Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer's disease and other aging-related disorders

Article Clinical Neurology

Results and insights from a phase I clinical trial of Lomecel-B for Alzheimer's disease

Mark Brody et al.

Summary: The study suggests that Lomecel-B is safe for AD patients and has the potential to modify the disease. In clinical and biomarker domains, Lomecel-B showed potential efficacy in treating mild AD patients.

ALZHEIMERS & DEMENTIA (2023)

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Article Materials Science, Biomaterials

Loading Nanoceria Improves Extracellular Vesicle Membrane Integrity and Therapy to Wounds in Aged Mice

Lei Gao et al.

Summary: Hypoxic nanozyme loaded extracellular vesicles derived from mesenchymal stem cells promote wound healing in aged mice. These vesicles have favorable biocompatibility and antioxidative and proangiogenic effects, potentially through the transfer of specific miRNAs.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

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Article Dermatology

Bone marrow mesenchymal stem cell-derived exosome miR-29b-3p alleviates UV irradiation-induced photoaging in skin fibroblast

Tingting Yan et al.

Summary: This study found that miR-29b-3p derived from bone marrow MSCs-exo plays an important role in improving skin photoaging. BMSCs-exo-miR-29b-3p can reverse the inhibition of cell migration, oxidative stress, and apoptosis caused by UVB irradiation, as well as inhibit the degradation of collagen and the production of MMPs in photoaging.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2023)

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Article Engineering, Biomedical

Exploring the Potential of Stem Cell-Based Therapy for Aesthetic and Plastic Surgery

Dang-Khoa Tran et al.

Summary: Over the past decade, the use of stem cell therapies in aesthetic and plastic surgery has increased due to their potential for self-renewal and multipotent differentiation. Adipose-derived stem cells have been particularly promising for fat grafting and have shown benefits in scar improvement, anti-aging, and skin rejuvenation. However, stem cell-based products have not yet received FDA approval for aesthetic medicine and plastic surgery, and the literature on the efficacy and potential of stem cell-based therapy in this field is limited. This review discusses the current status and recent advances in using stem cells for aesthetic and plastic surgery, highlighting the potential of cell-free therapy and tissue engineering.

IEEE REVIEWS IN BIOMEDICAL ENGINEERING (2023)

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Article Chemistry, Multidisciplinary

Young Exosome Bio-Nanoparticles Restore Aging-Impaired Tendon Stem/Progenitor Cell Function and Reparative Capacity

Shanshan Jin et al.

Summary: This study demonstrates that exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED-Exos) possess abundant anti-aging signals and can alleviate the aging phenotypes of aged tendon stem/progenitor cells. Mechanistically, SHED-Exos modulate histone methylation and inhibit nuclear factor-kappa B to reverse AT-SC aging. In a naturally aging mouse model, systemic administration of SHED-Exo nanoparticles retards tendon degeneration and local delivery of SHED-Exos-loaded microspheres rescues endogenous tendon regeneration and repair capacity in aged rats.

ADVANCED MATERIALS (2023)

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Article Clinical Neurology

MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease

Ashish Kumar et al.

Summary: By analyzing microRNAs in small extracellular vesicles in the blood, unique cellular and molecular information related to the onset and progression of Alzheimer's disease can be obtained. The study found that specific microRNAs in certain subtypes of small extracellular vesicles showed differential expression in individuals with normal cognition, mild cognitive impairment, MCI conversion to AD dementia, and AD dementia, and were correlated with cortical thickness on magnetic resonance imaging. These findings suggest that microRNA analysis in specific extracellular vesicles may serve as a novel blood-based molecular biomarker for Alzheimer's disease.

ALZHEIMERS & DEMENTIA (2023)

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Article Medicine, Research & Experimental

Depletion of gut microbiota resistance in 5?FAD mice enhances the therapeutic effect of mesenchymal stem cell-derived exosomes

Xuejia Hou et al.

Summary: This study demonstrates that the therapeutic effect of MSCs-exo for Alzheimer's disease is limited by gut microbiota dysbiosis, but can be enhanced by the application of antibiotics.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Cell Biology

The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review

Elzbieta Cecerska-Heryc et al.

Summary: Stem cells have shown great potential in treating neurological diseases such as MS, ALS, AD, PD, and HD. Different types of stem cells have demonstrated effectiveness in slowing down disease progression and improving symptoms. However, more research and refinement are needed to optimize the therapy's effectiveness in humans.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2023)

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Article Oncology

Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse livers

Mingying Ling et al.

Summary: This study aimed to investigate the effects and underlying mechanisms of exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) on aging livers. Results showed that hUCMSC-exos improved structural disorder and decreased senescence markers and genome instability in aging livers. Metabolomics and phosphoproteomics analyses revealed that hUCMSC-exos regulated lipid metabolism and phosphorylation levels of proteins involved in various cellular processes. Overall, hUCMSC-exos improved metabolic reprogramming and genome stability in aging livers, providing a basis for future research on the application of hUCMSC-exos in aging.

EXPERIMENTAL CELL RESEARCH (2023)

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Article Geriatrics & Gerontology

The profile of circulating extracellular vesicles depending on the age of the donor potentially drives the rejuvenation or senescence fate of hematopoietic stem cells

Parvaneh Abbasi Sourki et al.

Summary: Blood donor age has a significant impact on the behavior of hematopoietic stem cells (HSCs) due to age-associated variations in plasma-derived extracellular nano-sized vesicles (EVs) content. Young donor EVs improve HSCs' growth and self-renewal potential, while EVs from elderly donors induce senescence-associated differentiation towards the myeloid lineage. This study reveals the role of EVs in delivering youth or aging signals to HSCs and emphasizes the importance of understanding EVs' content for blood transfusion safety and efficacy.

EXPERIMENTAL GERONTOLOGY (2023)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Hype or Hope for Skeletal Muscle Anti-Frailty

Elancheleyen Mahindran et al.

Summary: Population ageing is increasing globally due to advancements in medical treatments and technologies. This leads to a higher prevalence of age-related diseases, such as muscle loss, among the older population. Current interventions only slow down and control symptoms, and there is no treatment to prevent or reverse age-related muscle frailty. Mesenchymal stem cell-derived extracellular vesicle (MSC-EV) therapy shows promise in attenuating age-related muscle frailty, but further studies, including large-scale clinical trials, are needed to determine its effectiveness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Chemistry, Multidisciplinary

MSC-derived extracellular vesicles as nanotherapeutics for promoting aged liver regeneration

Jiebin Zhang et al.

Summary: Aging impairs liver regeneration after hepatic surgery in the elderly population, and no effective treatment is available for clinical administration. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown therapeutic potential in liver diseases. This study found that MSCs can reduce senescence-associated markers and promote liver regeneration in aged mice through the secretion of MSC-EVs. Mechanistically, these effects were partially attributed to inducing mitophagy via the Atg4B pathway. The presence of DEAD-Box Helicase 5 (DDX5) in MSC-EVs was found to interact with E2F1 and activate the expression of Atg4B. These findings highlight the clinical application potential of MSC-EVs in preventing severe complications in aged individuals undergoing liver surgery.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Cell Biology

Biochemical study of the effect of mesenchymal stem cells-derived exosome versus l-Dopa in experimentally induced Parkinson's disease in rats

Asmaa S. S. Mohamed et al.

