☆ 4.8 Article

Artificial trachea design, construction, and application: Materials, cells, and growth factors

APPLIED MATERIALS TODAY (2023)

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Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications

Zia Ullah Arif et al.

Summary: This article systematically summarizes the recent advancements in PLA and PCL biodegradable polymer-based composites manufactured through 3DP, as well as their applications in bone, cardiac, neural, vascularized and skin tissue regeneration. The interaction between implanted polymers and evaluation methods are also illustrated. The final section discusses the current challenges and future opportunities in 3DP of PCL and PLA-based composites for biomedical engineering.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Otorhinolaryngology

3D bioprinting in airway reconstructive surgery: A pilot study

Miriam Torsello et al.

Summary: The study evaluates the feasibility of using 3D printing technology to create scaffolds for surgeries treating congenital subglottic stenosis. The preliminary data suggests that the excessive stiffness of the material is a major limitation due to inherent constraints. Future research may require developing a new biocompatible, more flexible and elastic graft for better integration into surrounding tissues.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2022)

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Article Surgery

Poly (L-Lactic Acid) Cell-Laden Scaffolds Applied on Swine Model of Tracheal Fistula

Bruna Maria Manzini et al.

Summary: This study aimed to develop a tissue-engineered alternative for the treatment of small TF and evaluate its association with suture filaments enriched with AT-MSCs. Through in vitro and in vivo experiments and tissue analysis, it was concluded that PLLA membranes with attached AT-MSCs have a high potential for extracellular matrix restoration, and their association with suture filaments enriched with AT-MSCs is advantageous.

JOURNAL OF SURGICAL RESEARCH (2022)

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Article Biochemical Research Methods

A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties

Yi Zhang et al.

Summary: This study successfully developed a bioactive 3D-printed PLA scaffold with MSC-Exo modification, which has potential immunoregulatory and osteogenic potential for bone tissue regeneration.

JOURNAL OF BIOLOGICAL ENGINEERING (2022)

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Article Biotechnology & Applied Microbiology

Biomimetic, mussel-inspired surface modification of 3D-printed biodegradable polylactic acid scaffolds with nano-hydroxyapatite for bone tissue engineering

Minghan Chi et al.

Summary: This study applied polydopamine coating and immobilized hydroxyapatite nanoparticles on the surface of 3D printed PLA scaffolds to enhance their bone regenerative properties. The functionalized PLA scaffold showed improved surface properties without compromising the physicochemical properties of the material.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

Viability and Adhesion of Periodontal Ligament Fibroblasts on a Hydroxyapatite Scaffold Combined with Collagen, Polylactic Acid-Polyglycolic Acid Copolymer and Platelet-Rich Fibrin: A Preclinical Pilot Study

Leonor C. Espitia-Quiroz et al.

Summary: This study evaluated the effect of a hydroxyapatite scaffold containing collagen, combined with polylactic acid-polyglycolic acid copolymer and Platelet-Rich Fibrin, on the adhesion and viability of periodontal ligament fibroblast cells. The results showed that the scaffold with collagen and Platelet-Rich Fibrin promoted cell adhesion and viability, potentially benefiting bone defect repair and periodontal ligament tissue regeneration.

DENTISTRY JOURNAL (2022)

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Review Biotechnology & Applied Microbiology

Review of the Developments of Bacterial Medium-Chain-Length Polyhydroxyalkanoates (mcl-PHAs)

V. Uttej Nandan Reddy et al.

Summary: Synthetic plastics derived from fossil fuels are non-degradable and pollute the environment. There is a need for biodegradable plastics, such as polyhydroxyalkanoates (PHAs), which have broad applicability. This review focuses on the production and extraction methods, physical/thermal properties, applications, and production scales of medium-chain-length PHAs in different regions.

BIOENGINEERING-BASEL (2022)

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Article Materials Science, Biomaterials

Adipose mesenchymal stem cell-based tissue engineering mesh with sustained bFGF release to enhance tissue repair

Xiaotong Wu et al.

Summary: A novel tissue engineering mesh for pelvic organ prolapse utilizing silk fibroin, basic fibroblast growth factor, and adipose-derived stem cells has been developed, showing good biocompatibility and cell-promoting effects, with potential to improve patient symptoms.

BIOMATERIALS SCIENCE (2022)

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Article Pediatrics

Development of a porcine acellular bladder matrix for tissue-engineered bladder reconstruction

Massimo Garriboli et al.

Summary: A protocol for creating a natural-derived bladder extracellular matrix (BEM) was established for developing tissue-engineered bladder, and its structural and functional characteristics were investigated. The results showed that BEM retained structural characteristics, increased strength and stiffness, and had better compliance compared to native tissue, as well as angiogenic potential. These findings suggest the potential use of BEM for developing tissue-engineered bladder for patients requiring bladder augmentation.

