☆ 4.8 Article

Near-infrared imaging of hepatocellular carcinoma and its medicinal treatment with a γ-glutamyl transpeptidase-monitoring fluorescence probe

BIOSENSORS & BIOELECTRONICS (2023)

Related references

Note: Only part of the references are listed.

Review Gastroenterology & Hepatology

Blood-based biomarkers for hepatocellular carcinoma screening: Approaching the end of the ultrasound era?

Neehar D. Parikh et al.

Summary: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths globally due to inadequate early detection strategies. Current screening recommendations have several deficiencies, including suboptimal sensitivity and poor adherence. Blood-based biomarkers show promise but require validation and logistical solutions before clinical implementation. Maturing validation cohorts, such as the Hepatocellular Carcinoma Early Detection Study and the Texas Hepatocellular Carcinoma Consortium, are expected to provide robust validation for candidate biomarkers.

JOURNAL OF HEPATOLOGY (2023)

Add to Collection

Review Pharmacology & Pharmacy

Expression and functions of transient receptor potential channels in liver diseases

Wenhui Wang et al.

Summary: Liver diseases, including acute hepatic injury, chronic hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC), are a major healthcare burden globally. Treatment strategies for these diseases are inadequate, highlighting the need to understand the underlying pathogenesis. Recent findings have shown that TRP channels play a crucial role in the development and progression of liver diseases, and targeting these channels pharmacologically may hold promise for their treatment.

ACTA PHARMACEUTICA SINICA B (2023)

Add to Collection

Article Biophysics

Constructing a novel fluorescence detection method for γ-glutamyltranspeptidase and application on visualizing liver injury

Kai Wang et al.

Summary: In this study, a fluorescence detection method for GGT based on fluorescent probes was developed. It could accurately evaluate the condition of liver injury by combining with clinical indexes, providing important information for the diagnosis and treatment of liver injury.

BIOSENSORS & BIOELECTRONICS (2023)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Dye encapsulation and one-pot synthesis of microporous-mesoporous zeolitic imidazolate frameworks for CO2 sorption and adenosine triphosphate biosensing

Hani Nasser Abdelhamid

Summary: One-pot co-precipitation method for synthesizing microporous-mesoporous zeolitic imidazolate frameworks-8 (ZIF-8) crystals, using organic dyes as target molecules, was reported. The crystal growth involves an intermediate phase of zinc hydroxyl nitrate nanosheets, allowing the adsorption of the dyes. The materials showed potential for CO2 adsorption and ATP biosensing.

DALTON TRANSACTIONS (2023)

Add to Collection

Review Gastroenterology & Hepatology

Patient-reported outcomes in HCC: A scoping review by the Practice Metrics Committee of the American Association for the Study of Liver Diseases

Marina Serper et al.

Summary: HCC is a major cause of mortality in patients with advanced liver disease and is associated with significant morbidity. The evaluation of patient-reported outcomes (PROs) in HCC is lacking in systematic assessment. A review of studies found that poor PROs were associated with worse prognosis in HCC patients, although some patients had better PROs compared to those with cirrhosis. Treatment methods were found to have an impact on symptom burden, but further research is needed for more specific effects.

HEPATOLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

Daniel Geh et al.

Summary: The success of atezolizumab plus bevacizumab treatment has led to a shift towards combination therapies in the treatment of hepatocellular carcinoma (HCC) that include cancer immunotherapies. The focus of cancer immunotherapy has primarily been on immune checkpoints, but emerging evidence supports the role of neutrophils as important contributors to the development and progression of HCC. Neutrophil-targeted therapies are now being explored in clinical trials and may have therapeutic benefits, including enhancing the effectiveness of conventional immunotherapy.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma

Danyu Du et al.

Summary: Hepatocellular carcinoma is an aggressive cancer with increasing incidence worldwide. Targeting abnormal metabolism has emerged as a new strategy for HCC treatment. This review highlights metabolic targets and discusses current pharmaceutical agents and studies in this field.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection

Review Gastroenterology & Hepatology

Emerging immunotherapy or HCC: A guide for hepatologists

Friedrich Foerster et al.

