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Antibacterial Chemodynamic Therapy: Materials and Strategies

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JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Article Nanoscience & Nanotechnology

AIEgen Intercalated Nanoclay-Based Photodynamic/Chemodynamic Theranostic Platform for Ultra-Efficient Bacterial Eradication and Fast Wound

Jiaxin Zhang et al.

Summary: An ultra-efficient photodynamic/chemodynamic theranostics platform was developed by incorporating an aggregation-induced emission (AIE) photosensitizer, TPCI, into iron-bearing montmorillonite (MMT) nanolayers. This platform combines efficient photodynamic therapy (PDT) and continuous chemodynamic therapy (CDT) to effectively eliminate bacteria and promote wound healing with low side effects.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Engineering, Biomedical

?-Fe2O3 based nanotherapeutics for near-infrared/dihydroartemisinin dual-augmented chemodynamic antibacterial therapy

Yueying Xu et al.

Summary: Chemodynamic therapy (CDT) is a promising treatment for bacterial infection. However, its therapeutic efficiency is hindered by various factors. In this study, researchers developed a nanotherapeutic agent for enhanced antibacterial CDT using NIR/DHA dual-augmentation. The results showed that the agent had satisfactory photothermal and peroxidase-like activities, and exhibited pH-responsive release behavior. In vitro and in vivo experiments demonstrated its effective bactericidal and anti-inflammatory abilities. These findings suggest that the developed nanotherapeutic agent has potential for clinical use.

ACTA BIOMATERIALIA (2022)

Article Engineering, Biomedical

A polydopamine coated nanoscale FeS theranostic platform for the elimination of drug-resistant bacteria via photothermal-enhanced Fenton reaction

Fupeng Li et al.

Summary: Infections caused by drug-resistant bacteria pose a great threat to human health. This study synthesized a multifunctional theranostic platform that combines photothermal treatment and chemical reaction to enhance the antibacterial effects, while also enabling early diagnosis of infection.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Inorganic & Nuclear

Growth of Cu2O Nanoparticles on Two-Dimensional Zr-Ferrocene- Metal-Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

Xinshuo Zhao et al.

Summary: This study demonstrates the growth of Cu2O nanoparticles on 2D Zr-ferrocene-MOF nanosheets to prepare 2D composites for photothermally enhanced chemodynamic antibacterial therapy. The Cu2O/Zr-Fc-MOF composite shows higher chemodynamic activity than the pristine Zr-Fc-MOF nanosheets, and this activity can be further enhanced by NIR laser irradiation.

INORGANIC CHEMISTRY (2022)

Article Engineering, Environmental

Engineering efficient artificial nanozyme based on chitosan grafted Fe-doped-carbon dots for bacteria biofilm eradication

Ting Pan et al.

Summary: A novel nanozyme CS@Fe/CDs was designed to combat bacterial biofilms. Through the peroxidase-like catalytic activity and antibacterial activity of CS, CS@Fe/CDs effectively cleaved extracellular DNA and caused cell death within bacterial biofilms. This approach shows great potential in managing bacterial biofilm fouling in food safety and environmental protection.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Engineering, Biomedical

Self-Propelling Nanomotors Integrated with Biofilm Microenvironment-Activated NO Release to Accelerate Healing of Bacteria-Infected Diabetic Wounds

Shuang Xie et al.

Summary: This study developed self-propelled nanomotors for the treatment of diabetic foot ulcers. The nanomotors released nitric oxide in the biofilm microenvironment to effectively kill bacteria and stimulate angiogenesis. Experimental results demonstrated that the treatment with nanomotors successfully eliminated bacterial infections and promoted wound healing.

ADVANCED HEALTHCARE MATERIALS (2022)

Article Engineering, Biomedical

Liquid exfoliation of V8C7 nanodots as peroxidase-like nanozymes for photothermal-catalytic synergistic antibacterial treatment

Yan Ma et al.

Summary: This study successfully prepared ultrasmall V8C7 nanodots and demonstrated their excellent photothermal and catalytic properties. V8C7 nanodots showed satisfactory photothermal-catalytic synergistic antibacterial treatment, indicating their potential as powerful and safe antibacterial agents.

ACTA BIOMATERIALIA (2022)

Article Chemistry, Applied

Glucose-responsive biomimetic nanoreactor in bacterial cellulose hydrogel for antibacterial and hemostatic therapies

Shumin Zhang et al.

Summary: In this study, a biomimetic nanoreactor encapsulated self-healing hydrogel was designed to provide both antibacterial defense and hemostatic properties. The nanoreactor released (OH)· for bacteria killing in the presence of glucose, while the hydrogel exhibited excellent hemostatic capacity by absorbing glucose from blood. This design brings new insights for nanozyme-based biomedical therapies.

CARBOHYDRATE POLYMERS (2022)

Article Chemistry, Applied

Copper boron-imidazolate framework incorporated chitosan membranes for bacterial-infected wound healing dressing

Guangyao Wang et al.