PEDIATRIC SURGERY INTERNATIONAL (2022)

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Article Dermatology

An acellular tissue engineered biomimetic wound healing device created using collagen and tropoelastin accelerates wound healing

Robert B. Diller et al.

Summary: The research aims to modulate the wound healing cascade using acellular scaffolds, which are designed to create an acellular electrospun dermal biomimetic. Results showed that treated wounds had enhanced re-epithelialization, thicker epidermis, and new elastin fibers, indicating accelerated wound healing.

JOURNAL OF TISSUE VIABILITY (2022)

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Article Engineering, Biomedical

Rapid preparation of decellularized trachea as a 3D scaffold for organ engineering

Zhihao Wang et al.

Summary: By increasing the concentration of DNase and reducing the number of decellularization cycles, the study successfully shortened the preparation time of rabbit tracheal matrix, preserved the integrity of the extracellular matrix, and enhanced the proliferation capacity of bone mesenchymal stem cells on the matrix. Immunohistochemical staining and biomechanical property testing showed that the obtained decellularized rabbit tracheal matrix exhibited good biocompatibility and suitable mechanical properties.

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS (2021)

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Article Cardiac & Cardiovascular Systems

Retrievable covered metallic segmented Yairway stent for gastrorespiratory fistula of carina or main bronchi

Wei Huang et al.

Summary: The new retrievable covered metallic segmented Y airway stents modified with 3D printing appear to be feasible for treating gastrorespiratory fistula involving carina or main bronchi, showing positive effects on improving patients' quality of life.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2021)

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Article Cell & Tissue Engineering

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

Finn J. Hawkins et al.

Summary: The directed differentiation of human iPSCs into airway basal cells (iBCs) demonstrates the functional characteristics of airway basal cells and can be used to model characteristic changes in airway diseases.

CELL STEM CELL (2021)

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Article Cell & Tissue Engineering

Combined Use of Detergents and Ultrasonication for Generation of an Acellular Pig Larynx

Nikhil B. Nayakawde et al.

Summary: The larynx is a complex organ consisting of various muscles, cartilages, mucosal membrane, and nerves, with larynx cancer being the most common type of head and neck cancer. Treatment options are limited for patients undergoing total or partial laryngectomy, but tissue-engineered organs have shown promise as an alternative. A novel decellularization method involving perfusion-agitation with detergents and ultrasonication was used to construct a pig larynx scaffold with preserved ECM proteins and angiogenic growth factors.

TISSUE ENGINEERING PART A (2021)

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Review Biology

Current Strategies for Tracheal Replacement: A Review

Giuseppe Damiano et al.

Summary: The incidence of airway cancers is increasing, and tracheal resection is commonly performed with significant post-operative complications affecting quality of life. Current research focuses on regenerative medicine for tracheal replacement using bio-prosthesis, with successful tracheal transplantation requiring an effective vascular supply. This review describes the current research efforts in the field of tracheal replacement, including attempts to use decellularized tissues and the importance of ensuring proper mechanical properties and biocompatibility.

LIFE-BASEL (2021)

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Review Neurosciences

Adipose tissue stem cells in peripheral nerve regeneration-In vitroandin vivo

Sophie Charlotte Rhode et al.

Summary: After peripheral nerve injury, Schwann cells play a crucial role in promoting nerve regeneration, with adipose tissue stem cells being a potential alternative for tissue reconstruction. These stem cells have the ability to differentiate into various cell types and secrete neurotrophic factors that support nerve growth.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

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Article Materials Science, Biomaterials

Photocrosslinked natural hydrogel composed of hyaluronic acid and gelatin enhances cartilage regeneration of decellularized trachea matrix

Yong Xu et al.

Summary: The repair of long segmental tracheal defects is a significant challenge in clinical practice. A novel strategy using a photocrosslinked natural hydrogel carrier was proposed to improve cell retention efficiency and enhance tracheal cartilage regeneration. This strategy significantly enhanced cell-seeding efficiency, achieved stable cell retention, and provided a natural three-dimensional biomimetic microenvironment for promoting chondrocyte survival, extracellular matrix production, and cartilage regeneration.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Long-Term Sustained Drug Delivery via 3D Printed Masks for the Development of a Heparin-Loaded Interlayer in Vascular Tissue Engineering Applications

Megan Kimicata et al.

