4.7 Article

Electrochemical multicomponent reaction toward vicinal sulfenyltetrazolation of unactivated alkenes

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 10, Issue 20, Pages 5064-5069

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qo01241g

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The electrochemical multicomponent reaction (e-MCR) enables the green and sustainable preparation of diverse vicinal sulfenyltetrazoles using readily available unactivated olefins, thiols, azidotrimethylsilane, and acetonitrile.
1,3-Dipole cycloaddition reaction represents the most straightforward method for the preparation of tetrazoles. However, this approach commonly requires the use of toxic isocyanides at evaluated temperatures, which raises considerable safety and environmental concerns. Herein we demonstrate that our recently developed electrochemical multicomponent reaction (e-MCR) is a green and sustainable solution to the sulfenyltetrazolation of unactivated alkenes with the readily available thiols azidotrimethylsilane, and acetonitrile, which are inaccessible with the existing methods. An electrochemical multicomponent reaction (e-MCR) enables the green and sustainable preparation of diverse vicinal sulfenyltetrazolation using the readily available unactivated olefins, thiols, azidotrimethylsilane, and acetonitrile.

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