Journal
INORGANIC CHEMISTRY FRONTIERS
Volume 10, Issue 21, Pages 6357-6368Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qi01167d
Keywords
-
Categories
Ask authors/readers for more resources
The challenge in imaging is to achieve accurate diagnosis by combining resolution and sensitivity. To overcome the limitations of single modality imaging, a solution is to design probes that combine the best features of different imaging modalities. In this study, we successfully combined photoacoustic imaging and magnetic resonance imaging within polysaccharide-based nanohydrogels to create an 'all in one' bimodal imaging system. The nanohydrogels showed significant signals in both MSOT and MRI experiments, demonstrating their potential for accurate imaging.
The challenge of imaging is to combine resolution and sensitivity in order to gain accuracy in diagnosis. No single modality can provide comprehensive information. Then, the solution is to design probes that are able to gather on a single platform the best features of the different imaging modalities. To achieve this objective, we have combined two types of probes, one associated with photoacoustic imaging (PAI) and the other with magnetic resonance imaging (MRI), within polysaccharide-based nanohydrogels. For that, chitosan (CS) which is a cationic polysaccharide was grafted with the photoacoustic probe ZW800-1. The synthesis of the corresponding CS-ZW800 and the purification conditions that allow to overcome ZW800 aggregation on the course of the protocol were carefully analyzed. Nanohydrogels that encapsulated gadolinium chelates as MRI probes were further obtained by ionic gelation between CS-ZW800 and the anionic hyaluronic acid (HA) in the presence of tripolyphosphate (TPP) as an ionogenic cross-linker. The bimodal nanohydrogels were then subjected to MSOT and MRI experiments. Upon excitation at 770 nm the nanoparticles were then able to produce a significant MSOT signal while in MRI at 3T, a significant positive contrast was obtained with low Gd doses. A new 'all in one' bimodal imaging system combining within nanohydrogels the photoacoustic probe ZW800-1 with magnetic resonance imaging contrast agents is presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available