Summary: This study introduces an innovative interlayer drug delivery system for small-diameter vascular grafts used in coronary artery bypass surgeries, which allows for precise temporal and spatial control of sustained heparin release. The method supports endothelial cell function and promotes an antithrombotic environment by controlling the release of heparin within a gelatin methacrylate interlayer.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Ice-Inspired Lubricated Drug Delivery Particles from Microfluidic Electrospray for Osteoarthritis Treatment

Lei Yang et al.

Summary: Particle-based drug delivery systems show significant value in osteoarthritis treatment. By developing functional particles with enhanced lubrication and therapeutic effects through microfluidic electrospray, potential applications in clinical settings are promising. This approach offers precise control over particle size, chemical modification, and drug loading, showcasing great potential for improved treatment outcomes.

ACS NANO (2021)

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Article Biochemistry & Molecular Biology

Partial Decellularized Scaffold Combined with Autologous Nasal Epithelial Cell Sheet for Tracheal Tissue Engineering

Luong Huu Dang et al.

Summary: Decellularization has been explored as a potential solution for tracheal replacement. Partial decellularization combined with autologous nasal epithelial cell sheets showed promising results in tracheal reconstruction, leading to integration with host tissue and adequate luminal surface healing two months post-operation. This hybrid scaffold protocol holds potential for future applications in tracheal reconstructions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Isolation of multipotent progenitor cells from pleura and pericardium for tracheal tissue engineering purposes

Rayna de Wit et al.

Summary: The study demonstrates the feasibility of isolating progenitor cells with stem cell features from pericardium and pleura, showing multipotency and capability to differentiate towards chondrogenic, osteogenic and adipogenic lineages. Despite subtle differences, based on gene expression, pericardium- and pleura-derived stem cells may offer a superior autologous cell source for tracheal tissue engineering.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Engineering, Biomedical

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs)

Cansu Gorgun et al.

Summary: The research demonstrates that the MSC secretome is strongly modulated by concurrent stimulation with hypoxia and pro-inflammatory cytokines, which mimics the harsh environment at the injury site. The environmental variations strongly influence the angiogenic potential of different secretome fractions.

BIOMATERIALS (2021)

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Article Materials Science, Biomaterials

Exosomes from 3T3-J2 promote expansion of tracheal basal cells to facilitate rapid epithelization of 3D-printed double-layer tissue engineered trachea

Xiaoyang Zhang et al.

Summary: Functional epithelization is crucial for maintaining long-term lumen patency of tissue-engineered trachea. A promising expansion strategy involving co-culturing tracheal basal cells (TBCs) with exosomes derived from 3T3J2 cells was proposed to accelerate the epithelization process. The use of a bionic tubular double-layer scaffold and pre-seeding TBCs on the inner layer facilitated the rapid epithelization of transplanted TET.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Biochemistry & Molecular Biology

Evaluating Feasibility of Human Tissue Engineered Respiratory Epithelium Construct as a Potential Model for Tracheal Mucosal Reconstruction

Mohd Heikal Mohd Yunus et al.

Summary: The normal function of the airway epithelium is crucial for host's well-being, and various factors may compromise its structure and functionality. The outbreak of COVID-19 has increased the demand for tracheal tissue replacement. Research has shown that human tissue respiratory epithelial construct (HTREC) constructed using tissue engineering approach supports cellular proliferation, differentiation, and distribution effectively.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Dual Delivery of TGF-β3 and Ghrelin in Microsphere/Hydrogel Systems for Cartilage Regeneration

Jianjing Lin et al.

Summary: Joint cartilage damage can easily lead to osteoarthritis due to its poor self-healing ability, but researchers have developed a microsphere/hydrogel system containing two growth factors to promote cartilage repair, which was characterized in vitro for biocompatibility.

MOLECULES (2021)

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Article Biochemical Research Methods

3D bioprinted silk fibroin hydrogels for tissue engineering

Soon Hee Kim et al.

Summary: The development of biocompatible and precisely printable bioink addresses the growing demand for three-dimensional bioprinting applications in tissue engineering. The versatile bioink, with high mechanical stability and biocompatibility, can be broadly used in nerve tissue engineering and wound healing, among other applications.

NATURE PROTOCOLS (2021)

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Article Orthopedics

Enhanced expression of hyaluronic acid in osteoarthritis-affected knee-cartilage chondrocytes during three-dimensional in vitro culture in a hyaluronic-acid-retaining polymer scaffold

Shojiro Katoh et al.

Summary: The study compared the HA retention capability and growth of chondrocytes in a 3D-TGP environment with conventional 2D cell culture methods, showing that 3D-TGP was better at retaining HA and supporting chondrocytes to form tissue-like architecture with higher HA expression.

KNEE (2021)

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Article Multidisciplinary Sciences

Design of epidermal growth factor immobilization on 3D biocompatible scaffolds to promote tissue repair and regeneration

Teodora Bavaro et al.

