☆ 4.3 Review

Astrocytic transcriptional and epigenetic mechanisms of drug addiction

JOURNAL OF NEURAL TRANSMISSION (2023)

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Summary: This study reveals the impact of cocaine on gene regulation and biological processes within the VTA, showing that cocaine alters distinct sets of genes in different exposure paradigms, but all paradigms are affected by processes important for energy regulation and synaptic plasticity. The research also found that cocaine changes gene networks in the VTA, indicating that transcriptional changes depend on the route, dose, and context of cocaine exposure.

NEUROPSYCHOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes

Mayur Doke et al.

Summary: Illicit drugs impact the central nervous system through histone modifications and chromatin remodeling, affecting neuronal function like memory and synaptic plasticity. The effects of these drugs on astrocytes and acetylation-regulating enzymes are still being studied.

PLOS ONE (2021)

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Article Neurosciences

Heterogeneity and Development of Fine Astrocyte Morphology Captured by Diffraction-Limited Microscopy

Daniel Minge et al.

Summary: The study introduces an indirect method for measuring the morphology of astrocytes by using volume fraction and segment density as parameters. These parameters are effective for describing the structure of astrocytes and can be used for online monitoring of astrocyte morphology with widely available microscopy techniques.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

Michael Lattke et al.

Summary: The study revealed extensive transcriptional and chromatin changes during astrocyte maturation in mice, and identified transcription factors that regulate the maturation of cultured astrocytes. Extrinsic signals can orchestrate the expression of multiple intrinsic regulators to induce transcriptional and chromatin changes underlying astrocyte maturation in a modular manner, improving cell maturity.

NATURE COMMUNICATIONS (2021)

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Article Clinical Neurology

Δ9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner

Javier Orihuel et al.

Summary: Adolescent exposure to THC affects specific aspects of reward-guided behavior and shows remarkable sex-specificity. This exposure leads to increased goal-tracking in both male and female rats, enhanced Pavlovian to instrumental transfer especially in males, but does not affect habit formation.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Francesco Petrelli et al.

MOLECULAR PSYCHIATRY (2020)

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Article Biochemistry & Molecular Biology

Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior

Mark D. Namba et al.

ADDICTION BIOLOGY (2020)

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Review Neurosciences

Epigenetic Mechanisms of Opioid Addiction

Caleb J. Browne et al.

BIOLOGICAL PSYCHIATRY (2020)

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Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release

Urszula Skupio et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Neurosciences

DNA methylation: A mechanism for sustained alteration of KIR4.1 expression following central nervous system insult

Jessica L. Boni et al.

GLIA (2020)

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Article Biochemistry & Molecular Biology

Single cell transcriptome profiling of the human alcohol-dependent brain

Eric Brenner et al.

HUMAN MOLECULAR GENETICS (2020)

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Review Neurosciences

Improved tools to study astrocytes

Xinzhu Yu et al.

NATURE REVIEWS NEUROSCIENCE (2020)

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Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Michelle Corkrum et al.

NEURON (2020)

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Identification of region-specific astrocyte subtypes at single cell resolution

Mykhailo Y. Batiuk et al.

NATURE COMMUNICATIONS (2020)

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Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities

Anna Yu-Szu Huang et al.

NEURON (2020)

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A dopamine-induced gene expression signature regulates neuronal function and cocaine response

Katherine E. Savell et al.

SCIENCE ADVANCES (2020)

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Glucose metabolism links astroglial mitochondria to cannabinoid effects

Daniel Jimenez-Blasco et al.

NATURE (2020)

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Making sense of astrocytic calcium signals - from acquisition to interpretation

Alexey Semyanov et al.

NATURE REVIEWS NEUROSCIENCE (2020)

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Article Cell Biology

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning

Noemie Mazare et al.

CELL REPORTS (2020)

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Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes

Kalaiselvi Sivalingam et al.

BRAIN SCIENCES (2020)

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Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

Wendy Xin et al.

NEUROPSYCHOPHARMACOLOGY (2019)

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Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood

Yan Jouroukhin et al.

