4.7 Article

Additively manufactured multiplexed electrochemical device (AMMED) for portable sample-to-answer detection

Related references

Note: Only part of the references are listed.
Article Nanoscience & Nanotechnology

Nanoplasmonic amplification in microfluidics enables accelerated colorimetric quantification of nucleic acid biomarkers from pathogens

Tamer AbdElFatah et al.

Summary: This study presents a molecular diagnostic platform that integrates plasmonic nano-surface technology to accelerate nucleic acid amplification reactions, providing an automated diagnostic platform for detecting respiratory viruses and bacteria.

NATURE NANOTECHNOLOGY (2023)

Review Biochemistry & Molecular Biology

Cell Free DNA as an Evolving Liquid Biopsy Biomarker for Initial Diagnosis and Therapeutic Nursing in Cancer- An Evolving Aspect in Medical Biotechnology

Suman Kumar Ray et al.

Summary: Cell-free DNA (cfDNA) is a promising tool in liquid biopsy, which investigates non-solid biological tissue and can provide important information for cancer diagnosis and treatment. cfDNA consists of nuclear DNA and mitochondrial DNA, and its analysis can offer insights into tumor-related pathological conditions.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2022)

Article Multidisciplinary Sciences

TBISTAT: An open-source, wireless portable, electrochemical impedance spectroscopy capable potentiostat for the point-of-care detection of S100B in plasma samples

Francisco Burgos-Florez et al.

Summary: This paper presents the development of an open-source, modular, wireless, low-cost potentiostat used for electrochemical detection of traumatic brain injury. The potentiostat was validated and compared to a commercial benchtop potentiostat, showing no significant differences in the results. It was also tested for S100B detection and achieved a limit of detection of 35.73 pg/mL. The modular design of the potentiostat allows for easy component changes and the use of minimal, easily accessible open-source hardware and software provides a framework for further development in the field of biosensors.

PLOS ONE (2022)

Article Biophysics

A capillary driven microfluidic chip for SERS based hCG detection

Elcin Ezgi Ahi et al.

Summary: This study developed a capillary driven microfluidic chip-based immunoassay for the determination of prohibited hCG protein. The method showed high selectivity and accuracy in detecting various proteins, with a regression coefficient of 0.9985 and a limit of detection of 0.61 IU/L. The analysis system developed for target proteins could serve as an alternative to traditional methods such as Western Blot, offering a more cost-effective and time-saving solution.

BIOSENSORS & BIOELECTRONICS (2022)

Article Biophysics

Hand-powered vacuum-driven microfluidic gradient generator for high-throughput antimicrobial susceptibility testing

Wenyi Zeng et al.

Summary: The article introduces a hand-powered vacuum-driven microfluidic device that can rapidly generate concentration gradients of different antibiotics for antibiotic susceptibility testing. The device is easy to operate, with advantages such as high throughput, cost efficiency, and shortened detection time.

BIOSENSORS & BIOELECTRONICS (2022)

Article Biophysics

Bi-ECDAQ: An electrochemical dual-immuno-biosensor accompanied by a customized bi-potentiostat for clinical detection of SARS-CoV-2 Nucleocapsid proteins

Razieh Salahandish et al.

Summary: This article introduces a multiplex electrochemical biosensor that utilizes a dual working electrode system and a customized potentiostat. It can accurately and selectively detect SARS-CoV-2 Nucleocapsid protein within 30 minutes, with low cost and high sensitivity.

BIOSENSORS & BIOELECTRONICS (2022)

Article Chemistry, Analytical

Experimental comparison of direct and indirect aptamer-based biochemical functionalization of electrolyte-gated graphene field-effect transistors for biosensing applications

Arash Khorrami Jahromi et al.

Summary: This study compared the effects of indirect and direct immobilization of BREs on EGFET, with direct immobilization being a simpler and more efficient method to maintain or even improve the carrier mobility of the graphene channel and sensitivity of the EGFET. The developed TNF- a EGFET aptasensor based on direct BREs immobilization showed outstanding sensing performance in detecting TNF-a in a non-invasively accessible biofluid, paving the way for development of graphene biosensors.

ANALYTICA CHIMICA ACTA (2022)

Article Biophysics

Electrochemical nano biosensors for the detection of extracellular vesicles exosomes: From the benchtop to everywhere?

Sima Singh et al.

Summary: Detection of extracellular vesicles is a challenge that requires a multidisciplinary approach to develop flexible, miniaturized point-of-care devices. Materials scientists and engineers have worked on this platform to create devices for exosome detection based on nanomaterials. Challenges and potential solutions for expanding clinical applications were discussed.

BIOSENSORS & BIOELECTRONICS (2022)

Article Chemistry, Multidisciplinary

A Versatile Biomimic Nanotemplating Fluidic Assay for Multiplex Quantitative Monitoring of Viral Respiratory Infections and Immune Responses in Saliva and Blood

Roozbeh Siavash Moakhar et al.

Summary: A cost-effective multiplexed fluidic device, NFluidEX, is proposed for parallel quantitative detection of viral infection and body's immune response. It achieves high sensitivity and specificity in detecting COVID-positive and COVID-negative samples.

ADVANCED SCIENCE (2022)

Article Biophysics

Ultrasensitive detection of SARS-CoV-2 spike protein in untreated saliva using SERS-based biosensor

Meiling Zhang et al.

Summary: A promising SERS-based COVID-19 biosensor was proposed for ultrasensitive detection of SARS-CoV-2 virus in untreated saliva. The biosensor exhibited excellent specificity and sensitivity for early diagnosis of COVID-19.

