Inflammation, mitochondrial dysfunction and physical performance: a possible association in older patients with persistent atrial fibrillation-the results of a preliminary study

Review Cardiac & Cardiovascular Systems

The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy

Santosh K. Sanganalmath et al.

Summary: Diabetes mellitus is a major risk factor for cardiovascular complications, and it is associated with high morbidity and mortality. Diabetic cardiomyopathy is characterized by reduced cardiac contractility, myocardial fibrosis, diastolic dysfunction, and chronic heart failure. Inflammation, changes in calcium handling, and cardiomyocyte loss play significant roles in the development and progression of this disease.

CARDIOVASCULAR DIABETOLOGY (2023)

Add to Collection

Letter Medicine, General & Internal

Arginine in older patients with persistent atrial fibrillation: A link to endothelial dysfunction?

Stefano Fumagalli et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2023)

Add to Collection

Article Geriatrics & Gerontology

Is there an association between inflammatory markers and lower physical performance in older adults?

Betty Manrique-Espinoza et al.

Summary: This study analyzed the association between tumor necrosis factor-alpha (TNF-alpha), Interleukin-10 (IL-10), C-reactive protein (CRP) and physical performance in a sample of older adults in rural Mexico. The results showed a significant association between higher CRP levels and low physical performance, while IL-10 and TNF-alpha did not show a significant association.

BMC GERIATRICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials

Maija Dambrova et al.

Summary: Acylcarnitines are fatty acid metabolites that play important roles in cellular energy metabolism and have potential as biomarkers and pharmaceutical agents for various diseases. This comprehensive review provides detailed information on the identity, nomenclature, classification, biochemistry, pathophysiology, and clinical trials of acylcarnitines. It also discusses their use as dietary supplements and the emerging opportunities for using them as biomarkers and interventions in different indications. The review lays a solid foundation for further understanding the physiological roles of acylcarnitines and the identification of new drug targets.

PHARMACOLOGICAL REVIEWS (2022)

Add to Collection

Article Rheumatology

Serum urate is related to subclinical inflammation in asymptomatic hyperuricaemia

Desiree Luis-Rodriguez et al.

Summary: This study found that serum uric acid levels are associated with inflammation in asymptomatic hyperuricaemia (AHU) patients, and UA levels may be an inducer of subclinical inflammation. Therapeutic reduction of UA levels was associated with modulation of inflammatory characteristics.

RHEUMATOLOGY (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems