☆ 4.8 Review

Synthesizing biomaterials in living organisms

CHEMICAL SOCIETY REVIEWS (2023)

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Enzyme-Instructed Peptide Assembly Favored by Preorganization for Cancer Cell Membrane Engineering

Yinghao Ding et al.

Summary: An enzyme-instructed peptide self-assembly (EISA) strategy is used to selectively modify cancer cell membranes, and different phosphorylation patterns in phosphopeptides targeting EGFR can impact their self-assembly abilities and binding affinity for EGFR. The phosphorylated peptide pY1 shows the highest capability for preorganization and the fastest dephosphorylation in the presence of alkaline phosphatase (ALP), making it the most effective at constructing stable peptide assemblies on cancer cell membranes. Additionally, peptide-protein and peptide-peptide co-assembly strategies are employed to apply antigens to cancer cell membranes, offering a potential technique for cancer immunotherapy.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Engineered PROTAC-CID Systems for Mammalian Inducible Gene Regulation

Dacheng Ma et al.

Summary: This study developed a scalable chemically inducible dimerization platform (PROTAC-CID) based on proteolysis-targeting chimera, which enables inducible gene regulation and gene editing. It can fine-tune gene expression at gradient levels or multiplex biological signals. By coupling it with genetic circuits, digitally inducible expression of DNA recombinases and base-and prime-editors for transient genome manipulation are achieved. Furthermore, a compact PROTAC-CID system is packaged into adeno-associated viral vectors for inducible and reversible gene activation in vivo. This work provides a versatile molecular toolbox for chemically inducible gene regulation in human cells and mice.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli-Responsive Cell-Adhesive Micromaterials

Tom Kamperman et al.

Summary: This study demonstrates that stimuli-responsive cell-adhesive micromaterials can self-assemble with cells into 3D living composite microtissues and provide control over the biomechanical and biochemical environment, influencing cell behavior.

ADVANCED SCIENCE (2023)

Add to Collection
Article Chemistry, Multidisciplinary

In Situ Enzyme-Induced Self-Assembly of Antimicrobial-Antioxidative Peptides to Promote Wound Healing

Runxin Teng et al.

Summary: A new type of antimicrobial peptides with inherent stability, antibacterial activity, and reactive oxygen species (ROS) scavenging has been developed to effectively heal infected wounds. The peptides are oxidized and assembled into nanoparticles in situ at the wound site, providing enhanced stability and significantly increased antibacterial efficiency. The nanoparticles demonstrate efficient antioxidant properties and effectively reduce ROS in vivo.

ADVANCED FUNCTIONAL MATERIALS (2023)

Add to Collection
Article Nanoscience & Nanotechnology

Cell spheroid creation by transcytotic intercellular gelation

Jiaqi Guo et al.

Summary: A method for creating cell spheroids using triggered d-peptide self-assembly is reported. The peptides are dephosphorylated in cells and assembled to facilitate fibronectin fibrillogenesis and spheroid formation. Cryogenic electron microscopy was used to determine the atomic structure of the self-assembled nanofibers, and fluorescent imaging showed that they interact with fibronectin to induce spheroid formation.

NATURE NANOTECHNOLOGY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Acidity-Triggered Transformable Polypeptide Self-Assembly to Initiate Tumor-Specific Biomineralization

Yang Liu et al.

Summary: Biomineralization is a normal physiological process involving nucleation, crystal growth, phase transformation, and orientation evolution. Inducing biomineralization in tumor tissue has shown promise as a therapy for malignancy. However, the limited ion-chelating capabilities of carboxyl-containing biomineralization initiators have hindered their efficacy. In this study, a biomineralization-inducing nanoparticle (BINP) was developed for blockade therapy of osteosarcoma. BINP exhibited tumor inhibition rates of 59.3% and 52.1% for subcutaneous and orthotopic osteosarcomas, respectively. The BINP-mediated blockade therapy also inhibited bone dissolution and pulmonary metastases. This selective biomineralization approach holds promise for clinical osteosarcoma therapy.

ADVANCED MATERIALS (2023)

Add to Collection
Article Chemistry, Multidisciplinary

In Situ Construction of Ferrocene-Containing Membrane-Bound Nanofibers for the Redox Control of Cancer Cell Death and Cancer Therapy

Xiangyang Zhang et al.

Summary: Manipulating cancer cell death through precise control of reactive oxygen species (ROS) is a promising strategy for treating malignant tumors. However, generating active ROS with spatial precision and regulating their biological outcomes is challenging. In this study, we successfully generated short-lived and lipid-reactive hydroxyl radicals ((OH)-O-·) adjacent to cancer cell membranes, leading to lipid peroxidation and ferroptosis. By using a phosphorylated self-assembling precursor, we selectively produced membrane-bound nanofibers and enriched ferrocene moieties on cancer cell membranes, resulting in the conversion of tumoral H2O2 to active (OH)-O-· through Fenton-like reactions. Our strategy effectively prevented tumor progression with good cellular selectivity and acceptable biocompatibility through intratumoral administration.

NANO LETTERS (2023)

Add to Collection
Article Multidisciplinary Sciences

Assembly theory explains and quantifies selection and evolution

Abhishek Sharma et al.

Summary: Scientists propose assembly theory (AT) as a framework that connects physics and biology. In AT, objects are redefined and measured by their possible formation histories. This theory provides a unified language for explaining selection, evolution, and novelty generation.

NATURE (2023)

Add to Collection
Article Multidisciplinary Sciences

Data-mining unveils structure–property–activity correlation of viral infectivity enhancing self-assembling peptides

Kübra Kaygisiz et al.

Nature Communications (2023)

Add to Collection
Review Nanoscience & Nanotechnology

In situ self-assembly for cancer therapy and imaging

Jaewon Kim et al.

Summary: This review discusses the design of in situ self-assembled nanomedicines for cancer therapy and imaging based on endogenous and exogenous stimuli in both the extracellular and the intracellular milieu. In situ self-assembly offers advantages such as efficient deep-tumour targeting, enhanced blood circulation, and negligible drug resistance. The challenges and potential of in situ self-assembled nanomedicine as advanced alternatives to existing cancer therapies are also discussed from a clinical viewpoint.

NATURE REVIEWS MATERIALS (2023)

Add to Collection
Review Multidisciplinary Sciences

Genetic engineering for biohydrogen production from microalgae

Jiaqi Zhang et al.

Summary: The development of biohydrogen as an alternative energy source has brought great economic and environmental benefits. Hydrogen production from microalgae is a clean and sustainable energy production method that can alleviate fuel shortages and recycle waste. However, the commercialization of algal hydrogen production has been hindered by low product yields, which has led to the development of various technologies to increase production.

