4.6 Review

Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Journal

RSC ADVANCES
Volume 13, Issue 46, Pages 32786-32823

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d3ra06054c

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Spiro-heterocycles have received special attention in medicinal chemistry due to their promising biological activity. This review presents representative synthetic approaches for spiro-heterocycles, especially in the past 20 years.
Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years. Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity.

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