☆ 4.8 Article

High-Precision Single-Cell microRNA Therapy by a Functional Nanopipette with Sensitive Photoelectrochemical Feedback

SMALL (2023)

Related references

Note: Only part of the references are listed.
Article Chemistry, Analytical

Biological Transformation of AgI on MOF-on-MOF-Derived Heterostructures: Toward Polarity-Switchable Photoelectrochemical Biosensors for Neuron-Specific Enolase

Feng-Zao Chen et al.

Summary: This study presents a biosensor based on MOF-on-MOF-derived semiconductor heterojunctions, which relies on the bioinduced AgI transition on ZnO@In2O3@AgI. The photocurrent switches from cathodic to anodic due to the generation of ZnO@In2O3@In2S3@Ag2S heterojunctions by bioproduced H2S. The biosensor shows good selectivity and sensitivity for detecting NSE with a low detection limit of 0.58 pg/mL.

ANALYTICAL CHEMISTRY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Checkpoint Nano-PROTACs for Activatable Cancer Photo-Immunotherapy

Chi Zhang et al.

Summary: This study reports the use of checkpoint nano-PROTACs combined with photodynamic tumor regression and immunosuppressive protein degradation to block checkpoint signaling pathways for activatable cancer photo-immunotherapy. The nano-PROTACs consist of a photosensitizer and an SHP2-targeting PROTAC peptide connected by a caspase 3-cleavable segment. By degrading SHP2, these nano-PROTACs can block immunosuppressive checkpoint signaling pathways and enhance antitumor immune response. This study represents a generalized PROTAC platform to modulate immune-related signaling pathways for improved anticancer therapy.

ADVANCED MATERIALS (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Intelligent Gold Nanoparticles with Oncogenic MicroRNA-Dependent Activities to Manipulate Tumorigenic Environments for Synergistic Tumor Therapy

Xiangdong Wang et al.

Summary: This study utilizes spherical nucleic acids (SNAs) to effectively utilize and manipulate oncogenic microRNAs for tumor therapy. SNAs capture overexpressed miR-21/miR-155 and exert their effects through gene therapy and chemotherapy, while also achieving photothermal therapy and enhancing tumor treatment outcomes.

ADVANCED MATERIALS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

An Activatable Hybrid Organic-Inorganic Nanocomposite as Early Evaluation System of Therapy Effect

Qinrui Fu et al.

Summary: The study developed a caspase-3 activated nanoprobe for early evaluation of radiotherapy efficacy. The nanoprobe connected nanogapped gold nanoparticles and near-infrared fluorescent molecules through a specific peptide sequence, showing a positive correlation between activated caspase-3 and imaging signals variation and tumor inhibition rate.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Engineering, Environmental

Delivery of therapeutic miRNAs using nanoscale zeolitic imidazolate framework for accelerating vascularized bone regeneration

Hao Feng et al.

Summary: This study utilized ZIF-8 as a delivery vector for miRNA, achieving efficient cellular uptake and intracellular release, with therapeutic effects demonstrated in angiogenesis and osteogenesis. The research provides new evidence for the potential of miR@ZIF-8 nanocomposites as efficient carriers for therapeutic nucleic acid drugs delivery.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Homeostasis inside Single Activated Phagolysosomes: Quantitative and Selective Measurements of Submillisecond Dynamics of Reactive Oxygen and Nitrogen Species Production with a Nanoelectrochemical Sensor

Yu-Ting Qi et al.

Summary: Reactive oxygen and nitrogen species (ROS/RNS) generated by macrophages play critical roles in phagocytosis and immune homeostasis. Researchers have developed a novel nanowire electrode to quantitatively and individually monitor the four primary ROS/RNS. The study provides insights into the rapid generation and concentration variations of ROS/RNS during phagocytosis and reveals the important mechanism of enzyme regulation for immune responses and immunotherapies.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Deep Learning-Assisted Automated Single Cell Electroporation Platform for Effective Genetic Manipulation of Hard-to-Transfect Cells

Prithvijit Mukherjee et al.

