Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 62, Issue 40, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202311266
Keywords
Benzofuranoindolines; Biosynthesis; Indole Alkaloids; Oxidative Cyclization
Categories
Ask authors/readers for more resources
We uncovered the biosynthetic pathway of (+)-azonazine A and generated a series of analogs through supplementation of indole-substituted tryptophan derivatives.
We uncovered and reconstituted a concise biosynthetic pathway of the strained dipeptide (+)-azonazine A from marine-derived Aspergillus insulicola. Formation of the hexacyclic benzofuranoindoline ring system from cyclo-(L-Trp-N-methyl-L-Tyr) is catalyzed by a P450 enzyme through an oxidative cyclization. Supplementing the producing strain with various indole-substituted tryptophan derivatives resulted in the generation of a series of azonazine A analogs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available