Summary: This study aimed to examine the effects of BM-MSCs-derived exosomes in rats induced with Parkinson's disease, and found that MSC-derived exosomes showed a greater suppression of neurodegenerative disease compared to l-Dopa in Parkinson's patients.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

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Article Neurosciences

Neuroprotective mechanism of human umbilical cord mesenchymal stem cell-derived extracellular vesicles improving the phenotype polarization of microglia via the PI3K/AKT/Nrf2 pathway in vascular dementia

Pengwei Wang et al.

Summary: The objective of this study was to investigate the mechanism of human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUCMSC-Evs) in the treatment of vascular dementia (VaD). The results showed that hUCMSC-Evs protected nerve functions in VaD rats by activating the PI3K/AKT/Nrf2 pathway, inhibiting microglial M1 polarization, inflammation, and oxidative stress.

SYNAPSE (2023)

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Article Anatomy & Morphology

Administration of stem cells against cardiovascular diseases with a focus on molecular mechanisms: Current knowledge and prospects

Mohammad Karimian et al.

Summary: Cardiovascular diseases (CVDs) are a major global health threat and remain the leading cause of death and disability worldwide. Stem cell-based therapies, particularly induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs), show promise in improving cardiovascular functioning and promoting heart regeneration. Extensive studies have demonstrated the efficacy and safety of using iPSCs and MSCs for the treatment of CVDs. This study focuses on the application of stem cells in CVD treatment, exploring cellular and molecular mechanisms and discussing the advantages, disadvantages, and future perspectives of this technology.

TISSUE & CELL (2023)

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Article Cell Biology

Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

Chao Wang et al.

Summary: With the expansion of the aging population, age-associated sarcopenia (AAS) has become a severe clinical disease of the elderly and a key challenge for healthy aging. Unfortunately, there are currently no approved therapies for treating AAS. In this study, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) were administered to two mouse models, and it was found that they significantly restored skeletal muscle strength and performance by raising the expression of crucial extracellular matrix proteins, activating satellite cells, enhancing autophagy, and impeding cellular aging. This study provides a novel model for AAS and highlights the potential of hUC-MSCs as a promising strategy for treating AAS and other age-associated muscle diseases.

CELL DEATH & DISEASE (2023)

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Review Geriatrics & Gerontology

The emerging double-edged sword role of exosomes in Alzheimer's disease

Tao Liang et al.

Summary: Alzheimer's disease (AD) is a common neurodegenerative disease characterized by memory loss and cognitive dysfunction. The pathological hallmarks of AD include senile plaques, neurofibrillary tangles, and neuronal loss. Recent research has shown that extracellular vesicles, specifically exosomes, play a significant role in AD. Exosomes can act as carriers for the transmission of toxic proteins, contribute to the amplification of misfolded proteins, and participate in the degradation and clearance of amyloid beta (A beta). This review summarizes the current research findings on the double-edged role of exosomes in AD.

FRONTIERS IN AGING NEUROSCIENCE (2023)

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Review Immunology

Mechanism of mesenchymal stem cells and exosomes in the treatment of age-related diseases

Jia Li et al.

Summary: Mesenchymal stem cells (MSCs) from multiple tissues have the capability of multidirectional differentiation and self-renewal, and their derived exosomes (MSC-Exos) may have a real role to play in treating age-related diseases. The review focuses on the biological characteristics of MSCs and exosomes, their mechanisms in treating age-related diseases, current trials, ongoing clinical trials, and the prospects and challenges for the future use of exosomes in disease treatment.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Chemistry, Multidisciplinary

Inducible Pluripotent Stem Cell-Derived Small Extracellular Vesicles Rejuvenate Senescent Blood-Brain Barrier to Protect against Ischemic Stroke in Aged Mice

Qing Li et al.

Summary: This study demonstrates that inducible pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs) can alleviate blood-brain barrier (BBB) senescence and improve stroke outcomes in aged mice.

ACS NANO (2023)

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Article Cell Biology

Urine-derived mesenchymal stem cells-derived exosomes enhances survival and proliferation of aging retinal ganglion cells

Qi-Qin Dan et al.

Summary: This study aimed to investigate the effects of exosomes from urine-derived mesenchymal stem cells (USCs) on aging retinal ganglion cells (RGCs) and explore the related mechanisms. Cultured and identified USCs were used to treat aging RGCs models. The results showed that USCs-derived exosomes reduced apoptosis and promoted cell viability and proliferation of aging RGCs. Gene sequencing analysis identified differentially expressed genes (DEGs) in aging RGCs and aging RGCs treated with USCs conditioned medium, revealing the involvement of multiple genetic variations and signaling pathways changes.

BMC MOLECULAR AND CELL BIOLOGY (2023)

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Article Chemistry, Multidisciplinary

A Redox Homeostasis Modulatory Hydrogel with GLRX3+ Extracellular Vesicles Attenuates Disc Degeneration by Suppressing Nucleus Pulposus Cell Senescence

Can Liu et al.

Summary: In this study, the authors found that Glutaredoxin3(GLRX3) is an important redox-regulating molecule associated with nucleus pulposus (NP) cell senescence and disc degeneration. They developed GLRX3(+) mesenchymal stem cell-derived extracellular vehicles (EVs-GLRX3) that enhanced antioxidant defense and prevented senescence cascade expansion. They also proposed a disc tissue-like biopolymer-based supramolecular hydrogel for delivering EVs-GLRX3 to treat disc degeneration. The EVs-GLRX3-loaded hydrogel attenuated mitochondrial damage, alleviated NP senescence, and restored ECM deposition.

ACS NANO (2023)

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Review Multidisciplinary Sciences

An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer's disease

Madhan Jeyaraman et al.

Summary: Globally, neurological diseases, particularly Alzheimer's disease, have a significant impact on healthcare professionals. Alzheimer's disease is a progressive neurological disorder that leads to the loss of neurons and synapses in the brain. The treatment of Alzheimer's disease remains controversial, and this paper examines the potential use of genetically modified stem cells and extracellular vesicles in regenerative medicine for Alzheimer's disease.

HELIYON (2023)

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Review Medicine, Research & Experimental

Engineered mesenchymal stem cell-derived extracellular vesicles: A state-of-the-art multifunctional weapon against Alzheimer?s disease

Tong Yin et al.

Summary: With the increasing population aging, the prevalence of Alzheimer's disease (AD) is also on the rise. However, there is currently no effective treatment available to slow down or stop the progression of AD. This review highlights the engineering strategies of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and discusses their potential as therapeutics for AD. The review also presents the challenges and prospects associated with the clinical applications of engineered MSC-EVs in AD therapy.