Summary: Genome engineering using CRISPR/Cas systems has provided new approaches for pharmacological screening and studying the molecular mechanisms of diseases. However, current methods for intracellular delivery and cell manipulation can be harsh, especially for sensitive cell types. In this study, an automated nanofountain probe electroporation (NFP-E) system is introduced, which offers superior cell viability and efficiency compared to traditional methods. The automated NFP-E, combined with microconfinement arrays for cell isolation, can potentially be used for CRISPR/Cas9 gene editing and cell tracking in screening studies and isogenic cell line generation.

SMALL (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Real-Time Fast Amyloid Seeding and Translocation of α-Synuclein with a Nanopipette

Nathan Meyer et al.

Summary: In this study, a proof of concept real-time fast amyloid seeding and translocation (RT-FAST) method based on a nanopipette was presented. It combines a reaction vessel and a nanopore sensor in one system to detect α-synuclein assemblies. The method allows rapid and accurate detection of α-synuclein seeds in a sample within 90 minutes, and it has the potential for quantitative analysis of seed concentration.

ACS CENTRAL SCIENCE (2022)

Add to Collection
Article Chemistry, Multidisciplinary

A Tetrahedral Framework DNA-Based Bioswitchable miRNA Inhibitor Delivery System: Application to Skin Anti-Aging

Songhang Li et al.

Summary: MicroRNA-based therapy shows great potential, but its biomedical functionality is limited by structural challenges. A novel bioswitchable miR inhibitor delivery system (BiRDS) is designed using a tetrahedral framework DNA (tFNA) as a vehicle to maximize miR inhibitor loading capacity and improve delivery efficacy.

ADVANCED MATERIALS (2022)

Add to Collection
Article Engineering, Environmental

A visible light-driven photoelectrochemical sensor for mercury (II) with turn-on signal output through in-situ formation of double type-II heterostructure using CdS nanowires and ZnS quantum dots

Luping Feng et al.

Summary: An ultrasensitive and selective photoelectrochemical platform has been developed for determining Hg2+ using CdS nanowires and ZnS quantum dots synergistically. The platform shows great potential for wide applications in detecting heavy metals like Hg2+ with turn-on signal output.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Probing RNA Conformations Using a Polymer-Electrolyte Solid-State Nanopore

Chalmers Chau et al.

Summary: This study presents a polymer-electrolyte solid-state nanopore system for analyzing biomolecular conformation under physiological conditions. By using specific salts, the system's performance is enhanced, allowing for the analysis of Chikungunya virus RNA conformation.

ACS NANO (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Translocation of Specific DNA Nanocarrier through an Ultrasmall Nanopipette: Toward Single-Protein-Molecule Detection with Superior Signal-to-Noise Ratio

Xian Zhang et al.

Summary: The use of functional DNA nanostructures as carriers to transport proteins through solid-state nanopores has shown significant progress in single-protein-molecule detection. In this study, a 6.8 nm DNA tetrahedron was used as a carrier to successfully detect acetylcholinesterase with high specificity, low detection limit, and superior signal-to-noise ratio through an ultrasmall nanopipet. The practical applicability of this method was validated using serum samples from patients with Alzheimer's disease.

ACS NANO (2022)

Add to Collection
Article Chemistry, Multidisciplinary

A Photoelectrochemical Nanoreactor for Single-Cell Sampling and Near Zero-Background Faradaic Detection of Intracellular microRNA

Hai-Yan Wang et al.

Summary: This study explores a new technological direction in single-cell analysis by utilizing the rich interplay between light and bio-matter. A PEC nanoreactor is designed for single-cell sampling and detection of intracellular microRNA. The use of light stimulation enables zero-background Faradaic detection of non-electrogenic miR at the single-cell level, revealing differences in miR concentration between the near-nucleus region and the main cytosol.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Chemistry, Multidisciplinary

The Key Role of Subtle Substitution for a High-Performance Ester-Modified Oligothiophene-Based Polymer Used in Photovoltaic Cells

Sunsun Li et al.