BIOLOGICAL PSYCHIATRY (2019)

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Article Biochemistry & Molecular Biology

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

Jun Nagai et al.

CELL (2019)

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Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster

Chad A. Highfill et al.

PLOS GENETICS (2019)

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Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking

Anna Kruyer et al.

BIOLOGICAL PSYCHIATRY (2019)

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Glial gene networks associated with alcohol dependence

Emma K. Erickson et al.

SCIENTIFIC REPORTS (2019)

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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

Min-Ho Nam et al.

CELL REPORTS (2019)

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Article Cell Biology

Opioid-Mediated Astrocyte-Neuron Signaling in the Nucleus Accumbens

Michelle Corkrum et al.

CELLS (2019)

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Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

Yizhi Wang et al.

NATURE NEUROSCIENCE (2019)

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Alcohol metabolism contributes to brain histone acetylation

P. Mews et al.

NATURE (2019)

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Epigenetics and addiction

Peter J. Hamilton et al.

CURRENT OPINION IN NEUROBIOLOGY (2019)

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Transcriptional mechanisms of drug addiction

Purva Bali et al.

DIALOGUES IN CLINICAL NEUROSCIENCE (2019)

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Review Biochemistry & Molecular Biology

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

Matthew Neal et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain's Reward Circuitry

Deena M. Walker et al.

BIOLOGICAL PSYCHIATRY (2018)

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Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

Laurie M. Robin et al.

NEURON (2018)

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Regulation of glutamate transporter 1 (GLT-1) gene expression by cocaine self-administration and withdrawal

Ronald Kim et al.

NEUROPHARMACOLOGY (2018)

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Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain

Clare J. Wilhelm et al.

NEUROPHARMACOLOGY (2018)

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Neonatal Ethanol and Choline Treatments Alter the Morphology of Developing Rat Hippocampal Pyramidal Neurons in Opposite Directions

C. M. Goeke et al.

NEUROSCIENCE (2018)

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Astrocyte-specific transcriptome responses to chronic ethanol consumption

Emma K. Erickson et al.

PHARMACOGENOMICS JOURNAL (2018)

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PHYSIOLOGY OF ASTROGLIA

Alexei Verkhratsky et al.

PHYSIOLOGICAL REVIEWS (2018)

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Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

Sonia Guerra-Gomes et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Medicine, Research & Experimental

Expression of mu-Opioid Receptor in CA1 Hippocampal Astrocytes

Min-Ho Nam et al.

EXPERIMENTAL NEUROBIOLOGY (2018)

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Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

Yihui Cui et al.

NATURE (2018)

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Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction

Anze Testen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Neurosciences

Activation of Astrocytic mu-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes

Dong Ho Woo et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Cell Biology

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia

Denis Avey et al.

CELL REPORTS (2018)

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Article Cell & Tissue Engineering

Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

Neha Tiwari et al.

CELL STEM CELL (2018)

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Article Biochemistry & Molecular Biology

Whole genome sequence study of cannabis dependence in two independent cohorts

Ian R. Gizer et al.

ADDICTION BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Morphine-induced inhibition of Ca2+-dependent D-serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens

Jian Wu et al.

ADDICTION BIOLOGY (2017)

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Synapse-specific astrocyte gating of amygdala-related behavior

Mario Martin-Fernandez et al.

NATURE NEUROSCIENCE (2017)

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Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

Hua Chai et al.

NEURON (2017)

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Cell Biology of Astrocyte-Synapse Interactions

Nicola J. Allen et al.

NEURON (2017)

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Astrocytic control of synaptic function

Thomas Papouin et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)

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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Philip Hasel et al.

NATURE COMMUNICATIONS (2017)

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Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-γ Impairs Glucose Metabolism and Estrous Cycling in Female Mice

Marina O. Fernandez et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2017)

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Article Substance Abuse

Mechanistic insights into epigenetic modulation of ethanol consumption

Igor Ponomarev et al.

ALCOHOL (2017)

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Emerging Role of Epigenetic Mechanisms in Alcohol Addiction

Tiffani D. M. Berkel et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2017)

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Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a

Yu-Yi Chu et al.

