4.6 Article

Role of advanced glycation endproducts in bone fragility in type 1 diabetes

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Bone Microarchitecture and Strength in Long-Standing Type 1 Diabetes

Lilian Sewing et al.

Summary: Type 1 diabetes (T1DM) is associated with an increased risk of nonvertebral fractures, and the influence of glycemic control and microvascular disease on skeletal health in long-standing T1DM is not well understood. This study found that patients with long-standing T1DM had lower bone mineral density (BMD), decreased bone turnover, and weaker bones at the ultradistal tibia compared to non-diabetic controls. The presence of diabetic peripheral neuropathy was found to contribute to the altered cortical microarchitecture and reduced bone strength in T1DM patients.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

Article Endocrinology & Metabolism

Greater Carboxy-Methyl-Lysine Is Associated With Increased Fracture Risk in Type 2 Diabetes

Ruban Dhaliwal et al.

Summary: Higher levels of CML are associated with increased risk of incident clinical fractures in individuals with type 2 diabetes, independent of bone mineral density. These results suggest a role for CML in the pathogenesis of bone fragility in diabetic patients.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

Article Endocrinology & Metabolism

Biochemical Markers of Bone Turnover in Older Adults With Type 1 Diabetes

Mishaela R. Rubin et al.

Summary: Poor glycemic control is associated with reduced bone formation in T1D patients, while reduced kidney function is associated with increased bone resorption and formation.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Article Endocrinology & Metabolism

Risk factors for lower bone mineral density in older adults with type 1 diabetes: a cross-sectional study

Ann Schwartz et al.

Summary: This study investigates the impact of diabetes-related factors on hip bone mineral density (BMD) in older adults with type 1 diabetes. The results suggest that poor glycemic control, advanced glycation end products (AGEs) accumulation, and kidney disease are independent risk factors for lower hip BMD in this population. Maintaining glycemic control and preventing kidney disease may reduce bone loss and fracture risk. Osteoporosis screening may be particularly important for individuals with these risk factors.

LANCET DIABETES & ENDOCRINOLOGY (2022)

Article Endocrinology & Metabolism

Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes

Praveer Sihota et al.

Summary: This study investigated alterations in bone tissue properties in individuals with type 2 diabetes following fragility hip fracture. The findings provide evidence of hyperglycemia's detrimental effects on trabecular bone quality at multiple scales, leading to reduced energy absorption and toughness, indicative of increased propensity to bone fragility.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Endocrinology & Metabolism

The Effects of Type 1 Diabetes and Diabetic Peripheral Neuropathy on the Musculoskeletal System: A Case-Control Study

Tatiane Vilaca et al.

Summary: The study found that fracture risk is increased in type 1 diabetes patients, and diabetic neuropathy may contribute to this. Patients with neuropathy had poorer performance in bone structure and physical tests compared to the control group.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

Article Cell & Tissue Engineering

Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis

Feng Wang et al.

Summary: The study demonstrates that ADM2 enhances diabetic bone regeneration by attenuating imbalances in macrophage polarization induced by AGEs, partly through the PPARγ/NF-κB signaling pathway, and by improving AGE-impaired osteogenic differentiation of BMSCs simultaneously.

STEM CELL RESEARCH & THERAPY (2021)

Article Biochemistry & Molecular Biology

Effects of advanced glycation end products on osteocytes mechanosensitivity

Xiao Yang et al.

Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biophysics

Fracture behavior of human cortical bone: Role of advanced glycation end-products and microstructural features

Ebrahim Maghami et al.

Summary: Diabetes increases fracture risk in human bone, and this study investigates the impact of simulated AGEs and materials heterogeneity on crack growth in cortical bone. Results show that AGEs level affects crack formation rate, and mismatch in fracture properties can alter post-yielding behavior, with cement lines capable of stopping crack propagation. Additionally, bone microstructural features influence toughening mechanisms such as crack merging and branching.