Summary: This study aimed to develop bioconjugates based on hEGF for tissue engineering applications, with immobilized EGF showing significantly high cell proliferative activity at 50 and 100 ng/mL. The results suggest that EGF immobilized on activated-agarose carriers has potential for treating skin-related disorders such as burns.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

Short-Term Preclinical Application of Functional Human Induced Pluripotent Stem Cell-Derived Airway Epithelial Patches

Ratna Varma et al.

Summary: Utilizing human induced pluripotent stem cells (hiPSCs) to engineer airway epithelial patches for transplantation has shown success in airway reconstruction, providing a significant advancement in this field.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Cardiac & Cardiovascular Systems

Recent Progress Toward Clinical Translation of Tissue- Engineered Heart Valves

Bahram Mirani et al.

Summary: Heart valve tissue engineering aims to provide a replacement that is capable of growth, self-repair, and long-term functionality to meet the needs of patients with valvular heart disease. While the long-term clinical success of decellularised pulmonary and aortic homografts demonstrates the potential of this technology, challenges still exist in preclinical testing.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

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Review Respiratory System

Airway complications in lung transplantation

Maria M. Crespo

Summary: Airway complications after lung transplantation are a significant source of morbidity and mortality, with varying rates of occurrence. Early recognition and advanced medical management, including interventional bronchoscopy procedures, are key to preventing and managing these complications.

JOURNAL OF THORACIC DISEASE (2021)

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Review Chemistry, Multidisciplinary

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Marta Kolodziejska et al.

Summary: Chitosan, with its unique chemical, biological, and physical properties, is extensively used in tissue engineering as a main component in biomaterials. It can be modified and blended to meet specific requirements, making it versatile for various applications such as membranes, scaffolds, drug carriers, and hydrogels.

NANOMATERIALS (2021)

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Article Cell & Tissue Engineering

Mineralized collagen scaffold bone graft accelerate the osteogenic process of HASCs in proper concentration

Weiyang Zuo et al.

Summary: The study investigated the feasibility and optimum condition of human adipose-derived stem cells cultured on mineralized collagen material, as well as the mechanism of osteogenic differentiation. Results showed that the cells grew stably and proliferated rapidly under the optimum condition of 0.5 mg/cm(2) bone graft material. After 14 days, the cells on the material exhibited more calcium deposition and higher alkaline phosphatase activities compared to the control group. This suggests that human adipose-derived stem cells can effectively differentiate into osteoblasts when cultured on bone graft material.

REGENERATIVE THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Vancomycin-Loaded Polycaprolactone Electrospinning Nanofibers Modulate the Airway Interfaces to Restrain Tracheal Stenosis

Yanan Zhao et al.

Summary: This study developed VA-loaded PCL composite nanofiber films via electrospinning technique, with PVNF-5 showing good antibacterial activity against MRSA and SPn and being applied successfully in repairing tracheal stenosis.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Regeneration of Subcutaneous Cartilage in a Swine Model Using Autologous Auricular Chondrocytes and Electrospun Nanofiber Membranes Under Conditions of Varying Gelatin/PCL Ratios

Rui Zheng et al.

Summary: This study demonstrates that nanofiber membranes with different GT/PCL ratios can support subcutaneous cartilage regeneration in an autologous swine model. The G5P5 (GT: PC = 50: 50) group showed the highest degree of homogeneity in cartilage tissues and the maximum cartilage formation ratio.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Respiratory System

Development and clinical translation of tubular constructs for tracheal tissue engineering: a review

Luis Soriano et al.

Summary: Effective restoration of extensive tracheal damage remains a clinical challenge in respiratory medicine, with tissue engineering showing promise in fabricating biocompatible tracheal implants. However, challenges such as inadequate re-epithelialisation, poor mechanical properties, and insufficient revascularisation hinder the widespread clinical use of tissue-engineered tracheal implants.

EUROPEAN RESPIRATORY REVIEW (2021)

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Review Biochemistry & Molecular Biology

Osteogenesis Imperfecta: Current and Prospective Therapies

Malwina Botor et al.

Summary: Osteogenesis Imperfecta is a group of connective tissue disorders characterized by bone fragility, with five types ranging from mild to lethal. Current treatments aim to prevent fractures, control symptoms, and increase bone mass, but have limitations in effectiveness and side effects. Experimental approaches, including stem cell transplantation and genetic engineering, show promise in improving therapeutic effects.

BIOMOLECULES (2021)

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Article Materials Science, Biomaterials

Low-temperature 3D printing of collagen and chitosan composite for tissue engineering

Hairui Suo et al.

