Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 262, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2023.115875
Keywords
Multiple myeloma; Drug resistance; Potential drugs; Structure-activity relationships
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This review article summarizes the characteristics, clinical investigations, and future development directions of multiple myeloma drugs, including their structures, mechanisms of action, clinical study progress, and the potential applications of drugs that have not yet entered clinical trials.
Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting antibodies have significantly improved the outcome of MM patient with increased survival, the incidence of drug resistance and severe treatment-related complications is gradually on the rise. This review article summarizes the characteristics and clinical investigations of several MM drugs in clinical trials, including their structures, mechanisms of action, structure activity relationships, and clinical study progress. Furthermore, the application potentials of the drugs that have not yet entered clinical trials are also reviewed. The review also outlines the future directions of MM drug development.
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