4.8 Review

Targeting of endothelial cells in brain tumours

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Single-cell spatial immune landscapes of primary and metastatic brain tumours

Elham Karimi et al.

Summary: Single-cell technologies have been used to study the tumour microenvironment and reveal cellular diversity in tumour cells and their surroundings. This study used imaging mass cytometry to analyze the immunological landscape of high-grade glioma and brain metastasis tumours. The analysis revealed differences in immune landscapes between primary tumours and brain metastases and identified a unique population of MPO-positive macrophages associated with long-term survival in glioblastoma patients. The findings highlight the importance of integrating spatial resolution into single-cell datasets to understand the microenvironment of cancer.

NATURE (2023)

Article Oncology

Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma

William Kelly et al.

Summary: In this study, TVB-2640 was found to be a well-tolerated oral drug that could be safely combined with bevacizumab in relapsed high-grade astrocytoma patients, showing potential therapeutic effects.

CLINICAL CANCER RESEARCH (2023)

Article Oncology

NRG Oncology/RTOG1205: A Randomized Phase II Trial of Concurrent Bevacizumab and Reirradiation Versus Bevacizumab Alone as Treatment for Recurrent Glioblastoma

Christina I. Tsien et al.

Summary: This study evaluated whether reirradiation (re-RT) and concurrent bevacizumab (BEV) improve overall survival (OS) and/or progression-free survival (PFS) compared to BEV alone in recurrent glioblastoma (GBM). The results showed that the combination of re-RT and BEV significantly improved PFS, but had no difference in OS.

JOURNAL OF CLINICAL ONCOLOGY (2023)

Article Engineering, Biomedical

3D bioprinted vascularized lung cancer organoid models with underlying disease capable of more precise drug evaluation

Yoo-mi Choi et al.

Summary: An advanced vascularized lung cancer model is proposed, which includes patient-derived LC organoids, lung fibroblasts, and perfusable vessels using 3D bioprinting. A porcine lung-derived decellularized extracellular matrix hydrogel was used to mimic the biochemical composition of native lung tissues. The model showed increased cell proliferation and drug resistance-related gene expression in LC organoids with fibrosis, and drug responsiveness changes were significantly greater in the decellularized extracellular matrix hydrogel.

BIOFABRICATION (2023)

Review Materials Science, Biomaterials

3D Bioprinting for Tumor Metastasis Research

Manqing Lin et al.

Summary: Tumor metastasis is a complex process involving dissemination of tumor cells and their adaptation to foreign microenvironments. 3D bioprinting strategies offer a realistic and species-homologous approach to model tumor metastasis, allowing the construction of customized and bionic structures.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

Article Oncology

A randomized Phase 2 study to compare erlotinib with or without bevacizumab in previously untreated patients with advanced non-small cell lung cancer with EGFR mutation

Youngjoo Lee et al.

Summary: This study aimed to evaluate whether the addition of bevacizumab to erlotinib improves clinical outcomes in EGFR-mutated non-small cell lung cancer patients. The results showed a trend towards improvement in progression-free survival with erlotinib plus bevacizumab compared to erlotinib alone, especially in patients with brain metastasis.

CANCER (2023)

Article Oncology

A Phase I Trial of VEGF-A Inhibition Combined with PD-L1 Blockade for Recurrent Glioblastoma

Daniel Chiu et al.

Summary: Treating GBM is challenging, and the use of ICI has been disappointing. Combination therapy involving ICI and other treatments may improve efficacy.

CANCER RESEARCH COMMUNICATIONS (2023)

Review Oncology

Targeting brain metastases in breast cancer

Chiara Corti et al.

Summary: Brain metastases from metastatic breast cancer are a significant cause of morbidity and mortality. Local interventions such as surgery or radiation therapy are the main management methods, with systemic treatments used to complement and improve control of central nervous system (CNS) disease. New anti-HER2 agents show effectiveness in treating brain metastases. Current research efforts aim to clarify the impact of existing treatments and develop new drugs and innovative approaches.