Summary: HCC is one of the most common and deadliest cancers globally. Immuno-oncology has shown promising results in the treatment of HCC, with immune checkpoint inhibition becoming the first-line therapy for advanced cases. However, challenges remain in determining the role of immunotherapy in earlier stages of HCC and identifying treatment strategies for non-responsive patients.

HEPATOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

NAFLD-driven HCC: Safety and efficacy of current and emerging treatment options

Friedrich Foerster et al.

Summary: Given the global increase in obesity and type 2 diabetes, non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are becoming important causes of hepatocellular carcinoma (HCC). HCCs caused by chronic inflammation mediated by lipotoxicity have unique characteristics, such as occurring in up to 50% of NAFLD-HCC patients without cirrhosis and having a lower annual incidence, leading to challenges in surveillance strategies. Locoregional treatments may be equally effective regardless of HCC etiology, but the effectiveness of systemic therapy is less clear. Tyrosine kinase inhibitors are likely equally effective, while there are initial signals that immune checkpoint inhibitors may be less effective in NAFLD-HCC compared to viral HCC.

JOURNAL OF HEPATOLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update

Maria Reig et al.

Summary: There have been significant advances in the treatment strategies for hepatocellular carcinoma since the last update in 2018. However, some interventions still lack sufficient data for clinical incorporation, and personalized clinical management requires consideration of multiple parameters.

JOURNAL OF HEPATOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

A genetic engineering strategy for editing near-infrared-II fluorophores

Rui Tian et al.

Summary: The authors propose a strategy to modify protein coatings with biofunctional molecules, resulting in long-wavelength fluorophores for in vivo imaging. These modified albumin variants protect inserted dyes, enhance their brightness, and can be genetically edited to develop size-tunable complexes with precise pharmacokinetics. This approach widens the clinical application prospects for NIR-II fluorophores.

NATURE COMMUNICATIONS (2022)

Add to Collection

Review Gastroenterology & Hepatology

Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma

Philip Johnson et al.

Summary: This review discusses biomarkers for hepatocellular carcinoma (HCC) that can improve early diagnosis, therapy monitoring, and prediction of therapy response. The sensitivity of surveillance methods for HCC, such as abdominal ultrasonography and alpha-fetoprotein (AFP) analysis, is limited. Two approaches, using AFP within statistical models and circulating nucleic acid biomarkers, show promise in overcoming this limitation.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing

Yuanqiang Sun et al.

Summary: Fluorescent probes that emit in the far-red, near-infrared I, and near-infrared II regions have unique advantages in biomedical applications. Flavylium compounds, found in flowers and fruits, are ideal platforms for constructing fluorescent probes due to their optical properties. The development of flavylium-inspired dyes has significantly advanced NIR-II in vivo imaging, and their applications in biomedical sensing and clinical treatments have shown great potential.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

γ-Glutamyltranspeptidase (GGT)-Activatable Fluorescence Probe for Durable Tumor Imaging

Rui Obara et al.

Summary: A novel functionalized fluorescence probe for GGT was developed, enabling prolonged in vivo cancer imaging and compatibility with fixation and immunostaining of cancer tissue.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumor Imaging

Ali Yasin Sonay et al.

Summary: Optical imaging probes are important in disease detection, and biodegradable harmonophores offer a new approach for cancer treatment through targeted high-resolution optical imaging.

ACS NANO (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback

Dengshuai Wei et al.

Summary: This study introduces a highly biodegradable polyester carrying tandem NIR-II fluorophores as a promising alternative for in vivo monitoring of drugs and real-time feedback on therapeutic effects. The polymer encapsulated a platinum intercalator and was conjugated with both a cell-targeting peptide and a caspase-3 cleavable peptide probe for simultaneous NIR-II and apoptosis imaging, demonstrating strong potency in vitro and significant inhibition of tumor growth in a mouse model. Through label-free mass spectrometry imaging, in situ release of the platinum intercalator in deeper tumors was observed.

