4.5 Article

The α1 adrenoceptor antagonist prazosin potentiates morphine induced conditioned place preference in rats

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Norepinephrine system at the interface of attention and reward

Yuxiao Zhang et al.

Summary: Reward learning is crucial for survival and attention plays a key role in the recognition of reward cues and formation of reward memories. However, the neurological processes of the interaction between reward and attention are not well understood due to the diverse neural substrates involved in these processes.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2023)

Article Biochemistry & Molecular Biology

Modafinil rescues repeated morphine-induced synaptic and behavioural impairments via activation of D1R-ERK-CREB pathway in medial prefrontal cortex

Fangyuan Yin et al.

Summary: Long-term opioid abuse leads to cognitive impairments, while modafinil shows potential in improving attention and memory. This study found that low dose modafinil can effectively ameliorate opioid-induced attention dysfunction and memory issues in mice, but high dose may have adverse effects. Altering signaling pathways in the medial prefrontal cortex can reverse drug-induced cognitive abnormalities.

ADDICTION BIOLOGY (2022)

Article Cell Biology

Association of miR-155, miR-187 and Inflammatory Cytokines IL-6, IL-10 and TNF-alpha in Chronic Opium Abusers

Purvi Purohit et al.

Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.

INFLAMMATION (2022)

Review Clinical Neurology

Pharmacological Management of Nightmares Associated with Posttraumatic Stress Disorder

Christoff Geldenhuys et al.

Summary: Post-traumatic nightmares are a significant component of posttraumatic stress disorder (PTSD) and have adverse effects on patients' well-being. Effective treatment of nightmares is critical for improving the quality of life and overall symptoms in PTSD patients. There are several pharmacological agents that have been studied for the treatment of nightmares, with varying levels of evidence and side effects.

CNS DRUGS (2022)

Article Biochemistry & Molecular Biology

Nicotine, cocaine, amphetamine, morphine, and ethanol increase norepinephrine output in the bed nucleus of stria terminalis of freely moving rats

Dragana Jadzic et al.

Summary: The bed nucleus of stria terminalis (BNST), an important limbic area, is involved in neuroendocrine, behavioral responses, and stress regulation. Drugs of abuse increase norepinephrine transmission in the BNST, contributing to the development of stress-induced drug seeking behavior.

ADDICTION BIOLOGY (2021)

Article Neurosciences

Dysregulated CRTC1-BDNF signaling pathway in the hippocampus contributes to Aβ oligomer-induced long-term synaptic plasticity and memory impairment

Peiyun Yan et al.

Summary: The study revealed that CRTC1 expression in the hippocampus is impaired in Alzheimer's disease, while the CRTC1-BDNF pathway is involved in hippocampal long-term potentiation (L-LTP) impairment and memory deficits induced by oA beta 42. Overexpression of CRTC1 effectively ameliorated oA beta 42-induced L-LTP suppression and cognitive deficits, suggesting a potential therapeutic target for Alzheimer's disease.

EXPERIMENTAL NEUROLOGY (2021)

Article Neurosciences

Minocycline alleviates the symptoms of morphine withdrawal via the CaMKII-Ras-ERK signaling pathway

Qiaofeng Liu et al.

Summary: Minocycline alleviates morphine withdrawal symptoms by inhibiting the activation of microglia and downregulating the expression of CaMKII, Ras, and p-ERK.

NEUROSCIENCE LETTERS (2021)

Review Psychiatry

A Systematic Review of Opioid Use Disorder and Related Biomarkers

Bianca M. Bryant et al.

Summary: This systematic review examines the relationship between OUD and its related biomarkers, as well as the effects of pharmacotherapy on biomarkers. Patients with OUD or opioid-related disorders have potential biomarkers that can be targeted for optimal treatment options.

FRONTIERS IN PSYCHIATRY (2021)

Article Endocrinology & Metabolism

Venlafaxine inhibits naloxone-precipitated morphine withdrawal symptoms: Role of inflammatory cytokines and nitric oxide

Mohammad Taghi Mansouri et al.

METABOLIC BRAIN DISEASE (2020)

Review Neurosciences

Sex differences in neural mechanisms mediating reward and addiction

Jill B. Becker et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Article Behavioral Sciences

Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal

Wojciech B. Solecki et al.

BEHAVIOURAL BRAIN RESEARCH (2019)

Review Neurosciences

CaM Kinase: Still Inspiring at 40

K. Ulrich Bayer et al.

NEURON (2019)

Article Biochemistry & Molecular Biology

BDNF at the synapse: why location matters

M. Song et al.

MOLECULAR PSYCHIATRY (2017)

Review Behavioral Sciences

Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence

Eva R. Zamora-Martinez et al.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2014)

Review Pharmacology & Pharmacy

Adrenaline Rush: The Role of Adrenergic Receptors in Stimulant-Induced Behaviors

Karl T. Schmidt et al.

MOLECULAR PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Activity-Dependent Transport of the Transcriptional Coactivator CRTC1 from Synapse to Nucleus

Toh Hean Ch'ng et al.

Review Neurosciences

Novel insights into CaMKII function and regulation during memory formation

Walter Lucchesi et al.

BRAIN RESEARCH BULLETIN (2011)

Article Substance Abuse

The α1-Adrenergic Receptor Antagonist, Prazosin, Reduces Alcohol Drinking in Alcohol-Preferring (P) Rats

Dennis D. Rasmussen et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)

Review Neurosciences

There and back again: A tale of norepinephrine and drug addiction

David Weinshenker et al.

NEUROPSYCHOPHARMACOLOGY (2007)

Article Behavioral Sciences

The role of alpha-adrenoceptor mechanism(s) in morphine-induced conditioned place preference in female mice

H Sahraei et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2004)

Review Pharmacology & Pharmacy

Alpha-adrenoceptor subtypes

BC Calzada et al.

PHARMACOLOGICAL RESEARCH (2001)