Summary: By controlling the temperature, a series of tunable hybrid collagen/chitosan bioinks with significantly improved printability were prepared and successfully printed into scaffolds with regulated properties. Chitosan could decrease the swelling ratio of the printed scaffolds, while the degradation rate increased with collagen proportion, and the values of Young's modulus and tensile strength increased with chitosan proportion. Scaffolds containing 2% (m/v) collagen and 2% (m/v) chitosan showed a homogeneous and compact honeycomb-like structure, demonstrating the strengthening effect of chitosan.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Cell & Tissue Engineering

Hyaluronic Acid Coating on Hydrophobic Tracheal Scaffold Enhances Mesenchymal Stem Cell Adhesion and Tracheal Regeneration

Ji Suk Choi et al.

Summary: This study evaluated the impact of hyaluronic acid (HA) coating on tracheal scaffolds for mesenchymal stem cell (MSC) adhesion and tracheal regeneration, with the findings showing that HA coating promotes MSC adhesion and enhances airway repair.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Multidisciplinary Sciences

Improved chondrogenic performance with protective tracheal design of Chitosan membrane surrounding 3D-printed trachea

Hyeonji Kim et al.

Summary: This study introduces a novel design of tissue-engineered trachea, composed of a chitosan-based nanofiber membrane and a 3D-printed biotracheal construct, which successfully enhances the chondrogenic performance of chondrocytes. This protective design opens a new avenue in engineered tissue research.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Multidisciplinary

Rapid Preparation Method for Preparing Tracheal Decellularized Scaffolds: Vacuum Assistance and Optimization of DNase I

Zhihao Wang et al.

Summary: By utilizing vacuum assistance and optimizing the concentration of DNase I, this study successfully developed a rapid method for preparing decellularized tracheal scaffolds, which demonstrated significant improvements in cell compatibility and in vivo experiments.

ACS OMEGA (2021)

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Article Engineering, Biomedical

Development of alginate and gelatin-based pleural and tracheal sealants

Nathan Gasek et al.

Summary: Pleural and tracheal injuries remain significant challenges, and the development of sealants based on alginate and gelatin biomaterials show promise in effectively addressing these issues. These sealants demonstrate strong mechanical characteristics, minimal toxicity, and successful performance in vitro and in vivo models, providing a platform for further clinical investigations.

ACTA BIOMATERIALIA (2021)

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Article Surgery

Single-stage long-segment tracheal transplantation

Eric M. Genden et al.

Summary: Tracheal transplantation has been successfully performed in a human patient without the need for a tracheostomy or stent six months post-operation. The use of narrow-band imaging and bronchoscopic biopsies showed promising results in terms of allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with a combination of Tacrolimus, Mycophenolate mofetil, and corticosteroids.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Cardiac & Cardiovascular Systems

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung

Jonas C. Schupp et al.

Summary: This study provides a comprehensive reference atlas of endothelial cells in the lungs, identifying over 15,000 vascular endothelial cells from 73 individuals. The research reveals previously unrecognized subpopulations of lung endothelial cells and confirms the maintenance of endothelial diversity in pulmonary hypertension.

CIRCULATION (2021)

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Article Cell Biology

Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration

Hirofumi Kiyokawa et al.

Summary: During development, TGF-beta signaling inhibits Id2 to slow down the cell cycle and specify slow-cycling basal cells. In adult tissue regeneration, reduced TGF-beta signaling restores Id2 expression and initiates regeneration.

DEVELOPMENTAL CELL (2021)

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Review Anatomy & Morphology

Advances in tissue engineering of vasculature through three-dimensional bioprinting

Junjin Zhu et al.

Summary: This review discusses the challenges and current technologies in fabricating vasculature constructs using 3D bioprinting, as well as future directions for development. Direct and indirect printing can both be used in vascular tissue engineering, with techniques such as extrusion bioprinting, inkjet bioprinting, and light-assisted bioprinting playing important roles in the fabrication process.

DEVELOPMENTAL DYNAMICS (2021)

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Review Biochemistry & Molecular Biology

Chitosan-based 3D-printed scaffolds for bone tissue engineering

L. Roshini Yadav et al.

Summary: Conventional bone grafting techniques have limitations, highlighting the need for novel approaches to overcome challenges. The combination of bone tissue engineering and 3D-printing technology offers the potential to create tissue-like scaffolds with natural bone characteristics.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Bio-Functionalized Chitosan for Bone Tissue Engineering

Paola Brun et al.

Summary: The study found that bio-functionalized chitosan enhances adhesion and proliferation of human osteoblasts. Among HVP and RGD functionalized chitosan, HVP showed better support for osteoblast differentiation and calcium deposition while preserving the antibacterial properties of the material.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Biomaterials

Directly construct microvascularization of tissue engineering trachea in orthotopic transplantation

Fei Sun et al.

