paper primarily discusses the properties, sources, and market status of gelatin, analyzing the commercialization process and traditional production methods and modern processing methods. It also mentions the impact of plant alternatives on the gelatin market, as well as recent research on market trends.

MATERIALS TODAY-PROCEEDINGS (2021)

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Review Cell & Tissue Engineering

Biomaterials for corneal endothelial cell culture and tissue engineering

Mohit Parekh et al.

Summary: The corneal endothelium plays a crucial role in maintaining corneal transparency, and its non-regenerative nature necessitates the need for corneal transplants. With limited availability of corneal donor tissues globally, researchers are exploring the cultivation of human corneal endothelial cells in vitro and investigating potential biomaterials for tissue engineering applications.

JOURNAL OF TISSUE ENGINEERING (2021)

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Article Materials Science, Biomaterials

3D bioprinting of a stem cell-laden, multi-material tubular composite: An approach for spinal cord repair

Omar A. Hamid et al.

Summary: The study developed a complex tubular scaffold using 3D printing technology to support neural differentiation and patterning of pluripotent stem cells. By controlling protein concentration and promoting neuronal development, the scaffold showed strong support and high porosity, serving as a promising tool in regenerative medicine.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury

Minghao Yao et al.

Summary: The study demonstrated the beneficial effects of using a dual-enzymatically cross-linked gelatin hydrogel combined with MSCs for promoting neural repair post-SCI. In both in vitro experiments and a clinically-relevant mouse model, the combination of hydrogel and MSCs led to decreased inflammation, promoted neurogenesis, and improved motor function recovery. The findings suggest that implantation of the designed hydrogel is a promising therapeutic strategy for treating SCI.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Polymer Science

The potential use of cross-linked alginate/gelatin hydrogels containing silver nanoparticles for wound dressing applications

Jeeraporn Baukum et al.

POLYMER BULLETIN (2020)

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Article Engineering, Biomedical

Glucosamine-grafted methacrylated gelatin hydrogels as potential biomaterials for cartilage repair

Hairui Suo et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

In situ formation of silver nanoparticles-contained gelatin-PEG-dopamine hydrogels via enzymatic cross-linking reaction for improved antibacterial activities

Thi-Ngoc Pham et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Clinical Neurology

Bioadhesives in neurosurgery: a review

Liming Qiu et al.

JOURNAL OF NEUROSURGERY (2020)

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Article Chemistry, Multidisciplinary

Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus

Wei Chen et al.

ADVANCED SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Uniaxial Stretching of Cell-Laden Microfibers for Promoting C2C12 Myoblasts Alignment and Myofibers Formation

Xiaoxiao Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Self-Healing and Highly Stretchable Gelatin Hydrogel for Self-Powered Strain Sensor

Jie Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Stem Cell Mechanosensation on Gelatin Methacryloyl (GelMA) Stiffness Gradient Hydrogels

Claire Kim et al.

ANNALS OF BIOMEDICAL ENGINEERING (2020)

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A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function

Chongyu Zhang et al.

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Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation

Onur Hasturk et al.

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Self-healing gelatin-based shape memory hydrogels via quadruple hydrogen bonding and coordination crosslinking for controlled delivery of 5-fluorouracil

Yuande Xu et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2020)

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Self-healing injectable gelatin hydrogels for localized therapeutic cell delivery

Arbel M. Sisso et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Gelatin/Montmorillonite and Gelatin/Polyvinyl Alcohol/Montmorillonite Bionanocomposite Hydrogels: Microstructural, Swelling and Drying Properties

Amin Zeinali et al.

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Free radical synthesis of cross-linking gelatin base poly NVP/acrylic acid hydrogel and nanoclay hydrogel as cephalexin drug deliver

Amir Hajikarimi et al.

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A Spray-Filming Self-Healing Hydrogel Fabricated from Modified Sodium Alginate and Gelatin as a Bacterial Barrier

Yan Du et al.

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Microchannel network hydrogel induced ischemic blood perfusion connection

Jung Bok Lee et al.

NATURE COMMUNICATIONS (2020)

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Gelatin Templated Polypeptide Co-Cross-Linked Hydrogel for Bone Regeneration

Yusen Qiao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Integrin α4 mediates ATDC5 cell adhesion to negatively charged synthetic polymer hydrogel leading to chondrogenic differentiation

Daiki Hashimoto et al.

