Journal
PARASITOLOGY INTERNATIONAL
Volume 98, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2023.102808
Keywords
Anti-helminthic; Cyclic peptides; Cyclotides; Medicinal plants
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The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
The mortality rate caused by parasitic worms on their hosts is of great concern and studies have been carried out to find molecules to reduce the prevalence, host-parasite interaction, and resistance of parasites to treatments. Existing drugs on the market are very often toxic and have many side effects, hence the need to find new, more active molecules. It has been demonstrated in several works that medicinal plants constitute a wide range of new molecules that can solve this problem. Several works have already been able to demonstrate that cyclic peptides of plant origin have shown good activity in the fight against different types of helminths. Therefore, this review aims to provide a general overview of the methods and techniques of extraction, isolation, activities and mechanisms of action of cyclotides and other cyclic peptides for application in the treatment of helminthic infections.
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