Journal
EXCLI JOURNAL
Volume 22, Issue -, Pages 1113-1128Publisher
EXCLI JOURNAL MANAGING OFFICE
DOI: 10.17179/excli2023-6328
Keywords
Virus; protein-protein interactions; short linear motifs; mimicry
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Viruses interact with their hosts by developing protein-protein interactions and mimic host proteins using short linear motifs. This mimicry can interfere with the function of host proteins. By studying viral mimicry, we can gain a better understanding of the mechanisms involved.
The virus interacts with its hosts by developing protein-protein interactions. Most viruses employ protein interactions to imitate the host protein: A viral protein with the same amino acid sequence or structure as the host protein attaches to the host protein's binding partner and interferes with the host protein's pathways. Being opportunistic, viruses have evolved to manipulate host cellular mechanisms by mimicking short linear motifs. In this review, we shed light on the current understanding of mimicry via short linear motifs and focus on viral mimicry by genetically different viral subtypes by providing recent examples of mimicry evidence and how high-throughput methods can be a reliable source to study SLiM-mediated viral mimicry.
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