Journal
FRONTIERS IN BIOINFORMATICS
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbinf.2023.1216362
Keywords
antimicrobial peptide prediction; geometric deep learning; antimicrobial peptide classification; antimicrobial peptide design; explainable artificial intelligence
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This review explores the latest developments in the use of geometric deep learning (GDL) techniques for designing and predicting antimicrobial peptides (AMPs), and discusses the current research gaps and future directions in this field.
Antimicrobial peptides (AMPs) are components of natural immunity against invading pathogens. They are polymers that fold into a variety of three-dimensional structures, enabling their function, with an underlying sequence that is best represented in a non-flat space. The structural data of AMPs exhibits non-Euclidean characteristics, which means that certain properties, e.g., differential manifolds, common system of coordinates, vector space structure, or translation-equivariance, along with basic operations like convolution, in non-Euclidean space are not distinctly established. Geometric deep learning (GDL) refers to a category of machine learning methods that utilize deep neural models to process and analyze data in non-Euclidean settings, such as graphs and manifolds. This emerging field seeks to expand the use of structured models to these domains. This review provides a detailed summary of the latest developments in designing and predicting AMPs utilizing GDL techniques and also discusses both current research gaps and future directions in the field.
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