Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 21, Issue 42, Pages 8584-8592Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ob01206a
Keywords
-
Categories
Ask authors/readers for more resources
Optical imaging is a non-invasive diagnostic imaging technology that utilizes fluorescent molecules emitting light in the near-infrared region to achieve tumor imaging. It has potential clinical applications.
Optical imaging (OI) is gaining increasing attention in medicine as a non-invasive diagnostic imaging technology and as a useful tool for image-guided surgery. OI exploits the light emitted in the near-infrared region by fluorescent molecules able to penetrate living tissues. Cyanines are an important class of fluorescent molecules and by their conjugation to peptides it is possible to achieve optical imaging of tumours by selective targeting. We report here the improvements obtained in the synthesis of DA364, a small fluorescent probe (1.5 kDa) prepared by conjugation of pentamethine cyanine Cy5.5 to an RGD peptidomimetic, which can target tumour cells overexpressing integrin alpha v beta 3 receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available