ISCIENCE (2023)

Add to Collection
Article Multidisciplinary Sciences

Assembly theory explains and quantifies selection and evolution

Abhishek Sharma et al.

Summary: Scientists have struggled to reconcile biological evolution with the laws of physics. To understand the emergence of diverse forms without a design blueprint, a new framework called assembly theory (AT) has been proposed. AT redefines the concept of an object and incorporates selection and novelty generation into the physics of complex objects. It provides a powerful interface between physics and biology, revealing new aspects of physics at the chemical scale.

NATURE (2023)

Add to Collection
Review Chemistry, Multidisciplinary

Metal-free bioorthogonal click chemistry in cancer theranostics

Dan Wu et al.

Summary: Bioorthogonal chemistry is a powerful tool for site-specific drug activation in living systems, offering high selectivity and efficiency. Metal-free bioorthogonal click reactions are more biocompatible compared to metal-catalyzed reactions. This review highlights the recent progress and advantages of metal-free bioorthogonal click chemistry in cancer theranostics.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Genetic-code-expanded cell-based therapy for treating diabetes in mice

Chao Chen et al.

Summary: The engineered NATS system allows for fast therapeutic protein expression triggered by noncanonical amino acids at the translational level, demonstrating potential for next-generation cell-based therapies with orally induced protein expression.

NATURE CHEMICAL BIOLOGY (2022)

Add to Collection
News Item Biochemistry & Molecular Biology

Treating diabetes with 'cookies'

Jicheng Yu et al.

Summary: Genetic code expansion serves as a promising strategy for precise control of protein expression, as demonstrated by a recent study that engineered cells to regulate blood glucose levels in a diabetic mouse model through noncanonical amino acid-triggered insulin expression.

NATURE CHEMICAL BIOLOGY (2022)

Add to Collection
Review Genetics & Heredity

Drug delivery systems for RNA therapeutics

Kalina Paunovska et al.

Summary: This article provides an overview of the importance of RNA-based gene therapy and describes the molecular mechanisms of RNA therapies and different drug delivery systems. It also discusses the path from preclinical research to clinical approval for these therapies.

NATURE REVIEWS GENETICS (2022)

Add to Collection
Article Polymer Science

Electrostatically Controlled ex Situ and in Situ Polymerization of Diacetylene-Containing Peptide Amphiphiles in Living Cells

Niannian Lv et al.

Summary: The precise control of diacetylene-containing peptide amphiphile (DPA) based supramolecular architectures is crucial for their polymerization behaviors and biomedical applications. This study explores the opposite polymerization behaviors of two DPAs with similar molecular structures and emphasizes the role of charge properties in their polymerization and cell interactions.

ACS MACRO LETTERS (2022)

Add to Collection
Review Nanoscience & Nanotechnology

Organelle-level precision with next-generation targeting technologies

Anand Saminathan et al.

Summary: Intracellular organelles are subsystems within a cell that reflect the metabolic state of the cell, and biological pathways can be exploited to target exogenous cargo to specific organelles with nucleic acids as suitable delivery vehicles.

NATURE REVIEWS MATERIALS (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Peptide Based AIEgens: From Molecular Design, Stimuli Responsiveness to Biomedical Application

Ben-Li Song et al.

Summary: Luminogens with aggregation-induced emission (AIEgens) have wide applications in biomedical field, and peptide-based AIEgens have better solubility and biocompatibility. This review summarizes the recent progress of peptide-based AIEgens nanomaterials, focusing on the advantages of peptides and AIE molecules as conjugates, and presents the challenges and opportunities for future clinical biomedical applications.

CCS CHEMISTRY (2022)

Add to Collection
Review Biotechnology & Applied Microbiology

Peptide ligases: A Novel and potential enzyme toolbox for catalytic cross-linking of protein/peptide-based biomaterial scaffolds for tissue engineering

Kannan Badri Narayanan et al.

Summary: The fabrication of novel biomaterial scaffolds with improved biological interactions and mechanical properties is crucial for tissue engineering. Protein/peptide-based polymeric scaffolds, especially those created through bioorthogonal enzymatic reactions, show great potential in replicating the in vivo microenvironment for cell differentiation and tissue formation. Peptide ligases, including natural ones like sortases and butelase 1, as well as engineered ones like trypsiligase and subtiligase, are efficient tools for enzymatic cross-linking of protein/peptide-based polymeric chains. These ligases can enhance cell attachment, growth, and differentiation by conjugating with cell-adhesive ECM proteins or motifs and growth factors. The review discusses the potential, limitations, and mechanisms of natural and engineered peptide ligases in the fabrication of (bio)polymeric scaffolds for various tissue engineering and regenerative applications.

ENZYME AND MICROBIAL TECHNOLOGY (2022)

Add to Collection
Article Chemistry, Medicinal

In Situ Coassembly Induced Mitochondrial Aggregation Activated Drug-Resistant Tumor Treatment

Xian-Yin Dai et al.

Summary: This study presents a multivalent supramolecular coassembly strategy for tumor treatment, which involves the aggregation of mitochondria and enhanced drug delivery. The approach achieves long-time phosphorescent labeling and significantly improves the efficiency of chemotherapy against drug-resistant tumors. The study also demonstrates the potential of using biological phosphorescent imaging for the treatment of drug-resistant cancers.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Intracellular Self-Assembly of Peptides to Induce Apoptosis against Drug-Resistant Melanoma

Min Sun et al.

Summary: By utilizing enzymatic catalysis, we have successfully developed a new tripeptide that can self-assemble into nanoparticles inside cells, exhibiting excellent interference capability and ultimately reversing drug resistance in melanoma. The tripeptide assembly can interfere with the self-polymerization of microtubules, resulting in cell cycle arrest and mitochondrial dysfunction, eventually inducing apoptosis. In vivo experiments have demonstrated that the tripeptide treatment significantly reduces the tumor volume of drug-resistant melanoma.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast

Ruibing Chen et al.

Summary: Advances in synthetic biology enable efficient and safe synthesis of valuable natural products by microbial hosts. However, the role of cofactors in microbial production of natural products has been largely ignored. In this study, the supply and recycling of cofactors in yeast cells were engineered to achieve high-level production of phenolic acids.

NATURE CHEMICAL BIOLOGY (2022)

Add to Collection
Article Chemistry, Physical

The living interface between synthetic biology and biomaterial design

Allen P. Liu et al.

Summary: Recent advancements in synthetic biology and biomaterials have provided exciting tools for creating new materials and extending the application of synthetic biology. Despite their transformative potential, these fields have mostly progressed separately. This Perspective reviews recent key advances and presents a roadmap for collaboration between the two communities, emphasizing the near-term applications in developing hierarchically structured biomaterials.