BIOSENSORS & BIOELECTRONICS (2021)

Article Multidisciplinary Sciences

Microfluidic on-chip production of microgels using combined geometries

Hamed Shieh et al.

Summary: This study explores the on-chip production of microgels using external gelation in microfluidic devices, proposing a novel design and utilizing a shielding oil phase to address challenges. The microfluidic device demonstrated the capability of generating highly monodispersed spherical droplets and alginate microgels effectively.

SCIENTIFIC REPORTS (2021)

Article Chemistry, Multidisciplinary

Gold Nano/Micro-Islands Overcome the Molecularly Imprinted Polymer Limitations to Achieve Ultrasensitive Protein Detection

Alireza Sanati et al.

Summary: The electrochemical biosensor based on the core-shell structure of gold NMIs and MIP shows high sensitivity, stability, lower detection time and limit in clinical applications compared to traditional methods like ELISA and lateral flow assay rapid test kits.

ACS SENSORS (2021)

Article Chemistry, Analytical

Electrochemical paper-based analytical device for multiplexed, point-of-care detection of cardiovascular disease biomarkers

Suchanat Boonkaew et al.

Summary: The study demonstrated an electrochemical paper-based analytical device (ePAD) combined with a label-free immunoassay for the simultaneous determination of three important cardiovascular disease biomarkers. The ePAD showed good linearity, low detection limits, and good reproducibility, enabling the simultaneous detection of the three biomarkers in serum samples. The proposed immunosensor can be a great alternative for the early detection of cardiovascular diseases at the point-of-care.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Review Chemistry, Analytical

Electrochemical sensors targeting salivary biomarkers: A comprehensive review

Veerappan Mani et al.

Summary: Salivary markers analysis has become a promising non-invasive approach for easy, safe, and pain-free monitoring, with the potential to impact clinical diagnosis and management. Advancements in sensing technology, novel materials, innovative fabrication technologies, and sampling accuracy have established saliva as a routine fluid for analysis, with applications in diagnosing various diseases.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

High-Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva

Zijie Zhang et al.

Summary: This study developed a simple and rapid saliva-based SARS-CoV-2 antigen test using a newly developed DNA aptamer, which showed high sensitivity and specificity in detecting the wildtype virus and its Alpha and Delta variants.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Chemistry, Analytical

How 3D printing can boost advances in analytical and bioanalytical chemistry

Adriano Ambrosi et al.

Summary: 3D printing fabrication methods have gained significant attention in the scientific community, particularly in analytical chemistry applications. While becoming more affordable, it is crucial to fully understand the benefits and limitations of 3D printing, as well as important aspects related to the properties of materials used for printing.

MICROCHIMICA ACTA (2021)

Article Chemistry, Multidisciplinary

Nanofluidics for Simultaneous Size and Charge Profiling of Extracellular Vesicles

Imman I. Hosseini et al.

Summary: Extracellular vesicles (EVs) are cell-derived membrane structures circulating in body fluids, showing potential for noninvasive diagnosis. To fully utilize the diagnostic potential of EVs, technologies that can analyze large populations of EVs without sacrificing single EV detail are needed.

NANO LETTERS (2021)

Review Materials Science, Multidisciplinary

Implantable bioelectronics toward long-term stability and sustainability

Yang Li et al.

Summary: Implantable bioelectronics have become important tools in medical technologies, offering symptom alleviation for chronic diseases and restoration of body functions. Combining electronics with biological systems has led to a spectrum of potent technologies, but challenges such as low biocompatibility and invasiveness in traditional silicon-based devices have prompted significant research progress in material and device innovations in recent years.

MATTER (2021)

Article Nanoscience & Nanotechnology

A Nanostructured Gold/Graphene Microfluidic Device for Direct and Plasmonic-Assisted Impedimetric Detection of Bacteria

Roozbeh Siavash Moakhar et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Multidisciplinary Sciences

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

Ana Rakita et al.

SCIENTIFIC REPORTS (2020)

Article Chemistry, Analytical

A sample-to-answer quantitative platform for point-of-care testing of biochemical markers in whole blood

Huan Xu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

Review Biophysics

Electrochemical biosensors for pathogen detection

Ellen Cesewski et al.

BIOSENSORS & BIOELECTRONICS (2020)

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

Review Chemistry, Multidisciplinary

Affinity-Based Detection of Biomolecules Using Photo-Electrochemical Readout

Amanda Victorious et al.

FRONTIERS IN CHEMISTRY (2019)

Review Electrochemistry

Review-Approaches for the Electrochemical Interrogation of DNA-Based Sensors: A Critical Review

Miguel Aller Pellitero et al.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2019)

Article Electrochemistry

ABE-Stat, a Fully Open-Source and Versatile Wireless Potentiostat Project Including Electrochemical Impedance Spectroscopy

Daniel M. Jenkins et al.

JOURNAL OF THE ELECTROCHEMICAL SOCIETY (2019)

Article Chemistry, Analytical

Open-Source Potentiostat for Wireless Electrochemical Detection with Smartphones

Alar Ainla et al.

ANALYTICAL CHEMISTRY (2018)

Article Chemistry, Physical

Mechanistic Control of the Growth of Three-Dimensional Gold Sensors

Sara Mahshid et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2016)

Review Chemistry, Multidisciplinary

Electrochemical biosensors

Niina J. Ronkainen et al.

CHEMICAL SOCIETY REVIEWS (2010)