Journal
CLINICAL AND EXPERIMENTAL MEDICINE
Volume -, Issue -, Pages -Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-023-01246-3
Keywords
AIDS-related Kaposi sarcoma; Non-AIDS-related Kaposi sarcoma; Sarcoma; Kaposi; Cohort Studies; Real-world evidence; Survival Analysis
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This study retrospectively assessed the treatment approaches and outcomes of patients with KS in Peru. The majority of patients had a high severity status and received systemic chemotherapy. Paclitaxel was the most commonly used first-line drug and showed relatively high overall response rates for both AIDS-related KS and CKS. The 5-year OS rates were slightly lower for AIDS-related KS patients compared to CKS patients.
The recommended first-line chemotherapy agents for managing Kaposi sarcoma (KS) in high-income countries are expensive and often unavailable in developing nations such as Peru. Limited data exist on whether management practices in these countries affect patient outcomes. We assessed the real-world treatment approaches and outcomes of patients with KS in Peru. We retrospectively reviewed the medical records of patients with acquired immunodeficiency syndrome-related KS (AIDS-related KS; n = 95) and classic KS (CKS; n = 81) diagnosed at a tertiary center between 2000 and 2014 in Lima, Peru. We used the Kaplan-Meier method to estimate overall survival (OS) rates. The median follow-up was 64 months for AIDS-related KS and 88 months for CKS. The median age of patients with AIDS-related KS was 35 years (range 20-63 years) and 70 years (range 33-91 years) for those with CKS. Most individuals had an Eastern Cooperative Oncology Group performance status of >= 2 (AIDS-related KS 75%; CKS 85%). Seventy-six percent and 40% of individuals with AIDS-related KS and CKS, respectively, received systemic chemotherapy. The most common first-line drug was paclitaxel, with relatively optimal overall response rates (ORRs) for AIDS-related KS (n = 64/72, 89%; ORR 61%) and CKS (n = 24/32, 75%; ORR 50%). The 5-year OS rates were 71% in the AIDS-related KS cohort and 81% in the CKS cohort. The findings from this real-world study may inform clinical practices and highlight the need for increased access to effective treatments and clinical trials for patients with KS in Peru and other developing countries.
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