NATURE MATERIALS (2022)

Add to Collection
Review Polymer Science

Living cell-me diate d in-situ polymerization for biome dical applications

Jingjing Liu et al.

Summary: This paper reviews the applications of synthetic polymers in biomedicine and discusses the method of cell-mediated in-situ polymerization. It also examines the biological effects of these polymers on living cells and animals.

PROGRESS IN POLYMER SCIENCE (2022)

Add to Collection
Article Materials Science, Multidisciplinary

ROS-initiated in-situ polymerization of diacetylene-containing lipidated peptide amphiphile in living cells

Niannian Lv et al.

Summary: This study presents a designed peptide micelle capable of undergoing in-situ polymerization inside cells, enabling cell labeling and long-term tracking using fluorescence. The polymerization process induces tumor cell apoptosis, increases cell viscosity, and decreases cell motility, potentially inhibiting tumor metastasis.

SCIENCE CHINA-MATERIALS (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Designing bioresponsive nanomaterials for intracellular self-assembly

Sarah Chagri et al.

Summary: Supramolecular assemblies are crucial in living organisms, and their synthetic counterparts have been developed to create non-natural assemblies inside mammalian cells. Controlling assembly formation in the dynamic cellular environment can be achieved through various strategies, and this review highlights the development of bioresponsive nanomaterials for intracellular self-assembly.

NATURE REVIEWS CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Alkaline Phosphatase-Controllable and Red Light-Activated RNA Modification Approach for Precise Tumor Suppression

Jing Fang et al.

Summary: RNA interference (RNAi) has shown promise as a disease treatment, but its clinical application is hindered by poor delivery efficiency and susceptibility to serum RNases. This study proposes a new RNA modification approach for anti-tumor therapy using an alkaline phosphatase (ALP)-controllable and red light-activated system. The system successfully targets liver carcinoma cells, detects ALP-positive tumors, and induces significant apoptosis through mitochondrial damage. The potential therapeutic mechanism was also explored on the transcriptomic level.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Nucleobase-Interaction-Directed Biomimetic Supramolecular Self-Assembly

Amrita Sikder et al.

Summary: This Account summarizes recent examples that employ nucleobase interactions to generate functional biomaterials by judicious design of the building blocks. Different strategies to employ nucleobase interactions in polymeric systems in order to achieve self-assembled nanomaterials with versatile properties are discussed. Moreover, the potential biological/material applications of complementary nucleobase interactions, such as enhanced drug encapsulation, superior adhesion, and fast self-healing properties, are emphasized. Issues and challenges faced by this class of materials are identified and future directions for the exploration of functional materials are proposed to advance the development of nucleobase-functionalized systems for biomaterial design.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Simple Preparation of Injectable Hydrogels with Phase-Separated Structures That Can Encapsulate Live Cells

Shohei Ishikawa et al.

Summary: Injectable hydrogels are promising artificial extracellular matrix materials that can be administered minimally invasively in liquid form. This study proposes a simple material design approach to introduce phase-separated structures to injectable hydrogels by adding inorganic salts. These phase-separated structures enhance the fracture toughness of the hydrogel and do not compromise the proliferative activity of encapsulated cells.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection
Article Chemistry, Medicinal

Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5

Francesco Fiorentino et al.

Summary: SIRT5 is a NAD+-dependent protein lysine deacylase primarily located in mitochondria. It plays important roles in metabolism and reactive oxygen species detoxification, and exhibits a dichotomous role in cancer as a context-dependent tumor promoter or suppressor. Research on SIRT5 inhibitors is limited, and the discovery of potent and selective small-molecule SIRT5 inhibitors remains a challenge.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism

Zhixuan Zhou et al.

Summary: Nanostructures play essential roles in nature and contribute to the diversity of life. In this study, we designed a platinum-containing tripeptide that forms intracellular fibrillar nanostructures upon rearrangement in the presence of endogenous H2O2. The formed nanostructures block metabolic functions and regulate ATP production, actin formation, and histone deacetylase activity. This research demonstrates the potential of assembly-driven nanomaterials in drug discovery.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Controlling Intracellular Enzymatic Self-Assembly of Peptide by Host-Guest Complexation for Programming Cancer Cell Death

Xuejiao Yang et al.

Summary: This study demonstrates that host-guest complexation can efficiently regulate enzymatic self-assembly, leading to controlled cancer cell death.

NANO LETTERS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Functional DNA-based cytoskeletons for synthetic cells

Pengfei Zhan et al.

Summary: This study demonstrates functional DNA-based cytoskeletons operating in microfluidic cell-sized compartments. These synthetic cytoskeletons can mimic features of natural cytoskeletons and possess engineerable characteristics.

NATURE CHEMISTRY (2022)

Add to Collection
Review Cell Biology

RNA-based therapeutics: an overview and prospectus

Yiran Zhu et al.

Summary: The growing understanding of RNA functions and their crucial roles in diseases has led to the development of RNA-based therapeutics. Despite challenges, progress has been made through the exploration of various techniques. This review comprehensively summarizes the mechanisms, challenges, solutions, and clinical applications of RNA-based therapeutics.

CELL DEATH & DISEASE (2022)

Add to Collection
Article Polymer Science

Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria

Mechelle R. Bennett et al.

Summary: Living organisms have the potential to synthesize new abiotic polymers from unnatural feedstocks, which can lead to greater materials diversity. In this study, an oxygen-tolerant RAFT polymerization platform was developed to synthesize a range of water-soluble polymers with controlled molar mass distribution. The platform also allowed for the production of block copolymer nanoparticles via polymerization-induced self-assembly. The use of a bacterial initiation system provided additional advantages.

ACS MACRO LETTERS (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Polymer Chemistry in Living Cells

Zhixuan Zhou et al.

Summary: The polymerization of biomolecules plays a crucial role in connecting molecular signals with various cellular events. It leads to the creation of functional capabilities and phase separation phenomena, and contributes to the formation of hierarchical structures in cell biology. Despite significant progress in synthetic polymer chemistry, studying polymer behavior in complex multicomponent systems remains challenging. Conducting polymer chemistry within cells offers a new perspective for understanding the nanoscale world of living cells and has the potential to revolutionize macromolecular therapeutics and biology.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Intranuclear Nanoribbons for Selective Killing of Osteosarcoma Cells

Shuang Liu et al.

Summary: In this study, intranuclear nanoribbons formed by dephosphorylation of phosphorylated peptides catalyzed by alkaline phosphatase were demonstrated to selectively kill osteosarcoma cells. These peptides rapidly kill the cancer cells by interacting with histone proteins, while being nontoxic to normal cells.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Probing and Manipulating Noncovalent Interactions in Functional Polymeric Systems

Jingsi Chen et al.

Summary: This review discusses the mechanical characterization of noncovalent interactions in polymeric systems and their correlation with macroscopic performance. By quantifying these interactions, it is possible to customize polymer materials with specific functions and provide insights for the rational design of advanced materials.

CHEMICAL REVIEWS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Morphological Transformation and In Situ Polymerization of Caspase-3 Responsive Diacetylene-Containing Lipidated Peptide Amphiphile for Self-Amplified Cooperative Antitumor Therapy

Teng Ma et al.

Summary: This study develops a tumor-targeting and caspase-3 responsive nanoparticle that undergoes in situ polymerization triggered by photodynamic treatment and activation of caspase-3. The locational nanofibers on the mitochondria membranes lead to mitochondrial reactive oxygen species (mtROS) burst and self-amplified circulation, offering persistent high oxidative stress to induce cell apoptosis.

SMALL (2022)

Add to Collection
Article Multidisciplinary Sciences

In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis

Xinyan Zhou et al.

Summary: This study presents a therapy for ulcerative colitis based on a multitargeted genetic circuit, which effectively targets multiple pathogenic genes and pathways in male mice with induced or spontaneous genetic colitis.

NATURE COMMUNICATIONS (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Macrocyclic Supramolecular Assemblies Based on Hyaluronic Acid and Their Biological Applications

Zhixue Liu et al.

Summary: Hyaluronic acid (HA) is a tumor-targeting drug that can assemble with macrocyclic compounds through hydrogen bonding and electrostatic interactions. Macrocycles play a crucial role in the construction of supramolecular drug carriers, targeted imaging agents, and hydrogels. The formed supramolecular assemblies can respond to various stimuli.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

Add to Collection
Article Chemistry, Medicinal

Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Cancer Theranostics

Mian Tang et al.

Summary: The advent of macrocycle-based supramolecular chemistry offers powerful strategies for regulating bioactivities in living systems. A suprabiomacromolecular nanosystem involving microtubules, cell-permeable porphyrins, and antimitotic peptide-decorated permethyl-beta-cyclodextrins is constructed to promote cell apoptosis. This innovative approach combines complexation-promoted photodynamic efficacy with controlled aggregation of natural biomacromolecules.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Engineered myoglobin as a catalyst for atom transfer radical cyclisation

Andriy Lubskyy et al.

Summary: By mutating the protein, wild-type myoglobin was transformed into an artificial metalloenzyme capable of catalyzing the cyclization reaction of halogenated unsaturated compounds for the synthesis of gamma-lactams. This new activity was achieved not only in purified protein, but also in crude cell lysate and in whole cells.

CHEMICAL COMMUNICATIONS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

In Situ Synthesis of an Anticancer Peptide Amphiphile Using Tyrosine Kinase Overexpressed in Cancer Cells

Kenta Morita et al.

Summary: Cell-selective killing using molecular self-assemblies is an emerging concept for cancer therapy. In this study, a self-assembling molecule was synthesized in situ using a tyrosine kinase overexpressed in cancer cells. The self-assembled molecule exhibited selective cytotoxicity towards cancer cells and induced apoptotic cell death. Animal experiments demonstrated the antitumor activity of the self-assembled molecule.

JACS AU (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Noncovalent interactions in proteins and nucleic acids: beyond hydrogen bonding and π-stacking

Subhrakant Jena et al.

Summary: This article discusses the significant relevance of noncovalent interactions (NCIs) in biomolecular structure and function, such as hydrogen bonding, halogen bonding, and the more recently discovered n→π* interactions. These interactions are crucial for understanding the dynamics of biological systems, enzymatic activities, and drug design.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted Enrichment of Enzyme-Instructed Assemblies in Cancer Cell Lysosomes Turns Immunologically Cold Tumors Hot

Shenglu Ji et al.

Summary: This study introduces a novel LMP inducer named TPE-Py-pYK(TPP)pY, which can effectively convert immunologically cold tumors to hot by inducing ICD, providing a new strategy for cancer immunotherapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Clinical Neurology

Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs

Li Zhang et al.

Summary: This study presents a synthetic biology strategy that integrates the exosome-circulating system with genetic circuits for self-assembly and delivery of mHTT-silencing siRNA to the cortex and striatum, successfully reducing levels of mHTT protein and toxic aggregates in mouse models of Huntington's disease. This strategy may provide a significant therapeutic benefit for Huntington's disease by efficiently delivering siRNAs in vivo.

BRAIN (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Materials design by synthetic biology

Tzu-Chieh Tang et al.

Summary: Synthetic biology utilizes genetic tools to engineer living cells and organisms, similar to machine programming; materials synthetic biology integrates principles from synthetic biology and materials science to redesign living systems into dynamic and responsive materials.

NATURE REVIEWS MATERIALS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments

Maksymilian Marek Zegota et al.

Summary: Dynamic covalent chemistry is a versatile tool for designing stable and stimuli-responsive linkers or conjugates. Dual responsive dynamic covalent peptide tags, combining pH responsive boronate ester and redox-active disulfide, showed improved complex stability and responsiveness to pH and redox conditions. These tags hold great promise for controlling bioconjugate stability under dilution in aqueous media and designing intelligent pharmaceutics that react to distinct biological stimuli in cells through cooperative effects.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection
Article Multidisciplinary Sciences

Metabolic modulation of tumours with engineered bacteria for immunotherapy

Fernando P. Canale et al.

Summary: Engineered bacteria were developed to convert ammonia to l-arginine in tumors, increasing intratumoral l-arginine concentrations, T cell infiltration, and synergistic effects with PD-L1 blocking antibodies in tumor clearance. These results indicate that microbial therapies can enhance immunotherapy efficacy by modulating the tumor microenvironment.

NATURE (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Engineering living therapeutics with synthetic biology

Andres Cubillos-Ruiz et al.

Summary: Cell-based therapeutics designed with synthetic biology is an emerging strategy in medicine, utilizing genetically engineered cells for precise therapeutic control and potential treatment of various diseases. Compared to traditional therapies, synthetic biology approaches offer greater flexibility, specificity, and predictability in combating human diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

In vivo self-assembled nanomedicine

Muhetaerjiang Mamuti et al.

Summary: The emergence of nanomedicine has significantly improved the pharmacokinetics of conventional therapeutic agents. However, biological barriers and changes in stability and surface properties during transportation hinder its clinical translation. Therefore, a strategy of in vivo self-assembly has been proposed to overcome these challenges and enhance targeted accumulation towards disease sites.

NANO TODAY (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

Joshua J. Rennick et al.

Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.

NATURE NANOTECHNOLOGY (2021)

Add to Collection
Review Pharmacology & Pharmacy

Peptide-based supramolecular hydrogels for local drug delivery

Zhenghao Zhang et al.