JOURNAL OF BIOMECHANICS (2021)

Article Endocrinology & Metabolism

Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data

J. Ha et al.

Summary: The population-based cohort study in Korea revealed that patients with diabetes have a higher risk of fractures compared to nondiabetic subjects. Among patients with diabetes, type 1 diabetes patients were found to have a higher risk of fractures than type 2 diabetes patients across all measurement sites.

OSTEOPOROSIS INTERNATIONAL (2021)

Article Endocrinology & Metabolism

Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study

Unni Syversen et al.

Summary: This study found compromised bone material strength and microarchitecture in men with T1D. Additionally, the data confirmed a modest decrease in BMD and low bone turnover in T1D patients, indicating that bone should be recognized as a target of diabetic complications.

ENDOCRINE CONNECTIONS (2021)

Article Medicine, General & Internal

Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts

So Young Park et al.

Summary: Advanced glycation end products (AGEs) suppress the differentiation and function of osteoclasts and osteoblasts, potentially leading to decreased bone quality and turnover.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

Article Pharmacology & Pharmacy

Increased Risk of Falls, Fall-related Injuries and Fractures in People with Type 1 and Type 2 Diabetes - A Nationwide Cohort Study

Nicklas H. Rasmussen et al.

Summary: This study aimed to estimate the risk of falls in people with diabetes and identify related risk factors. Results showed that people with diabetes have a higher incidence of falls and specific risk factors such as age, sex, diabetic complications, alcohol abuse history, and medication use. Additionally, the incidence of fall-related injuries was higher in individuals with diabetes compared to the general population, with specific localized fractures showing increased risk in diabetes patients.

CURRENT DRUG SAFETY (2021)

Article Endocrinology & Metabolism

The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients

S. Ballesta et al.

OSTEOPOROSIS INTERNATIONAL (2020)

Article Endocrinology & Metabolism

Intracellular Accumulation of Advanced Glycation End Products Induces Osteoblast Apoptosis Via Endoplasmic Reticulum Stress

Ryusuke Suzuki et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Endocrinology & Metabolism

Sclerostin Regulation, Microarchitecture, and Advanced Glycation End-Products in the Bone of Elderly Women With Type 2 Diabetes

Alessandra Piccoli et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Endocrinology & Metabolism

Altered Tissue Composition, Microarchitecture, and Mechanical Performance in Cancellous Bone From Men With Type 2 Diabetes Mellitus

Heather B. Hunt et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

Article Endocrinology & Metabolism

Poor Glycemic Control Is Associated With Impaired Bone Accrual in the Year Following a Diagnosis of Type 1 Diabetes

David R. Weber et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Endocrinology & Metabolism

Hypoglycaemia and type 1 diabetes are associated with an increased risk of fractures

M. H. Jensen et al.

OSTEOPOROSIS INTERNATIONAL (2019)

Article Endocrinology & Metabolism

Risk factors for fragility fractures in type 1 diabetes

Giulia Leanza et al.

Article Endocrinology & Metabolism

FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions

Citong Zhang et al.

JOURNAL OF DIABETES RESEARCH (2019)

Article Endocrinology & Metabolism

Accumulation of carboxymethyl-lysine (CML) in human cortical bone

Corinne J. Thomas et al.

Article Multidisciplinary Sciences

Influence of hyperbaric oxygen on biomechanics and structural bone matrix in type 1 diabetes mellitus rats

Pedro Henrique Justino Oliveira Limirio et al.

PLOS ONE (2018)

Article Endocrinology & Metabolism

Nonenzymatic Glycation and Degree of Mineralization Are Higher in Bone From Fractured Patients With Type 1 Diabetes Mellitus

Delphine Farlay et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

Article Endocrinology & Metabolism

Diabetes mellitus and risk of hip fractures: a meta-analysis

Y. Fan et al.

OSTEOPOROSIS INTERNATIONAL (2016)

Review Endocrinology & Metabolism

Biochemical bone turnover markers in diabetes mellitus - A systematic review

Jakob Starup-Linde et al.

