Graphene-based biosensors for detecting coronavirus: a brief review

The coronavirus (SARS-CoV-2) disease has affected the globe with 770 437 327 confirmed cases, including about 6 956 900 deaths, according to the World Health Organization (WHO) as of September 2023. Hence, it is imperative to develop diagnostic technologies, such as a rapid cost-effective SARS-CoV-2 detection method. A typical biosensor enables biomolecule detection with an appropriate transducer by generating a measurable signal from the sample. Graphene can be employed as a component for ultrasensitive and selective biosensors based on its physical, optical, and electrochemical properties. Herein, we briefly review graphene-based electrochemical, field-effect transistor (FET), and surface plasmon biosensors for detecting the SARS-CoV-2 target. In addition, details on the surface modification, immobilization, sensitivity and limit of detection (LOD) of all three sensors with regard to SARS-CoV-2 were reported. Finally, the point-of-care (POC) detection of SARS-CoV-2 using a portable smartphone and a wearable watch is a current topic of interest. The coronavirus (SARS-CoV-2) disease has affected the globe with 770 437 327 confirmed cases, including about 6 956 900 deaths, according to the World Health Organization (WHO) as of September 2023.

Automated summary

The outbreak of the novel coronavirus has caused millions of confirmed and death cases worldwide. Therefore, it is crucial to develop a rapid and cost-effective detection method for the virus. Graphene, with its unique physical, optical, and electrochemical properties, can be utilized in biosensors to achieve high sensitivity and selectivity. This review article focuses on graphene-based electrochemical, field-effect transistor, and surface plasmon biosensors for detecting the novel coronavirus, providing insights into the surface modification, immobilization, sensitivity, and limit of detection of these sensors.