Summary: Peptide-based supramolecular hydrogels have shown great promise as drug delivery systems due to their excellent biocompatibility, response to external stimuli, and ability to self-assemble into specific nanostructures in different environments. Utilizing inherent biological microenvironment as stimuli can provide spatiotemporal controllability for transporting therapeutics more accurately. These materials formed by weak non-covalent interactions exhibit shear-thinning and immediate recovery behavior, making them injectable and ideal for drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Bioinspired Tumor Calcification Enables Early Detection and Elimination of Lung Cancer

Jicheng Wu et al.

Summary: A synthesized polypeptide selectively targets lung cancer cells and induces calcium precipitation on the cell membrane, aiding in the diagnosis and treatment of early-stage lung cancer without harming normal tissue. This tumor cell-selective calcification process extends the survival of tumor-bearing individuals.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic Assemblies of Thiophosphopeptides Instantly Target Golgi Apparatus and Selectively Kill Cancer Cells**

Weiyi Tan et al.

Summary: Introducing a sulfur atom into phosphopeptides enables rapid targeting of Golgi apparatus and selective killing of cancer cells. The resulting thiophosphopeptide self-assembles after alkaline phosphatase-catalyzed dephosphorylation, enters cells, and accumulates in Golgi apparatus, inhibiting cancer cells effectively.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Cell Biology

In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

Zheng Fu et al.

Summary: This study introduces a novel RNAi therapy strategy by genetically reprogramming the host liver to synthesize and deliver siRNA in vivo, showing potential therapeutic value for various diseases.

CELL RESEARCH (2021)

Add to Collection
Review Chemistry, Multidisciplinary

A comparison of RAFT and ATRP methods for controlled radical polymerization

Nghia P. Truong et al.

Summary: RAFT and ATRP are two commonly used controlled radical polymerization methods that can produce functional polymers with specific properties, but they have slightly different mechanisms and applications.

NATURE REVIEWS CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

A Strategy Based on the Enzyme-Catalyzed Polymerization Reaction of Asp-Phe-Tyr Tripeptide for Cancer Immunotherapy

Qiu-Ling Zhang et al.

Summary: Immunotherapy presents a promising strategy for cancer treatment, but systemic inhibition of antigen presentation limits its effectiveness. A tumor protein-engineering system based on the DFY tripeptide was developed to collect and deliver tumor proteins to immune cells, enhancing immune response. This system successfully enriched and transported tumor antigen-containing proteins in melanoma cells and suppressed tumor growth and recurrence in murine melanoma study.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Intramitochondrial Disulfide Polymerization Controls Cancer Cell Fate

Sangpil Kim et al.

Summary: The study developed an intramitochondrial polymerization-induced self-assembly system for regulating the fate of cancer cells, inducing cell necroptosis by increasing ROS levels. This in situ polymerization system shows great potential for cancer treatment, including drug-resistant cancers.

ACS NANO (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Ruthenium (II)-Coordinated Supramolecular Metallodrug Complex Realizing Oxygen Self-Supply In Situ for Overcoming Hypoxic Tumors

Chengfei Liu et al.

Summary: A stable and efficient in-situ oxygen self-supply system for hypoxic tumors is proposed using organometallic drug complexes with a supramolecular interaction strategy. The ruthenium (II)-coordinated supramolecular metallodrug complex (RuSMDC) is designed to produce oxygen by catalyzing the decomposition of hydrogen peroxide, leading to improved therapeutic effects of chemotherapy and photodynamic therapy oncotherapy in anaerobic tumor environments. Further studies confirm that Ru-containing supramolecular metallodrug micelles effectively alleviate the tumor hypoxic environment and reduce systemic toxicity.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Spatiotemporal Control over Chemical Assembly in Living Cells by Integration of Acid-Catalyzed Hydrolysis and Enzymatic Reactions

Xuejiao Yang et al.

Summary: The study presents an efficient and general platform for controlling the formation of assemblies in living cells, using a protective strategy to resist hydrolysis and enable selective unmasking in the lysosomes. Demonstrated in vitro and in living cells, this spatiotemporal control of chemical assembly may have applications in various fields including supramolecular chemistry, materials science, synthetic biology, and chemical biology.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Structure-Based Programming of Supramolecular Assemblies in Living Cells for Selective Cancer Cell Inhibition

Liangbo Hu et al.

Summary: By designing, synthesizing, and assembling an enzymatic programmable peptide system, we induced molecular assemblies formation spatiotemporally in living cancer cells, resulting in mainly necroptosis of glioblastoma cells. The stability and glycosylation of molecules play a crucial role in determining the bioactivity, as evidenced by detailed mechanistic studies showing site-specific formation of assemblies capable of activating the downstream cell death pathway.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Medicinal

Optimization of CAR-T Cell-Based Therapies Using Small-Molecule-Based Safety Switches

Yanjun Zheng et al.

Summary: CAR-T cell therapy has shown efficacy in antileukemia treatment, but is hindered by severe cytokine release syndrome. Engineering small-molecule safety switches for CAR-T cells can enhance safety and therapeutic efficiency, providing pharmacological control over activities and toxicities associated with cancer immunotherapies.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Oxidative Polymerization in Living Cells

Yiheng Dai et al.

Summary: This study demonstrates a novel oxidative polymerization reaction in cells triggered by intracellular ROS, selectively inducing apoptosis in cancer cells. The polymerization products disrupt intracellular antioxidant systems, leading to increased oxidative stress, further promoting oxidative polymerization and activating apoptosis pathways related to ROS. The anticancer efficacy and biosafety of this strategy are proven in vitro and in vivo, suggesting a new possibility for chemists to manipulate cellular behavior through artificial chemical reactions.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells

Shuang Liu et al.

Summary: The study demonstrates a novel approach using a L-phosphopentapeptide catalyzed by overexpressed ALP in iPSCs to selectively kill the undifferentiated cells, with harmless effects on normal cells. This work may lead to a new way to eliminate other pathological cells expressing high levels of specific enzymes.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection
Article Multidisciplinary Sciences

Rapid discovery of self-assembling peptides with one-bead one-compound peptide library

Pei-Pei Yang et al.

Summary: Self-assembling peptides have shown great potential in various fields, but identifying self-assembling sequences can be challenging. The authors developed an experimental method using a fluorescence-based screening approach to rapidly identify self-assembling peptides. They found that some pentapeptides can self-assemble into nanoparticles and interact efficiently with HeLa cells.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Endocrinology & Metabolism

Insulin action at a molecular level-100 years of progress

Morris F. White et al.

Summary: The discovery and application of insulin marked a major turning point in medical history, playing a crucial role in blood glucose regulation and the treatment of diseases like diabetes.

