Microfluidic-based plasmonic microneedle biosensor for uric acid ultrasensitive monitoring

Article Chemistry, Multidisciplinary

Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect

Rongchao Mei et al.

Summary: Skin interstitial fluid (ISF)-based microneedle (MN) sensing using surface-enhanced Raman scattering (SERS) tags allows for the tracking of acute peritonitis progression and evaluation of treatment efficacy.

ACS SENSORS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

A Hydrogel Microneedle Assay Combined with Nucleic Acid Probes for On-Site Detection of Small Molecules and Proteins

Fatemeh Keyvani et al.

Summary: This article introduces a versatile assay that combines hydrogel microneedles with a graphene oxide-nucleic acid-based fluorescence biosensor to detect biomarkers in a minimally invasive manner. The assay successfully measures four clinically important biomarkers ex vivo and accurately detects glucose and uric acid in vivo.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Add to Collection

Article Biophysics

Laser transparent multiplexed SERS microneedles for in situ and real-time detection of inflammation

Cheng Peng et al.

Summary: This study developed a multiplexed surface enhanced Raman scattering (SERS) diagnostic platform using polydopamine-modified, silver nanoparticle-decorated poly (methyl methacrylate) microneedles (AgNPs@PDA@MNs) to perform painless invasive detection of inflammation progression in relation to pH, redox potential, and reactive oxygen species (ROS) levels. The platform showed significant enhancement and reasonable linearity with a low limit of detection, enabling the real-time and in situ detection of complex inflammation.

BIOSENSORS & BIOELECTRONICS (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Hollow Microneedle-based Plasmonic Sensor for on Patch Detection of Molecules in Dermal Interstitial Fluid

Bruno Miranda et al.

Summary: Hollow MicroNeedles (HMNs) technology overcomes challenges in interstitial fluid (ISF) extraction and analysis, integrating a plasmonic transducer in the inner cavity for biomarker detection at the point-of-care. The wearable HMN-based patch allows minimally invasive pierce of the skin and the large swelling capability of the transducer enables uptake of ISF by capillarity. Recognition of biotin, a small model molecule, is achieved through localized surface plasmon resonance and metal-enhanced fluorescence. This HMN-based patch represents a novel point-of-use device for biomarker detection in ISF, aiding faster medical decision-making.

ADVANCED MATERIALS TECHNOLOGIES (2023)

Add to Collection

Article Biophysics

Wearable microneedle array-based sensor for transdermal monitoring of pH levels in interstitial fluid

Muamer Dervisevic et al.

Summary: Microneedle-based wearable sensors provide an alternative approach for health monitoring and disease diagnostics by detecting pH levels in the skin interstitial fluid. This technology significantly contributes to the advancement of wearable sensors, simplifies the manufacturing process, and improves cost-effectiveness.

BIOSENSORS & BIOELECTRONICS (2023)

Add to Collection

Article Chemistry, Analytical

Interstitial Fluid Biomarkers' Minimally Invasive Monitoring Using Microneedle Sensor Arrays

Jinze Li et al.

Summary: The study introduces an attractive Microneedle (MN) sensor array for minimally invasive monitoring of ISF microRNA and Cu2+, cross-linked through blue-light irradiation. The array displays good mechanical properties and a high swelling ratio for efficient and quantitative detection of miRNA and Cu2+.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Article Multidisciplinary Sciences

Wearable plasmonic paper-based microfluidics for continuous sweat analysis

Umesha Mogera et al.

Summary: Wearable sweat sensors have the potential to provide clinically meaningful information associated with the health and disease states of individuals. Researchers have introduced a wearable plasmonic paper-based microfluidic system that utilizes label-free surface-enhanced Raman spectroscopy (SERS) to detect and quantify metabolites in sweat. This system allows for continuous and simultaneous analysis of sweat loss, sweat rate, and specific biomarkers, providing valuable information for monitoring individual health.

SCIENCE ADVANCES (2022)

Add to Collection

Article Engineering, Biomedical

An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid

Farshad Tehrani et al.

Summary: The study presents a fully integrated wearable array of microneedles for wireless and continuous real-time sensing of metabolites in interstitial fluid. The device shows robust analytical performance and good correlation with gold-standard measurements.

NATURE BIOMEDICAL ENGINEERING (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Toward Quantitative Surface-Enhanced Raman Scattering with Plasmonic Nanoparticles: Multiscale View on Heterogeneities in Particle Morphology, Surface Modification, Interface, and Analytical Protocols

Jiwoong Son et al.

Summary: This article discusses the principles and applications of surface-enhanced Raman scattering (SERS) and focuses on the design principles and key issues of plasmonic nanoparticle substrates. The article highlights the limited controllability and uniformity of plasmonic nanoparticles, as well as the challenges in molecular modification chemistry and analytical protocols for SERS. The article also introduces recent advances in the uniform and controllable synthesis of plasmonic nanoparticle systems and the emerging machine learning-based analysis for quantitative SERS. Overall, this perspective provides insights into the challenges and potential solutions in utilizing plasmonic nanoparticle systems for reliable quantitative measurement of molecules.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Article Biophysics

Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic

Yi-Jyun Chen et al.

Summary: Chronic kidney disease is a neglected chronic disease affecting over 750 million people worldwide. During the COVID-19 pandemic, many patients with other chronic diseases struggle to receive treatment or examination, increasing the risk of death. This study developed a method to rapidly detect chronic kidney disease using the naked eye in skin fluid, aiming to reduce the impact on an individual's quality of life and life expectancy.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection

Article Engineering, Environmental

Plasmonic microneedle arrays for rapid extraction, SERS detection, and inactivation of bacteria

Yanbo Wang et al.

Summary: In this study, a plasmonic microneedle (MN) array patch was developed for rapid extraction and detection of Escherichia coli (E. coli) using surface-enhanced Raman spectroscopy (SERS). The proposed method offers a rapid and efficient approach for evaluating E. coli contamination in commercial food samples.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

In Vivo Transdermal Multi-Ion Monitoring with a Potentiometric Microneedle-Based Sensor Patch

Agueda Molinero-Fernandez et al.

Summary: Microneedle sensor technology offers exciting opportunities for decentralized clinical analyses. This paper introduces a novel method using membrane-based microneedles for real-time, on-body monitoring of multiple ions simultaneously. This technology is clinically relevant for assessing electrolyte disorders and other clinical conditions.

ACS SENSORS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Wearable chemical sensors for biomarker discovery in the omics era

Juliane R. Sempionatto et al.

Summary: Wearable chemical sensors are effective tools for discovering new biomarkers, providing real-time analysis in non-invasive body fluids. They can enable personalized health monitoring at home and reduce healthcare costs.

NATURE REVIEWS CHEMISTRY (2022)

Add to Collection

Article Biophysics

Colorimetric microneedle patches for multiplexed transdermal detection of metabolites

Dan Dan Zhu et al.

Summary: In this study, a highly swellable microneedle patch was developed to painlessly and bloodlessly extract skin interstitial fluid (ISF) for rapid detection of multiple biomarkers through color change. The experimental results demonstrated the feasibility of this method to detect various biomarkers in ISF within minutes.

BIOSENSORS & BIOELECTRONICS (2022)

Add to Collection

Article Multidisciplinary Sciences

Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows

Shuyu Lin et al.

Summary: The study introduces a microneedle-based electrochemical aptamer biosensing patch for minimally invasive monitoring of interstitial fluid and real-time measurement of drug pharmacokinetics. By transforming a clinical-grade needle into a high-quality gold nanoparticle-based substrate through a cost-effective fabrication scheme, reliable in vivo detection of ISF analytes, including those without natural recognition elements, is achieved.

SCIENCE ADVANCES (2022)

Add to Collection

Article Chemistry, Analytical

Highly Sensitive and Reliable Internal-Standard Surface-Enhanced Raman Scattering Microneedles for Determination of Bacterial Metabolites as Infection Biomarkers in Skin Interstitial Fluid

Rongchao Mei et al.

Summary: Highly sensitive internal-standard surface-enhanced Raman scattering microneedles (IS-SERS-MNs) were developed to detect bacterial metabolites in skin interstitial fluid (ISF) as new detectable biomarkers for infection diagnosis.

ANALYTICAL CHEMISTRY (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Advanced plasmonic technologies for multi-scale biomedical imaging

Jia-Sheng Lin et al.

Summary: The use of imaging technologies is crucial in understanding biological phenomena. Traditional imaging modalities lack the necessary spatial resolution for high-precision research and diagnosis in the biomedical field. Plasmon resonance, an interaction between light and matter, allows for intense electromagnetic fields and enhances various processes such as ablation, scattering, and photoluminescence. By combining spatially resolved capability with molecular spectrometry techniques, excellent imaging techniques have been developed for studying biological processes. This review provides an overview of plasmonics and discusses the working principles and achievable spatial resolutions of various plasmon-based imaging techniques.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects

Liping Song et al.

Summary: This study provides a comprehensive review of the recent advances in flexible plasmonic biosensors for the healthcare sector, covering design, integration, exploration, and applications. The research indicates the critical importance of flexible plasmonic biosensors in monitoring human health indicators.

ACS NANO (2021)

Add to Collection

Article Multidisciplinary Sciences

Transdermal electroosmotic flow generated by a porous microneedle array patch

Shinya Kusama et al.

Summary: The authors discuss the utilization of porous polymer microneedles combined with electroosmosis powered by enzymatic batteries to deliver small and large molecules across the skin efficiently.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-Related Biomarkers

Rongyan He et al.

Summary: The colorimetric dermal tattoo biosensor developed in this study allows for simultaneous detection and monitoring of multiple health-related biomarkers, showing great potential for long-term health monitoring with its features of minimal invasion, easy operation, and equipment-free result reading.

ADVANCED SCIENCE (2021)

Add to Collection

Article Chemistry, Physical

Bioinspired plasmonic nanoflower-decorated microneedle for label-free intradermal sensing

Vo Thi Nhat Linh et al.

Summary: A bioinspired nanoflower structure was fabricated on microneedle to serve as a surface-enhanced Raman scattering (SERS) sensor for intradermal sensing applications. The sensor was capable of detecting methylene blue down to a concentration of 50 nM and 1 nM in a skin phantom model.

APPLIED SURFACE SCIENCE (2021)

Add to Collection

Article Biotechnology & Applied Microbiology