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A well defect-suitable and high-strength biomimetic squid type II gelatin hydrogel promoted in situ costal cartilage regeneration via dynamic immunomodulation and direct induction manners

Meilu Dai et al.

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Thermo/photo dual-crosslinking chitosan-gelatin methacrylate hydrogel with controlled shrinking property for contraction fabrication

Xin Luo et al.

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Hydrophobically-modified gelatin hydrogel as a carrier for charged hydrophilic drugs and hydrophobic drugs

Takayuki Takei et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma

Bin Kong et al.

NATURE COMMUNICATIONS (2020)

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3D printing of hydrogels: Rational design strategies and emerging biomedical applications

Jinhua Li et al.

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Structure and Function of Human Matrix Metalloproteinases

Helena Laronha et al.

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Gelatin Nanoparticles-HPMC Hybrid System for Effective Ocular Topical Administration of Antihypertensive Agents

Sergio Esteban-Perez et al.

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Biomimetic hydrogels based on L-Dopa conjugated gelatin as pH-responsive drug carriers and antimicrobial agents

Thi-Ngoc Pham et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection Ablation

Juliana S. Ribeiro et al.

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Extraction and characterization of gelatin from camel skin (potential halal gelatin) and production of gelatin nanoparticles

Mohammed Asif Ahmed et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Enzyme-Cross-linked Gelatin Hydrogel Enriched with an Articular Cartilage Extracellular Matrix and Human Adipose-Derived Stem Cells for Hyaline Cartilage Regeneration of Rabbits

Ching-Cheng Tsai et al.

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A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-beta 1 release system

Teruki Nii et al.

REGENERATIVE THERAPY (2020)

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Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering

Pilar Montero et al.

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Ultrafast and Programmable Shape Memory Hydrogel of Gelatin Soaked in Tannic Acid Solution

Shurui Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels

Pelin Erkoc et al.

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A New Method of Gelatin Modified Collagen and Viscoelastic Study of Gelatin-Collagen Composite Hydrogel

Lang He et al.

MACROMOLECULAR RESEARCH (2020)

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Self-assembled dodecyl group-modified gelatin microparticle-based hydrogels with angiogenic properties

Yosuke Mizuno et al.

NPG ASIA MATERIALS (2020)

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Pulp regeneration with hemostatic matrices as a scaffold in an immature tooth minipig model

Ji-Hyun Jang et al.

SCIENTIFIC REPORTS (2020)

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Physically Crosslinked Hydrogels Based on Poly (Vinyl Alcohol) and Fish Gelatin for Wound Dressing Application: Fabrication and Characterization

Teng Ren et al.

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Fe (III)@TA@IGF-2 microspheres loaded hydrogel for liver injury treatment

Jie Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Effect of gelatin on dimensional stability of silk fibroin hydrogel structures fabricated by digital light processing 3D printing

Hyunji Lee et al.

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Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels

Ashlyn T. Young et al.

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Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair

Yinji Jin et al.

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Dual source co-electrospun tubular scaffold generated from gelatin-vinyl acetate and poly-ε-caprolactone for smooth muscle cell mediated blood vessel engineering

Neelima Thottappillil et al.

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Carbon Dot Cross-Linked Gelatin Nanocomposite Hydrogel for pH-Sensing and pH-Responsive Drug Delivery

Swarup Krishna Bhattacharyya et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Self-contracting oxidized starch/gelatin hydrogel for noninvasive wound closure and wound healing

Qin Mao et al.

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Development of an oxygen-releasing electroconductive in-situ crosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applications

Sara Nejati et al.

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Enzyme-Crosslinked Gelatin Hydrogel with Adipose-Derived Stem Cell Spheroid Facilitating Wound Repair in the Murine Burn Model

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Tubular Silk Fibroin/Gelatin-Tyramine Hydrogel with Controllable Layer Structure and Its Potential Application for Tissue Engineering

Sheng Xu et al.

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Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques

Margaux Vigata et al.

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Recent Development in Therapeutic Cardiac Patches

Xuan Mei et al.

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Tunable physical and mechanical properties of gelatin hydrogel after transglutaminase crosslinking on two gelatin types

Yexue Liu et al.

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Enzymatically crosslinked gelatin-laminin hydrogels for applications in neuromuscular tissue engineering

Rachel R. Besser et al.

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3D printing and characterization of human nasoseptal chondrocytes laden dual crosslinked oxidized alginate-gelatin hydrogels for cartilage repair approaches

Silke Schwarz et al.