THERANOSTICS (2023)

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Article Immunology

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

Sen Liu et al.

Summary: Lateral ventricle administration of BMSC-exos improved AD-like behaviors and inhibited glial activation and neuroinflammation in the hippocampus of mice. Additionally, it upregulated the expression of synapse-related proteins and BDNF.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Cell & Tissue Engineering

Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche

Francesca Natale et al.

Summary: The depletion of neural stem and progenitor cells (NSPCs) may contribute to cognitive impairment in age-related diseases, and insulin resistance has been linked to brain dysfunction. In an experimental model of insulin-resistant NSPCs, researchers identified a molecular circuit involving insulin receptor substrate-1 (IRS-1)/Forkhead box O (FoxO) signaling cascade that inhibits the activation of transcription factors FoxO1 and FoxO3a, which regulate cell proliferation and self-renewal. Insulin resistance also increased the expression of cyclin-dependent kinase inhibitor 1 (p21) and accelerated NSPC senescence. However, stimulation of NSPCs with NSPC-derived exosomes (exo-NSPC) rescued IRS-1/FoxO activation and countered the reduced proliferation and senescence of stem cells. Administration of exo-NSPC via the nasal route also restored the balance between proliferating and senescent NSPCs in the hippocampus of mice on a high-fat diet, improving adult hippocampal neurogenesis. These findings provide insights into the metabolic control of NSPC fate and the role of extracellular vesicles in regulating cell fate in the adult neurogenic niche.

STEM CELLS (2022)

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Article Geriatrics & Gerontology

Mesenchymal stromal cell-derived small extracellular vesicles promote neurological recovery and brain remodeling after distal middle cerebral artery occlusion in aged rats

Danut-Adrian Dumbrava et al.

Summary: The study found that MSC-sEVs can improve neurological recovery and brain tissue remodeling in aged rats post-stroke by promoting angiogenesis and neurogenesis to alleviate the inflammatory environment after stroke.

GEROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

News about Therapies of Alzheimer's Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments

Jacopo Meldolesi

Summary: Alzheimer's, a neurodegenerative disease affecting millions of patients worldwide, has lacked effective therapy. Recent advancements include BACE-1 enzyme blockers and extracellular vesicles secreted by mesenchymal stem cells, which show promising therapeutic effects. However, these treatments have limitations in treating established, irreversible lesions.

BIOMEDICINES (2022)

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Article Dermatology

Rise of stem cell therapies in aesthetics

Nina Semsarzadeh et al.

Summary: Stem cells have the potential to be used in regenerative medicine and cosmetic dermatology due to their ability to self-renew and differentiate into other cell types. Adipose-derived stem cells, which are relatively easy to collect and abundant, have gained particular attention in aesthetics. While promising results have been seen in the treatment of androgenetic alopecia and skin rejuvenation, the use of stem cells in cosmeceuticals is still in its early stages. Further research, including randomized controlled trials and treatment standardization, is needed to fully understand the role of stem cells in aesthetics.

CLINICS IN DERMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Exosomes Derived from Human Amniotic Fluid Mesenchymal Stem Cells Preserve Microglia and Neuron Cells from Aβ

Manuela Zavatti et al.

Summary: This study found that exosomes derived from human amniotic fluid stem cells can alleviate inflammatory injury caused by microglia and significantly recover neurotoxicity. This suggests that hAFSC-exo may serve as a potential therapeutic agent for inflammation-related neurological conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biotechnology & Applied Microbiology

Extracellular vesicles derived from inflammatory-educated stem cells reverse brain inflammation-implication of miRNAs

Eleni Markoutsa et al.

Summary: Inflammation plays a crucial role in age-related diseases, and the release of miRNAs from primed stem cells can inhibit neuro-inflammation.

MOLECULAR THERAPY (2022)

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Letter Cell Biology

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Jinghui Lei et al.

PROTEIN & CELL (2022)

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Article Biotechnology & Applied Microbiology

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-dependent Manner

Pascal Fichtel et al.

Summary: Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis. The communication between HSPCs and MSCs is mediated by direct cell-cell contacts or extracellular vesicles (EVs) that carry bioactive substances. Aging MSCs secrete fewer miRNAs, but aged MSC-EVs contain higher levels of specific miRNAs such as miR-29a and miR-34a. Young EVs enhance the cell number and viability of HSPCs, while aged MSC-EVs promote the differentiation of HSPCs into erythroid and erythroid-megakaryocytic progenitor cells. The therapeutic relevance of MSC-derived EVs in modulating HSPC characteristics needs further investigation.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases

Jorge Sanz-Ros et al.

Summary: Aging is associated with changes in intercellular communication, and extracellular vesicles (EVs) play an important role in these changes. EVs regulate the aging process, promote tissue regeneration, and have potential as a cell-free therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Cell & Tissue Engineering

Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging

Jin-Yan Wu et al.

Summary: Senescence is a natural process involving tissue and organ degeneration, and skin aging has gained attention recently. Stem cell transplantation and the molecular transfer mechanism within exosomes could potentially be novel approaches to delay skin aging.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Article Biotechnology & Applied Microbiology

The Antisenescence Effect of Exosomes from Human Adipose-Derived Stem Cells on Skin Fibroblasts

Ji-An Guo et al.

Summary: This study isolated ADSC-Exos and found that it can alleviate human dermal fibroblast senescence, stimulate cell migration, and inhibit the expression levels of senescence-related proteins.

BIOMED RESEARCH INTERNATIONAL (2022)

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Article Chemistry, Multidisciplinary

Engineered Extracellular Vesicles with SHP2 High Expression Promote Mitophagy for Alzheimer's Disease Treatment

Fang Xu et al.

Summary: This study develops a platform for Alzheimer's disease (AD) therapy using nanosized mesenchymal-stem-cells-derived extracellular vesicles with high expression of tyrosine phosphatase-2 (SHP2). The platform demonstrates high blood-brain barrier penetration ability, delivers SHP2 to the brain, and induces significant mitophagy of neuronal cells, thereby alleviating mitochondrial damage, apoptosis, and neuroinflammation, leading to improved synaptic loss and cognitive decline in an AD mouse model.

ADVANCED MATERIALS (2022)

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Article Cell & Tissue Engineering

Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges

Tian-Tian Li et al.

Summary: Chronic liver diseases are a significant global health issue and require the development of novel therapeutic approaches. Cell-based therapies have shown promise in improving chronic liver diseases and restoring liver function through tissue repair and immunomodulation. This review summarizes the progress and challenges of different cell therapies explored in clinical trials and animal studies, with a focus on the use of mesenchymal stem cells (MSCs).

STEM CELLS TRANSLATIONAL MEDICINE (2022)

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Review Genetics & Heredity

Mesenchymal-Stem-Cell-Based Strategies for Retinal Diseases

Xiteng Chen et al.