Summary: In this study, a chitosan membrane loaded with copper boron-imidazolate framework (Cu-BIF) was successfully prepared as a wound dressing. The Cu-BIF/CS membrane showed desirable biocompatibility and exhibited antibacterial activity against bacterial infections. It also accelerated wound closure rate and skin regeneration. This research provides important insights for clinical treatment of bacterial-infected wounds.

CARBOHYDRATE POLYMERS (2022)

Article Chemistry, Applied

Novel chitosan based metal-organic polyhedrons/enzyme hybrid hydrogel with antibacterial activity to promote wound healing

Jie Song et al.

Summary: This study developed a novel chitosan based metal-organic polyhedrons (MOPs)/enzyme hybrid hydrogel with superior antimicrobial properties for wound healing treatment. The hydrogel exhibited excellent bactericidal effect on both gram-negative and gram-positive bacteria, and also showed good cell compatibility. In vivo experiments demonstrated that the hydrogel effectively promoted wound healing. These findings suggest that chitosan based MOPs/enzyme hybrid hydrogel holds great potential for antibacterial therapy in clinical applications.

CARBOHYDRATE POLYMERS (2022)

Article Engineering, Environmental

Bacterial biofilm microenvironment responsive copper-doped zinc peroxide nanocomposites for enhancing chemodynamic therapy

Yuxiang Zhang et al.

Summary: Dental plaque, a natural biofilm, plays a crucial role in caries and periodontal disease. The pathogenicity of S. mutans is based on the formation of extracellular polysaccharides (EPS) and its survival in acidic environments. Chemodynamic therapy (CDT) is an ideal treatment modality that utilizes the biofilm microenvironment. A novel nanocomposite, ZnO2-Cu@RB NPs, has been developed for enhanced CDT, effectively killing S. mutans in acidic biofilm and reducing demineralization of apatite. Furthermore, it inhibits acid production and EPS formation, showing promising therapeutic efficacy in a rat model.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Environmental

Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic antibacterial therapy

Tongyao Wang et al.

Summary: This study developed a novel nanoreactor that utilizes glucose oxidation to generate highly active radicals for starvation therapy and chemodynamic therapy. It also incorporates photothermal enhancement and release of copper ions for enhanced angiogenesis, thereby combating persistent inflammation and bacterial infection during wound healing.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Biochemistry & Molecular Biology

Hybrid Ag nanoparticles/polyoxometalate-polydopamine nano-flowers loaded chitosan/gelatin hydrogel scaffolds with synergistic photothermal/chemodynamic/Ag+ anti-bacterial action for accelerated wound healing

Kunpeng Zhou et al.

Summary: Bacterial infections significantly affect wound healing process, and developing new bactericides and therapeutic strategies is crucial. In this study, a three-in-one bactericidal nanocomposite was developed, which demonstrated photo-thermal therapy (PTT) and chemodynamic therapy (CDT) to synergistically combat bacterial infections and accelerate wound healing. Additionally, a multifunctional wound dressing was obtained by embedding the nanocomposite into a biocomposite hydrogel, which showed excellent biocompatibility and hydro-absorptivity for enhanced wound healing in vivo.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Materials Science, Multidisciplinary

Cu2Se/Bi2S3 nanocomposites as chemodynamic and photothermal agents for synergetic antibacterial therapy

Xuan Yu et al.

Summary: Microbial infection is a significant threat to human health globally, and with increasing bacterial resistance, the development of nonantibiotic-dependent therapies is crucial. In this study, Cu2Se/Bi2S3 nanocomposites were constructed as agents for both chemodynamic therapy and photothermal therapy. These nanocomposites demonstrated synergistic bactericidal efficiency through peroxidase-like activity and near-infrared-induced hyperthermia, effectively targeting Escherichia coli and Staphylococcus aureus without causing significant cytotoxicity. Furthermore, the Cu2Se/Bi2S3 nanocomposites showed excellent healing outcomes in treating S. aureus-infected wounds.

MATERIALS LETTERS (2022)

Article Chemistry, Multidisciplinary

Bioheterojunction-Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin-Engine Powered Disinfection for Boosted Osteogenicity

Bin Li et al.

Summary: The study presents a bioheterojunction-engineered orthopedic implant that addresses the challenges of infection and high glucose levels in diabetic patients. The engineered implant uses a combination of bioheterojunctions and chemical reactions to kill bacteria and promote bone integration. In vivo experiments confirm the effectiveness of the implant in eliminating biofilm and promoting vascularization for improved osseointegration.

SMALL (2022)

Article Chemistry, Physical

Facile One-Pot Synthesis of Meteor Hammer-like Au-MnOX Nanozymes with Spiky Surface for NIR-II Light-Enhanced Bacterial Elimination

Xiaonan Li et al.