MOLECULAR NEUROBIOLOGY (2016)

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Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder

Amy W. Lasek

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2016)

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Cocaine Self-Administration and Extinction Leads to Reduced Glial Fibrillary Acidic Protein Expression and Morphometric Features of Astrocytes in the Nucleus Accumbens Core

Michael D. Scofield et al.

BIOLOGICAL PSYCHIATRY (2016)

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Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats

Erica Zamberletti et al.

PHARMACOLOGICAL RESEARCH (2016)

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Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

W. Todd Farmer et al.

SCIENCE (2016)

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Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

Michael D. Scofield et al.

BIOLOGICAL PSYCHIATRY (2015)

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Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease

Kou Takahashi et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Astrocyte development: A Guide for the Perplexed

Anna Victoria Molofsky et al.

GLIA (2015)

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GLAST But Not Least-Distribution, Function, Genetics and Epigenetics of L-Glutamate Transport in Brain-Focus on GLAST/EAAT1

Omar Sery et al.

NEUROCHEMICAL RESEARCH (2015)

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Astrocytes Control Synapse Formation, Function, and Elimination

Won-Suk Chung et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

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Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking

Ana Weiland et al.

FRONTIERS IN PHARMACOLOGY (2015)

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Astrocytic abnormalities and global DNA methylation patterns in depression and suicide

C. Nagy et al.

MOLECULAR PSYCHIATRY (2015)

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N-Acetyl Cysteine Mitigates the Acute Effects of Cocaine-Induced Toxicity in Astroglia-Like Cells

Ramesh B. Badisa et al.

PLOS ONE (2015)

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Chronic Ethanol Exposure Produces Time-and Brain Region-Dependent Changes in Gene Coexpression Networks

Elizabeth A. Osterndorff-Kahanek et al.

PLOS ONE (2015)

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Article Biochemistry & Molecular Biology

Acute and Chronic Mu Opioids Differentially Regulate Thrombospondins 1 and 2 Isoforms in Astrocytes

Ellen Phamduong et al.

ACS CHEMICAL NEUROSCIENCE (2014)

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Exploring the Role of Central Astrocytic Glutamate Uptake in Ethanol Reward inMice

Karen L. Smith et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014)

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Review Biochemistry & Molecular Biology

A star is born: new insights into the mechanism of astrogenesis

Regina Kanski et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

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Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders

Steven A. Sloan et al.

CURRENT OPINION IN NEUROBIOLOGY (2014)

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DNA Methylation Functions as a Critical Regulator of Kir4.1 Expression During CNS Development

Sinifunanya E. Nwaobi et al.

GLIA (2014)

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Article Biochemistry & Molecular Biology

Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes

Xiaolu Zhang et al.

JOURNAL OF NEUROCHEMISTRY (2014)

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Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

Hao-wei Shen et al.

JOURNAL OF NEUROSCIENCE (2014)

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Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

Cecilia Bull et al.

NEUROPSYCHOPHARMACOLOGY (2014)

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Astrocytic Dysfunction and Addiction: Consequences of Impaired Glutamate Homeostasis

Michael D. Scofield et al.

NEUROSCIENTIST (2014)

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Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease

Emma V. Jones et al.

NEURAL PLASTICITY (2014)

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Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling

Rongqing Chen et al.

CELL (2013)

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CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression

Tony Valente et al.

NEUROBIOLOGY OF AGING (2013)

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Recovering from cocaine: Insights from clinical and preclinical investigations

Colleen A. Hanlon et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

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Cocaine-related behaviors in mice with deficient gliotransmission

Jill R. Turner et al.

PSYCHOPHARMACOLOGY (2013)

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Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway

Leonardo Pignataro et al.

BRAIN AND BEHAVIOR (2013)

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Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels

Nicole Zimmermann et al.

BIOCHEMICAL JOURNAL (2012)

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Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

Jing Han et al.

CELL (2012)

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Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training

Heather Trantham-Davidson et al.

JOURNAL OF NEUROSCIENCE (2012)

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Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST

Rose-Marie Karlsson et al.

