Synthesis of amphiphilic hydantoin-based universal peptidomimetics as antibiotic agents

Three model hydantoin-based universal peptidomimetics were designed and synthetized. Their preferred amphiphilic beta-turn conformation was assessed using molecular modeling and NMR experiments, and their antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains, which demonstrated that these compounds could be a captivating class of antibiotics to fight emergent drug resistance. Three model hydantoin-based universal peptidomimetics were designed, synthetized, and investigated as Gram positive and Gram negative antimicrobial agents.

Automated summary

Three model hydantoin-based universal peptidomimetics were designed, synthesized, and investigated for their conformation and antibacterial activity. The results demonstrated that these compounds could be promising antibiotics to combat drug resistance.