Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway

Article Chemistry, Medicinal

Pectolinarigenin shows lipid-lowering effects by inhibiting fatty acid biosynthesis in vitro and in vivo

Zhou Lan et al.

Summary: The study reveals that pectolinarigenin may inhibit fatty acid biosynthesis by targeting PPAR gamma and can reduce serum and hepatic triglyceride levels while improving insulin sensitivity.

PHYTOTHERAPY RESEARCH (2023)

Add to Collection

Article Immunology

Dexmedetomidine attenuates hepatic ischemia-reperfusion injury-induced apoptosis via reducing oxidative stress and endoplasmic reticulum stress

Shixia Zhang et al.

Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Add to Collection

Article Plant Sciences

Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners

Qian Li et al.

Summary: The study found that Pectolinarigenin (PEC), an abundant constituent in Cirsii Japonici Herba Carbonisata (Dajitan), has hepatoprotective effects against acetaminophen (APAP)-induced liver injury (AILI). PEC reduced liver inflammation, increased the activity of APAP detoxification enzymes, and activated the Nrf2 and PPAR alpha signaling pathways. PEC may be a promising therapeutic drug against AILI.

PHYTOMEDICINE (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Nrf2 and oxidative stress in liver ischemia/reperfusion injury

Raquel G. Bardallo et al.

Summary: In response to stress signal, Nrf2 regulates the expression of genes involved in antioxidant defense and detoxification, maintaining cellular homeostasis. During ischemia-reperfusion injury, Nrf2 activation can enhance cellular defense and promote hepatic recovery by mitigating oxidative stress and inflammation.

FEBS JOURNAL (2022)

Add to Collection

Article Gastroenterology & Hepatology

E3 ubiquitin ligase ring finger protein 5 protects against hepatic ischemia reperfusion injury by mediating phosphoglycerate mutase family member 5 ubiquitination

Ming-Jie Ding et al.

Summary: The study reveals that RNF5 protects against HIR by interacting with PGAM5 to inhibit the activation of ASK1 and the downstream JNK/p38 signaling cascade. This finding suggests that the RNF5-PGAM5 axis may be a potential therapeutic target for HIR.

HEPATOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization

Jiangqiao Zhou et al.

Summary: GALNT4 has been identified as a potential therapeutic target for liver I/R injury by inhibiting the ASK1-JNK/p38 signaling pathway, independent of its glycosyltransferase activity. This study highlights the importance of GALNT4 in protecting against hepatic ischemia-reperfusion injury and improving surgical outcomes for liver transplantation.

HEPATOLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity

Hirofumi Hirao et al.

Summary: The authors of this Review examine the roles of macrophages, platelets, and neutrophils in liver ischaemia-reperfusion injury (LIRI), discussing potential therapeutic strategies for treating LIRI in transplant recipients. They highlight the unanswered questions in understanding the mechanisms underlying the responses of these cells in the acute phase of LIRI, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Sizhen Li et al.

Summary: This study identified the protective effect of gastrodin on the injury of R28 cells induced by oxygen and glucose deprivation/reoxygenation. The activation of the PI3K/AKT/Nrf2 signaling pathway was involved in this process.

BIOENGINEERED (2022)

Add to Collection

Review Health Care Sciences & Services

Role of the PI3K/Akt signaling pathway in liver ischemia reperfusion injury: a narrative review

Mengqin Wang et al.

Summary: The PI3K/Akt signaling pathway plays a crucial role in regulating liver ischemia reperfusion injury. Activation of the PI3K/Akt signaling pathway can exert anti-inflammatory, antioxidant stress, antiapoptosis, and autophagy regulation effects, thus alleviating liver ischemia reperfusion injury.

ANNALS OF PALLIATIVE MEDICINE (2022)

Add to Collection

Article Immunology

Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress

Jinjin Li et al.

Summary: Isolongifolene (ISO) has a protective effect against liver ischemia/reperfusion (I/R) injury by regulating the AMPK-PGC1 alpha signaling pathway, resulting in anti-inflammatory, antioxidant, and anti-apoptotic effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Immunology

Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/ Akt/Nrf2 signaling pathway

Li Liu et al.

Summary: FGF10 protects against PM-induced lung injury by activating the PI3K/Akt/Nrf2 pathway, thereby alleviating oxidative damage and pyroptosis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury

Jianhong Ye et al.

Summary: MCTR1 exerts a protective effect in several inflammatory disease models, but its role in hepatic HIRI remains unknown. We confirm that the MCTR1 ameliorates ferroptosis-induced hepatic ischemia-reperfusion injury by promoting NRF2 expression. Our study illustrates the mechanism that MCTR1 protects from HIRI and identifies a therapeutic target for liver transplantation ischemia-reperfusion injury from the perspective of ferroptosis.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2022)

Add to Collection

Review Medicine, Research & Experimental

Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

Mehrdokht Sadrkhanloo et al.

Summary: This review focuses on the role of Nrf2 in alleviating ischemic/reperfusion (I/R) injury. Stimulating Nrf2 signaling reduces oxidative stress, inflammation, and apoptosis, and improves cell viability, thus ameliorating I/R injury in organs including lung, liver, brain, testis, and heart.