MOLECULAR METABOLISM (2021)

Add to Collection
Review Nanoscience & Nanotechnology

Engineered living biomaterials

Aleixandre Rodrigo-Navarro et al.

Summary: Engineered living materials consist of living cells and polymeric matrices, allowing for controllable responses and dynamic functions. Microorganisms as the active component in these materials can respond to environmental stimuli and have a wide range of biomedical applications.

NATURE REVIEWS MATERIALS (2021)

Add to Collection
Review Materials Science, Multidisciplinary

Bottom-up approaches to engineered living materials: Challenges and future directions

Sara Molinari et al.

Summary: The passage discusses the similar organization of biomaterials made by living systems and the growing interest in engineered living materials (ELMs) with tailored functions. It highlights the technologies still missing from the field of ELMs, such as designing novel matrix elements, producing and incorporating biominerals, and improving critical material properties. Overcoming these challenges will bring us closer to unlocking the potential and versatility of biomaterials in creating designer ELMs.

MATTER (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Inorganic nanomaterials with rapid clearance for biomedical applications

Xianwen Wang et al.

Summary: Inorganic nanomaterials have great potential in biomedicine, but long-term accumulation in healthy tissues can cause toxicity. The emergence of biodegradable and clearable inorganic nanomaterials provides a way to prevent such toxicity, and a comprehensive understanding of their design and metabolic pathways is essential for expanding therapeutic applications for various diseases.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection
Review Materials Science, Biomaterials

Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity

Yuqi Wang et al.

Summary: This review summarizes recent advances in the development of different modality imaging probes based on in situ self-assembly strategy for in vivo imaging of enzymatic activity. It discusses the applications of stimuli-mediated proteolysis and stimuli-triggered biocompatible reaction in designing fluorescence, MRI, PET, PA, and bimodality imaging probes for in vivo imaging of different enzymes. Challenges and prospects in the stimuli-responsive in situ self-assembly strategy for in vivo imaging are also discussed.

BIOMATERIALS SCIENCE (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Cell-Membrane-Based Biomimetic Systems with Bioorthogonal Functionalities

Li-Li Huang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Pre-targeted Imaging of Protease Activity through In Situ Assembly of Nanoparticles

Zixin Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection
Article Biochemical Research Methods

A New γ-Glutamyltranspeptidase-Based Intracellular Self-Assembly of Fluorine-18 Labeled Probe for Enhancing PET Imaging in Tumors

Siqin Ye et al.

BIOCONJUGATE CHEMISTRY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

β-galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells

Zhengfeng Gao et al.

SCIENCE CHINA-CHEMISTRY (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host-Guest Interactions

Danyu Xia et al.

CHEMICAL REVIEWS (2020)

Add to Collection
Article Multidisciplinary Sciences

Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals

Jia Liu et al.

SCIENCE (2020)

Add to Collection
Article Multidisciplinary Sciences

Genetically encoded X-ray cellular imaging for nanoscale protein localization

Huating Kong et al.

NATIONAL SCIENCE REVIEW (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Aerobic radical polymerization mediated by microbial metabolism

Gang Fan et al.

NATURE CHEMISTRY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

A Self-Evaluating Photothermal Therapeutic Nanoparticle

Yanfang Wang et al.

ACS NANO (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Recent Developments and Future Challenges in Controlled Radical Polymerization: A 2020 Update

Kostas Parkatzidis et al.

CHEM (2020)

Add to Collection
Article Engineering, Biomedical

Tumour sensitization via the extended intratumoural release of a STING agonist and camptothecin from a self-assembled hydrogel

Feihu Wang et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Add to Collection
Review Genetics & Heredity

mRNAs, proteins and the emerging principles of gene expression control

Christopher Buccitelli et al.

NATURE REVIEWS GENETICS (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Enzymatic Noncovalent Synthesis

Hongjian He et al.

CHEMICAL REVIEWS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Controlled Supramolecular Assembly Inside Living Cells by Sequential Multistaged Chemical Reactions

Michaela Pieszka et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Reduction Triggered In Situ Polymerization in Living Mice

Lina Cui et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Desuccinylation-Triggered Peptide Self-Assembly: Live Cell Imaging of SIRT5 Activity and Mitochondrial Activity Modulation

Liu Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Multidisciplinary Sciences

Directly observing intracellular nanoparticle formation with nanocomputed tomography

Miaomiao Zhang et al.

SCIENCE ADVANCES (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells

Hongjian He et al.

CELL REPORTS PHYSICAL SCIENCE (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Artificial Intracellular Filaments

Zhaoqianqi Feng et al.

CELL REPORTS PHYSICAL SCIENCE (2020)

Add to Collection
Review Biochemical Research Methods

Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review

Shambojit Roy et al.

BIOCONJUGATE CHEMISTRY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Therapeutic siRNA: state of the art

Bo Hu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production

Yoo-Sung Ko et al.

CHEMICAL SOCIETY REVIEWS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Instructed Assembly as Context-Dependent Signaling for the Death and Morphogenesis of Cells

Huaimin Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Review Biotechnology & Applied Microbiology

The current state and future directions of RNAi-based therapeutics

Ryan L. Setten et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Add to Collection
Review Biotechnology & Applied Microbiology

Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering

Kyeong Rok Choi et al.

TRENDS IN BIOTECHNOLOGY (2019)

Add to Collection
Article Multidisciplinary Sciences

Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions

Jung-Chen Lin et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Article Multidisciplinary Sciences

Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis

Omar Rifaie-Graham et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Article Nanoscience & Nanotechnology

Self-Assembled Injectable Nanocomposite Hydrogels Coordinated by in Situ Generated CaP Nanoparticles for Bone Regeneration

Lijun Kuang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection
Review Pharmacology & Pharmacy

Strategies, design, and chemistry in siRNA delivery systems

Yizhou Dong et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted Polypeptide-Microtubule Aggregation with Cucurbit[8]uril for Enhanced Cell Apoptosis

Ying-Ming Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly

Runqi Yan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection
Review Multidisciplinary Sciences

Synthetic biology strategies for microbial biosynthesis of plant natural products

Aaron Cravens et al.

NATURE COMMUNICATIONS (2019)

Add to Collection
Article Biochemical Research Methods

Assemblies of D-Peptides for Targeting Cell Nucleolus

Huaimin Wang et al.

BIOCONJUGATE CHEMISTRY (2019)

Add to Collection
Review Biology

Dynamic modifications of biomacromolecules: mechanism and chemical interventions

Chu Wang et al.

SCIENCE CHINA-LIFE SCIENCES (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Oxidation-Responsive Nanoassemblies for Light-Enhanced Gene Therapy

Na Zhang et al.

SMALL (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics

Li-Li Li et al.