CANCER TREATMENT REVIEWS (2022)

Article Oncology

IMpower150 Final Exploratory Analyses for Atezolizumab Plus Bevacizumab and Chemotherapy in Key NSCLC Patient Subgroups With EGFR Mutations or Metastases in the Liver or Brain

Naoyuki Nogami et al.

Summary: This study presents the final overall survival (OS) analyses for EGFR mutations and liver or brain metastases subgroups in the IMpower150 study. The results show that ABCP has sustained OS improvements compared to BCP in sensitizing EGFR mutations and baseline liver metastases subgroups. However, ACP does not provide a survival benefit in these subgroups compared to BCP. The study also suggests further investigation into the impact of ABCP on delaying the development of new brain lesions.

JOURNAL OF THORACIC ONCOLOGY (2022)

Review Oncology

Tumor organoids: applications in cancer modeling and potentials in precision medicine

Hanxiao Xu et al.

Summary: Cancer is a life-threatening disease with intratumor heterogeneity. Personalized tumor models capturing individual patients' tumor heterogeneity are urgently needed for precision medicine. Organoid technology, which can generate three-dimensional tissues that accurately recapitulate the characteristics of primary tumors, has shown great potential in accurately modeling cancer. Tumoroids serve as a valuable tool for the discovery of therapeutic targets, prediction of treatment response, and exploration of potential therapies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Oncology

Metabolism in the progression and metastasis of brain tumors

Abhishek Tyagi et al.

Summary: Malignant brain tumors and metastases are significant health problems with high morbidity and mortality rates. Recent studies have found distinct metabolic traits in metastatic cancer cells, providing new directions for finding therapeutic targets and predicting treatment biomarkers.

CANCER LETTERS (2022)

Article Oncology

Single-cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

He-Fen Sun et al.

Summary: Using single-cell RNA sequencing, we analyzed immune and nonimmune cells in gliomas and brain metastases from lung cancer. We found heterogeneity in the tumor microenvironment and tumor cells, which is crucial for the development of immunotherapy for lung cancer brain metastasis.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Article Multidisciplinary Sciences

The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis

Qi Zhang et al.

Summary: Brain metastases (BrMs) are a common occurrence in lung cancer with poor prognosis. The tumor microenvironment in the brain undergoes extensive remodeling to create an immunosuppressive and fibrogenic niche for BrMs. Differential gene expression analysis identifies fibrosis and immune regulation as the major functional modules disrupted in both the lung and brain tumor microenvironments.

NATURE COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Cancer metastasis chemoprevention prevents circulating tumour cells from germination

Xiaodong Xie et al.

Summary: This article presents a new cancer pre-metastasis chemoprevention strategy that can potentially prevent lethal metastasis by interrupting the adhesion of circulating tumor cells (CTCs) to their metastasis niche.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Biochemistry & Molecular Biology

Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response

Hao Zeng et al.

Summary: Endothelial cells can undergo endothelial-to-mesenchymal transition (EndoMT) in cardiac fibrosis, and this process is driven by abnormal glycolysis mediated by 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3). Pharmacological intervention of PFKFB3 with salvianolic acid C (SAC) can attenuate EndoMT and fibrotic response.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Oncology

Identification of diverse tumor endothelial cell populations in malignant glioma

Jeff C. Carlson et al.

Summary: This study established molecular and morphological benchmarks for tumor associated vessels and tumor derived endothelial cells during glioblastoma progression. The research found progressive alteration of vessel function and morphogenesis over time, with TDECs identified as a rare subpopulation contributing to vessels within the tumor. Additionally, transcriptional profiling demonstrated molecular distinctiveness and extensive heterogeneity within both TAVs and TDECs, with these findings also present in human glioma.

NEURO-ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Blood-Brain Barrier in Brain Tumors: Biology and Clinical Relevance

Francesca Mo et al.

