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Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Journal

EMERGING INFECTIOUS DISEASES
Volume 29, Issue 3, Pages 649-652

Publisher

CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2903.221388

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Monkeypox virus was introduced to Finland in late May-early June 2022. Analysis of viral genome in a patient's sample showed a major variant with 3 lineage B.1.3-specific mutations and a minor variant with ancestral B.1 nucleotides. The results suggest ongoing evolution mediated by APOBEC3 enzyme or co-infection.
Monkeypox virus was imported into Finland during late May-early June 2022. Intrahost viral genome variation in a sample from 1 patient comprised a major variant with 3 lineage B.1.3-specific mutations and a minor variant with ancestral B.1 nucleotides. Results suggest either ongoing APOBEC3 enzyme-mediated evolution or co-infection.

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