Summary: Inspired by the effective interfacial interactions between natural creatures and their bio-hosts, researchers developed a novel gold-manganese oxide nanoparticle (Au-MnOx) nanoenzyme with a spiky surface for NIR-II light-induced synergistic antibacterial therapy. The Au-MnOx nanoenzyme demonstrated broad-spectrum antibacterial ability and satisfactory bactericidal efficacy in a rat wound model.

CHEMISTRY OF MATERIALS (2022)

Article Materials Science, Biomaterials

Multifunctional nanoreactors with nutrient consumption and ROS generation capabilities for antibacterial and skin repair

Han Yang et al.

Summary: The study presents a multifunctional nanoreactor that possesses the capabilities of nutrient consumption, generation of reactive oxygen species (ROS), and promotion of angiogenesis for antibacterial effects and skin wound repair. The nanoreactor is able to consume bacterial nutrients through oxidation reactions and kill bacteria through a Fenton-like reaction, while promoting angiogenesis for accelerated wound healing by releasing Zn2+.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Materials Science, Biomaterials

Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO

Hanzhu Shi et al.

Summary: This study prepared HM-CuO nanozymes with peroxidase-like catalytic activity, photothermal performance, and GSH depletion ability, which effectively kills bacteria and improves sterilization effect, showing good inhibitory effect against E. coli and S. aureus.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Chemistry, Multidisciplinary

Biodegradable Fe(ii)/Fe(iii)-coordination-driven nanoassemblies for chemo/photothermal/chemodynamic synergistic therapy of bacterial infection

Xiaomei Dai et al.

Summary: A biodegradable nanoassembly with synergistic antibacterial effects was synthesized in this study. By utilizing photothermal and chemodynamic therapies, the nanoassembly selectively inhibited bacterial growth while promoting wound healing.

NEW JOURNAL OF CHEMISTRY (2022)

Article Nanoscience & Nanotechnology

Injectable Antibacterial Gelatin-Based Hydrogel Incorporated with Two-Dimensional Nanosheets for Multimodal Healing of Bacteria- Infected Wounds

Shayesteh Bochani et al.

Summary: The study developed a multifunctional hydrogel with high photothermal antibacterial activity and shape adaptability to accelerate bacteria-infected wound healing, showing promising potential for clinical applications.

ACS APPLIED BIO MATERIALS (2022)

Article Chemistry, Physical

A triple-enhanced chemodynamic approach based on glucose-powered hybrid nanoreactors for effective bacteria killing

Jintao Fu et al.

Summary: The rapid evolution of bacterial resistance has outpaced the development of new antibiotics, making chemodynamic therapy a promising alternative. In this study, antibacterial nanoreactors were constructed using zeolitic imidazolate framework-8 nanoparticles coated with a metal polyphenol network. These nanoreactors overcame pH and H2O2 limitations, generating hyperthermia and achieving high-efficiency sterilization. Furthermore, the nanoreactors combined chemodynamic therapy with photothermal therapy and photodynamic therapy, enhancing bactericidal efficiency and addressing antibiotic resistance.

NANO RESEARCH (2022)

Article Nanoscience & Nanotechnology

Rapid In Situ Deposition of Iron-Chelated Polydopamine Coating on the Polyacrylamide Hydrogel Dressings for Combined Photothermal and Chemodynamic Therapy of Skin Wound Infection

Yaoyao Li et al.

Summary: A bactericidal hydrogel dressing, FePDA-PAM, was developed for combined photothermal therapy (PTT) and chemodynamic therapy (CDT). In vitro and in vivo experiments demonstrated its excellent antibacterial effectiveness and wound healing capabilities.

ACS APPLIED BIO MATERIALS (2022)

Article Materials Science, Biomaterials

A biofilm microenvironment-responsive one-for-all bactericidal nanoplatform for photothermal-augmented multimodal synergistic therapy of pathogenic bacterial biofilm infection

Ke Yang et al.

Summary: This study presents a responsive nano-platform for biofilm microenvironment (BME)-activatable antibacterial therapy. The platform can deliver dual metal ions and perform photodynamic antibacterial activity, as well as inhibit biofilm formation and eliminate bacteria in mature biofilms. In vivo experiments demonstrate excellent therapeutic performance and minimal toxicity of this nano-platform.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Materials Science, Biomaterials

A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion

Xiaohua Huang et al.

Summary: This study developed an injectable multifunctional hydrogel with tumor therapy, antibacterial treatment, and wound healing properties. The hydrogel, GG@PANI(Fe)-borax, exhibited injectability, self-healing ability, and reversible gel-sol transformations. The hydrogel also had near-infrared responsive photothermal conversion capability and showed excellent photothermal effects and controllable drug release for melanoma treatment. Additionally, the hydrogel demonstrated antibacterial activity and promoted wound repair.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Article Chemistry, Multidisciplinary

Virus-like-inspired nanoparticles facilitate bacterial internalization for enhanced eradication of drug-resistant pathogens

Yufei Zhang et al.

Summary: The study successfully designed and developed a virus-like spiky nanoplatform that enhances bacterial capture and internalization, and efficiently eliminates bacteria through light-to-heat conversion. The spiny structure and chemical modification of the nanoplatform also protect host cells from bacterial damage.

