4.3 Article

Kalkitoxin attenuates calcification of vascular smooth muscle cells via RUNX-2 signaling pathways

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Kalkitoxin: A Potent Suppressor of Distant Breast Cancer Metastasis

Saroj Kumar Shrestha et al.

Summary: In this study, it was found that kalkitoxin, a toxin derived from marine cyanobacterium, inhibits cancer cell migration and invasion. It also suppresses the secondary growth of breast cancer cells in the bone, brain, and lungs by inhibiting the expression of CXCL5 and CXCR2.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Cell Biology

Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation

Abu Shufian Ishtiaq Ahmed et al.

Summary: Impaired coupled bone formation is a major cause of osteoporosis. This study suggests that the release of bone calcium during osteoclastic bone resorption is essential for coupled bone formation. Calcium signaling plays a significant role in regulating bone cell anabolic activities and is a major regulator of coupled bone formation.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

Article Medicine, Research & Experimental

A multi-omics view of the complex mechanism of vascular calcification

Yongjiang Qian et al.

Summary: Vascular calcification is a high incidence and high mortality disease, strongly associated with poor outcomes in diabetes and chronic kidney disease. Despite numerous studies, the specific mechanism of the disease remains unclear. Omics has advantages over single pathway analysis in revealing the mechanisms of vascular calcification.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Kalkitoxin Reduces Osteoclast Formation and Resorption and Protects against Inflammatory Bone Loss

Liang Li et al.

Summary: Kalkitoxin (KT) significantly inhibited osteoclast formation and inflammatory bone loss through NFATc1 and mitogen-activated protein kinase (MAPK) signaling pathways, suggesting its potential as a treatment for destructive bone diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Aloe-emodin inhibits osteogenic differentiation and calcification of mouse vascular smooth muscle cells

Mahesh Sapkota et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Hematology

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

Matthias Derwall et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo

Rong-Rong Cui et al.

CARDIOVASCULAR RESEARCH (2012)

Review Cardiac & Cardiovascular Systems

The Regulation of Valvular and Vascular Sclerosis by Osteogenic Morphogens

Kristina I. Bostroem et al.

CIRCULATION RESEARCH (2011)

Article Multidisciplinary Sciences

Apelin Attenuates the Osteoblastic Differentiation of Vascular Smooth Muscle Cells

Peng-Fei Shan et al.

PLOS ONE (2011)

Review Cell Biology

Genetic Control of Bone Formation

Gerard Karsenty et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling

Chang Hyun Byon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Urology & Nephrology

The vascular biology of calcification

Rukshana C. Shroff et al.

SEMINARS IN DIALYSIS (2007)

Review Cardiac & Cardiovascular Systems

Vascular calcification - Pathobiological mechanisms and clinical implications

Rebecca C. Johnson et al.

CIRCULATION RESEARCH (2006)

Review Hematology

Molecular mechanisms of vascular calcification - Lessons learned from the aorta

Jian-Su Shao et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Review Cardiac & Cardiovascular Systems

Bone morphogenetic proteins in vascular calcification

KA Hruska et al.

CIRCULATION RESEARCH (2005)

Review Endocrinology & Metabolism

Molecular, endocrine, and genetic mechanisms of arterial calcification

TM Doherty et al.

ENDOCRINE REVIEWS (2004)

Review Hematology

Vascular calcification - Mechanisms and clinical ramifications

M Abedin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

Review Endocrinology & Metabolism

Osteogenic regulation of vascular calcification: an early perspective

R Vattikuti et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Article Transplantation

Arterial media calcification in end-stage renal disease:: impact on all-cause and cardiovascular mortality

GM London et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2003)

Article Urology & Nephrology

Vascular calcification: In vitro evidence for the role of inorganic phosphate

CM Giachelli

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)

Review Chemistry, Medicinal

Arterial calcification: A review of mechanisms, animal models, and the prospects for therapy

R Wallin et al.

MEDICINAL RESEARCH REVIEWS (2001)