Summary: In this study, a pair of wide-band-gap polymers were designed and synthesized, with the fluorine substituent greatly enhancing interchain aggregation. The aggregation effect of the donor polymer was found to be associated with energy level shifts and voltage losses. The device based on PBDE4T-2F:BTP-eC9 achieved an impressive power conversion efficiency of 16.1%.

CHINESE JOURNAL OF CHEMISTRY (2022)

Add to Collection
Review Chemistry, Inorganic & Nuclear

Photoelectrochemical biosensing platforms for tumor marker detection

Jiaju Shi et al.

Summary: Tumor metastasis is a leading cause of patient mortality. Tumor markers play a crucial role in improving the treatment success rate by reflecting tumor progression and prognosis. Recently, photoelectrochemical (PEC) sensors have emerged as a highly promising strategy for tumor marker analysis due to their high sensitivity and cost-effectiveness. Combining PEC technique with biosensing strategies offers higher specificity and sensitivity compared to conventional sensing methods. The development of novel PEC nanosensors using nanotechnology holds great potential for building more powerful signal amplification systems. This review focuses on the signal amplification strategies of PEC biosensors for tumor marker detection in the past 5 years, and discusses the future prospects and challenges in PEC biosensor development.

COORDINATION CHEMISTRY REVIEWS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Electrochemical Molecule Trap-Based Sensing of Low-Abundance Enzymes in One Living Cell

Rongrong Pan et al.

Summary: This study establishes a new method based on an electrochemical molecule trap for single-molecule electrochemical detection in a living cell, enabling the measurement of low-abundance enzyme activity. By creating an electrochemical molecule trap at the tip of a nanopipette and utilizing an electrochemical detector and electro-osmotic flow to prevent molecule diffusion, the limited amount of enzymes can continuously catalyze substrate conversion and generate enough byproduct for electrochemical measurements. The successful implementation of this method solves the challenge of studying low-abundance enzyme activity in cells and greatly enhances understanding of protein roles in cellular behavior.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Multidisciplinary Sciences

Smartphone-Based Photoelectrochemical Immunoassay with Co9S8@ZnIn2S4 for Point-of-Care Diagnosis of Breast Cancer Biomarker

Ruijin Zeng et al.

Summary: A portable smartphone-based photoelectrochemical immunoassay was developed for the on-site detection of breast cancer biomarkers. The method showed high sensitivity and good accuracy, with results in good agreement with the traditional enzyme-linked immunosorbent assay (ELISA).

RESEARCH (2022)

Add to Collection
Review Chemistry, Multidisciplinary

The application of single molecule nanopore sensing for quantitative analysis

Yanfang Wu et al.

Summary: This review provides an overview of the concepts, fabrication, and applications of nanopore sensors, with a focus on their potential and recent developments in quantitative analysis.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

A Supersmall Single-Cell Nanosensor for Intracellular K+ Detection

Xiao-Mei Shi et al.

Summary: A supersmall biomimetic K+ nanosensor was developed for electrochemically detecting intracellular K+ in a minimally invasive manner, showing sensitive and reversible response to K+ fluctuations. This nanosensor is proven to be an accessible tool for tracking stimulus-induced K+ fluctuation under physiological conditions.

CCS CHEMISTRY (2021)

Add to Collection
Review Chemistry, Multidisciplinary

Bio-inspired Track-Etched Polymeric Nanochannels: Steady-State Biosensors for Detection of Analytes

Jian Wang et al.

Summary: Bio-inspired polymeric nanochannel-based biosensors have shown promising potential in meeting the demand for high-performance biosensors, with opportunities for further advancements in the field.