NEW JOURNAL OF CHEMISTRY (2022)

Article Nanoscience & Nanotechnology

A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

Yan Zu et al.

Summary: Bacterial infection is a significant threat to wound healing due to antibiotic abuse and drug resistance. In this study, a novel wound dressing called CP@Tf-hy was developed, which has the ability to release copper peroxide nanoparticles and stimulate the release of copper ions, thereby effectively eliminating antibiotic-resistant bacteria and promoting wound healing.

ACS APPLIED BIO MATERIALS (2022)

Article Materials Science, Multidisciplinary

NIR-II Absorbing Charge Transfer Complexesfor Synergistic Photothermal-ChemodynamicAntimicrobial Therapy and Wounds Healing

Niu Niu et al.

Summary: A smart light-responsive drug-delivery hydrogel has been developed for efficient antibacterial therapy through photothermal-chemodynamic treatment, accelerating wound healing. The hydrogel exhibits excellent antibacterial performance and good biocompatibility.

ACS MATERIALS LETTERS (2022)

Article Chemistry, Applied

Novel chitosan based metal-organic polyhedrons/enzyme hybrid hydrogel with antibacterial activity to promote wound healing

Jie Song et al.

Summary: This study aims to develop a novel chitosan based metal-organic polyhedrons (MOPs)/enzyme hybrid hydrogel with superior antimicrobial properties for wound healing treatment. The results show that the hydrogel exhibits better bactericidal effect and good cell compatibility, effectively facilitating wound healing. Therefore, the chitosan based MOPs/enzyme hybrid hydrogel holds great promise for antibacterial therapy in clinical applications.

CARBOHYDRATE POLYMERS (2022)

Article Materials Science, Multidisciplinary

The chemodynamic antibacterial effect of MnOX nanosheet decorated silicon nanowire arrays

Mingkang Li et al.

Summary: Bacteria are widespread and pose a threat to human health. ROS, highly reactive chemical substances, play a crucial role in oxidizing and damaging bacteria. The modified SN@PDA@MnOX can effectively generate ROS and exhibit a strong antibacterial effect.

MATERIALS ADVANCES (2022)

Review Microbiology

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Jessa Marie V. Makabenta et al.

Summary: Nanomaterial-based therapies offer a promising approach to combat antibiotic-resistant bacterial infections by targeting biofilms and overcoming recalcitrant infections. Their unique size and physical properties enable them to evade existing mechanisms associated with acquired drug resistance.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Nanoscience & Nanotechnology

pH-Responsive Oxygen and Hydrogen Peroxide Self-Supplying Nanosystem for Photodynamic and Chemodynamic Therapy of Wound Infection

Yunsu Ma et al.

Summary: The study designed a pH-responsive nanosystem that combines photodynamic therapy and chemodynamic therapy for wound infection. The system showed a combined PDT/CDT effect, killing bacteria through oxidative stress and enhancing therapeutic effects by activating the immune response.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Physical

A photothermal and self-induced Fenton dual-modal antibacterial platform for synergistic enhanced bacterial elimination

Xianghong Xie et al.

Summary: The synergistic antibacterial strategy presented in this study utilizes copper peroxide and tungsten disulfide nanoflowers to activate the Fenton reaction under acidic conditions and eliminate bacteria by transforming light into localized heat under near-infrared laser irradiation. This system has shown significant antibacterial effects on Escherichia coli and Staphylococcus aureus both in vitro and in vivo, suggesting its potential for rational design of synergistic antibacterial systems.

APPLIED CATALYSIS B-ENVIRONMENTAL (2021)

Article Engineering, Biomedical

Nano-metal-organic-frameworks for treating H2O2-Secreting bacteria alleviate pulmonary injury and prevent systemic sepsis

Yi Wu et al.

Summary: The study demonstrates the potential use of H2O2-reactive metal-organic framework nanosystems (MOFs) for treating H2O2-secreting bacteria, showing efficient therapeutic effects in a mouse model infected with Streptococcus pneumoniae. Combining MOFs with the antibiotic ampicillin can effectively eliminate bacterial invasion and improve the survival rate of mice.

BIOMATERIALS (2021)

Article Engineering, Environmental

Injectable multi-responsive micelle/nanocomposite hybrid hydrogel for bioenzyme and photothermal augmented chemodynamic therapy of skin cancer and bacterial infection

Hua Zheng et al.

Summary: An activatable theranostic strategy, combining bioenzyme and photothermal augmented chemodynamic therapy, was successfully developed for effective treatment of skin tumor and bacterial infection, demonstrating promising potential for simultaneous skin cancer therapy and antibacterial treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

Review Chemistry, Multidisciplinary

Biomedicine Meets Fenton Chemistry

Zhongmin Tang et al.

Summary: This review provides a comprehensive overview of the importance and representative applications of Fenton chemistry in the field of biomedicine, as well as future directions for development, which is essential for further advancement in this field.