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Preparation of gelatin/poly (γ-glutamic acid) hydrogels with stimulated response by hot-pressing preassembly and radiation crosslinking

Bo Liu et al.

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Developing super tough gelatin-based hydrogels by incorporating linear poly(methacrylic acid) to facilitate sacrificial hydrogen bonding

Hui Jie Zhang et al.

SOFT MATTER (2020)

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Fabrication of Polypyrrole-Grafted Gelatin-Based Hydrogel with Conductive, Self-Healing, and Injectable Properties

Shen Wang et al.

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Regenerative Effects and Development Patterns of Solid Neural Tissue Grafts Located in Gelatin Hydrogel Conduit for Treatment of Peripheral Nerve Injury

Kirill K. Sukhinich et al.

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN (2020)

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A terpolymeric hydrogel of hyaluronate-hydroxyethyl acrylate-gelatin methacryloyl with tunable properties as biomaterial

Dipankar Das et al.

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Development of a gelatin-g-poly(acrylic acid-co-acrylamide)-montmorillonite superabsorbent hydrogels for in vitro controlled release of vitamin B12

Jayashree Nath et al.

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Photo-crosslinked gelatin-hyaluronic acid methacrylate hydrogel-committed nucleus pulposus-like differentiation of adipose stromal cells for intervertebral disc repair

Pengfei Chen et al.

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Stretchable gelatin/silver nanowires composite hydrogels for detecting human motion

Xin Jing et al.

MATERIALS LETTERS (2019)

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Gelatin-Based Hydrogels through Homobifunctional Triazolinediones Targeting Tyrosine Residues

Roberto Guizzardi et al.

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Prevention of tooth extraction-triggered bisphosphonate-related osteonecrosis of the jaws with basic fibroblast growth factor: An experimental study in rats

Mitsuhiko Imada et al.

PLOS ONE (2019)

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Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes

Janne T. Koivisto et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats

Xiao-Tao He et al.

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Growth factor delivery: Defining the next generation platforms for tissue engineering

Lilith M. Caballero Aguilar et al.

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Enhanced osteogenic healing process of rat tooth sockets using a novel simvastatin-loaded injectable microsphere-hydrogel system

Xiangwei Li et al.

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Multipotency expression of human adipose stem cells in filament-like alginate and gelatin derivative hydrogel fabricated through visible light-initiated crosslinking

Mehdi Khanmohammadi et al.

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Multicellular Co-Culture in Three-Dimensional Gelatin Methacryloyl Hydrogels for Liver Tissue Engineering

Juan Cui et al.

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Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers

Youngjoo Choi et al.

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Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules

Jianbin Xu et al.

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Pullulan dialdehyde crosslinked gelatin hydrogels with high strength for biomedical applications

Liru Zhang et al.

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Alginate/gelatin blended hydrogel fibers cross-linked by Ca2+ and oxidized starch: Preparation and properties

Quan-Quan Wang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Synthesis of poly(acrylic acid)-Fe3+/gelatin/poly(vinyl alcohol) triple-network supramolecular hydrogels with high toughness, high strength and self-healing properties

Zhanxin Jing et al.

POLYMER INTERNATIONAL (2019)

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Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds

Fei Gao et al.

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Development of chitosan/gelatin hydrogels incorporation of biphasic calcium phosphate nanoparticles for bone tissue engineering

Lei Nie et al.

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Methacrylated gelatin hydrogels as corneal stroma substitutes: in vivo study

Cemile Kilic Bektas et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2019)

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Fabrication and characterization of microwave assisted carboxymethyl cellulose-gelatin silver nanoparticles imbibed hydrogel: Its evaluation as dye degradation

Sapna Sethi et al.

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A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues

Barbara J. Klotz et al.

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Tailoring swelling of alginate-gelatin hydrogel microspheres by crosslinking with calcium chloride combined with transglutaminase

Nadezhda Pilipenko et al.

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Physicochemical and Biological Properties of Gelatin Extracted from Marine Snail Rapana venosa

Alexandra Gaspar-Pintiliescu et al.

MARINE DRUGS (2019)

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An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin

Xiaowei Xu et al.

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Cross-Linking Strategies for Electrospun Gelatin Scaffolds

Chiara Emma Campiglio et al.

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Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Somasundar Mantha et al.