ACS NANO (2021)

Add to Collection

Article Gastroenterology & Hepatology

Analysis and Validation of Human Targets and Treatments Using a Hepatocellular Carcinoma-Immune Humanized Mouse Model

Yue Zhao et al.

Summary: This study established humanized-immune-system HCC mouse models for testing combinational therapies, showing that triple-combination therapy had superior anti-HCC effects compared to single or dual treatments. It was found that human immune cells in the tumor microenvironment were strongly modulated by HCC, promoting HCC proliferation and angiogenesis through specific signaling pathways.

HEPATOLOGY (2021)

Add to Collection

Review Gastroenterology & Hepatology

Mechanistic Rationales Guiding Combination Hepatocellular Carcinoma Therapies Involving Immune Checkpoint Inhibitors

Jacinth Wing-Sum Cheu et al.

Summary: Hepatocellular carcinoma (HCC) is a deadly cancer with late symptom manifestation causing delayed diagnosis, limiting curative surgical treatment for patients. Immune checkpoint inhibitors (ICIs) show promise in HCC treatment, but more research is needed to improve response rates.

HEPATOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

Non-alcoholic fatty liver disease

Elizabeth E. Powell et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a common global health issue with significant associations with metabolic syndrome and type 2 diabetes, leading to serious complications like cirrhosis and hepatocellular carcinoma. While cardiovascular disease and extrahepatic malignancy are the main causes of death in NAFLD patients, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and overall mortality.

LANCET (2021)

Add to Collection

Review Biochemistry & Molecular Biology

A Systematic Review of Serum γ-Glutamyltransferase as a Prognostic Biomarker in Patients with Genitourinary Cancer

Kosuke Takemura et al.

Summary: Gamma-glutamyltransferase (GGT) is a membrane-bound enzyme that plays a critical role in the metabolism of glutathione (GSH) and has been proposed as a potential biomarker for carcinogenesis and tumor progression. Elevated serum GGT activity may indicate an increased risk of developing genitourinary cancers, such as prostate cancer.

ANTIOXIDANTS (2021)

Add to Collection

Review Medicine, General & Internal

Serum Biomarkers of Liver Fibrosis Staging in the Era of the Concept Compensated Advanced Chronic Liver Disease

Koji Fujita et al.

Summary: In recent years, non-invasive indexes of liver fibrosis based on blood examinations have been developed, partially replacing liver biopsy examinations. The concept of liver cirrhosis has been revised to compensated advanced chronic liver diseases, as serum biomarkers are unable to differentiate cirrhosis from severe fibrosis.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Chemistry, Analytical

Noninvasive ratiometric fluorescence imaging of γ-glutamyltransferase activity using an activatable probe

Zheng Huang et al.

Summary: The study presents a GGT-activatable ratiometric fluorescent probe for evaluating GGT levels in different tumor cells, enabling the detection and study of GGT-positive tumor tissues.

ANALYST (2021)

Add to Collection

Article Chemistry, Analytical

Cell-Membrane-Localizing, Two-Photon Probe for Ratiometric Imaging of γ-Glutamyl Transpeptidase in Cancerous Cells and Tissues

Ye Jin Reo et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Analytical

A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models

Na He et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Animal models for hepatocellular carcinoma

Hui Emma Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Self-Immolative Fluorescent and Raman Probe for Real-Time Imaging and Quantification of gamma-Glutamyl Transpeptidase in Living Cells

Yang Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Article Chemistry, Analytical

Ratiometric Imaging of γ-Glutamyl Transpeptidase Unperturbed by pH, Polarity, and Viscosity Changes: A Benzocoumarin-Based Two-Photon Fluorescent Probe

Ye Jin Reo et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection

Article Chemistry, Analytical

Fluorescence-Guided Cancer Diagnosis and Surgery by a Zero Cross Talk Ratiometric Near-Infrared γ-Glutamyltranspeptidase Fluorescent Probe

Juan Ou-Yang et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection

Article Medicine, Research & Experimental

Point-of-care Ratiometric Fluorescence Imaging of Tissue for the Diagnosis of Ovarian Cancer

Xiaobo Zhou et al.