Review Endocrinology & Metabolism

Type 2 Diabetes and Aging: A Not so Sweet Scenario for Bone

R. Dhaliwal et al.

HORMONE AND METABOLIC RESEARCH (2016)

Article Endocrinology & Metabolism

Bone Structure and Predictors of Fracture in Type 1 and Type 2 Diabetes

Jakob Starup-Linde et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Biochemistry & Molecular Biology

Effects of high glucose and advanced glycation end products on the expressions of sclerostin and RANKL as well as apoptosis in osteocyte-like MLO-Y4-A2 cells

Ken-ichiro Tanaka et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

Deficits in Trabecular Bone Microarchitecture in Young Women With Type 1 Diabetes Mellitus

Naiemh Abdalrahaman et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Article Cell Biology

Stable Incretin Mimetics Counter Rapid Deterioration of Bone Quality in Type 1 Diabetes Mellitus

Sity Aishah Mansur et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Article Engineering, Biomedical

A direct role of collagen glycation in bone fracture

Atharva A. Poundarik et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)

Article Endocrinology & Metabolism

Clinical and endocrine correlates of circulating sclerostin levels in patients with type 1 diabetes mellitus

Thomas Neumann et al.

CLINICAL ENDOCRINOLOGY (2014)

Article Endocrinology & Metabolism

Circulating Levels of Carboxy-Methyl-Lysine ( CML) Are Associated With Hip Fracture Risk: The Cardiovascular Health Study

Joshua I. Barzilay et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Geriatrics & Gerontology

Advanced glycation end product associated skin autofluorescence: A mirror of vascular function?

Britt Hofmann et al.

EXPERIMENTAL GERONTOLOGY (2013)

Article Endocrinology & Metabolism

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes

Luigi Gennari et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Endocrinology & Metabolism

Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes

Ann V. Schwartz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Endocrinology & Metabolism

Poor glycemic control is associated with low BMD detected in premenopausal women with type 1 diabetes

K. K. Danielson et al.

OSTEOPOROSIS INTERNATIONAL (2009)

Article Endocrinology & Metabolism

Pentosidine effects on human osteoblasts in vitro

Roberta Sanguineti et al.

MAILLARD REACTION: RECENT ADVANCES IN FOOD AND BIOMEDICAL SCIENCES (2008)

Article Endocrinology & Metabolism

Young women with type 1 diabetes have lower bone mineral density that persists over time

Lucy D. Mastrandrea et al.

DIABETES CARE (2008)

Article Endocrinology & Metabolism

Effects of non-enzymatic glycation on cancellous bone fragility

S. Y. Tang et al.

Article Biochemistry & Molecular Biology

Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation

Ulrich Valcourt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Public, Environmental & Occupational Health

Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture

Mohsen Janghorbani et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2007)

Article Endocrinology & Metabolism

Bone density and markers of bone remodeling in type 1 male diabetic patients

O. Alexopoulou et al.

DIABETES & METABOLISM (2006)

Article Immunology

Regulation of osteoclast function and bone mass by RAGE

Z Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Orthopedics

Effect of diabetes mellitus on the material properties of the distal tibia

JG Fleischli et al.

JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION (2006)

Article Endocrinology & Metabolism

The effects of vanadium treatment on bone in diabetic and non-diabetic rats

DM Facchini et al.

Article Endocrinology & Metabolism

Elevated hip fracture risk in type 1 diabetic patients

JM Miao et al.

DIABETES CARE (2005)

Article Endocrinology & Metabolism

Simple non-invasive assessment of advanced glycation endproduct accumulation

R Meerwaldt et al.

DIABETOLOGIA (2004)

Article Biochemistry & Molecular Biology

Advanced glycation endproducts interfere with integrin-mediated osteoblastic attachment to a type-I collagen matrix

AD McCarthy et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)

Article Endocrinology & Metabolism

Age-related changes in the collagen network and toughness of bone

X Wang et al.