CHEMICAL REVIEWS (2021)

Article Engineering, Environmental

Copper ferrite heterojunction coatings empower polyetheretherketone implant with multi-modal bactericidal functions and boosted osteogenicity through synergistic photo/Fenton-therapy

Junchuan Zhang et al.

Summary: Drug-free antibacterial therapies, such as photodynamic therapy and chemodynamic therapy, have shown significant potential in effectively eradicating pathogenic bacteria by generating reactive oxygen species (ROS). A new photo-activated copper ferrite heterojunction coating on bioinert polyetheretherketone (PEEK) implants has been developed, capable of localized hyperthermia and ROS production for antibacterial therapy. The coatings also trigger Fenton-like reactions and glutathione depletion in the bacterial infectious microenvironment, leading to robust antibacterial effects. Additionally, the coated implants demonstrate excellent biocompatibility and promote osteogenesis, with micronutrient elements (Cu, Fe) released under NIR light exposure enhancing osteogenicity.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Biochemistry & Molecular Biology

Multifunctional chitosan-copper-gallic acid based antibacterial nanocomposite wound dressing

Xinyu Sun et al.

Summary: In this study, chitosan-copper-gallic acid nanocomposites with dual-functional nanoenzyme characteristics were successfully prepared, showing oxidase-like and peroxidase-like activities that promote the generation of hydrogen peroxide and hydroxyl radicals, leading to excellent antibacterial properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Surface-Textured Mixed-Metal-Oxide Nanocrystals as Efficient Catalysts for ROS Production and Biofilm Eradication

Nitee Kumari et al.

Summary: The new magneto-catalytic platform MTex is able to effectively diffuse into biofilms and kill bacteria, providing key antifouling efficacy through its unique surface topography.

NANO LETTERS (2021)

Article Chemistry, Physical

Cationic chitosan@Ruthenium dioxide hybrid nanozymes for photothermal therapy enhancing ROS-mediated eradicating multidrug resistant bacterial infection

Xufeng Zhu et al.

Summary: By constructing a nanozyme with antibacterial activity, the research successfully disrupted bacterial biofilms and demonstrated its therapeutic efficacy in rescuing skin wound infections and chronic lung infections in mice.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Nanoscience & Nanotechnology

Copper Sulfide Nanoassemblies for Catalytic and Photoresponsive Eradication of Bacteria from Infected Wounds

Amit Nain et al.

Summary: BSA-encapsulated copper sulfide nanocrystals (CuS NCs) were prepared and exhibited enzyme-like and photodynamic activities. under NIR laser irradiation, the antimicrobial response was significantly enhanced and >99% of bacteria were eradicated in just 1 min. The BSA-CuS NCs showed insignificant cytotoxicity and hemolysis, making them highly biocompatible bactericides for effective bacteria eradication in preclinical applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Materials Science, Biomaterials

Magnetically retained and glucose-fueled hydroxyl radical nanogenerators for H2O2-self-supplying chemodynamic therapy of wound infections

Minhui Gong et al.

Summary: A glucose-fueled and H2O2-self-supplying nanogenerator has been developed for enhanced antibacterial efficacy through catalytic reactions, providing a potential nano-antibacterial agent for the treatment of wound infections.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Chemistry, Multidisciplinary

Bacteria-Triggered Multifunctional Hydrogel for Localized Chemodynamic and Low-Temperature Photothermal Sterilization

Xiaodong Lin et al.

Summary: A bacteria-triggered multifunctional hydrogel for low-temperature photothermal sterilization was constructed, combining localized chemodynamic therapy for efficient antibacterial treatment. The hydrogel showed great potential for clinical application by promoting wound healing process infected with Staphylococcus aureus.

SMALL (2021)

Review Biotechnology & Applied Microbiology

Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications

Peipei Feng et al.

Summary: Hydrogels are effective wound dressings with unique properties, while chitosan is a polymeric biomaterial obtained by the deacetylation of chitin. Hydrogel-like functional wound dressings made from chitosan and its derivatives have received extensive attention for their effectiveness in promoting skin wound repair.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Engineering, Biomedical

A Biofilm Microenvironment-Activated Single-Atom Iron Nanozyme with NIR-Controllable Nanocatalytic Activities for Synergetic Bacteria-Infected Wound Therapy

Qiqi Xu et al.

Summary: A novel FePN SAzyme is introduced in this study for photothermal/chemodynamic synergistic therapy of bacterial-infected wounds in the biofilm microenvironment. The nanozyme shows high efficiency, specificity, and sensitivity, and can be activated by internal and external stimuli in the biofilm, minimizing side effects on healthy tissue.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Nanoscience & Nanotechnology

Pomegranate-Like CuO2@SiO2 Nanospheres as H2O2 Self-Supplying and Robust Oxygen Generators for Enhanced Antibacterial Activity

Xiang Li et al.