Summary: Research on stem cell therapy for retinal diseases suggests that the paracrine effect may play a dominant role, and MSC-derived extracellular vesicles have emerged as a novel and powerful alternative for cell-free therapy.

GENES (2022)

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Article Multidisciplinary Sciences

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Jorge Sanz-Ros et al.

Summary: This study found that treatment of old animals with ADSC-sEVs derived from young animals can improve various parameters associated with aging and reduce frailty. This treatment induces proregenerative effects and reduces oxidative stress, inflammation, and senescence in muscle and kidney. Additionally, tissue epigenetic age decreases and metabolome shifts to a youth-like pattern after this treatment.

SCIENCE ADVANCES (2022)

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Review Biochemistry & Molecular Biology

The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Yuyi Han et al.

Summary: Mesenchymal stromal/stem cells (MSCs) possess the potential of multi-lineage differentiation and self-renewal, and their therapeutic effects in treating inflammatory diseases are mainly achieved through the secretion of factors that regulate immune response, tissue remodeling, and cellular homeostasis.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Cell & Tissue Engineering

Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by beta-amyloid

Dorota Kaniowska et al.

Summary: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (EVs) have therapeutic effects in various degenerative and inflammatory diseases. EVs, loaded with proteins, lipids, and RNA, serve as intercellular communicators. In this study, we demonstrate that EVs can be internalized by murine microglial cells and partially reduce their activation against beta-amyloid aggregates. This inhibition of microglia activation may present an effective strategy for controlling/treating neurodegenerative diseases such as Alzheimer's disease.

STEM CELL REVIEWS AND REPORTS (2022)

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Article Cell Biology

Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP/PS1 mice

Han Wang et al.

Summary: The study demonstrated that MSC-EVs therapy can improve cognitive impairments, reduce neuronal loss, and restore intracellular changes in the hippocampus of AD mice. Additionally, the involvement of the Nrf2 signaling pathway in the actions of MSC-EVs in cell and animal models was also identified.

CELL DEATH DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

Current understandings of the relationship between extracellular vesicles and cilia

Koji Ikegami et al.

Summary: Mammalian cells have tiny hair-like protrusions called primary cilia that are believed to act as antennae, receiving signals from the environment and interacting with extracellular vesicles (EVs). Single-celled organisms like Chlamydomonas release EVs to communicate with their surroundings using long cilia known as flagella. Evidence suggests that primary cilia not only receive external signals, but also release EVs that impact cellular physiological and pathological processes.

JOURNAL OF BIOCHEMISTRY (2021)

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Article Dentistry, Oral Surgery & Medicine

Extracellular Vesicles of GMSCs Alleviate Aging-Related Cell Senescence

H. Z. Shi et al.

Summary: The study demonstrates that extracellular vesicles released by gingiva-derived mesenchymal stem cells can effectively inhibit cellular aging induced by oxidative stress and restore cellular function. Systemic administration can reduce the expression of aging-related genes in the skin and heart tissues of aged mice.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis

Guowen Hu et al.

Summary: The study demonstrates that neural stem cell senescence can lead to cognitive impairment, and treatment with ESC-sEVs in mice models can effectively reverse this process by rejuvenating the senescent stem cells, improving regeneration capacity, and ameliorating cognitive deficits.

MOLECULAR THERAPY (2021)

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Article Dermatology

Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

Young In Lee et al.

Summary: The study found that post-laser topical application of adipocyte-derived stem cell-containing medium (ADSC-CM) in combination with niacinamide has anti-aging effect on skin, as demonstrated by improved wrinkle and melanin indices, along with decreased pro-inflammatory cytokines and increased Type 1 collagen expression in in vitro assays.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Review Cell Biology

Stem cells for treatment of cardiovascular diseases: An umbrella review of randomized controlled trials

Jacopo Demurtas et al.

Summary: Through an umbrella review study, it was found that the efficacy of stem cells in the treatment of cardiovascular diseases is better than placebo, especially in the cases of acute myocardial infarction and refractory angina.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

ASCs-derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury

Jia Fang et al.

Summary: Acute liver injury is a condition of short-term liver cell damage, for which there is currently no effective treatment, but stem cell-derived exosomes show therapeutic potential. Loading quercetin and vitamin A enhances the efficacy and liver targeting of mesenchymal stem cell exosomes, reducing rapid senescence-like response induced by acute liver injury.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Dental pulp stem cell-derived small extracellular vesicle in irradiation-induced senescence

Jiao Dong et al.

Summary: The study showed that hDPSC-sEV can slow down radiation-induced cellular senescence and reduce inflammatory cytokine expression. These findings provide hope for the development of innovative treatment methods for salivary gland dysfunction following radiotherapy for head and neck cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cell Biology

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway

Xinhui Wang et al.

Summary: Exosomes play a role in the development and progression of Alzheimer's disease, with potential to reduce A beta deposition and promote cognitive function recovery in AD mice by activating the SphK/S1P signaling pathway. This suggests that exosomes containing S1P/SphK could be explored as a potential AD cure.

CELL BIOLOGY INTERNATIONAL (2021)

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Review Cell Biology

Therapeutic effects and perspective of stem cell extracellular vesicles in aging and cancer

Yu-Run Liu et al.

Summary: Cancer is now considered an age-related disease, and reversing cell senescence can prevent and treat cancer fundamentally. Current anticancer treatments induce both cancer cells apoptosis and normal cells senescence, promoting a vicious circle. In the tumor microenvironment, EVs of senescent cells can change the expression profile of cancer cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Exosome Derived from ADSCs Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

Wei Gao et al.

Summary: The study found that exosomes (Exo) derived from ADSCs have significant effects in preventing skin photoaging, by inhibiting DNA damage and overexpression of harmful substances through regulating multiple signaling pathways. Additionally, Exo can enhance the expression of procollagen type I and activate related pathways to protect the skin.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells

Chieh Ming Liao et al.

Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell & Tissue Engineering

Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice

Liyang Dong et al.

Summary: Hypoxic human umbilical cord MSC-derived EVs attenuated allergic airway inflammation and airway remodeling in chronic asthma mice, potentially offering new avenues for asthma treatment.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Exosomes derived from miR-301a-3p-overexpressing adipose-derived mesenchymal stem cells reverse hypoxia-induced erectile dysfunction in rat models

Li Liang et al.

Summary: The study demonstrated that miR-301a-3p-enriched exosome treatment significantly restored erectile function in rats and CCSMCs by promoting autophagy and inhibiting apoptosis. Furthermore, bioinformatics predicted that PTEN and TLR4 might be targets of miR-301a-3p.

STEM CELL RESEARCH & THERAPY (2021)

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Article Medicine, General & Internal

Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone

Ashish Kumar et al.

Summary: The study found that long-term oxycodone use led to a significant decrease in gray matter volumes in specific lobes of the monkey brain, as well as an increase in neurodegenerative biomarker expression correlated with changes in brain volumes. Additionally, oxycodone use had a significant impact on specific miRNA and protein loading associated with neurocognitive disorders.