ACS NANO (2021)

Add to Collection
Article Chemistry, Multidisciplinary

An Integrated Photoelectrochemical Nanotool for Intracellular Drug Delivery and Evaluation of Treatment Effect

Yi-Fan Ruan et al.

Summary: A dual-functional photocathodic single-cell nanotool has been developed for direct intracellular drug delivery and evaluation of oxidative stress, pushing the boundary of current single-cell electroanalysis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Analytical

Activity-Based Probe for Ratiometric Fluorescence Imaging of Caspase-3 in Living Cells

Yulong Jin et al.

Summary: The newly developed cell-permeable fluorescent probe can selectively exhibit a ratiometric response towards the apoptotic key enzyme caspase-3, offering potential for real-time quantification of caspase-3 activity to estimate apoptotic stages in living cells.

ANALYTICAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Enhancing the Sensitivity of Photoelectrochemical DNA Biosensing Using Plasmonic DNA Barcodes and Differential Signal Readout

Amanda Victorious et al.

Summary: The study developed a new PEC biosensing strategy that increases the detection sensitivity and specificity of DNA biosensors in biological samples by combining signals from two related binding events using differential signal generation. This new strategy demonstrated a detection limit of 3 fM, showing up to a 15- and three-fold increase in limit of detection and sensitivity, respectively, compared to previous PEC assays with a single binding event.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

High-Preservation Single-Cell Operation through a Photo-responsive Hydrogel-Nanopipette System

Zi-Yuan Li et al.

Summary: The newly developed photo-responsive hydrogel-nanopipette hybrid system enables precise single-cell operation with negligible cell damage, overcoming traditional issues associated with nanopipette operations. The light-triggered injection allows for precisely dose-controllable single-cell drug delivery, significantly reducing lethal doses of doxorubicin.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Editorial Material Cell Biology

Global miRNA to miRNA Interactions: Impacts for miR-21

Meredith Hill et al.

Summary: miRNAs play a crucial role in altering cellular environment by regulating target genes, and they may also influence other miRNAs and mRNA expression. This study focuses on exploring the regulatory effects of oncogenic miR-21 and its impact on other miRNA species.

TRENDS IN CELL BIOLOGY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

A Self-Catabolic Multifunctional DNAzyme Nanosponge for Programmable Drug Delivery and Efficient Gene Silencing

Jing Wang et al.

Summary: We designed a self-catabolic DNA nanocapsule for sustained activation of therapeutic DNAzyme in cancer cells, utilizing a hierarchical rolling circle replication (RCR) nanostructure. Through tumor-anchoring aptamer strands, the nanocapsule was specifically accumulated in cancer cells and sequentially activated for gene silencing. By employing a programmable RCR assembly strategy, our DNAzyme nanoplatform shows promise for developing smart gene therapeutics and personalized nanomedicines.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

FRET Modulated Signaling: A Versatile Strategy to Construct Photoelectrochemical Microsensors for In Vivo Analysis

Xiaoxue Ye et al.

Summary: The study proposed a new method of modulating PEC output through FRET process to address the issue of limited selectivity in sensors. By employing optical modulation, the as-fabricated PEC microelectrode showed good stability and reproducibility in vivo, enabling monitoring of fluctuations in SO2 levels in rat brains.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Cell Biology

microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

Richard Y. Kim et al.

Summary: miR-21 aberrant expression in COPD is associated with lung disease and can be a therapeutic target. Using a specific miR-21 inhibitor can effectively prevent and treat COPD, improving lung function.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection
Review Cell Biology

Cell type-specific microRNA therapies for myocardial infarction

Bohao Liu et al.

Summary: This review discusses current microRNA-based therapeutic strategies, highlighting outcomes and limitations of key microRNAs and offering a perspective on the outlook of microRNA therapies for myocardial infarction.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection
Review Oncology

miR-21: a non-specific biomarker of all maladies

Ana E. Jenike et al.

