Related references
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Article
Clinical Neurology
Peter Novak et al.
Summary: This study aimed to describe the cerebrovascular, neuropathic, and autonomic features of post-acute sequelae of COVID-19 (PASC). The study found that PASC is associated with multisystem abnormalities, including cerebrovascular dysregulation, small fiber neuropathy, and autonomic dysfunction, along with chronic inflammation.
ANNALS OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Magdalini Alexandridi et al.
Summary: Since 2019, Cytokine & Growth Factor Reviews has published multiple Special Issues focusing on the biology, pathogenesis, and therapeutic options for COVID-19. Despite progress in vaccines and treatments, there are challenges posed by misinformation and anti-vaccine sentiment.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
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Endocrinology & Metabolism
Emre Urhan et al.
Summary: COVID-19 infection may affect pituitary functions, particularly the HPA and GH axes. These insufficiencies should be kept in mind in post-COVID follow-up. Long-term data are needed to determine whether these deficiencies are permanent or not.
Article
Medicine, General & Internal
Ravindra Ganesh et al.
Summary: This study described the clinical data from the first 108 patients seen in the Mayo Clinic post-COVID-19 care clinic (PCOCC). Several distinct clinical phenotypes were observed, with the fatigue predominant phenotype being the most common and associated with female sex and elevated IL-6 levels.
MAYO CLINIC PROCEEDINGS
(2022)
Letter
Gastroenterology & Hepatology
Yanfei Chen et al.
Article
Medicine, General & Internal
Michael C. Sneller et al.
Summary: This study aimed to characterize medical sequelae and persistent symptoms in COVID-19 survivors. The results showed a high burden of persistent symptoms after COVID-19, but extensive diagnostic evaluation did not reveal a specific cause in most cases. Women and individuals with a history of anxiety disorder had an increased risk for post-acute sequelae of SARS-CoV-2 infection.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Douglas B. Kell et al.
Summary: Post-acute sequelae of COVID, commonly known as Long COVID, is a frequent consequence of SARS-CoV-2 infection. Fibrin amyloid microclots may underpin the majority of symptoms by blocking capillaries and limiting oxygen exchange.
BIOCHEMICAL JOURNAL
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Virology
Ignacio Perez Catalan et al.
Summary: This study analyzed the long-term symptoms of COVID-19 patients and found that treatment with corticosteroids during the acute phase may attenuate the presence of long-term symptoms and improve patients' quality of life.
JOURNAL OF MEDICAL VIROLOGY
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Endocrinology & Metabolism
Anello Marcello Poma et al.
Summary: This study found that the pituitary glands of lethal cases of COVID-19 had the SARS-CoV-2 genome and antigens, confirming viral infection in the pituitary gland. Activation of type I interferon signaling and increased levels of neutrophil and cytotoxic cell scores were observed in virus-positive glands, while mRNA transcripts of pituitary hormones and pituitary developmental/regulatory genes were suppressed in all COVID-19 cases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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Clinical Neurology
Lavienraj Premraj et al.
Summary: Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. A systematic review analyzed data from multiple studies and found that fatigue, cognitive dysfunction, and sleep disturbances were key features of post-COVID-19 syndrome. Psychiatric manifestations such as anxiety and depression were also common and increased in prevalence over time.
JOURNAL OF THE NEUROLOGICAL SCIENCES
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Multidisciplinary Sciences
Miriam Merad et al.
Summary: Considerable research effort has been focused on deciphering the immune response to SARS-CoV-2 infections and understanding the pathophysiology of COVID-19, including Long Covid syndrome. The hope is that knowledge gained from this research will be applied to studies of inflammatory processes in critical and chronic illnesses in the future.
Editorial Material
Immunology
Michael J. J. Peluso et al.
Summary: Intense investigation is being carried out to understand the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including 'long COVID'. Recent studies provide clues to the mechanisms behind this condition, aiming to identify host or virus factors that can be intervened upon to prevent or reverse PASC.
TRENDS IN IMMUNOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Sarah E. Key-DeLyria et al.
Summary: This study examines the relationship between cognitive control and the processing of ambiguous garden path sentences in adults with mild traumatic brain injury (mTBI). The results suggest that individuals with mTBI perform worse on ambiguous sentence tasks and that this performance is correlated with measures of cognitive control and working memory. These findings highlight the importance of assessing complex cognitive and linguistic processing in cognitive communication following mTBI.
INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS
(2022)
Article
Andrology
Andrea Salonia et al.
Summary: Although total testosterone levels increased over time after COVID-19, more than 50% of men who recovered from the disease still had circulating testosterone levels suggestive for a condition of hypogonadism at 7-month follow-up. In as many as 10% of cases, testosterone levels even further decreased. Of clinical relevance, the higher the burden of comorbid conditions at presentation, the lower the probability of testosterone levels recovery over time.
Review
Medicine, General & Internal
Shirley Sylvester et al.
Summary: This study conducted literature reviews and found differential effects of sex on sequelae from COVID-19 and long COVID syndrome. Few studies reported sex-disaggregated data for COVID-19, highlighting the need for further sex-based research and reporting.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Psychiatry
Andrei L. Iosifescu et al.
Summary: This study investigated the clinical characteristics of COVID-19 patients with neuro-PASC and compared them to flu patients with similar symptoms. The results showed that COVID-19 patients with neuro-PASC were older, developed symptoms more quickly, and were prescribed psychiatric drugs more often compared to flu patients.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Jennifer A. Frontera et al.