Summary: A robust pH-responsive Fenton nanosystem was constructed by assembling copper peroxide nanodots in pomegranate-like mesoporous silica nanoshells, which are capable of self-supplying H2O2 and sustainably generating O-2, resulting in enhanced antimicrobial performance and accelerated skin wound closure.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Chemistry, Multidisciplinary

Rough Carbon-Iron Oxide Nanohybrids for Near-Infrared-II Light-Responsive Synergistic Antibacterial Therapy

Zhiwen Liu et al.

Summary: This study developed carbon-iron oxide nanohybrids with rough surfaces (RCF) for NIR-II light-responsive synergistic antibacterial therapy, showing broad-spectrum synergistic antibacterial effects and satisfactory biocompatibility in vivo.

ACS NANO (2021)

Review Chemistry, Multidisciplinary

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

Xiaotong Cheng et al.

Summary: Overexpression of glutathione in cancer cells leads to resistance to anticancer therapies, making GSH depletion a potential target for cancer treatments. By combining with mainstream cancer therapies, GSH-depleting agents can enhance cancer cells responses to cell death stimuli.

ACS NANO (2021)

Article Chemistry, Physical

Antibacterial carbon dots/iron oxychloride nanoplatform for chemodynamic and photothermal therapy

Xiang Yan et al.

Summary: The combination of iron oxychloride nanosheets catalyst and photothermal therapy using carbon dots with near-infrared emission has been shown to effectively inhibit bacterial growth and reduce inflammation in infected wound areas.

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Cu ions and cetyltrimethylammonium bromide loaded into montmorillonite: a synergistic antibacterial system for bone scaffolds

Li Yu et al.

Summary: The synergistic antibacterial system developed in this study by modifying Cu2+ and CTAB into montmorillonite (MMT) for a polyglycolic acid (PGA) scaffold showed significantly improved antibacterial activities against E. coli, with an antibacterial rate of 98.1%, due to enhanced bacterial adsorption capacity and increased zeta potential.

MATERIALS CHEMISTRY FRONTIERS (2021)

Article Chemistry, Multidisciplinary

Na+ inserted metal-organic framework for rapid therapy of bacteria-infected osteomyelitis through microwave strengthened Fenton reaction and thermal effects

Shubin Wei et al.

Summary: In this study, a rapid and noninvasive therapeutic strategy was developed using Prussian blue as a microwave-responsive material to effectively treat bacteria-induced osteomyelitis. The released Fe2+ and Fe3+ from PB could easily penetrate bacterial membrane by microwave, react with H2O2 and GSH inside bacteria, leading to the final death of the bacteria due to the synergistic action of microwave, microwave thermal effect and Fe2+/Fe3+ induced Fenton reaction/GSH consumption. This study provides novel insight for designing remote and noninvasive antibacterial systems for treating deep bacteria-infected diseases.

NANO TODAY (2021)

Review Chemistry, Medicinal

Recent Innovations in Bacterial Infection Detection and Treatment

Carly Deusenbery et al.

Summary: Bacterial infections pose a significant threat to human health, aggravated by the rise of antibiotic resistance. Recent advances in detection methods focus on enhancing sensitivity, specificity, and ease of operation, while developments in antibacterial treatment center around targeted delivery and responsive antibiotic administration.

ACS INFECTIOUS DISEASES (2021)

Article Nanoscience & Nanotechnology

Acid-Induced Self-Catalyzing Platform Based on Dextran-Coated Copper Peroxide Nanoaggregates for Biofilm Treatment

Min Li et al.

Summary: The acid-induced self-catalyzing DCPNAs can inhibit and destroy bacterial biofilms through the generation of reactive oxygen species without the need for additional H2O2. They exhibit low cytotoxicity and excellent antibacterial properties, showing great therapeutic outcomes in in vivo wound healing.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Nanoscience & Nanotechnology

Gold-Platinum Nanodots with High-Peroxidase-like Activity and Photothermal Conversion Efficiency for Antibacterial Therapy

Shengnan Zhang et al.

Summary: The study introduces a simple and fast synthesized gold-platinum nanodots that exhibit broad-spectrum antibacterial properties against bacterial infections and have been shown to promote wound healing in in vivo experiments. These nanodots have good biocompatibility and low toxicity, showing potential as a new option for future antibacterial therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Engineering, Biomedical

Construction of a photothermal hydrogel platform with two-dimensional PEG@zirconium-ferrocene MOF nanozymes for rapid tissue repair of bacteria-infected wounds

Xin Wang et al.

Summary: This study successfully developed a powerful hydrogel with bactericidal properties and rapid tissue repair effects for the treatment of bacterial wound infections. The synergistic effect of phototherm-nanozyme-hydrogel holds great potential in bacterial wound infection therapy.

ACTA BIOMATERIALIA (2021)

Review Chemistry, Multidisciplinary

Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

Xin Fan et al.