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Tailoring Cod Gelatin Structure and Physical Properties with Acid and Alkaline Extraction

Svetlana R. Derkach et al.

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Double-Network Physical Cross-Linking Strategy To Promote Bulk Mechanical and Surface Adhesive Properties of Hydrogels

Li Tang et al.

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Mimicked hybrid hydrogel based on gelatin/PVA for tissue engineering in subchondral bone interface for osteoarthritis surgery

Atsadaporn Thangprasert et al.

MATERIALS & DESIGN (2019)

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Bioactivation Routes of Gelatin-Based Scaffolds to Enhance at Nanoscale Level Bone Tissue Regeneration

Maria Grazia Raucci et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Advances in crosslinking strategies of biomedical hydrogels

Weikang Hu et al.

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Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Samson Afewerki et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

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A dual-enzymatically cross-linked injectable gelatin hydrogel loaded with BMSC improves neurological function recovery of traumatic brain injury in rats

Minghao Yao et al.

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Poly(ethylene-co-propylene)/poly(ethylene glycol) elastomeric hydrogels with thermoreversibly cross-linked networks

Zongke He et al.

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Quadruple hydrogen bonds and thermo-triggered hydrophobic interactions generate dynamic hydrogels to modulate transplanted cell retention

Sa Liu et al.

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Dual Cross-Link Networks To Preserve Physical Interactions Induced by Soaking Methods: Developing a Strong and Biocompatible Protein-Based Hydrogel

Qingyan He et al.

ACS APPLIED BIO MATERIALS (2019)

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Stiffness of thermoresponsive gelatin-based dynamic hydrogels affects fibroblast activation

M. Mario Perera et al.

POLYMER CHEMISTRY (2019)

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Magnetically responsive gels based on crosslinked gelatin: An overview on the synthesis, properties, and their potential in water remediation

Maria Fernanda Horst et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2018)

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Preparation of a Strong Gelatin-Short Linear Glucan Nanocomposite Hydrogel by an in Situ Self-Assembly Process

Shengju Ge et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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The Formation Mechanism of Hydrogels

Liyan Lu et al.

CURRENT STEM CELL RESEARCH & THERAPY (2018)

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Magnetically responsive gels based on crosslinked gelatin: An overview on the synthesis, properties, and their potential in water remediation

Maria Fernanda Horst et al.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2018)

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Gelatin-Based Photocurable Hydrogels for Corneal Wound Repair

Lingli Li et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Synthesis of gelatin-based biodegradable hydrogel nanocomposite and their application as drug delivery agent

Asghar Bakravi et al.

ADVANCES IN POLYMER TECHNOLOGY (2018)

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Hydrogen bonds autonomously powered gelatin methacrylate hydrogels with super-elasticity, self-heal and underwater self-adhesion for sutureless skin and stomach surgery and E-skin

Bingcheng Liu et al.

BIOMATERIALS (2018)

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Bioprinted gelatin hydrogel platform promotes smooth muscle cell contractile phenotype maintenance

Ajay Tijore et al.

BIOMEDICAL MICRODEVICES (2018)

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One-pot construction of cellulose-gelatin supramolecular hydrogels with high strength and pH-responsive properties

Qilin Lu et al.

CARBOHYDRATE POLYMERS (2018)

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Mechanical properties of gelatin/polyacrylamide/graphene oxide nanocomposite double-network hydrogels

Xiaoqiang Yan et al.

COMPOSITES SCIENCE AND TECHNOLOGY (2018)

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Gelatin-genipin-based biomaterials for skeletal muscle tissue engineering

Francesca Gattazzo et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2018)

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Radiation Crosslinking of Modifying Super Absorbent (Polyacrylamide/Gelatin) Hydrogel as Fertilizers Carrier and Soil Conditioner

Mohamed Mohamady Ghobashy et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2018)

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Mechanical behaviour of alginate-gelatin hydrogels for 3D bioprinting

Michael Di Giuseppe et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2018)

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Interpenetrating polymer network hydrogels composed of chitosan and photocrosslinkable gelatin with enhanced mechanical properties for tissue engineering

Hairui Suo et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Tailoring the mechanical properties of gelatin methacryloyl hydrogels through manipulation of the photocrosslinking conditions

Cathal D. O'Connell et al.

SOFT MATTER (2018)

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Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel

Ke-Hung Chien et al.