NEUROPHARMACOLOGY (2012)

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Ceftriaxone, a Beta-Lactam Antibiotic, Reduces Ethanol Consumption in Alcohol-Preferring Rats

Youssef Sari et al.

ALCOHOL AND ALCOHOLISM (2011)

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Interferon Regulatory Factor 3 Inhibits Astrocyte Inflammatory Gene Expression Through Suppression of the Proinflammatory miR-155 and miR-155

Leonid Tarassishin et al.

GLIA (2011)

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Local Ca2+ detection and modulation of synaptic release by astrocytes

Maria Amalia Di Castro et al.

NATURE NEUROSCIENCE (2011)

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Cocaine-induced metaplasticity in the nucleus accumbens: Silent synapse and beyond

Brian R. Lee et al.

NEUROPHARMACOLOGY (2011)

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Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking

Lori A. Knackstedt et al.

BIOLOGICAL PSYCHIATRY (2010)

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Epigenetic Regulation of Neuron-Dependent Induction of Astroglial Synaptic Protein GLT1

Yongjie Yang et al.

GLIA (2010)

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Article Biochemistry & Molecular Biology

Morphine Modulation of Thrombospondin Levels in Astrocytes and Its Implications for Neurite Outgrowth and Synapse Formation

Hiroko Ikeda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Biochemistry & Molecular Biology

Functional Distribution of Nicotinic Receptors in CA3 Region of the Hippocampus

Michael Grybko et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2010)

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Developmental genetics of vertebrate glial-cell specification

David H. Rowitch et al.

NATURE (2010)

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Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

Marta Navarrete et al.

NEURON (2010)

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THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA

R. Kryger et al.

NEUROSCIENCE (2010)

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Uniquely Hominid Features of Adult Human Astrocytes

Nancy Ann Oberheim et al.

JOURNAL OF NEUROSCIENCE (2009)

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Effects of nicotine on K+ currents and nicotinic receptors in astrocytes of the hippocampal CA1 region

Miriam Hernandez-Morales et al.

NEUROPHARMACOLOGY (2009)

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The role of astrocyte-secreted matricellular proteins in central nervous system development and function

Cagla Eroglu

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Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex

Traute Flatscher-Bader et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)

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Article Biochemistry & Molecular Biology

Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

Seok-Geun Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation

Michelle L. Olsen et al.

JOURNAL OF NEUROCHEMISTRY (2008)

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Endocannabinoids mediate neuron-astrocyte communication

Marta Navarrete et al.

NEURON (2008)

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DNA methylation dependent silencing of the human glutamate transporter EAAT2 gene in glial cells

Juergen Zschocke et al.

GLIA (2007)

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Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals

Jianwen Liu et al.

NEUROPSYCHOPHARMACOLOGY (2006)

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Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats

M Fujio et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

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An increase in intracellular free calcium ions by nicotinic acetylcholine receptors in a single cultured rat cortical astrocyte

H Oikawa et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

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Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

KS Christopherson et al.

CELL (2005)

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Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development

EA Bushong et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2004)

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Neuronal and astrocyte expression of nicotinic receptor subunit β4 in the adult mouse brain

LC Gahring et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2004)

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Article Substance Abuse

Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures

M Zink et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2004)

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Article Multidisciplinary Sciences

Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)

ZZ Su et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users

KY Little et al.

AMERICAN JOURNAL OF PSYCHIATRY (2003)

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Reduced glial fibrillary acidic protein and glutamine synthetase expression in astrocytes and Bergmann glial cells in the rat cerebellum caused by Δ9-tetrahydrocannabinol administration during development

I Suárez et al.

DEVELOPMENTAL NEUROSCIENCE (2002)

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Astrocyte-derived factors modulate the inhibitory effect of ethanol on dendritic development

PA Yanni et al.

GLIA (2002)

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Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains

EA Bushong et al.

JOURNAL OF NEUROSCIENCE (2002)

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Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal

T Ozawa et al.

BRAIN RESEARCH (2001)

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Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores

G Sharma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Medicine, Research & Experimental

Effect of morphine on the number and branching of astrocytes in various regions of rat brain

IL Lazriev et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2001)

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