EBIOMEDICINE (2021)

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Article Neurosciences

Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys

Veronica Go et al.

Summary: Cortical injury can trigger neurotoxic reactions, especially damaging axons and myelin, which impacts neuronal function recovery. Interventions targeting oligodendrocytes show potential in enhancing myelin maintenance and improving functional recovery in the aged brain after injury.

EXPERIMENTAL NEUROLOGY (2021)

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Review Biochemistry & Molecular Biology

Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview

Farzane Sivandzade et al.

Summary: Neurodegenerative diseases lead to paralysis, cognitive decline, and sensory loss. Stem cell therapy shows promise in treating these disorders by repairing damaged neural tissue and protecting healthy cells. Progress in stem cell technologies may lead to realistic and efficacious treatments for neurodegenerative disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Geriatrics & Gerontology

Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Ameliorate HaCaT Cell Photo-Aging

Shi-Jie Liu et al.

Summary: Exosomes derived from umbilical cord mesenchymal stem cells have the potential to enhance proliferation and migration of normal skin cells, inhibit UV-induced damage, reduce apoptosis and senescence, and ultimately suppress skin aging.

REJUVENATION RESEARCH (2021)

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Article Cell Biology

Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration

Qian Lei et al.

Summary: Research has shown that extracellular vesicles derived from neonatal umbilical cord mesenchymal stem cells have anti-aging effects on aging adult stem cells, enhancing their vitality and function. These UC-EVs promote self-renewal and delay senescence in stem cells by transferring specific signaling molecules. These findings demonstrate the significant potential of UC-EVs in anti-aging interventions.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Clinical Neurology

Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease

Lauren A. Apodaca et al.

Summary: The study demonstrated the regenerative potential of EVs derived from human neural stem cells in mitigating neurocognitive and neuropathologic hallmarks of Alzheimer's disease. The EV treatment showed neuroprotective effects in restoring fear extinction memory, reducing anxiety, decreasing amyloid plaque accumulation, and protecting against synaptic loss in the AD brain. MiRNA analysis of the EV cargo revealed promising candidates targeting neuroinflammation and synaptic function.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Article Cell Biology

Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

Akaitz Dorronsoro et al.

Summary: The injection of BM-MSCs from young mice can prolong lifespan and healthspan, while conditioned media (CM) from young BM-MSCs can rescue the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM can extend lifespan in mice, and EVs from MSCs generated from human ES cells can reduce senescence and improve healthspan.

AGING CELL (2021)

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Article Cell Biology

HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation

Peipei Wu et al.

Aging-US (2021)

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Article Biotechnology & Applied Microbiology

Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence

Huifeng Zheng et al.

Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Clinical Neurology

Intravenous infusion of auto serum-expanded autologous mesenchymal stem cells in spinal cord injury patients: 13 case series

Osamu Honmou et al.

Summary: This study investigated the safety and feasibility of intravenous infusion of MSCs for spinal cord injury (SCI) patients, as well as the functional status after MSC infusion. Results showed no serious adverse events associated with MSC injection and improvements in neurological function and daily living ability in some patients after MSC infusion.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Article Cell Biology

Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells

Tamako Nishimura et al.

Summary: Research has shown that I-BAR proteins, especially MIM, generate large EVs by scission of filopodia, containing lysophospholipids and proteins that stimulate cell migration. These filopodia-dependent large EVs, named filopodia-derived vesicles (FDVs), can modify cellular behavior.

DEVELOPMENTAL CELL (2021)

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Article Immunology

hPMSCs-Derived Exosomal miRNA-21 Protects Against Aging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis

Yanlian Xiong et al.

Summary: The study demonstrated that exosomes derived from human placenta MSCs can effectively reduce oxidative stress damage and senescent-related protein expression in CD4(+) T cells, and activate PTEN/PI3K-Nrf2 axis to enhance exogenous antioxidant defenses, thereby attenuating T cell senescence.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p

Kyoung Soo Lee et al.

Summary: EVs derived from adipose tissue-derived stem cells (ASGEVs) show promising therapeutic effects on osteoporosis by containing rich growth factors and cytokines related to bone metabolism and MSC migration. They attenuate bone loss, inhibit osteoclast differentiation, and promote MSC migration. High expression of OPG in ASCEVs is critical for the therapeutic effects.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicle-Based Therapy for Alzheimer's Disease: Progress and Opportunity

Yi-An Chen et al.

Summary: This review focuses on the potential therapeutic application of extracellular vesicles (EVs) in Alzheimer's disease treatment, particularly emphasizing the neuroprotective and immunomodulatory effects of EVs derived from mesenchymal stem cells. Numerous studies have suggested the promising role of EVs in reprogramming molecular machinery and communication between cells in AD.

MEMBRANES (2021)

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Article Cell & Tissue Engineering

Human placenta mesenchymal stem cell-derived exosomes delay H2O2-induced aging in mouse cholangioids

Wenyi Chen et al.

Summary: Cholangiocyte senescence is a significant process in diseases like PSC and PBC. This study demonstrated that hPMSC-derived exosomes could delay aging and reduce inflammation-related components in senescent cholangioids.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell & Tissue Engineering

Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

Yongjin Sun et al.

Summary: iMSC-sEVs could delay the progression of intervertebral disc degeneration and rejuvenate senescent nucleus pulposus cells (NPCs) by activating the Sirt6 pathway. Moreover, miR-105-5p enriched in iMSC-sEVs plays a crucial role in the therapeutic effect by downregulating PDE4D and leading to Sirt6 activation.

STEM CELL RESEARCH & THERAPY (2021)

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Article Cell Biology

Human adipose tissue-derived mesenchymal stem cells and their extracellular vesicles modulate lipopolysaccharide activated human microglia

Marta Garcia-Contreras et al.

Summary: Research suggests that human adipose tissue-derived mesenchymal stem cells and their secreted extracellular vesicles can modulate activated microglial cells by inhibiting the secretion of inflammatory factors and promoting the expression of anti-inflammatory mediators.

CELL DEATH DISCOVERY (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

Jeremy Boulestreau et al.

Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Cell Biology

Mesenchymal stem cells-derived extracellular vesicles ameliorate Alzheimer’s disease in rat models via the microRNA-29c-3p/BACE1 axis and the Wnt/β-catenin pathway

Sha Sha et al.

Aging-US (2021)

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Article Neurosciences

BMSCs-exosomes containing GDF-15 alleviated SH-SY5Y cell injury model of Alzheimer's disease via AKT/GSK-3β/β-catenin

Wen-Ping Xiong et al.

Summary: BMSCs-exosomes containing GDF-15 alleviate SH-SY5Y cell damage via AKT/GSK-3 beta/beta-catenin pathway, providing a promising therapeutic strategy for Alzheimer's disease.