SCIENTIFIC REPORTS (2018)

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Assessment of the characteristics and biocompatibility of gelatin sponge scaffolds prepared by various crosslinking methods

Gang Yang et al.

SCIENTIFIC REPORTS (2018)

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3D Porous Gelatin/PVA Hydrogel as Meniscus Substitute Using Alginate Micro-Particles as Porogens

Alessandra Marrella et al.

POLYMERS (2018)

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Intervertebral disc needle puncture injury can be repaired using a gelatin-poly (gamma-glutamic acid) hydrogel: an in vitro bovine biomechanical validation

Jui-Jung Yang et al.

EUROPEAN SPINE JOURNAL (2018)

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Preclinical alveolar ridge preservation using small-sized particles of bone replacement graft in combination with a gelatin cryogel scaffold

Po-Chun Chang et al.

JOURNAL OF PERIODONTOLOGY (2018)

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Enhanced skeletal muscle formation on microfluidic spun gelatin methacryloyl (GelMA) fibres using surface patterning and agrin treatment

Majid Ebrahimi et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Composite Biomaterials as Long-Lasting Scaffolds for 3D Bioprinting of Highly Aligned Muscle Tissue

Andrea Garcia-Lizarribar et al.

MACROMOLECULAR BIOSCIENCE (2018)

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Gamma Irradiation-Assisted Synthesis of Cellulose Nanocrystal-Reinforced Gelatin Hydrogels

Wan Hafizi Wan Ishak et al.

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Gelatin Hydrogel Combined with Polydopamine Coating To Enhance Tissue Integration of Medical Implants

Thanh N. Dinh et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

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Development of pH-sensitive and antibacterial gelatin/citric acid/Ag nanocomposite hydrogels with potential for biomedical applications

Nima Shafagh et al.

JOURNAL OF POLYMER RESEARCH (2018)

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Injectable polyphosphazene/gelatin hybrid hydrogel for biomedical applications

Zhaohui Huang et al.

MATERIALS & DESIGN (2018)

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Injectable Macroporous Hydrogel Formed by Enzymatic Cross-Linking of Gelatin Microgels

Shujie Hou et al.

ACS APPLIED BIO MATERIALS (2018)

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Photocrosslinkable Gelatin Hydrogels Modulate the Production of the Major Pro-inflammatory Cytokine, TNF-α, by Human Mononuclear Cells

Amy R. Donaldson et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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One-pot solvent exchange preparation of non-swellable, thermoplastic, stretchable and adhesive supramolecular hydrogels based on dual synergistic physical crosslinking

Qian Feng et al.

NPG ASIA MATERIALS (2018)

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Hofmeister Effect-Assisted One Step Fabrication of Ductile and Strong Gelatin Hydrogels

Qingyan He et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Contact guidance for cardiac tissue engineering using 3D bioprinted gelatin patterned hydrogel

Ajay Tijore et al.

BIOFABRICATION (2018)

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Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects

Jose R. Perez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Synthesis and characterization of graphene-grafted gelatin nanocomposite hydrogels as emerging drug delivery systems

Amir Hossein Zeinali Kalkhoran et al.

BIOMEDICAL PHYSICS & ENGINEERING EXPRESS (2018)

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Mechanical properties and biocompatibility of in situ enzymatically cross-linked gelatin hydrogels

Nada Z. Alarake et al.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2017)

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Injectable hydrogel based on quaternized chitosan, gelatin and dopamine as localized drug delivery system to treat Parkinson's disease

Yizhuo Ren et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Injectable photo crosslinked enhanced double-network hydrogels from modified sodium alginate and gelatin

Liu Yuan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Current advances in electrospun gelatin-based scaffolds for tissue engineering applications

Ana A. Aldana et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Regulation of the fate of dental-derived mesenchymal stem cells using engineered alginate-GelMA hydrogels

Sahar Ansari et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2017)

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Characteristics and gelling properties of gelatin from goat skin as affected by drying methods

Sulaiman Mad-Ali et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2017)

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Gelatin and Non-Gelatin Capsule Dosage Forms

Rampurna P. Gullapalli et al.

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Tightening of gelatin chemically crosslinked networks assisted by physical gelation

Marcelo A. da Silva et al.

