Journal
CLINICAL EPIGENETICS
Volume 8, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13148-016-0224-3
Keywords
Epigenetics; Sirtuins; SIRT modulators; Drug discovery; Cancer; Neurodegeneration
Categories
Funding
- EU: COST-Action: EPICHEMBIO [CM1406]
- FP7: BLUEPRINT [282510]
- FP7: A-PARADDISE [602080]
- PRIN [RF-2010-2318330]
- IIT-Sapienza Project
- Sapienza Award Project
- AIRC: Fondazione Cariplo TRIDEO [17515]
- AIRC: AIRC-IG [17217]
Ask authors/readers for more resources
Sirtuins are NAD(+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available