Summary: The presence of barriers like the BBB and BTB make it difficult for antineoplastic drugs to penetrate the brain, but various techniques and molecular strategies have been developed to overcome these limitations, showing promising results in clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Efficacy of Osimertinib Plus Bevacizumab vs Osimertinib in Patients With EGFR T790M-Mutated Non-Small Cell Lung Cancer Previously Treated With Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor West Japan Oncology Group 8715L Phase 2 Randomized Clinical Trial

Hiroaki Akamatsu et al.

Summary: This study aimed to compare the efficacy and safety of osimertinib plus bevacizumab with osimertinib alone in patients with lung adenocarcinoma with EGFR T790M mutation. The combination therapy showed a better overall response rate but did not prolong progression-free survival compared to osimertinib monotherapy.

JAMA ONCOLOGY (2021)

Article Oncology

Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study

Qing Zhou et al.

Summary: Dual inhibition of EGFR and VEGF pathways may delay therapeutic resistance in NSCLC, and a study on the efficacy and safety of erlotinib plus bevacizumab regimen in untreated patients showed significantly prolonged PFS, indicating potential benefits in advanced NSCLC treatment.

CANCER CELL (2021)

Article Multidisciplinary Sciences

Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Lena Neufeld et al.

Summary: Current cancer models lack tumor-stroma interactions, affecting the proper representation of cancer's complex biology. By creating bioink with patient-derived cells, tumor heterogenic microenvironment can be recapitulated, leading to similar growth curves, drug response, and genetic signature in 3D models compared to traditional 2D cultures. This 3D-bioprinted model has the potential to replace cell cultures and animal models for rapid and robust target discovery, personalized therapy screening, and drug development.

SCIENCE ADVANCES (2021)

Article Oncology

Inflammatory Environment Promotes the Adhesion of Tumor Cells to Brain Microvascular Endothelial Cells

Ke Wang et al.

Summary: Research findings indicate that TNF-alpha treatment activates brain microvascular endothelial cells and increases the expression of multiple adhesion molecules, enhancing the adhesion between lung cancer cells and endothelial cells. These results contribute to a better understanding of the mechanisms underlying brain metastasis.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Fatty acid synthesis is required for breast cancer brain metastasis

Gino B. Ferraro et al.

Summary: Ferraro et al. found that fatty acid synthesis is crucial for brain cancer metastasis, and inhibiting this process can reduce the metastatic growth of breast cancer cells in the brain. Metabolic adaptations required for brain metastatic breast cancer growth may introduce vulnerabilities that can be exploited for therapy, as shown by differences in nutrient availability across metastatic sites.

NATURE CANCER (2021)

Article Oncology

Hypofractionated stereotactic re-irradiation with pembrolizumab and bevacizumab in patients with recurrent high-grade gliomas: results from a phase I study

Solmaz Sahebjam et al.

Summary: The combination of hypofractionated stereotactic irradiation (HFSRT) with pembrolizumab and bevacizumab is generally safe and well tolerated in patients with recurrent high-grade gliomas. In patients without prior bevacizumab treatment, 83% showed complete or partial response, while in bevacizumab-resistant patients, 62% achieved partial response. This treatment approach warrants further investigation for its potential in improving outcomes for high-grade glioma patients.

NEURO-ONCOLOGY (2021)

Review Peripheral Vascular Disease

Pathological features of vessel co-option versus sprouting angiogenesis

Emily Latacz et al.

ANGIOGENESIS (2020)

Review Peripheral Vascular Disease

Vascular co-option in brain metastasis

Pedro Garcia-Gomez et al.

ANGIOGENESIS (2020)

Article Biochemistry & Molecular Biology

Investigating Programmed Cell Death and Tumor Invasion in a Three-Dimensional (3D) Microfluidic Model of Glioblastoma

Ehsan Samiei et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, Research & Experimental

Novel insights into astrocyte-mediated signaling of proliferation, invasion and tumor immune microenvironment in glioblastoma

Hao Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Maria Peleli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Medicine, General & Internal

Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1

Celine A. Schoonjans et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Oncology

The blood-brain barrier and blood-tumour barrier in brain tumours and metastases

Costas D. Arvanitis et al.