BRAIN RESEARCH BULLETIN (2021)

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Article Pharmacology & Pharmacy

Preconditioning of mesenchymal stem cells with ghrelin exerts superior cardioprotection in aged heart through boosting mitochondrial function and autophagy flux

Liqiang Sun et al.

Summary: The study demonstrates that preconditioning MSCs with ghrelin can enhance cardioprotective effects, especially in elderly subjects, following IR injury. Preconditioned MSCs increase autophagy flux by downregulating Beclin-1 and P62 protein overexpression, and increasing LC3-II expression and the LC3-II/LC3-I ratio. Moreover, combining NMN with ghrelin-preconditioned MSCs synergistically enhances protective effects on infarct size and mitochondrial function.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Engineering, Biomedical

Microneedle based adipose derived stem cells-derived extracellular vesicles therapy ameliorates UV-induced photoaging in SKH-1 mice

Zhi Cao et al.

Summary: The study found that microneedle (MN) treatment alone could improve the epidermal structure and function of photoaging skin, and a combination with adipose derived stem cells extracellular vesicles (ADSCs-EVs) could accelerate the inflammation recovery and improve collagen content.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Cell Biology

ADMSC Exo-MicroRNA-22 improve neurological function and neuroinflammation in mice with Alzheimer's disease

Liping Zhai et al.

Summary: The study showed that miRNA-22-loaded ADMSC-derived exosomes can reduce inflammatory factor release by inhibiting pyroptosis, thus playing a synergistic role with exosomes in the treatment of AD.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Cell Biology

The role of lipids in exosome biology and intercellular communication: Function, analytics and applications

Javier Donoso-Quezada et al.

Summary: Exosomes are important extracellular vesicles with compositions related to the progression of various diseases. Lipids, as crucial components of exosomes, play significant roles in exosome biology and intercellular communication. Exosome lipidomics is an emerging discipline that offers insights into the discovery of new lipid species for biomedical applications.

TRAFFIC (2021)

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Review Dermatology

Stem cell-derived exosomes: A supernova in cosmetic dermatology

Xu Shen et al.

Summary: Stem cell-derived exosomes play a crucial role in cell-to-cell communication by carrying functional proteins and genetic information. Research has shown their potential in skin cosmetology, such as wound healing, skin aging, and scar formation. Further studies are needed to explore the full potential of stem cell-derived exosomes in cosmetic dermatology.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Cell & Tissue Engineering

Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition

Yan Zhang et al.

Summary: Both UCB-MSCs and UCB-MSC-exo can accelerate wound healing, reduce scar formation, and improve the regeneration of skin appendages, nerves, and vessels, as well as regulate the natural distribution of collagen fibers in wound healing. UCB-MSC-exo also suppress excessive formation of myofibroblasts and collagen I.

STEM CELL RESEARCH & THERAPY (2021)

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Review Cell & Tissue Engineering

Mesenchymal Stem Cell Therapy for Alzheimer's Disease

A. E. Hernandez et al.

Summary: Alzheimer's disease is a neurodegenerative disease characterized by neuronal cell death and cognitive impairment. Current treatments have limited impact on altering the underlying pathology, but studies show that mesenchymal stem cells and extracellular vesicles have potential therapeutic effects on AD.

STEM CELLS INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

Xian Xiao et al.

Summary: Research has shown that small extracellular vesicles play a crucial role in mitigating endothelial cell senescence and stimulating angiogenesis through the miR-146a/Src mechanism.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Geriatrics & Gerontology

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease

Chunling Xue et al.

Summary: This study revealed that exosomes derived from MSCs can promote angiogenesis of HBMECs by increasing ICAM1 expression, and alleviate damage in PD cases. ICAM1 facilitates HBMECs angiogenesis by activating the SMAD3 and P38MAPK signaling pathways.

AGING AND DISEASE (2021)

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Article Medicine, Research & Experimental

Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer's disease-like phenotypes in a preclinical mouse model

Allaura S. Cone et al.

Summary: Research has shown that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have potential therapeutic effects for Alzheimer's disease, slowing down disease progression and improving cognitive function when administered intranasally in mice.

THERANOSTICS (2021)

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Review Biochemistry & Molecular Biology

Ageing and mesenchymal stem cells derived exosomes: Molecular insight and challenges

Mahdi Ahmadi et al.

Summary: Ageing is a significant risk factor for various degenerative diseases, affecting the senescence and function of Mesenchymal Stem Cells (MSCs) and their exosomes. Exosomes derived from aged MSCs exhibit accelerated biogenesis, altered cargoes, and reduced regenerative potential, potentially impacting recipient cell function negatively. Further research is required to elucidate the detailed mechanisms and translation of preclinical results into clinically relevant exosome therapies for combating ageing.

CELL BIOCHEMISTRY AND FUNCTION (2021)

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Article Orthopedics

Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair

Hua Shen et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

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Article Geriatrics & Gerontology

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys

Veronica Go et al.

GEROSCIENCE (2020)

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Article Cell Biology

Emerging role of stem cell-derived extracellular microRNAs in age-associated human diseases and in different therapies of longevity

Mujib Ullah et al.

AGEING RESEARCH REVIEWS (2020)

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Review Biochemical Research Methods

Applications of extracellular vesicles in tissue regeneration

Zhijie Ma et al.

BIOMICROFLUIDICS (2020)

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Article Endocrinology & Metabolism

Exosomes Secreted by Young Mesenchymal Stem Cells Promote New Bone Formation During Distraction Osteogenesis in Older Rats

Yachao Jia et al.

CALCIFIED TISSUE INTERNATIONAL (2020)

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Review Cell Biology

The Na+/Ca2+ exchanger in Alzheimer's disease

Anna Pannaccione et al.

CELL CALCIUM (2020)

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Article Biotechnology & Applied Microbiology

HucMSC-Derived Exosomes Mitigate the Age-Related Retardation of Fertility in Female Mice

Weijie Yang et al.

MOLECULAR THERAPY (2020)

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Article Chemistry, Multidisciplinary

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

Lingyan Yang et al.

SMALL (2020)

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Review Cell Biology

Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging

Jeremy Boulestreau et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Cell Biology

miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

Yimei Hong et al.

AGING CELL (2020)

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Article Nanoscience & Nanotechnology

Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging

Keda Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Cell & Tissue Engineering

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Vikram Sengupta et al.

STEM CELLS AND DEVELOPMENT (2020)

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Article Biochemistry & Molecular Biology

Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease

Bo Li et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Cell Biology

Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy

Hong-Xu Chen et al.

CELL DEATH & DISEASE (2020)

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Article Chemistry, Multidisciplinary

An Analysis of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Preclinical Use

Alvin Tieu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

Chuyue Zhang et al.

ACS NANO (2020)

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Article Engineering, Biomedical

Exosomes from adipose-derived stem cells protect against high glucose-induced erectile dysfunction by delivery of corin in a streptozotocin-induced diabetic rat model

Jian Wang et al.

