4.6 Article

Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence

Related references

Note: Only part of the references are listed.
Review Immunology

Contribution to pathogenesis of accessory proteins of deadly human coronaviruses

Jesus Hurtado-Tamayo et al.

Summary: Coronaviruses have a large genome and include essential genes as well as variable accessory genes. The functions of accessory proteins in virus-host interactions and pathogenesis are important. Analysis of accessory proteins in the scientific literature generally involves deleting or mutating the genes, but the complexities of protein interactions during virus infection are often overlooked. A critical review of the literature helps to explain discrepancies in experimental results obtained through different approaches.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2023)

Review Multidisciplinary Sciences

Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis

Fusheng Si et al.

Summary: In this review, the current knowledge of the ORF3 protein in PEDV is summarized, with focus on its unique biological features and potential role in viral behavior and pathogenesis. Gaps in understanding are identified, and intriguing questions are proposed to stimulate further studies and collaboration among virologists worldwide.

ISCIENCE (2023)

Article Immunology

Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids

Lingdan Yin et al.

Summary: Swine enteric coronaviruses (SECoVs), including PEDV, TGEV, and PDCoV, are the main pathogens causing lethal watery diarrhea in neonatal pigs. Different types of SECoVs induce different transcriptional profiles and immune responses in host epithelial cells, which helps us gain a better understanding of host-SECoVs interactions.

FRONTIERS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

Courtney E. Comar et al.

Summary: MERS-CoV optimizes its replication by suppressing early innate immune pathways, including interferon production and signaling, through the actions of endoribonuclease (EndoU) and accessory proteins NS4a and NS4b.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Review Biochemistry & Molecular Biology

Recent insights into the structure and function of coronavirus ribonucleases

Meredith N. Frazier et al.

Summary: This review discusses the nucleases involved in the replication and transcription of coronaviruses and their implications for drug discovery.

FEBS OPEN BIO (2022)

Article Virology

Coronavirus Endoribonuclease Ensures Efficient Viral Replication and Prevents Protein Kinase R Activation

Jing Zhao et al.

Summary: The study confirmed the endoribonuclease activity of the infectious bronchitis virus and identified the active sites and its role in viral replication. By mutating the viral endoribonuclease, attenuated viruses were generated, providing a new approach for live attenuated vaccine candidates for emerging coronaviruses.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

Monica C. Pillon et al.

Summary: Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. The cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, together with biochemical experiments, mass spectrometry, and molecular dynamics simulations, provide insights into the catalytic mechanism of Nsp15 and its conformational dynamics.

NATURE COMMUNICATIONS (2021)

Article Immunology

The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract

Yuejun Shi et al.

Summary: The study found that in a mouse model infected with SARS-CoV-2, GS441524 effectively blocked the replication of the virus through intranasal and intramuscular treatment, whereas the efficacy of GC376 was weaker. A low-dose combination of GS441524 and GC376 could effectively protect mice from infection and showed a synergistic effect when used together.

EMERGING MICROBES & INFECTIONS (2021)

Article Biochemistry & Molecular Biology

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

Jason K. Perry et al.

Summary: The SARS-CoV-2 replication-transcription complex is a hexameric assembly of nonstructural viral proteins centered on nsp15, which recruit various other proteins to perform different functions such as RNA unwinding and mRNA capping. The model provides insights into the intricate processes involved in viral genome replication and mRNA transcription.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Virology

Establishment of Full-Length cDNA Clones and an Efficient Oral Infection Model for Feline Coronavirus in Cats

Gang Wang et al.

Summary: This study successfully constructed an effective infection model of feline infectious peritonitis and achieved reverse genetics of different virulent and attenuated feline coronaviruses. High titers of neutralizing antibodies were found to potentially prolong the survival time of cats.

JOURNAL OF VIROLOGY (2021)

Review Microbiology

Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses

Souvik Ghosh et al.

MICROORGANISMS (2020)

Review Microbiology

Origin and evolution of pathogenic coronaviruses

Jie Cui et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Article Multidisciplinary Sciences

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Xufang Deng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biotechnology & Applied Microbiology

ORF7-encoded accessory protein 7a of feline infectious peritonitis virus as a counteragent against IFN-α-induced antiviral response

Annelike Dedeurwaerder et al.

JOURNAL OF GENERAL VIROLOGY (2014)

Article Virology

MERS: emergence of a novel human coronavirus

V. Stalin Raj et al.

CURRENT OPINION IN VIROLOGY (2014)

Article Virology

Alphacoronavirus Protein 7 Modulates Host Innate Immune Response

Jazmina L. G. Cruz et al.

JOURNAL OF VIROLOGY (2013)

Review Microbiology

Coronaviruses post-SARS: update on replication and pathogenesis

Stanley Perlman et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Multidisciplinary Sciences

Crystal structure and mechanistic determinants of SARS coronavirus nonstructural protein 15 define an endoribonuclease family

Stefano Ricagno et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Immunology

Feline coronavirus serotypes 1 and 2: Seroprevalence and association with disease in Switzerland

M Kummrow et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2005)

Article Multidisciplinary Sciences

Major genetic marker of nidoviruses encodes a replicative endoribonuclease

KA Ivanov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)