Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model

Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain. sEVs from mononuclear cells (MNCs) showed superior effects in vitro to sEVs from mesenchymal stem cells (MSCs) and were able to promote neuroprotection and decrease microglia reactivity in a stroke mouse model. Herein, we investigate the bioactivity of small extracellular vesicles (sEVs), focusing on their local effect in the brain.

Automated summary

In this study, we investigated the local effect and bioactivity of small extracellular vesicles (sEVs) in the brain. sEVs derived from mononuclear cells (MNCs) showed superior effects in promoting neuroprotection and reducing microglia reactivity in a stroke mouse model compared to sEVs from mesenchymal stem cells (MSCs).