Summary: This review focuses on the recent efforts in developing BCN-based biomedical applications to combat bacterial infections. The mechanisms, classification, antibacterial activities triggered or augmented by energy conversion, and biofilm eradication with BCNs are systematically introduced and discussed. The current challenges and prospects of BCNs for biocatalytic disinfection are also summarized.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

A Glucose-Powered Activatable Nanozyme Breaking pH and H2O2 Limitations for Treating Diabetic Infections

Lifang Chen et al.

Summary: This study presents an activatable nanozyme with targeting capability to overcome the local pH and H2O2 limitations under physiological conditions, demonstrating potential for treating chronic wounds.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Engineering, Biomedical

Infection microenvironment-activated nanoparticles for NIR-II photoacoustic imaging-guided photothermal/chemodynamic synergistic anti-infective therapy

Nan Yang et al.

Summary: A novel theranostic platform based on Cu2O nanoparticles was successfully constructed, which can precisely identify and eliminate bacteria in the infection microenvironment, showing a good antibacterial effect against drug-resistant bacteria.

BIOMATERIALS (2021)

Article Chemistry, Applied

A novel biodegradable injectable chitosan hydrogel for overcoming postoperative trauma and combating multiple tumors

Wentao Wang et al.

Summary: A novel therapeutic nanocomposite was developed for wound bacterial infections and tumor recurrence, utilizing released reactive oxygen species to kill bacteria and inhibit tumor cell regeneration, as well as utilizing photothermal properties to penetrate the blood tumor barrier for brain tumor treatment. The combination of the nanocomposite with immunotherapy showed potential for improving postoperative therapy and multi-tumor treatments.

CARBOHYDRATE POLYMERS (2021)

Article Materials Science, Biomaterials

Ferrocene-functionalized hybrid hydrogel dressing with high-adhesion for combating biofilm

Yanling Peng et al.

Summary: This study successfully developed an antibacterial hydrogel dressing with high adhesion, which can effectively prevent bacterial infections and inhibit the formation of biofilms, providing a new opportunity for the treatment of clinical bacterial infections.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Engineering, Biomedical

Synergistical Starvation and Chemo-Dynamic Therapy for Combating Multidrug-Resistant Bacteria and Accelerating Diabetic Wound Healing

Danxia Li et al.

Summary: By designing metal-organic framework-based nanoreactors loaded with glucose oxidase and peroxidase-like bovine hemoglobin, an effective cascaded catalytic antibacterial system has been constructed. This system can both starve and kill multidrug-resistant bacteria, and accelerate diabetic wound healing.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Chemistry, Multidisciplinary

An amino acid-based supramolecular nanozyme by coordination self-assembly for cascade catalysis and enhanced chemodynamic therapy towards biomedical applications

Enhui Song et al.

Summary: The research team developed a supramolecular nanozyme through a simple coordination self-assembly method to increase H2O2 levels in diseased tissues, achieving synergistic starvation-chemodynamic cancer therapy and exhibiting antibacterial activity.

NANOSCALE ADVANCES (2021)

Article Materials Science, Biomaterials

An MSN-based synergistic nanoplatform for root canal biofilm eradication via Fenton-enhanced sonodynamic therapy

Jingmei Guo et al.

Summary: The study successfully developed a Fenton reaction-enhanced antimicrobial sonodynamic therapy platform for root canal disinfection, showcasing strong oxidative capabilities and good biocompatibility. The platform effectively eradicated biofilms and bacteria within root canals.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Review Nanoscience & Nanotechnology

Recent Advances on Stimuli-Responsive Combination Therapy against Multidrug-Resistant Bacteria and Biofilm

Antara Sikder et al.

Summary: The widespread occurrence of infections from multidrug-resistant bacteria is a global health problem that has been exacerbated in recent years due to increased adaptive traits in bacteria and a lack of advanced treatment strategies. Stimuli-responsive drug delivery systems and combinatorial therapeutic systems based on nanoparticles, metal-organic frameworks, hydrogels, and organic chromophores have been developed to improve antibiotic efficacy by reducing drug resistance and side effects. These systems are designed with specific chemical and physical properties that respond to triggers and allow for controlled release and transportability to specific sites.

ACS APPLIED BIO MATERIALS (2021)

Article Materials Science, Biomaterials

Cascade catalytic nanoplatform constructed by laterally-functionalized pillar[5]arenes for antibacterial chemodynamic therapy

Fei Li et al.

Summary: Chemodynamic therapy (CDT) is a promising approach for combating bacterial infections by converting H2O2 into highly toxic OH, but developing safe and effective CDT strategies is challenging. The designed cascade catalytic nanoplatform can effectively catalyze glucose to produce H2O2, trigger Fenton reaction, and achieve antibacterial CDT, with little to no cytotoxicity towards mammalian cells.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Multidisciplinary

A multifunctional Fenton nanoagent for microenvironment-selective anti-biofilm and anti-inflammatory therapy

Yuqing Li et al.

Summary: FePS3 nanosheets show selective generation or elimination of ROS in different microenvironments, providing effective anti-biofilm and anti-inflammatory effects in the treatment of bacterial biofilm infections.