Summary: miRNA-21 is considered as a specific predictive or prognostic biomarker for at least 29 diseases, but lacks specificity for any one disease, thus making it not an ideal candidate for a biomarker despite continued evaluation. This issue of non-specificity in biomarker designation is shared with other common, ubiquitous miRNAs and warrants concern for their use as biomarkers as well.

BIOMARKER RESEARCH (2021)

Add to Collection
Review Pharmacology & Pharmacy

Nucleic acid delivery for therapeutic applications

Akash Gupta et al.

Summary: This review discusses various therapeutic applications of nucleic acids targeted at specific diseases and tissues, highlighting recent technologies that have advanced to late-stage clinical trials and received FDA approval.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

Sonja Schmid et al.

Summary: The NEOtrap, formed by a DNA-origami sphere docked onto a passivated solid-state nanopore, allows the trapping and observation of single proteins for hours with high sensitivity and resolution. It can distinguish between nucleotide-dependent protein conformations and is a promising tool for studying the molecular kinetics underlying protein function.

NATURE NANOTECHNOLOGY (2021)

Add to Collection
Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection
Article Multidisciplinary Sciences

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Reina Bassil et al.

Summary: Researchers have developed an automated long-term culturing platform for human iPSC neurons, astrocytes, and microglia to model cellular aspects of Alzheimer's disease.

NATURE COMMUNICATIONS (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Carbon nitride of five-membered rings with low optical bandgap for photoelectrochemical biosensing

Hong Yang et al.

Summary: Carbon nitrides, analogs of graphene, are gaining increasing attention for applications ranging from artificial photosynthesis to synthetic organic chemistry. The study reveals that both the common six-membered ring units and the rare five-membered ring units of carbon nitrides exhibit unique structural and property characteristics.

CHEM (2021)

Add to Collection
Article Engineering, Biomedical

Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts

Jaeyeaon Cho et al.

Summary: The direct reprogramming of mouse fibroblasts into cardiomyocytes, endothelial cells, and smooth muscle cells to form cardiac tissue structures improved cardiac function when implanted into infarcted mouse hearts.

NATURE BIOMEDICAL ENGINEERING (2021)

Add to Collection
Article Chemistry, Physical

Regulating Light-Sensitive Gate of Organic Photoelectrochemical Transistor toward Sensitive Biodetection at Zero Gate Bias

Meng-Jiao Lu et al.

Summary: This study introduces the bio-dependent regulation of a light-sensitive gate electrode for transducing biological events. By connecting to an immunoassay event associated with a specific analyte, the model system demonstrates target-dependent tunability and good analytical performance.

SMALL STRUCTURES (2021)

Add to Collection
Review Oncology

RNA in cancer

Gregory J. Goodall et al.

Summary: Recent findings have shown that RNA processing is systematically altered in cancer, with mutations in RNA splicing factor genes and the shortening of 3' untranslated regions widely observed. Additionally, evidence suggests that other types of RNAs, including circular RNAs, can contribute to tumorigenesis.

NATURE REVIEWS CANCER (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Specific Inhibition of Viral MicroRNAs by Carbon Dots-Mediated Delivery of Locked Nucleic Acids for Therapy of Virus-Induced Cancer

Enguo Ju et al.

ACS NANO (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Low-Noise Nanopore Enables In-Situ and Label-Free Tracking of a Trigger-Induced DNA Molecular Machine at the Single-Molecular Level

Zhentong Zhu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Resistive-Pulse Sensing Inside Single Living Cells

Rongrong Pan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

A Self-Evaluating Photothermal Therapeutic Nanoparticle

Yanfang Wang et al.

ACS NANO (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Correlating Molecule Count and Release Kinetics with Vesicular Size Using Open Carbon Nanopipettes

Keke Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Review Nanoscience & Nanotechnology

Solid-state nanopore sensors

Liang Xue et al.

