Journal
MOLECULAR AND CELLULAR PROBES
Volume 72, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mcp.2023.101935
Keywords
NK cells; ncRNAs; Long non-coding RNAs
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This review provides a comprehensive examination of the role of different non-coding RNAs in the activity and development of NK cells, highlighting the detrimental effects of dysregulated non-coding RNAs on NK cell function and the potential contribution to diverse disorders.
Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which are involved in innate immunity, alongside with assisting with adaptive immune response. Since they have cytotoxic effects, disruptions in their functionality and development leads to a variety of conditions, whether malignant or non-malignant. The profile and interaction of these non-coding RNAs and NK cells in different conditions is extensively studied, and it is now approved that if dysregulated, non-coding RNAs have detrimental effects on NK cell activity and can contribute to the pathogenesis of diverse disorders. In this review, we aim at a thorough inspection on the role of different non-coding RNAs on the activity and development of NK cells, in a broad spectrum of conditions, including blood-related disorders, viral infections, neurological diseases, gastrointestinal disorders, lung disorders, reproductive system conditions and other types of maladies, alongside with providing insight to the future noncoding RNA-NK cell studies.
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