Bioparameter-directed nanoformulations as MRI CAs enable the specific visualization of hypoxic tumour

A malignant tumour has hypoxic cells of varying degrees. The more severe the hypoxic degree, the more difficult the prognosis of the tumour and the higher the recurrence rate. Therefore, tumour hypoxia imaging is crucial. Magnetic resonance imaging (MRI) shows its strength in high resolution, depth of penetration and noninvasiveness. However, it needs more excellent contrast agents (CAs) to combat the complex tumour microenvironment (TME) and increased targeting of tumours to enhance clinical safety. Many research studies have focused on developing hypoxia-responsive MRI CAs that take advantage of the unique characteristics of hypoxic tumours. The low oxygen pressure, acidic TME, and up-regulated redox molecule levels found in hypoxic tumours serve as biological stimuli for nanoformulations that can accurately image the hypoxic region. This review highlights the importance of developing bioparameter-directed nanoformulations as MRI CAs for accurate tumour diagnosis. The design strategies and mechanisms of tumour-hypoxia imaging with nanoformulations are exemplified, with a focus on pH-responsiveness, redox-responsiveness, and p(O2)-responsiveness. The promising future of bioparameter-responsive nanoformulations for accurate tumour diagnosis and personalised cancer treatment is discussed. The significant development of bioparameter-directed nanoformulations as MRI contrast agents for tumour diagnosis has been explained.

Automated summary

Hypoxia imaging of tumors plays a crucial role in prognosis and recurrence rate. Magnetic resonance imaging (MRI) has advantages in accurate tumor imaging but requires better contrast agents for enhanced clinical safety. The development of bioparameter-directed nanoformulations as MRI contrast agents for accurate tumor diagnosis is important and promising.