THERANOSTICS (2019)

Add to Collection

Article Chemistry, Analytical

A novel AIE plus ESIPT near-infrared nanoprobe for the imaging of γ-glutamyl transpeptidase in living cells and the application in precision medicine

Yi Liu et al.

ANALYST (2019)

Add to Collection

Article Chemistry, Analytical

Red-Emitting Fluorescent Probe for Detection of γ-Glutamyltranspeptidase and Its Application of Real-Time Imaging under Oxidative Stress in Cells and in Vivo

Feiyan Liu et al.

ANALYTICAL CHEMISTRY (2018)

Add to Collection

Article Chemistry, Analytical

Targeted Delivery of a gamma-Glutamyl Transpeptidase Activatable Near-Infrared-Fluorescent Probe for Selective Cancer Imaging

Zhiliang Luo et al.

ANALYTICAL CHEMISTRY (2018)

Add to Collection

Article Engineering, Biomedical

Visualizing glioma margins by real-time tracking of gamma-glutamyltranspeptidase activity

Yingchao Liu et al.

BIOMATERIALS (2018)

Add to Collection

Article Cell Biology

The extent of liver injury determines hepatocyte fate toward senescence or cancer

Chao Wang et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Detecting and Imaging of gamma-Glutamytranspeptidase Activity in Serum, Live Cells, and Pathological Tissues with a High Signal-Stability Probe by Releasing a Precipitating Fluorochrome

Juan Ou-Yang et al.

ACS SENSORS (2018)

Add to Collection

Article Oncology

Increased γ-glutamyl transferase positively contributed to the poor prognosis in lung cancer patients

Jing Jing Ran et al.

TRANSLATIONAL CANCER RESEARCH (2018)

Add to Collection

Article Chemistry, Analytical

A novel mitochondrial-targeting near-infrared fluorescent probe for imaging γ-glutamyl transpeptidase activity in living cells

Haijuan Liu et al.

ANALYST (2018)

Add to Collection

Article Chemistry, Analytical

An efficient two-photon fluorescent probe for measuring γ-glutamyltranspeptidase activity during the oxidative stress process in tumor cells and tissues

Peng Wang et al.

ANALYST (2017)

Add to Collection

Review Chemistry, Analytical

Serum protein biomarkers relevant to hepatocellular carcinoma and their detection

Eric Waidely et al.

ANALYST (2016)

Add to Collection

Article Chemistry, Analytical

Enzymatic Cleavage and Subsequent Facile Intramolecular Transcyclization for in Situ Fluorescence Detection of γ-Glutamyltranspetidase Activities

Hongjuan Tong et al.

ANALYTICAL CHEMISTRY (2016)

Add to Collection

Article Biophysics

Monitoring γ-glutamyl transpeptidase activity and evaluating its inhibitors by a water-soluble near-infrared fluorescent probe

Lihong Li et al.

BIOSENSORS & BIOELECTRONICS (2016)

Add to Collection

Review Pharmacology & Pharmacy

Advances of diagnostic and mechanistic studies of γ-glutamyl transpeptidase in hepatocellular carcinoma

Jufeng Xia et al.

DRUG DISCOVERIES AND THERAPEUTICS (2016)

Add to Collection

Article Chemistry, Analytical

Sensitive Fluorescence Probe with Long Analytical Wavelengths for γ-Glutamyl Transpeptidase Detection in Human Serum and Living Cells

Lihong Li et al.

ANALYTICAL CHEMISTRY (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase

Feiyi Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Add to Collection

Review Gastroenterology & Hepatology

Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways

Ekihiro Seki et al.

HEPATOLOGY (2015)

Add to Collection

Review Oncology

Circulating specific biomarkers in diagnosis of hepatocellular carcinoma and its metastasis monitoring

Li Wang et al.

TUMOR BIOLOGY (2014)

Add to Collection

© Peeref 2019-2024. All rights reserved.