Related references
Note: Only part of the references are listed.Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice
Stephanie A. Renna et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)
The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population
Maria Selvadurai et al.
THROMBOSIS AND HAEMOSTASIS (2022)
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis
Bhanu Kanth Manne et al.
BLOOD (2022)
Treatments in Ischemic Stroke: Current and Future
Maria Giulia Mosconi et al.
EUROPEAN NEUROLOGY (2022)
Stroke genetics informs drug discovery and risk prediction across ancestries
Aniket Mishra et al.
NATURE (2022)
Neutrophil extracellular traps regulate ischemic stroke brain injury
Frederik Denorme et al.
JOURNAL OF CLINICAL INVESTIGATION (2022)
Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake
Frederik Denorme et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)
Genetic and Genomic Epidemiology of Stroke in People of African Ancestry
Savvina Prapiadou et al.
GENES (2021)
Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies
Nicole D. Armstrong et al.
FRONTIERS IN GENETICS (2021)
Brothers in arms: platelets and neutrophils in ischemic stroke
Frederik Denorme et al.
CURRENT OPINION IN HEMATOLOGY (2021)
US racial and ethnic participation in global clinical trials by therapeutic areas
Milena Lolic et al.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2021)
Stroke in Africa: profile, progress, prospects and priorities
Rufus O. Akinyemi et al.
NATURE REVIEWS NEUROLOGY (2021)
Benefits and Risks of Dual Versus Single Antiplatelet Therapy for Secondary Stroke Prevention: A Systematic Review for the 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Devin L. Brown et al.
STROKE (2021)
Platelet necrosis mediates ischemic stroke outcome in mice
Frederik Denorme et al.
BLOOD (2020)
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Theo Vos et al.
LANCET (2020)
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation
Elena Y. Senchenkova et al.
CIRCULATION (2019)
Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions
Rachel A. Rigg et al.
PLATELETS (2019)
Protease-activated receptor-mediated platelet aggregation in acute coronary syndrome patients on potent P2Y12 inhibitors
Patricia P. Wadowski et al.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2019)
Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors
Hiromi Miura et al.
NATURE PROTOCOLS (2018)
Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics
Benjamin E. Tourdot et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial
Pierluigi Tricoci et al.
BLOOD CELLS MOLECULES AND DISEASES (2018)
Thromboinflammatory Functions of Platelets in Ischemia-Reperfusion Injury and Its Dysregulation in Diabetes
Sophie Maiocchi et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2018)
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y(12) inhibition
M. J. Whitley et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)
A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant
Shauna L. French et al.
BLOOD ADVANCES (2018)
Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials
Joseph P. Broderick et al.
STROKE (2017)
Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes
Ashley M. Jacobi et al.
METHODS (2017)
Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease
K. I. Ataga et al.
NEW ENGLAND JOURNAL OF MEDICINE (2017)
Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia
Yuping Yuan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding
Pancras C. Wong et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Procoagulant platelets: generation, function, and therapeutic targeting in thrombosis
Ejaife O. Agbani et al.
BLOOD (2017)
Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins
Rolen M. Quadros et al.
GENOME BIOLOGY (2017)
Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice
Carsten Deppermann et al.
BLOOD (2017)
Stroke Risk Factors, Genetics, and Prevention
Amelia K. Boehme et al.
CIRCULATION RESEARCH (2017)
Protease receptor antagonism to target blood platelet therapies
M. Holinstat et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular Research
Joseph M. Miano et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood
S. L. French et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study
Jonathan Rosand et al.
LANCET NEUROLOGY (2016)
Pretreatment with rivaroxaban attenuates stroke severity in rats by a dual antithrombotic and anti-inflammatory mechanism
Melanie Dittmeier et al.
THROMBOSIS AND HAEMOSTASIS (2016)
Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets
Shauna L. French et al.
PLOS ONE (2016)
Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race
Leonard C. Edelstein et al.
BLOOD (2014)
Proteasome function is required for platelet production
Dallas S. Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Platelet Specific Promoters Are Insufficient to Express Protease Activated Receptor 1 (PAR1) Transgene in Mouse Platelets
Amal Arachiche et al.
PLOS ONE (2014)
Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Walter N. Kernan et al.
STROKE (2014)
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
Leonard C. Edelstein et al.
NATURE MEDICINE (2013)
Protease-Activated Receptor (PAR) 1 and PAR4 Differentially Regulate Factor V Expression from Human Platelets
Matthew Duvernay et al.
MOLECULAR PHARMACOLOGY (2013)
Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia
Bo Chen et al.
JOURNAL OF NEUROSCIENCE (2012)
Disparities in Stroke Incidence Contributing to Disparities in Stroke Mortality
Virginia J. Howard et al.
ANNALS OF NEUROLOGY (2011)
P-Selectin-Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease
Renata Polanowska-Grabowska et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)
Parental Occurrence of Stroke and Risk of Stroke in Their Children The Framingham Study
Sudha Seshadri et al.
CIRCULATION (2010)
Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice
Yingying Mao et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2010)
A Gi-independent mechanism mediating Akt phosphorylation in platelets
B. Xiang et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Targeting platelets in acute experimental stroke - Impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
Christoph Kleinschnitz et al.
CIRCULATION (2007)
The unchanging incidence and case-fatality of stroke in the 1990s - A population-based study
Dawn Kleindorfer et al.
STROKE (2006)
The reasons for geographic and racial differences in stroke study: Objectives and design
VJ Howard et al.
NEUROEPIDEMIOLOGY (2005)
Stroke in a Biracial Population - The excess burden of stroke among blacks
B Kissela et al.
STROKE (2004)
Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
M Ishikawa et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)
Characterization of thrombin-induced leukocyte rolling and adherence: A potential proinflammatory role for proteinase-activated receptor-4
N Vergnolle et al.
JOURNAL OF IMMUNOLOGY (2002)