NATURE REVIEWS CANCER (2020)

Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Cell Biology

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

Amanda Linkous et al.

CELL REPORTS (2019)

Article Engineering, Biomedical

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

Hee-Gyeong Yi et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Multidisciplinary Sciences

Endothelial cells promote 3D invasion of GBM by IL-8-dependent induction of cancer stem cell properties

Michael G. McCoy et al.

SCIENTIFIC REPORTS (2019)

Review Cell Biology

Hallmarks of Endothelial Cell Metabolism in Health and Disease

Xuri Li et al.

CELL METABOLISM (2019)

Review Oncology

Vasculogenic Mimicry: Become an Endothelial Cell But Not So Much

Monica Fernandez-Cortes et al.

FRONTIERS IN ONCOLOGY (2019)

Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

Di Zhang et al.

NATURE (2019)

Article Biochemical Research Methods

Engineering of human brain organoids with a functional vascular-like system

Bilal Cakir et al.

NATURE METHODS (2019)

Review Engineering, Biomedical

Three-dimensional (3D) printed scaffold and material selection for bone repair

Lei Zhang et al.

ACTA BIOMATERIALIA (2019)

Article Biochemistry & Molecular Biology

N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1

Hongsheng Wang et al.

MOLECULAR CANCER (2019)

Article Biotechnology & Applied Microbiology

An in vivo model of functional and vascularized human brain organoids

Abed AlFatah Mansour et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

Neibla Priego et al.

NATURE MEDICINE (2018)

Article Biochemical Research Methods

Genetically engineered cerebral organoids model brain tumor formation

Shan Bian et al.

NATURE METHODS (2018)

Review Oncology

Comparison of glioblastoma (GBM) molecular classification methods

Eunjee Lee et al.

SEMINARS IN CANCER BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors in the Management of Brain Metastases

Eric J. Lehrer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis

Samah A. Jassam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Cell Biology

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation

Elizabeth Allen et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Oncology

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

Timothy N. Phoenix et al.

CANCER CELL (2016)

Article Biochemistry & Molecular Biology

ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier

Aurore Drolez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Biochemistry & Molecular Biology

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

Manuel Valiente et al.

Review Oncology

Interleukin-6: An angiogenic target in solid tumours

Kathryn Middleton et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2014)

Article Cell Biology

The perivascular niche regulates breast tumour dormancy

Cyrus M. Ghajar et al.

NATURE CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Elevated PLGF contributes to small-cell lung cancer brain metastasis

B. Li et al.

ONCOGENE (2013)

Review Oncology

Crossing the endothelial barrier during metastasis

Nicolas Reymond et al.

NATURE REVIEWS CANCER (2013)

Correction Neurosciences

The brain tumor microenvironment (vol 59, pg 1169, 2011)

Nikki A. Charles et al.

Article Biochemistry & Molecular Biology

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)

Lyle W. Ostrow et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Multidisciplinary Sciences

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Lucia Ricci-Vitiani et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Real-time imaging reveals the single steps of brain metastasis formation

Yvonne Kienast et al.

NATURE MEDICINE (2010)

Article Oncology

SAFETY AND EFFICACY OF BEVACIZUMAB WITH HYPOFRACTIONATED STEREOTACTIC IRRADIATION FOR RECURRENT MALIGNANT GLIOMAS

Philip H. Gutin et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

Article Multidisciplinary Sciences

The Vascular Basement Membrane as Soil'' in Brain Metastasis

W. Shawn Carbonell et al.

PLOS ONE (2009)

Review Oncology

The roles of chemokine CXCL12 in embryonic and brain tumor angiogenesis

Meizhang Li et al.

SEMINARS IN CANCER BIOLOGY (2009)

Review Cardiac & Cardiovascular Systems

Adhesion mechanisms in platelet function

Zaverio M. Ruggeri et al.

CIRCULATION RESEARCH (2007)

Review Neurosciences

Astrocyte-endothelial interactions at the blood-brain barrier

NJ Abbott et al.

NATURE REVIEWS NEUROSCIENCE (2006)