Journal
VETERINARY RESEARCH
Volume 54, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13567-023-01232-3
Keywords
Non-aureus staphylococci; mastitis; mammary epithelial cell; S. aureus; dairy cow
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This study found that cell-free supernatants from bovine non-aureus staphylococcal isolates can prevent adhesion and internalization of Staphylococcus aureus into bovine mammary epithelial cells, potentially through the S. aureus accessory gene regulator system. These findings provide new anti-virulence strategies for treating and controlling bovine S. aureus mastitis.
This study investigated whether cell-free supernatants (SN) from four bovine non-aureus staphylococcal (NAS) isolates prevent Staphylococcus aureus adhesion to and internalization into bovine mammary epithelial cells (MAC-T cells) and if so, to determine whether such effects were potentially associated with the S. aureus accessory gene regulator (agr) system. Overall, we demonstrated that all SN obtained from the NAS isolates promoted adhesion of a S. aureus agr+ strain to, yet reduced the internalization into MAC-T cells, while similar effects were not observed for its agr- mutant strain. Our findings provide novel anti-virulence strategies for treating and controlling bovine S. aureus mastitis.
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