Summary: Tissue engineering technology provides effective alternative treatments for tracheal reconstruction by constructing a functional microvascular network to support cell metabolism. The one-step method of microvascularization described in this study successfully addresses the challenges of inadequate blood supply in tracheal transplantation.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Materials Science, Biomaterials

Bio-functional strontium-containing photocrosslinked alginate hydrogels for promoting the osteogenic behaviors

Delu Zhao et al.

Summary: The novel doped strontium photocrosslinked methacrylated alginate hydrogel possesses adjustable physical performances, excellent biocompatibility and osteogenic differentiation capabilities, which could be potentially applied to bone tissue engineering and regenerative medicine.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Cell & Tissue Engineering

Vascularization strategies for tissue engineering for tracheal reconstruction

Fei Sun et al.

Summary: Tissue engineering technology is an effective alternative treatment for tracheal reconstruction, and the formation of a functional microvascular network plays a critical role in supporting cell metabolism and ensuring the long-term survival of grafts.

REGENERATIVE MEDICINE (2021)

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Article Cell & Tissue Engineering

Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells

Michio Arakura et al.

Summary: The study demonstrated that implantation of chondrogenically differentiated iPSC-derived iMSCs can successfully promote bone regeneration, with significantly higher bone union rates in the experimental groups compared to the control group. The transition of hypertrophic chondrocytes to newly formed bone post-transplantation supports the notion that the cartilaginous template can trigger endochondral bone ossification.

TISSUE ENGINEERING PART A (2021)

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Review Polymer Science

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

Xiangjun Yang et al.

Summary: PCL is widely used in bone tissue engineering for its good biocompatibility and slow degradation rate, and can be blended with other polymers and hydrogels to improve its properties. 3D printing techniques are utilized to fabricate PCL-based composite scaffolds for various clinical applications.

POLYMERS (2021)

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Article Polymer Science

Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering

Asmak Abdul Samat et al.

Summary: This study evaluated the mechanical and in vitro properties of a TPU and PLA blend as a potential material for 3D printed tracheal scaffolds. Despite being not miscible, TPU and PLA are biocompatible and have promising properties for future applications in tracheal tissue engineering.

POLYMERS (2021)

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Review Immunology

Glucocorticoid Therapy in Inflammatory Bowel Disease: Mechanisms and Clinical Practice

Stefano Bruscoli et al.

Summary: Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn's disease (CD) and involves immune cell alteration and chronic inflammatory cascade activation against unknown environmental triggers. Therapy focuses on supporting measures and use of anti-inflammatory and immunosuppressive drugs, with glucocorticoids (GCs) being a cornerstone treatment for moderate-to-severe IBD. However, their use is limited by important adverse drug effects, leading researchers to explore newer, safer alternatives.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Patterned Drug-Eluting Coatings for Tracheal Stents Based on PLA, PLGA, and PCL for the Granulation Formation Reduction: In Vivo Studies

Olga A. Sindeeva et al.

Summary: The study demonstrates that films based on PLA, PCL, and PLGA can be used as drug-eluting coatings for effective suppression of granulation tissue. Different polymers exhibit varying stability and retention capabilities when composing coatings, contributing significantly to tissue suppression in practical applications.

PHARMACEUTICS (2021)

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Review Materials Science, Biomaterials

Biomimetic hydrogels designed for cartilage tissue engineering

Kresanti D. Ngadimin et al.

Summary: Cartilage regeneration and repair present a clinical challenge due to limited self-regenerative capability, with costs estimated at around 30,000 pounds per patient for producing and supplying cells. Regenerative approaches include cell therapies and tissue engineering using hydrogels as 3D substrates for cartilage cell cultivation, but current biomimetic hydrogels with necessary biological and physicochemical properties have yet to succeed.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Polyphenol scaffolds in tissue engineering

Xueqian Zhang et al.

Summary: Polyphenols are a group of compounds with biocompatible, antioxidant, and antibacterial properties that form strong non-covalent and covalent interactions. This review discusses the structures and functions of polyphenols and their application in wound healing, bone regeneration, and tissue engineering, offering insights for the design and preparation of next-generation polyphenol scaffolds.

MATERIALS HORIZONS (2021)

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Review Biochemistry & Molecular Biology

Printability and Critical Insight into Polymer Properties during Direct-Extrusion Based 3D Printing of Medical Grade Polylactide and Copolyesters

Shubham Jain et al.

BIOMACROMOLECULES (2020)

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Article Pediatrics

Tracheal cartilage growth promotion by intra-tracheal administration of basic FGF

Makoto Komura et al.