Summary: Neuropsychiatric symptoms are a prominent feature of post-acute sequelae of COVID-19 (PASC), including cognitive impairment, sleep difficulties, depression, posttraumatic stress, and substance use disorders. The mechanisms of neuropsychiatric PASC are not well understood, and there is a lack of a standard definition for the syndrome. Studies have found that at least one PASC neuropsychiatric symptom has been reported in as many as 90% of hospitalized patients after 6 months of COVID-19 and in approximately 25% of nonhospitalized adults with COVID-19.
Article
Clinical Neurology
Jacqueline E. Shanley et al.
Summary: This study aimed to assess the initial features and evolution of neurologic Postacute Sequelae of SARS-CoV-2 infection (neuro-PASC). The most common symptoms early in neuro-PASC were fatigue and headaches, while memory impairment and decreased concentration were most prominent at 6 months. Only one-third of participants had complete resolution of neuro-PASC at 6 months, although persistent symptoms showed improvement at follow-up.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Frontera et al.
Summary: This study identified three clinically relevant phenotypes of post-acute sequelae of COVID-19 (PASC), which received different therapeutic interventions and had varying response rates. These findings can aid in the development of personalized treatment plans.
Article
Endocrinology & Metabolism
Naruhiko Sunada et al.
Summary: Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. This study evaluated laboratory data of long COVID patients to clarify the hormonal characteristics. Patients had various symptoms, with general malaise and dysosmia/dysgeusia being the most frequent. Younger patients were more likely to experience fatigue and dysosmia/dysgeusia, while hair loss was more common in older and female patients. Patients with fatigue had higher levels of cortisol and free thyroxin (FT4), while patients with dysosmia/dysgeusia had significantly lower levels of cortisol. The study suggests that hormonal changes are at least partially involved in the persistent symptoms of long COVID.
Article
Virology
Stephen M. Smith et al.
Summary: The study analyzed clinical characteristics associated with severe COVID-19 in 184 hospitalized patients in Livingston, New Jersey, and found that diabetes was common among COVID-19 patients and severe disease was often accompanied by impaired glucose metabolism.
JOURNAL OF MEDICAL VIROLOGY
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Medicine, General & Internal
Ioannis Ilias et al.
Summary: This study assessed glucose, glycemic gap, and insulin sensitivity in patients with Covid-19. Findings showed that both diabetic and non-diabetic patients with Covid-19 may experience hyperglycemia upon admission, with critically ill patients potentially having compromised insulin secretion and sensitivity to insulin.
MEDICINA-LITHUANIA
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Immunology
Michael J. Peluso et al.
Summary: This study found that persistent immune activation may be associated with ongoing symptoms following COVID-19, with cytokine levels during early recovery period being related to the development of PASC. This suggests potential therapeutic targets for those experiencing PASC.
JOURNAL OF INFECTIOUS DISEASES
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Andrology
Andrea Salonia et al.
Summary: This study revealed that male patients with COVID-19 had lower levels of androgens, particularly testosterone, upon hospital admission, indicating a high prevalence of hypogonadism. Furthermore, the research showed an independent association between SARS-CoV-2 infection and decreased testosterone levels, as well as a higher risk of hypogonadism. Lower testosterone levels were also linked to increased risk of ICU admission and death outcomes.
Letter
Medicine, General & Internal
Jacqueline H. Becker et al.
Summary: This study aims to examine rates of cognitive impairment among COVID-19 survivors and investigate the association between care setting and cognitive impairment rates.
Review
Medicine, General & Internal
Destin Groff et al.
Summary: This systematic review found that more than half of COVID-19 survivors experienced PASC 6 months after recovery, with the most common effects being functional mobility impairments, pulmonary abnormalities, and mental health disorders.
Article
Clinical Neurology
Edith L. Graham et al.
Summary: This study investigated the neurologic manifestations in non-hospitalized Covid-19 long haulers, revealing prominent symptoms such as brain fog and fatigue which negatively affect their cognition and quality of life.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Clinical Neurology
Narges Moghimi et al.
Summary: Neuro-PASC, a global health challenge following COVID-19 infection, presents with diverse pathophysiological mechanisms such as viral invasion and immune dysregulation. Comprehensive treatment involving rehabilitation, cognitive therapy, and medications is essential for affected individuals, emphasizing the importance of early recognition and effective intervention.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Review
Microbiology
Amy D. Proal et al.
Summary: The novel coronavirus SARS-CoV-2 has led to a pandemic of COVID-19, with some patients developing persistent symptoms known as Long COVID or PASC. These patients may have different underlying biological factors driving their symptoms, such as organ damage, persistent viral reservoirs, re-activation of pathogens, and immune dysregulation. Therapeutic approaches may need to be individualized to effectively manage care for specific patients with PASC.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Evasio Pasini et al.
Summary: Patients with long-Covid syndrome exhibit abnormalities in blood markers related to coagulation, protein disarrangement, and inflammation, indicating ongoing metabolic alterations contributing to the persistence of PASC. Long-term elevated D-Dimer levels suggest potential risks for thromboembolic disease.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Timothy L. Wong et al.
Summary: Early studies on long COVID symptoms show significant overlaps with ME/CFS, highlighting the need for monitoring and treatment. Further research into the similarities and differences between long COVID and ME/CFS is warranted.
MEDICINA-LITHUANIA
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Randall J. Urban et al.
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Tao Li et al.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
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Kevin C. J. Yuen et al.
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EUROPEAN JOURNAL OF NEUROLOGY
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ZS Nasreddine et al.
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