MATERIALS HORIZONS (2021)

Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

Article Nanoscience & Nanotechnology

Redox-Channeling Polydopamine-Ferrocene (PDA-Fc) Coating To Confer Context-Dependent and Photothermal Antimicrobial Activities

Jialin Song et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Nanoscience & Nanotechnology

Biomimetic Metal-Organic Framework Composite-Mediated Cascade Catalysis for Synergistic Bacteria Killing

Xiqing Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Biotechnology & Applied Microbiology

Release of manganese and in situ regeneration of manganese dioxide during the degradation of ciprofloxacin

Yanan Cai et al.

BIOCHEMICAL ENGINEERING JOURNAL (2020)

Article Chemistry, Multidisciplinary

Iron nanoparticles augmented chemodynamic effect by alternative magnetic field for wound disinfection and healing

Fei Gao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Chemistry, Multidisciplinary

Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections

Geyong Guo et al.

ACS NANO (2020)

Article Nanoscience & Nanotechnology

Rational Design of Self-Assembled Cationic Porphyrin-Based Nanoparticles for Efficient Photodynamic Inactivation of Bacteria

Junying Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Review Medicine, Research & Experimental

Phototherapy-based combination strategies for bacterial infection treatment

Guoqing Wei et al.

THERANOSTICS (2020)

Review Materials Science, Multidisciplinary

Conjugated Polymer-Based Photothermal Therapy for Killing Microorganisms

Fengming Lin et al.

ACS APPLIED POLYMER MATERIALS (2020)

Review Chemistry, Multidisciplinary

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

Zhongmin Tang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Engineering, Environmental

Facile synthesis of ZnO QDs@GO-CS hydrogel for synergetic antibacterial applications and enhanced wound healing

Ying Liang et al.

CHEMICAL ENGINEERING JOURNAL (2019)

Review Biotechnology & Applied Microbiology

Host-directed therapies for bacterial and viral infections

Stefan H. E. Kaufmann et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Chemistry, Multidisciplinary

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

Lian-Hua Fu et al.

CHEMICAL SOCIETY REVIEWS (2018)

Review Microbiology

Implant infections: adhesion, biofilm formation and immune evasion

Carla Renata Arciola et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Infectious Diseases

Antimicrobial use of reactive oxygen therapy: current insights

Mohammad Yousef Memar et al.

INFECTION AND DRUG RESISTANCE (2018)

Review Pharmacology & Pharmacy

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

G. Aviello et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Chemistry, Multidisciplinary

Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy

Zijian Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Review Pharmacology & Pharmacy

Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria

J. M. Ageitos et al.

BIOCHEMICAL PHARMACOLOGY (2017)

Article Chemistry, Multidisciplinary

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Chen Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Multidisciplinary

Polymeric micellar nanoplatforms for Fenton reaction as a new class of antibacterial agents

Seong-Cheol Park et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Article Biochemistry & Molecular Biology

The neglected role of copper ions in wound healing

Allison Paige Kornblatt et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2016)

Editorial Material Biotechnology & Applied Microbiology

Targeted, triggered drug delivery to tumor and biofilm microenvironments

Danielle S. W. Benoit et al.

NANOMEDICINE (2016)

Article Infectious Diseases

ESCMID* guideline for the diagnosis and treatment of biofilm infections 2014

N. Hoiby et al.

CLINICAL MICROBIOLOGY AND INFECTION (2015)

Article Biochemistry & Molecular Biology

Sonodynamic antimicrobial chemotherapy: First steps towards a sound approach for microbe inactivation

Loredana Serpe et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2015)

Review Microbiology

Biosensors for Whole-Cell Bacterial Detection

Asif Ahmed et al.

CLINICAL MICROBIOLOGY REVIEWS (2014)

Review Engineering, Environmental

Review of iron-free Fenton-like systems for activating H2O2 in advanced oxidation processes

Alok D. Bokare et al.

JOURNAL OF HAZARDOUS MATERIALS (2014)

Review Chemistry, Multidisciplinary

Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal

Svitlana Chernousova et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

Review Biotechnology & Applied Microbiology

Applying insights from biofilm biology to drug development - can a new approach be developed?

Thomas Bjarnsholt et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Microbiology

Antimicrobial activity of metals: mechanisms, molecular targets and applications

Joseph A. Lemire et al.

NATURE REVIEWS MICROBIOLOGY (2013)

News Item Multidisciplinary Sciences

The bacteria fight back

Gary Taubes

SCIENCE (2008)

Review Cell Biology

Zinc in wound healing: Theoretical, experimental, and clinical aspects

Alan B. G. Lansdown et al.

WOUND REPAIR AND REGENERATION (2007)

Review Acoustics

Sonodynamic therapy - a review of the synergistic effects of drugs and ultrasound

I Rosenthal et al.

ULTRASONICS SONOCHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Antibacterial resistance worldwide: causes, challenges and responses

SB Levy et al.

NATURE MEDICINE (2004)