Regenerative Therapy (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation

Cristina Mas-Bargues et al.

BIOMOLECULES (2020)

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Article Multidisciplinary Sciences

Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus

Masako Nakano et al.

SCIENTIFIC REPORTS (2020)

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Article Cell & Tissue Engineering

Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair

Ning Zhang et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Extracellular vesicles from adipose-derived stem cells ameliorate ultraviolet B-induced skin photoaging by attenuating reactive oxygen species production and inflammation

Peng Xu et al.

STEM CELL RESEARCH & THERAPY (2020)

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Article Cell & Tissue Engineering

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

Morris Losurdo et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

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Review Oncology

Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

Mariusz Z. Ratajczak et al.

LEUKEMIA (2020)

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Review Clinical Neurology

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer's disease

Mengtian Guo et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

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Article Biotechnology & Applied Microbiology

Antiaging Properties of Exosomes from Adipose-Derived Mesenchymal Stem Cells in Photoaged Rat Skin

Jun-Xian Liang et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Pharmacology & Pharmacy

Stem Cell-Derived Exosomes and Nanovesicles: Promotion of Cell Proliferation, Migration, and Anti-Senescence for Treatment of Wound Damage and Skin Ageing

Hyeonjin Cha et al.

PHARMACEUTICS (2020)

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Article Biotechnology & Applied Microbiology

Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Mitigate Trained Immunity in the Brain

Yiwei Feng et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease

Xinyi Ma et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Cell Biology

Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells

Liangzhi Gong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Cell Biology

Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension

Rui Feng et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Cell Biology

Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia

Baishijiao Bian et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Geriatrics & Gerontology

Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Zikuan Leng et al.

AGING AND DISEASE (2020)

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Article Clinical Neurology

2020 Alzheimer's disease facts and figures

[Anonymous]

ALZHEIMERS & DEMENTIA (2020)

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Review Cell Biology

Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

Elmira Iranifar et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles from Mesenchymal Stem Cells Exert Pleiotropic Effects on Amyloid-β, Inflammation, and Regeneration: A Spark of Hope for Alzheimer's Disease from Tiny Structures?

Chiara A. Elia et al.

BIOESSAYS (2019)

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Article Chemistry, Multidisciplinary

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

Nisim Perets et al.

NANO LETTERS (2019)

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Article Geriatrics & Gerontology

Frailty and Rejuvenation with Stem Cells: Therapeutic Opportunities and Clinical Challenges

Xue-Lian Sun et al.

REJUVENATION RESEARCH (2019)

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Article Cell & Tissue Engineering

Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells

Senquan Liu et al.

STEM CELLS (2019)

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Review Cell & Tissue Engineering

Stem cells: past, present, and future

Wojciech Zakrzewski et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Cell Biology

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway

Bao Zhu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Cell & Tissue Engineering

Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells

Bi Chen et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Geriatrics & Gerontology

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease

Guo-hong Cui et al.

IMMUNITY & AGEING (2019)

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Review Biochemistry & Molecular Biology

Biological functions of mesenchymal stem cells and clinical implications

Abderrahim Naji et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Materials Science, Biomaterials

Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb

Chaoshan Han et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Editorial Material Cell Biology

Extracellular vesicles: a new communication paradigm?

Graca Raposo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Cell Biology

Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury

Ruoqiong Huang et al.

AGING-US (2019)

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Article Cell Biology

Mesenchymal stem cell-derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury

Yangzhou Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Article Cell Biology

Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer's Disease

Chiara A. Elia et al.

CELLS (2019)

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Article Multidisciplinary Sciences

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

Yuqin Men et al.

NATURE COMMUNICATIONS (2019)

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Article Cell & Tissue Engineering

Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Victor Bodart-Santos et al.

STEM CELL RESEARCH & THERAPY (2019)

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Article Reproductive Biology

Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model

Federica Marinaro et al.

BIOLOGY OF REPRODUCTION (2019)

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Review Engineering, Biomedical

Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders

Xudong Yao et al.

BIOMATERIALS (2019)

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Article Endocrinology & Metabolism

Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice

Yin Hu et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

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Article Medicine, Research & Experimental

Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells

Yan Zhang et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Hao Wang et al.

NANOSCALE (2019)

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Article Biochemistry & Molecular Biology

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid- oligomers

Mariana A. de Godoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Hematology

Haploidentical Stem Cell Transplantation for Refractory/Relapsed Neuroblastoma

Toni Illhardt et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)

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Article Neurosciences

The exosome of adipose-derived stem cells reduces beta-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer's disease

Mijung Lee et al.

BRAIN RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Guo-Hong Cui et al.

FASEB JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts

Myeongsik Oh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Neurosciences

Mesenchymal Stem Cell-Derived Extracellular Vesicles Suppresses iNOS Expression and Ameliorates Neural Impairment in Alzheimer's Disease Mice

Shan-Shan Wang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Cardiac & Cardiovascular Systems

Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction

Philippe Menasche et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Cell Biology

Exosomes: a novel therapeutic target for Alzheimer's disease?

Zhi-You Cai et al.

NEURAL REGENERATION RESEARCH (2018)

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Article

Exosomal microRNA profiling to identify hypoxia-related biomarkers in prostate cancer

Gati K. Panigrahi et al.

Oncotarget (2018)

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Article Multidisciplinary Sciences

Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer's disease model

Dong Hyun Kim et al.

SCIENTIFIC REPORTS (2018)

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Article Cell & Tissue Engineering

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

Mahesh Khatri et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Chemistry, Multidisciplinary

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

Mengke Qu et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Biochemistry & Molecular Biology

Exosomes Isolated From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Neuroinflammation and Reduce Amyloid-Beta Deposition by Modulating Microglial Activation in Alzheimer's Disease

Mao Ding et al.

NEUROCHEMICAL RESEARCH (2018)

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Article Cell & Tissue Engineering

Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD

Boxian Huang et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Cell & Tissue Engineering

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

Guping Mao et al.

STEM CELL RESEARCH & THERAPY (2018)

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Article Cell & Tissue Engineering

MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury

Xi Ouyang et al.

STEM CELL RESEARCH & THERAPY (2018)

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Review Cell Biology

Extracellular Vesicles, Ageing, and Therapeutic Interventions

Nikolaos Panagiotou et al.

CELLS (2018)

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Article Medicine, Research & Experimental

Human Umbilical Cord Wharton's Jelly Derived Mesenchymal Stromal Cells May Attenuate Sarcopenia in Aged Mice Induced by Hindlimb Suspension

Quan-Quan Wang et al.

MEDICAL SCIENCE MONITOR (2018)

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Article Biochemistry & Molecular Biology

Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model

Xue Li et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Review Cell Biology

Role of exosomes in the protection of cellular homeostasis

Gabriela Desdin-Mico et al.

CELL ADHESION & MIGRATION (2017)

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Review Immunology

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease

Lee Chuen Liew et al.