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (2017)

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Article Polymer Science

Self-Healing Gelatin Hydrogels Cross-Linked by Combining Multiple Hydrogen Bonding and Ionic Coordination

Guangzhao Zhang et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2017)

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Article Materials Science, Biomaterials

Engineered 3D-scaffolds of photocrosslinked chitosan-gelatin hydrogel hybrids for chronic wound dressings and regeneration

Isadora C. Carvalho et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Materials Science, Biomaterials

Injectable natural polymer compound for tissue engineering of intervertebral disc: In vitro study

Masoud Ghorbani et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Chemistry, Physical

Influence of high energy electron irradiation on the network structure of gelatin hydrogels as investigated by small-angle X-ray scattering (SAXS)

Emilia I. Wisotzki et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2017)

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Article Chemistry, Multidisciplinary

Reverse thermo-responsive hydrogels prepared from Pluronic F127 and gelatin composite materials

Mei-Yu Yeh et al.

RSC ADVANCES (2017)

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Article Chemistry, Multidisciplinary

Oxidized cyclodextrin-functionalized injectable gelatin hydrogels as a new platform for tissue-adhesive hydrophobic drug delivery

Thai Thanh Hoang Thi et al.

RSC ADVANCES (2017)

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Article Medicine, Research & Experimental

The Anti-Tumor Effects of M1 Macrophage-Loaded Poly (ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma

Alberto Daniel Guerra et al.

THERANOSTICS (2017)

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Review Materials Science, Multidisciplinary

Gelatin-based hydrogels for biomedical applications

Panupong Jaipan et al.

MRS COMMUNICATIONS (2017)

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Review Polymer Science

Gelatin-Based Hydrogels for Organ 3D Bioprinting

Xiaohong Wang et al.

POLYMERS (2017)

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Article Materials Science, Biomaterials

A thermally and water activated shape memory gelatin physical hydrogel, with a gel point above the physiological temperature, for biomedical applications

R. Zamani Alavijeh et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Materials Science, Biomaterials

In situ forming gelatin hydrogels by dual-enzymatic cross-linking for enhanced tissue adhesiveness

Phuong Le Thi et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Materials Science, Biomaterials

High strength and self-healable gelatin/polyacrylamide double network hydrogels

Xiaoqiang Yan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Review Chemistry, Multidisciplinary

Gelatin nanoparticles: a potential candidate for medical applications

Rehana Yasmin et al.

NANOTECHNOLOGY REVIEWS (2017)

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Article Materials Science, Biomaterials

Bioprinting-Based PDLSC-ECM Screening for in Vivo Repair of Alveolar Bone Defect Using Cell-Laden, Injectable and Photocrosslinkable Hydrogels

Yufei Ma et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Article Materials Science, Biomaterials

Bioprinting-Based PDLSC-ECM Screening for in Vivo Repair of Alveolar Bone Defect Using Cell-Laden, Injectable and Photocrosslinkable Hydrogels

Yufei Ma et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2017)

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Review Pharmacology & Pharmacy

Cross-Linked Hydrogel for Pharmaceutical Applications: A Review

Rabinarayan Parhi

ADVANCED PHARMACEUTICAL BULLETIN (2017)

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Article Engineering, Biomedical

Tissue-specific extracellular matrix promotes myogenic differentiation of human muscle progenitor cells on gelatin and heparin conjugated alginate hydrogels

Hualin Yi et al.

ACTA BIOMATERIALIA (2017)

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Article Chemistry, Applied

Rapid shape memory TEMPO-oxidized cellulose nanofibers/polyacrylamide/gelatin hydrogels with enhanced mechanical strength

Nan Li et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Applied

High strength, biocompatible hydrogels with designable shapes and special hollow-formed character using chitosan and gelatin

Shuiping Wu et al.

CARBOHYDRATE POLYMERS (2017)

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Article Biochemical Research Methods

Bioprinted 3D vascularized tissue model for drug toxicity analysis

Solange Massa et al.

BIOMICROFLUIDICS (2017)

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Article Otorhinolaryngology

Drug delivery system of basic fibroblast growth factor using gelatin hydrogel for restoration of acute vocal fold scar

Toshiki Kobayashi et al.

AURIS NASUS LARYNX (2017)

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Review Polymer Science

Hydrogels for Biomedical Applications: Their Characteristics and the Mechanisms behind Them

Qinyuan Chai et al.

GELS (2017)

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Review Polymer Science

A Review: Tailor-made Hydrogel Structures(Classifications and Synthesis Parameters)

Reena Singhal et al.