LIFE SCIENCES (2022)

Add to Collection

Review Immunology

The Role of Neutrophils as a Driver in Hepatic Ischemia-Reperfusion Injury and Cancer Growth

Christof Kaltenmeier et al.

Summary: The innate immune system, particularly neutrophils and Neutrophil Extracellular Traps (NETs), plays a crucial role in liver ischemia and reperfusion injury (IRI) by promoting inflammation, tissue damage, and tumor progression. Understanding the role of innate immune cells and targeting neutrophils and NETs can contribute to the prevention and treatment of IRI.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Cell Biology

Role of Immuno-Inflammatory Signals in Liver Ischemia-Reperfusion Injury

Christof Kaltenmeier et al.

Summary: Ischemia reperfusion injury (IRI) is a common complication in liver surgery and transplantation, involving the activation of various cytokines and chemokines, as well as the release of damage-associated molecular patterns. The injury leads to cell death and a cytokine/chemokine storm, which attracts immune cells to the site and worsens the damage.

CELLS (2022)

Add to Collection

Review Medicine, Research & Experimental

Comprehensive overview of Nrf2-related epigenetic regulations involved in ischemia-reperfusion injury

Jun Zhang et al.

Summary: This article provides a comprehensive overview of the role and mechanism of Nrf2-related epigenetic modifications in ischemic-reperfusion injury (IRI) of various organs. It also summarizes potential agonists that target the epigenetic regulation of Nrf2.

THERANOSTICS (2022)

Add to Collection

Article Food Science & Technology

Neuroprotective and anti-inflammatory effect of pectolinarigenin, a flavonoid from Amazonian Aegiphila integrifolia (Jacq.), against lipopolysaccharide-induced inflammation in astrocytes via NFΚB and MAPK pathways

Luana Heimfarth et al.

Summary: PNG, an active flavonoid compound, has been found to possess anti-inflammatory and anti-metastatic properties. The study showed that PNG has significant biological effects in macrophage and astrocyte cultures, protecting astrocytes from LPS-induced inflammatory toxicity through the inhibition of inflammatory signaling pathways.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Add to Collection

Article Cell Biology

Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway

Yan Wu et al.

Summary: This study demonstrates that Dex exerts a protective effect in hepatic I/R injury by regulating miR-494 to increase JUND, reducing pyroptosis and inflammation. Additionally, Dex represses NLRP3 inflammasome by activating the PI3K/AKT/Nrf2 pathway, as confirmed in in vivo experiments, highlighting its therapeutic potential for hepatic I/R injury.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Plant Sciences

Arbutin attenuates LPS-induced acute kidney injury by inhibiting inflammation and apoptosis via the PI3K/Akt/Nrf2 pathway

Beibei Zhang et al.

Summary: This study demonstrated that Arbutin may inhibit LPS-induced AKI by exerting an anti-inflammatory effect and regulating the Akt signaling pathway. Experimental results showed that Arbutin significantly improved renal function, attenuated inflammation and cell apoptosis through the PI3K/Akt/Nrf2 pathway following LPS challenge in vivo, which was effectively blocked by GDC in vitro.

PHYTOMEDICINE (2021)

Add to Collection

Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Nanotheranostics for the Management of Hepatic Ischemia-Reperfusion Injury

Yu Guan et al.

Summary: Nanomaterials offer targeted delivery and controllable release of contrast agents and therapeutic drugs in hepatic IRI regions, improving imaging sensitivity and therapeutic effects, making them a novel alternative for hepatic IRI diagnosis and therapy.

SMALL (2021)

Add to Collection

Article Gastroenterology & Hepatology

TNFAIP3 Interacting Protein 3 Is an Activator of Hippo-YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury

Junjie Zhou et al.

Summary: The study reveals that TNIP3 attenuates hepatic I/R injury by facilitating the ubiquitination and degradation of LATS2 and subsequent activation of YAP. This finding suggests that TNIP3 could serve as a promising therapeutic target for hepatic I/R injury to improve the prognosis of liver surgery.

HEPATOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

New Insights in Mechanisms and Therapeutics for Short- and Long-Term Impacts of Hepatic Ischemia Reperfusion Injury Post Liver Transplantation

Hui Liu et al.

Summary: Liver transplantation is effective for end-stage liver disease patients, but may lead to hepatic ischemia reperfusion injury (IRI) causing acute inflammation, graft dysfunction, acute rejection, chronic rejection, cancer recurrence, and fibrogenesis. Understanding the mechanisms of inflammation and immune activation during IRI, as well as developing therapeutic strategies, is crucial for improving transplant outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD

Jingda Li et al.

Summary: Hesperetin, a citrus flavonoid, demonstrates anti-inflammatory effects in NAFLD by activating the PI3 K/AKT-Nrf2 pathway to alleviate oxidative stress, suppress NF-kappa B activation, and reduce inflammatory cytokine secretion. These findings suggest that hesperetin may be an effective dietary supplement for improving NAFLD by targeting both oxidative stress and inflammation pathways.

FOOD & FUNCTION (2021)

Add to Collection

Review Infectious Diseases