NATURE REVIEWS MATERIALS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Unexpected Boosted Solar Water Oxidation by Nonconjugated Polymer-Mediated Tandem Charge Transfer

Zhi-Quan Wei et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Review Chemistry, Multidisciplinary

Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

Ru-Jia Yu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Multidisciplinary

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin

Matthew G. Costales et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Unimolecular Chemo-fluoro-luminescent Reporter for Crosstalk-Free Duplex Imaging of Hepatotoxicity

Penghui Cheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection
Review Chemistry, Inorganic & Nuclear

Bismuth-containing semiconductors for photoelectrochemical sensing and biosensing

Si-Yuan Yu et al.

COORDINATION CHEMISTRY REVIEWS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Rationally Engineered Photonic-Plasmonic Synergistic Resonators in Second Near-Infrared Window for in Vivo Photoelectrochemical Biodetection

Baihe Fu et al.

NANO LETTERS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Light-Inducible Exosome-Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells

Lin Huang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Nanostars on Nanopipette Tips: A Raman Probe for Quantifying Oxygen Levels in Hypoxic Single Cells and Tumours

Thanh Danh Nguyen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Multidisciplinary Sciences

A Nanopore Phosphorylation Sensor for Single Oligonucleotides and Peptides

Yi-Lun Ying et al.

RESEARCH (2019)

Add to Collection
Article Nanoscience & Nanotechnology

Nanoscale tweezers for single-cell biopsies

Binoy Paulose Nadappuram et al.

NATURE NANOTECHNOLOGY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Ultrasmall Nanopipette: Toward Continuous Monitoring of Redox Metabolism at Subcellular Level

Juan Song et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Chemistry, Analytical

Ultrafast Mapping of Subcellular Domains via Nanopipette-Based Electroosmotically Modulated Delivery into a Single Living Cell

Ruo-Can Qian et al.

ANALYTICAL CHEMISTRY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Regulating miRNA-21 Biogenesis By Bifunctional Small Molecules

Hao Yan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection
Review Biotechnology & Applied Microbiology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

Rajesha Rupaimoole et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Add to Collection
Review Oncology

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer

Alexander A. Svoronos et al.

CANCER RESEARCH (2016)

Add to Collection
Review Chemistry, Multidisciplinary

Photoelectrochemical DNA Biosensors

Wei-Wei Zhao et al.

CHEMICAL REVIEWS (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Targeted Theranostic Platinum(IV) Prodrug with a Built-In Aggregation-Induced Emission Light-Up Apoptosis Sensor for Noninvasive Early Evaluation of Its Therapeutic Responses in Situ

Youyong Yuan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection
Review Biotechnology & Applied Microbiology

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

Hui Ling et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Add to Collection
Article Chemistry, Multidisciplinary

The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR-21 Function by Directly Targeting Its Precursor

Debojit Bose et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Add to Collection
Review Biotechnology & Applied Microbiology

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

Eva van Rooij et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Add to Collection
Article Nanoscience & Nanotechnology

Controlling protein translocation through nanopores with bio-inspired fluid walls

Erik C. Yusko et al.

NATURE NANOTECHNOLOGY (2011)

Add to Collection
Article Immunology

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

Frederick J. Sheedy et al.

NATURE IMMUNOLOGY (2010)

Add to Collection
Review Biotechnology & Applied Microbiology

Targeting microRNAs in cancer: rationale, strategies and challenges

Ramiro Garzon et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Add to Collection
Article Gastroenterology & Hepatology

MicroRNA-21 Is Overexpressed in Human Cholangiocarcinoma and Regulates Programmed Cell Death 4 and Tissue Inhibitor of Metalloproteinase 3

Florin M. Selaru et al.

HEPATOLOGY (2009)

Add to Collection
Article Cell Biology

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

Shuomin Zhu et al.

CELL RESEARCH (2008)

Add to Collection
Article Chemistry, Multidisciplinary

Enhanced photoelectrochemistry in CdS/Au nanoparticle bilayers

L Sheeney-Haj-Ichia et al.

ADVANCED FUNCTIONAL MATERIALS (2004)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.