Journal
CURRENT RHEUMATOLOGY REPORTS
Volume 18, Issue 11, Pages -Publisher
SPRINGER
DOI: 10.1007/s11926-016-0615-7
Keywords
Lupus; Autoimmunity; Tcells; Bcells; Myeloid cells; Immunometabolism; Therapeutic targets
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Funding
- NIAID NIH HHS [R01 AI128901] Funding Source: Medline
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Cellular metabolism represents a newly identified checkpoint of effector functions in the immune system. A solid body of work has characterized the metabolic requirements of normal T cells during activation and differentiation into polarized effector subsets. Similar studies have been initiated to characterize the metabolic requirements for B cells and myeloid cells. Only a few studies though have characterized the metabolism of immune cells in the context of autoimmune diseases. Here, we review what is known on the altered metabolic patterns of CD4+T cells, B cells, and myeloid cells in lupus patients and lupus-prone mice and how they contribute to lupus pathogenesis. We also discuss how defects in immune metabolism in lupus can be targeted therapeutically.
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