ADVANCED MATERIALS (2019)

Add to Collection
Review Chemistry, Physical

Synthesis and biocompatibility of two-dimensional biomaterials

Shige Wang et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2019)

Add to Collection
Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Add to Collection
Article Chemistry, Physical

Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions

Hideki Nakamura et al.

NATURE MATERIALS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Nano-Biohybrids: In Vivo Synthesis of Metal-Organic Frameworks inside Living Plants

Joseph J. Richardson et al.

SMALL (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Nucleopeptide Assemblies Selectively Sequester ATP in Cancer Cells to Increase the Efficacy of Doxorubicin

Huaimin Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Tandem Molecular Self-Assembly in Liver Cancer Cells

Jie Zhan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis

Jie Zhou et al.

BIOCHEMISTRY (2018)

Add to Collection
Article Engineering, Biomedical

Imaging γ-Glutamyltranspeptidase for tumor identification and resection guidance via enzyme-triggered fluorescent probe

Haidong Li et al.

BIOMATERIALS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic Cleavage of Branched Peptides for Targeting Mitochondria

Hongjian He et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic Assemblies Disrupt the Membrane and Target Endoplasmic Reticulum for Selective Cancer Cell Death

Zhaoqianqi Feng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection
Review Cell Biology

The multifaceted contributions of mitochondria to cellular metabolism

Jessica B. Spinelli et al.

NATURE CELL BIOLOGY (2018)

Add to Collection
Article Chemistry, Physical

Therapeutic luminal coating of the intestine

Yuhan Lee et al.

NATURE MATERIALS (2018)

Add to Collection
Review Biotechnology & Applied Microbiology

Kinase inhibitors: the road ahead

Fleur M. Ferguson et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas

Melis Kayikci et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Add to Collection
Article Multidisciplinary Sciences

Quantitative mass imaging of single biological macromolecules

Gavin Young et al.

SCIENCE (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas

Melis Kayikci et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Ultraparamagnetic Cells Formed through Intracellular Oxidation and Chelation of Paramagnetic Iron

Pradeep Ramesh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Review Physiology

MECHANISMS OF INSULIN ACTION AND INSULIN RESISTANCE

Max C. Petersen et al.

PHYSIOLOGICAL REVIEWS (2018)

Add to Collection
Article Polymer Science

Repurposing Biocatalysts to Control Radical Polymerizations

Kyle J. Rodriguez et al.

ACS MACRO LETTERS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor-Targeting Nanocarriers Based on Host-Guest Interaction between a Pillar[5]arene-Based Prodrug and a RGD-Sulfonate Guest

Xiao-Yu Hu et al.

SMALL (2018)

Add to Collection
Review Biochemistry & Molecular Biology

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

Thanigaimalai Pillaiyar et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

Yue Lu et al.

NANO LETTERS (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Hua Wang et al.

NATURE CHEMICAL BIOLOGY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization

Jia Niu et al.

NATURE CHEMISTRY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

Add to Collection
Review Cell Biology

The mystery of membrane organization: composition, regulation and roles of lipid rafts

Erdinc Sezgin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Add to Collection
Article Multidisciplinary Sciences

Intracellular construction of topology-controlled polypeptide nanostructures with diverse biological functions

Li-Li Li et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Review Chemistry, Multidisciplinary

Design Strategies of Stimuli-Responsive Supramolecular Hydrogels Relying on Structural Analyses and Cell-Mimicking Approaches

Hajime Shigemitsu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

Add to Collection
Review Chemistry, Multidisciplinary

Bioinspired assembly of small molecules in cell milieu

Huaimin Wang et al.

CHEMICAL SOCIETY REVIEWS (2017)

Add to Collection
Review Engineering, Biomedical

The case for applying tissue engineering methodologies to instruct human organoid morphogenesis

Carlos R. Marti-Figueroa et al.

ACTA BIOMATERIALIA (2017)

Add to Collection
Review Biochemistry & Molecular Biology

The Principles of Engineering Immune Cells to Treat Cancer

Wendell A. Lim et al.

CELL (2017)

Add to Collection
Review Biochemistry & Molecular Biology

The endoplasmic reticulum: structure, function and response to cellular signaling

Dianne S. Schwarz et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Add to Collection
Review Oncology

The role of lysosome in cell death regulation

Feifei Yu et al.

TUMOR BIOLOGY (2016)

Add to Collection
Review Pharmacology & Pharmacy

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

Maggie L. Bobbin et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)

Add to Collection
Review Cell Biology

Phase separation in biology; functional organization of a higher order

Diana M. Mitrea et al.

CELL COMMUNICATION AND SIGNALING (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Integrating Enzymatic Self-Assembly and Mitochondria Targeting for Selectively Killing Cancer Cells without Acquired Drug Resistance

Huaimin Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

Quanyin Hu et al.

NANO LETTERS (2016)

Add to Collection
Review Multidisciplinary Sciences

Unravelling biological macromolecules with cryo-electron microscopy

Rafael Fernandez-Leiro et al.

NATURE (2016)

Add to Collection
Review Chemistry, Physical

Supramolecular biomaterials

Matthew J. Webber et al.

NATURE MATERIALS (2016)

Add to Collection
Review Microbiology

Synthetic biology to access and expand nature's chemical diversity

Michael J. Smanski et al.

NATURE REVIEWS MICROBIOLOGY (2016)

Add to Collection
Article Polymer Science

Laccase-catalyzed controlled radical polymerization of N-vinylimidazole

Csaba Fodor et al.

POLYMER CHEMISTRY (2016)

Add to Collection
Review Polymer Science

Photomediated controlled radical polymerization

Xiangcheng Pan et al.

PROGRESS IN POLYMER SCIENCE (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Confined-space synthesis of nanostructured anatase, directed by genetically engineered living organisms for lithium-ion batteries

Hang Ping et al.

CHEMICAL SCIENCE (2016)

Add to Collection
Article Multidisciplinary Sciences

The dynamics of filament assembly define cytoskeletal network morphology

Giulia Foffano et al.

NATURE COMMUNICATIONS (2016)

Add to Collection
Article Materials Science, Biomaterials

Safe and Efficient Colonic Endoscopic Submucosal Dissection Using an Injectable Hydrogel

Luping Cao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Add to Collection
Article Materials Science, Biomaterials

Safe and Efficient Colonic Endoscopic Submucosal Dissection Using an Injectable Hydrogel

Luping Cao et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Add to Collection
Article Nanoscience & Nanotechnology

Ultrasensitive ROS-Responsive Coassemblies of Tellurium-Containing Molecules and Phospholipids

Lu Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance

Yue Yuan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase

Feiyi Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Ultra-sensitive ROS-responsive tellurium-containing polymers

Wei Cao et al.