INTERNATIONAL IMMUNOLOGY (2017)

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Review Endocrinology & Metabolism

Therapeutic potential of mesenchymal stem cells for diabetes

Alvaro Moreira et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)

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Article Geriatrics & Gerontology

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, PlaceboControlled Clinical Trial

Bryon A. Tompkins et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)

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Article Geriatrics & Gerontology

Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty

Samuel Golpanian et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)

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Article Cell Biology

DNA damage in the oligodendrocyte lineage and its role in brain aging

Kai-Hei Tse et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

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Article Multidisciplinary Sciences

C-elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Ilija Melentijevic et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

Tetsuhiro Kikuchi et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

Yalin Zhang et al.

NATURE (2017)

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Article Cell Biology

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts

Miguel Tofino-Vian et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

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Article Multidisciplinary Sciences

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Akiko Takahashi et al.

NATURE COMMUNICATIONS (2017)

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Article Cell & Tissue Engineering

Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Ligia Lins de Castro et al.

STEM CELL RESEARCH & THERAPY (2017)

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Article Neurosciences

Alzheimer's Disease and the Amyloid-β Peptide

M. Paul Murphy et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Cell Biology

Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation

Panagiotis Mistriotis et al.

AGEING RESEARCH REVIEWS (2017)

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Review Urology & Nephrology

Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?

Mohammad Ayodhia Soebadi et al.

SEXUAL MEDICINE REVIEWS (2017)

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Review Biotechnology & Applied Microbiology

Therapeutic application of mesenchymal stem cells in osteoarthritis

Maxime Ruiz et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

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Article Cell Biology

Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

Sylvia Weilner et al.

AGING-US (2016)

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Article Clinical Neurology

Alzheimer Disease and Its Growing Epidemic Risk Factors, Biomarkers, and the Urgent Need for Therapeutics

Richard A. Hickman et al.

NEUROLOGIC CLINICS (2016)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model

Taisuke Furuta et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Article Cell & Tissue Engineering

Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial

Yves-Marie Pers et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Review Cell & Tissue Engineering

Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response

Arman Saparov et al.

STEM CELLS INTERNATIONAL (2016)

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Article Multidisciplinary Sciences

Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy

Guan-Yu Xiao et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA

Ruenn Chai Lai et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Article Medicine, Research & Experimental

Wharton's Jelly-derived mesenchymal stem cells alleviate memory deficits and reduce amyloid-β deposition in an APP/PS1 transgenic mouse model

Zhao-Hong Xie et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2016)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles as New Players in Cellular Senescence

Lorena Urbanelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Cardiac & Cardiovascular Systems

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

Bin Yu et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Review Biotechnology & Applied Microbiology

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Sweta Rani et al.

MOLECULAR THERAPY (2015)

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Article Cell Biology

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

Melanie Dieude et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Article Oncology

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

Isabel R. Schlaepfer et al.

ONCOTARGET (2015)

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Article Cell & Tissue Engineering

Oxygen Tension Regulates Human Mesenchymal Stem Cell Paracrine Functions

Joseph Paquet et al.

STEM CELLS TRANSLATIONAL MEDICINE (2015)

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Article Biotechnology & Applied Microbiology

Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells

Andrea Del Fattore et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

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Article Biochemistry & Molecular Biology

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

Anand Ramteke et al.

MOLECULAR CARCINOGENESIS (2015)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Article Biochemistry & Molecular Biology

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Review Biochemistry & Molecular Biology

The root of reduced fertility in aged women and possible therapentic options: Current status and future perspects

Jie Qiao et al.

MOLECULAR ASPECTS OF MEDICINE (2014)

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Review Multidisciplinary Sciences

The role of senescent cells in ageing

Jan M. van Deursen

NATURE (2014)

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Article Neurosciences

Adult neural stem cells in distinct microdomains generate previously unknown interneuron types

Florian T. Merkle et al.

NATURE NEUROSCIENCE (2014)

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Article Biochemistry & Molecular Biology

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

Makiko Ono et al.

SCIENCE SIGNALING (2014)

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Review Endocrinology & Metabolism

Role of the hypothalamus in mediating protective effects of dietary restriction during aging

Penny A. Dacks et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2013)

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Review Oncology

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Johnny C. Akers et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

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Article Multidisciplinary Sciences

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

Guo Zhang et al.

NATURE (2013)

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Article Biochemical Research Methods

A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells

Nicolas Pallet et al.

PROTEOMICS (2013)

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Article Cell Biology

Neural Stem Cell-Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies

Karen S. Aboody et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

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Article Clinical Neurology

Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice

Nobukazu Miyamoto et al.

STROKE (2013)

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Article Multidisciplinary Sciences

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

Takeshi Katsuda et al.

SCIENTIFIC REPORTS (2013)

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Article Biochemistry & Molecular Biology

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication

Carsten Fruehbeis et al.

PLOS BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Kohei Yuyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Geriatrics & Gerontology

Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging

M. Noa Valcarcel-Ares et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

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Article Cell Biology

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

Juxue Li et al.

NATURE CELL BIOLOGY (2012)

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Article Multidisciplinary Sciences

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

Joseph F. Nabhan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Cell & Tissue Engineering

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Hongqi Xin et al.

STEM CELLS (2012)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Article Neurosciences

Age Changes in Myelinated Nerve Fibers of the Cingulate Bundle and Corpus Callosum in the Rhesus Monkey

Michael P. Bowley et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2010)

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Article Neurosciences

MicroRNA Regulation of Neural Stem Cells and Neurogenesis

Yanhong Shi et al.

JOURNAL OF NEUROSCIENCE (2010)

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Article Cell & Tissue Engineering

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

Andrzej Swistowski et al.

STEM CELLS (2010)

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Article Biochemistry & Molecular Biology

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

Vandhana Muralidharan-Chari et al.

CURRENT BIOLOGY (2009)

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Review Endocrinology & Metabolism

Ovarian Aging: Mechanisms and Clinical Consequences

F. J. Broekmans et al.

ENDOCRINE REVIEWS (2009)

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Article Multidisciplinary Sciences

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

Jae W. Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Cell & Tissue Engineering

Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells

Lior Zangi et al.

STEM CELLS (2009)

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Editorial Material Cell & Tissue Engineering

MicroRNA regulation of stem cell fate

Qintong Li et al.

CELL STEM CELL (2008)

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Review Biology

Exosomal transfer of proteins and RNAs at synapses in the nervous system

Neil R. Smalheiser

BIOLOGY DIRECT (2007)

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Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

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Article Hematology

Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting

Alma J. Nauta et al.

BLOOD (2006)

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Article Multidisciplinary Sciences

Alzheimer's disease β-amyloid peptides are released in association with exosomes

Lawrence Rajendran et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Immunology

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

C Nathan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Article Cell & Tissue Engineering

Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells

YP Yan et al.

STEM CELLS (2005)

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Therapeutic efficacy and promise of stem cell-derived extracellular vesicles in Alzheimer's disease and other aging-related disorders

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