PEDIATRIC SURGERY INTERNATIONAL (2020)

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Article Engineering, Biomedical

Deconstructing tissue engineered trachea: Assessing the role of synthetic scaffolds, segmental replacement and cell seeding on graft performance

Sayali Dharmadhikari et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Digital light processing 3D printed silk fibroin hydrogel for cartilage tissue engineering

Heesun Hong et al.

BIOMATERIALS (2020)

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Review Biochemistry & Molecular Biology

An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells

Dinh-Toi Chu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Otorhinolaryngology

Diagnosis and management of complete tracheal rings with concurrent tracheoesophageal fistula

Nikolaus E. Wolter et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2020)

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Review Pharmacology & Pharmacy

Conditional reprogramming: next generation cell culture

Xiaoxiao Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Multidisciplinary Sciences

Clinical outcomes of self-expandable metallic stents for malignant obstructive atelectasis

Yonghua Bi et al.

SCIENTIFIC REPORTS (2020)

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Article Respiratory System

Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds

Nick J. I. Hamilton et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Physiology

A Role for Exosomes in Craniofacial Tissue Engineering and Regeneration

Lyndon F. Cooper et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Anatomy & Morphology

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The Fabrication and in vitro Evaluation of Retinoic Acid-Loaded Electrospun Composite Biomaterials for Tracheal Tissue Regeneration

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4D-bioprinted silk hydrogels for tissue engineering

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In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering

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Advancing Toward 3D Printing of oresorbable Shape Memory Polymer Stents

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CURRENT OPINION IN ORGAN TRANSPLANTATION (2020)

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Electrochemical Deposition of Nanostructured Hydroxyapatite Coating on Titanium with Enhanced Early Stage Osteogenic Activity and Osseointegration

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Evaluation of regenerated tracheal cilia function on a collagen-conjugated scaffold in a canine model

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Potential Functional Restoration of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy by ROCK Inhibitor (Ripasudil)

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Tubular Silk Fibroin/Gelatin-Tyramine Hydrogel with Controllable Layer Structure and Its Potential Application for Tissue Engineering

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ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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IGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering

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Biodegradable electrospun patch containing cell adhesion or antimicrobial compounds for trachea repair in vivo

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Non-woven bilayered biodegradable chitosan-gelatin-polylactide scaffold for bioengineering of tracheal epithelium

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Collagen sponge scaffolds containing growth factors for the functional regeneration of tracheal epithelium

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Tissue-engineered trachea from a 3D-printed scaffold enhances whole-segment tracheal repair in a goat model

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Insulin immobilized PCL-cellulose acetate micro-nanostructured fibrous scaffolds for tendon tissue engineering

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Carbon Nanofibers in Pure Form and in Calcium Alginate Composites Films: New Cost-Effective Antibacterial Biomaterials against the Life-Threatening Multidrug-Resistant Staphylococcus epidermidis

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Hyaluronic Acid (HA), Platelet-Rich Plasm and Extracorporeal Shock Wave Therapy (ESWT) promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

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Vascular Endothelial Cell Biology: An Update

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Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

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Fast cyclical-decellularized trachea as a natural 3D scaffold for organ engineering

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PDGF is a potent initiator of bone formation in a tissue engineered model of pathological ossification

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MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

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In vivo degradation and neovascularization of silk fibroin implants monitored by multiple modes ultrasound for surgical applications

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Polycaprolactone/carboxymethyl chitosan nanofibrous tissue engineering application

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3D Bioprinted Artificial Trachea with Epithelial Cells and Chondrogenic-Differentiated Bone Marrow-Derived Mesenchymal Stem Cells

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FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer

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Lyophilized Scaffolds Fabricated from 3D-Printed Photocurable Natural Hydrogel for Cartilage Regeneration

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Optimal biomaterials for tracheal epithelial grafts: An in vitro systematic comparative analysis

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Macroporous alginate foams crosslinked with strontium for bone tissue engineering

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Long-term follow-up of tracheal cartilage growth promotion by intratracheal injection of basic fibroblast growth factor

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Evaluation of the potential of kartogenin encapsulated poly(L-lactic acid-co-caprolactone)/collagen nanofibers for tracheal cartilage regeneration

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Tracheal cartilage growth by intratracheal injection of basic fibroblast growth factor

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In-vivo characterization of a 3D hybrid scaffold based on PCL/decellularized aorta for tracheal tissue engineering

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A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment

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Tissue-engineered trachea regeneration using decellularized trachea matrix treated with laser micropore technique

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In vitro and in vivo evaluation of strontium-containing nanostructured carbonated hydroxyapatite/sodium alginate for sinus lift in rabbits

