4.6 Article

Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho

Wei Zhou et al.

Summary: This study found that dihydroartemisinin (DHA), a derivative of artemisinin, exhibits anti-fibrotic effects by targeting DNMT1 to reverse Klotho repression, providing evidence for its potential clinical application in the treatment of renal fibrosis.

ACTA PHARMACOLOGICA SINICA (2022)

Article Biology

Whole-mount Senescence-Associated Beta-Galactosidase (SA-β-GAL) Activity Detection Protocol for Adult Zebrafish

Marta Marzullo et al.

Summary: This study presents a protocol for detecting senescent cell accumulation in adult zebrafish organs using SA-beta-GAL assay and identifies previously unreported organs with increased cellular senescence in telomerase mutants.

BIO-PROTOCOL (2022)

Article Multidisciplinary Sciences

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Yue Wang et al.

Summary: The study demonstrated that quercetin (QCT), a natural flavonoid, inhibited ferroptosis in renal proximal tubular epithelial cells by reducing lipid ROS levels and increasing glutathione (GSH) levels. QCT also ameliorated acute kidney injury induced by ischemia-reperfusion (I/R) or folic acid (FA). Furthermore, RNA-sequence analysis revealed ATF3 as a key factor in QCT's inhibition of ferroptosis. Additionally, QCT inhibited the recruitment of pro-inflammatory macrophages in AKI.

JOURNAL OF ADVANCED RESEARCH (2021)

Article Biochemistry & Molecular Biology

Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence

Caizhen Li et al.

Summary: The study confirmed that eliminating senescent cells through pharmacological intervention can reduce renal aging and improve renal fibrosis, providing a new therapeutic approach for treating CKD post-AKI.

FASEB JOURNAL (2021)

Article Biochemistry & Molecular Biology

Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis

Yue Zhang et al.

Summary: Cigarette smoke induces senescence of AT2 cells via a SIRT1/autophagy dependent pathway, involving mitochondrial reactive oxygen species and DNA damage. Activating SIRT1 can reduce senescence by promoting autophagy.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Pharmacology & Pharmacy

Klotho as Potential Autophagy Regulator and Therapeutic Target

Hongjing Zhou et al.

Summary: Klotho protein can delay aging and is associated with various aging-related diseases. By increasing Klotho expression, therapeutic effects can be achieved for these diseases, as Klotho plays a role in regulating the autophagic process.

FRONTIERS IN PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

Marie Helena Docherty et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Urology & Nephrology

AKI: an increasingly recognized risk factor for CKD development and progression

J. T. Kurzhagen et al.

JOURNAL OF NEPHROLOGY (2020)

Review Pharmacology & Pharmacy

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Jie Xu et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

The Molecular Mechanisms of Protective Role of Se on the G0/G1 Phase Arrest Caused by AFB1 in Broiler's Thymocytes

Ke Guan et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2019)

Article Medicine, Research & Experimental

Dihydroartemisinin attenuates lipopolysaccharide-induced acute kidney injury by inhibiting inflammation and oxidative stress

Xinhui Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Physiology

Mechanisms of Renal Fibrosis

Benjamin D. Humphreys

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Article Urology & Nephrology

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

Congwei Luo et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Hematology

DNA damage responses and p53 in the aging process

Hui-Ling Ou et al.

BLOOD (2018)

Article Biochemistry & Molecular Biology

Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity

Rachel A. Murphy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Urology & Nephrology

Structural and Functional Changes in Human Kidneys with Healthy Aging

Musab S. Hommos et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Editorial Material Cell Biology

How autophagy both activates and inhibits cellular senescence

Chanhee Kang et al.

AUTOPHAGY (2016)

Review Urology & Nephrology

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

David A. Ferenbach et al.

NATURE REVIEWS NEPHROLOGY (2015)

Article Pharmacology & Pharmacy

The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep?

Rachel W. Goehe et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Multidisciplinary Sciences

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

Hyun Tae Kang et al.

PLOS ONE (2011)

Review Cell Biology

Eaten alive: a history of macroautophagy

Zhifen Yang et al.

NATURE CELL BIOLOGY (2010)

Review Physiology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Brinda Ravikumar et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Cell Biology

Autophagy mediates the mitotic senescence transition

Andrew R. J. Young et al.

GENES & DEVELOPMENT (2009)

Article Multidisciplinary Sciences

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

Priyamvada Rai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)