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING (2016)

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Article Biochemistry & Molecular Biology

Synthetic Biodegradable Hydrogels with Excellent Mechanical Properties and Good Cell Adhesion Characteristics Obtained by the Combinatorial Synthesis of Photo-Cross-Linked Networks

Erwin Zant et al.

BIOMACROMOLECULES (2016)

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Article Pharmacology & Pharmacy

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro

Monika Dubiak-Szepietowska et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)

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Article Materials Science, Biomaterials

Biomimetic gelatin methacrylamide hydrogel scaffolds for bone tissue engineering

Xingxing Fang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Article Multidisciplinary Sciences

Structural insight for chain selection and stagger control in collagen

Sergei P. Boudko et al.

SCIENTIFIC REPORTS (2016)

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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

Kan Yue et al.

BIOMATERIALS (2015)

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Review Polymer Science

Biomedical applications of hydrogels: A review of patents and commercial products

Enrica Calo et al.

EUROPEAN POLYMER JOURNAL (2015)

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Article Engineering, Biomedical

Influence of 3D porous galactose containing PVA/gelatin hydrogel scaffolds on three-dimensional spheroidal morphology of hepatocytes

Kirthanashri S. Vasanthan et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2015)

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Article Cell & Tissue Engineering

Extracellular-Matrix-Based and Arg-Gly-Asp-Modified Photopolymerizing Hydrogels for Cartilage Tissue Engineering

Hwan D. Kim et al.

TISSUE ENGINEERING PART A (2015)

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Review Food Science & Technology

Collagen and Gelatin

Dasong Liu et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6 (2015)

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Article Materials Science, Biomaterials

Development of a hybrid gelatin hydrogel platform for tissue engineering and protein delivery applications

Xiaodi Sun et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

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Review Multidisciplinary Sciences

Hydrogel: Preparation, characterization, and applications: A review

Enas M. Ahmed

JOURNAL OF ADVANCED RESEARCH (2015)

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Article Multidisciplinary Sciences

Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction

Kazuaki Nakajima et al.

PLOS ONE (2015)

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Article Engineering, Biomedical

Poly(vinyl alcohol)/gelatin Hydrogels Cultured with HepG2 Cells as a 3D Model of Hepatocellular Carcinoma: A Morphological Study

Stefania Moscato et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2015)

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Article Nanoscience & Nanotechnology

Grafting of Cross-Linked Hydrogel Networks to Titanium Surfaces

Beinn V. O. Muir et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

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Synthesis and Characterization of Gelatin-Based Magnetic Hydrogels

Maria Helminger et al.

ADVANCED FUNCTIONAL MATERIALS (2014)

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Article Clinical Neurology

In vivo biofunctional evaluation of hydrogels for disc regeneration

Sandra Reitmaier et al.

EUROPEAN SPINE JOURNAL (2014)

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Article Multidisciplinary Sciences

Evaluation of Fibroblasts Adhesion and Proliferation on Alginate-Gelatin Crosslinked Hydrogel

Bapi Sarker et al.

PLOS ONE (2014)

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Increasing Mechanical Strength of Gelatin Hydrogels by Divalent Metal Ion Removal

Qi Xing et al.

SCIENTIFIC REPORTS (2014)

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Article Biotechnology & Applied Microbiology

Preparation and Characterization of Gelatin-Based Mucoadhesive Nanocomposites as Intravesical Gene Delivery Scaffolds

Ching-Wen Liu et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Pharmacology & Pharmacy

Chemically cross-linked and grafted cyclodextrin hydrogels: From nanostructures to drug-eluting medical devices

Angel Concheiro et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

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Article Chemistry, Applied

Physically crosslinked hydrogels from polysaccharides prepared by freeze-thaw technique

Hongbin Zhang et al.

REACTIVE & FUNCTIONAL POLYMERS (2013)

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Article Biotechnology & Applied Microbiology

Cell adhesion and proliferation enhancement by gelatin nanofiber scaffolds

Shih-Ching Wu et al.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS (2011)

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Article Engineering, Biomedical

Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use

Jui-Yang Lai

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2010)

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Review Pharmacology & Pharmacy

Hydrogels for biomedical applications

AS Hoffman

ADVANCED DRUG DELIVERY REVIEWS (2002)

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Article Biochemistry & Molecular Biology

Structural and rheological properties of methacrylamide modified gelatin hydrogels

AI Van den Bulcke et al.

BIOMACROMOLECULES (2000)

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