A new dual functional H2S donor for fluorescence imaging and anti-inflammatory application

This study explored FL-H2S, a novel fluorescein-based H2S donor, as an anti-inflammatory agent. The results demonstrated the efficient release of H2S by FL-H2S, along with its biocompatibility, real-time intracellular H2S release and imaging capability. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H2S, evidenced by reduced foot swelling. We also successfully elucidated the anti-inflammatory mechanism through ELISA and WB analysis.

Automated summary

This study explored a novel fluorescein-based H2S donor, FL-H2S, as an anti-inflammatory agent. The results showed that FL-H2S efficiently released H2S, had good biocompatibility, and enabled real-time intracellular H2S release and imaging. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H2S, and the anti-inflammatory mechanism was elucidated through ELISA and WB analysis.