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Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering

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Collagen/chitosan porous bone tissue engineering composite scaffold incorporated with Ginseng compound K

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Electrospun nanofibers of poly(ε-caprolactone)/depolymerized chitosan for respiratory tissue engineering applications

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Fabrication of Poly(epsilon-caprolactone) Scaffolds Reinforced with Cellulose Nanofibers, with and without the Addition of Hydroxyapatite Nanoparticles

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In vitro and in vivo co-culture of chondrocytes and bone marrow stem cells in photocrosslinked PCL-PEG-PCL hydrogels enhances cartilage formation

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Glottic regeneration with a tissue-engineering technique, using acellular extracellular matrix scaffold in a canine model

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TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor

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Engineered cartilaginous tubes for tracheal tissue replacement via self-assembly and fusion of human mesenchymal stem cell constructs

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PCL/Alginate Composite Scaffolds for Hard Tissue Engineering: Fabrication, Characterization, and Cellular Activities

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In vitro chondrogenesis and in vivo repair of osteochondral defect with human induced pluripotent stem cells

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The use of BDNF to enhance the patency rate of small-diameter tissue-engineered blood vessels through stem cell homing mechanisms

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Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study

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Enhanced Cartilage Formation via Three-Dimensional Cell Engineering of Human Adipose-Derived Stem Cells

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Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid

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Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the various zones of articular cartilage

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Isolation and Biological Characteristics of Chicken Adipose-Derived Progenitor Cells

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Tissue engineered human tracheas for in vivo implantation

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A tissue-engineered trachea derived from a framed collagen scaffold, gingival fibroblasts and adipose-derived stem cells

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Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction

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Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications

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Sustained local application of epidermal growth factor to accelerate reepithelialization of tracheal grafts

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Esterified hyaluronic acid improves cartilage viability in experimental tracheal reconstruction with an auricular graft

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Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation

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Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering

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Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?

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Accelerated angiogenesis by continuous medium flow with vascular endothelial growth factor inside tissue-engineered trachea

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Modulating bone cells response onto starch-based biomaterials by surface plasma treatment and protein adsorption

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Article Cell & Tissue Engineering

Effect of fibroblasts on tracheal epithelial regeneration in vitro

Ken Kobayashi et al.

TISSUE ENGINEERING (2006)

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Article Engineering, Biomedical

The use of poly(L-lactide) and RGD modified microspheres as cell carriers in a flow intermittency bioreactor for tissue engineering cartilage

Rui Chen et al.

BIOMATERIALS (2006)

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Article Biochemistry & Molecular Biology

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Kazutoshi Takahashi et al.

CELL (2006)

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Article Endocrinology & Metabolism

Effect of IGF-1 in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-β signaling

L Longobardi et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

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Review Biochemistry & Molecular Biology

Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family

LJ Reigstad et al.

FEBS JOURNAL (2005)

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Article Biochemistry & Molecular Biology

Embryonic stem cells generate airway epithelial tissue

C Coraux et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)

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Article Biochemistry & Molecular Biology

Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization

M Ohtsuka et al.

FASEB JOURNAL (2004)

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Article Orthopedics

Coating of titanium implants with type-I collagen

S Rammelt et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2004)

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Article Otorhinolaryngology

Tissue-engineered cartilage as a graft source for laryngotracheal reconstruction - A pig model

SH Kamil et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2004)

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Review Pharmacology & Pharmacy

Collagens -: structure, function, and biosynthesis

K Gelse et al.

ADVANCED DRUG DELIVERY REVIEWS (2003)

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Review Developmental Biology

Roles of PDGF in animal development

RV Hoch et al.

DEVELOPMENT (2003)

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Article Orthopedics

Combined effects of insulin-like growth factor-1 and transforming growth factor-beta 1 on periosteal mesenchymal cells during chondrogenesis in vitro

T Fukumoto et al.

OSTEOARTHRITIS AND CARTILAGE (2003)

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Article Medicine, Research & Experimental

Resorbable fixation in facial plastic and head and neck reconstructive surgery: An initial report on polylactic acid implants

KS Moe et al.

LARYNGOSCOPE (2001)

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Article Cardiac & Cardiovascular Systems

Transplantation of tracheal epithelial cells onto a prefabricated capsule pouch with fibrin glue as a delivery vehicle

C Rainer et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2001)

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Article Cell & Tissue Engineering

Multilineage cells from human adipose tissue: Implications for cell-based therapies

PA Zuk et al.

TISSUE ENGINEERING (2001)

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Article Physiology

Differentiated and functional human airway epithelium regeneration in tracheal xenografts

F Dupuit et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)

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