CHEMICAL COMMUNICATIONS (2015)

Add to Collection
Editorial Material Chemistry, Multidisciplinary

Introduction: Supramolecular Chemistry

Feihe Huang et al.

CHEMICAL REVIEWS (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Cancer Cell Death Induced by the Intracellular Self-Assembly of an Enzyme-Responsive Supramolecular Gelator

Akiko Tanaka et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Controlling Cancer Cell Fate Using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile

Ricardo A. Pires et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Add to Collection
Article Multidisciplinary Sciences

Protein folding guides disulfide bond formation

Meng Qin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis of Metal Nanoparticles Inside Living Human Cells Based on the Intracellular Formation Process

Waleed A. El-Said et al.

ADVANCED MATERIALS (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Cell- Permeant and Photocleavable Chemical Inducer of Dimerization

Mirjam Zimmermann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Add to Collection
Review Chemistry, Multidisciplinary

Click reactions: a versatile toolbox for the synthesis of peptide-conjugates

Wen Tang et al.

CHEMICAL SOCIETY REVIEWS (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic synthesis of ionic responsive lignin nanofibres through surface poly(N-isopropylacrylamide) immobilization

Guangzheng Gao et al.

GREEN CHEMISTRY (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Intracellular Protein-Responsive Supramolecules: Protein Sensing and In-Cell Construction of Inhibitor Assay System

Tatsuyuki Yoshii et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection
Article Chemistry, Multidisciplinary

A Robust and Versatile Photoinduced Living Polymerization of Conjugated and Unconjugated Monomers and Its Oxygen Tolerance

Jiangtao Xu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection
Article Chemistry, Physical

Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling

E. Peter Magennis et al.

NATURE MATERIALS (2014)

Add to Collection
Review Biochemistry & Molecular Biology

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

Jing L. Guo et al.

NATURE MEDICINE (2014)

Add to Collection
Review Microbiology

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

Chris J. Paddon et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Add to Collection
Review Oncology

The Role of Matrix Metalloproteinases in Colorectal Cancer

Anan H. Said et al.

CANCERS (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Mechanism-Oriented Controllability of Intracellular Quantum Dots Formation: The Role of Glutathione Metabolic Pathway

Yong Li et al.

ACS NANO (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Hemoglobin and Red Blood Cells Catalyze Atom Transfer Radical Polymerization

Tilana B. Silva et al.

BIOMACROMOLECULES (2013)

Add to Collection
Article Chemistry, Medicinal

Tissue transglutaminase: An emerging target for therapy and imaging

Markus Pietsch et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Add to Collection
Review Genetics & Heredity

How cells get the message: dynamic assembly and function of mRNA-protein complexes

Michaela Mueller-McNicoll et al.

NATURE REVIEWS GENETICS (2013)

Add to Collection
Review Pharmacology & Pharmacy

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

Longfa Kou et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Rapid and orthogonal logic gating with a gibberellin-induced dimerization system

Takafumi Miyamoto et al.

NATURE CHEMICAL BIOLOGY (2012)

Add to Collection
Article Multidisciplinary Sciences

Imaging enzyme-triggered self-assembly of small molecules inside live cells

Yuan Gao et al.

NATURE COMMUNICATIONS (2012)

Add to Collection
Review Oncology

Spatial regulation of receptor tyrosine kinases in development and cancer

Jessica B. Casaletto et al.

NATURE REVIEWS CANCER (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Construction and Potential Applications of a Functionalized Cell with an Intracellular Mineral Scaffold

Xiaoming Ma et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Add to Collection
Article Chemistry, Multidisciplinary

Controlling Intracellular Macrocyclization for the Imaging of Protease Activity

Deju Ye et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Add to Collection
Article Polymer Science

Horseradish Peroxidase as a Catalyst for Atom Transfer Radical Polymerization

Severin J. Sigg et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2011)

Add to Collection
Review Chemistry, Multidisciplinary

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

Tore-Geir Iversen et al.

NANO TODAY (2011)

Add to Collection
Article Chemistry, Multidisciplinary

A biocompatible condensation reaction for controlled assembly of nanostructures in living cells

Gaolin Liang et al.

NATURE CHEMISTRY (2010)

Add to Collection
Review Polymer Science

Transition metal catalysts for controlled radical polymerization

Fabio di Lena et al.

PROGRESS IN POLYMER SCIENCE (2010)

Add to Collection
Review Biotechnology & Applied Microbiology

Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development

D. D. Rao et al.

CANCER GENE THERAPY (2009)

Add to Collection
Article Chemistry, Physical

Self-assembly approaches for the construction of cell architecture mimics

A. M. Brizard et al.

SOFT MATTER (2009)

Add to Collection
Review Chemistry, Multidisciplinary

Enzymatic hydrogelation of small molecules

Zhimou Yang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

Add to Collection
Letter Cell Biology

A unified vision of the building blocks of life

Jamey D. Marth

NATURE CELL BIOLOGY (2008)

Add to Collection
Article Chemistry, Multidisciplinary

Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death

Zhimou Yang et al.

ADVANCED MATERIALS (2007)

Add to Collection
Review Biochemistry & Molecular Biology

Chemistry in living systems

JA Prescher et al.

NATURE CHEMICAL BIOLOGY (2005)

Add to Collection
Article Engineering, Biomedical

Crosslinking of collagen gels by transglutaminase

JM Orban et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2004)

Add to Collection
Article Chemistry, Multidisciplinary

Enzymatic formation of supramolecular hydrogels

ZM Yang et al.

ADVANCED MATERIALS (2004)

Add to Collection
Review Chemistry, Multidisciplinary

NMR characterization of the dynamics of biomacromolecules

AG Palmer

CHEMICAL REVIEWS (2004)

Add to Collection
Article Biochemistry & Molecular Biology

Bacterial biosynthesis of cadmium sulfide nanocrystals

RY Sweeney et al.

CHEMISTRY & BIOLOGY (2004)

Add to Collection
Review Engineering, Biomedical

Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility

E Fournier et al.

BIOMATERIALS (2003)

Add to Collection
Article Biochemistry & Molecular Biology

Pyocyanin induces oxidative stress in human endothelial cells and modulates the glutathione redox cycle

M Muller

FREE RADICAL BIOLOGY AND MEDICINE (2002)

Add to Collection
Article Engineering, Biomedical

In situ crosslinking of a biomimetic peptide-PEG hydrogel via thermally triggered activation of factor XIII

TJ Sanborn et al.

BIOMATERIALS (2002)

Add to Collection
Review Biochemistry & Molecular Biology

Cell signaling by receptor tyrosine kinases

J Schlessinger

CELL (2000)

Add to Collection
Article Multidisciplinary Sciences

Cell surface engineering by a modified Staudinger reaction

E Saxon et al.

SCIENCE (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.