☆ 4.6 Review

Tailoring biomaterials for biomimetic organs-on-chips

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Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System

Min Zhang et al.

Summary: A biomimetic human disease model on chip has been created to recapitulate lung injury and immune responses induced by SARS-CoV-2, revealing distinctive responses in different cell types and the crucial role of immune cells in alveolar barrier injury and inflammation. The organ chip model closely mirrors human-relevant responses to SARS-CoV-2 infection, providing a unique platform for COVID-19 research and drug development.

ADVANCED SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Bioscaffold Stiffness Mediates Aerosolized Nanoparticle Uptake in Lung Epithelial Cells

Austin H. Williams et al.

Summary: Highly porous and ultrasoft polymeric mats mimicking human tissues were formed from novel polyurethane soft dendritic colloids, which have a unique fibrillar morphology. The mechanical properties of the mats can be tuned for physiological relevance, and they were found to support cellular growth and viability, with implications for nanoparticle uptake and cytokine secretion.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Engineering, Biomedical

Biomaterial-guided stem cell organoid engineering for modeling development and diseases

Plansky Hoang et al.

Summary: Organoids are miniature models of organs that can recapitulate spatial-temporal cellular organization and tissue functionality. By engineering proper tissue microenvironment, functional organoids exhibit spatial-distinct tissue patterning and morphogenesis. Utilizing biofabrication and organoid-on-chip platforms enhances organoid systems for therapeutic applications, enabling the assembly of complex organoid systems for in vitro modeling of development and diseases.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Heterogeneous Structural Color Microfibers for Cardiomyocytes Tug-of-War

Zhuoyue Chen et al.

Summary: A novel heterogeneous structural color microfiber designed for dynamic cardiac mechanics sensing is presented in this study. The microfiber contains non-close-packed colloidal arrays for quantitative optical sensing and bioactive GelMA for cardiac culture. It transforms microcosmic cell-generated force into macroscopic optical signals and has the potential to be an ideal platform for biomedical fields.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biotechnology & Applied Microbiology

In vitro hepatic steatosis model based on gut-liver-on-a-chip

Joong-Won Jeon et al.

Summary: The development of a microfluidic gut-liver chip capable of recapitulating gut absorption of fatty acids and subsequent lipid accumulation in liver cells was reported. A series of experiments were conducted to verify the chip's ability to reproduce various aspects of hepatic steatosis, including evaluating fatty acid absorption and testing the anti-steatotic effects of drugs with different mechanisms of action. The study demonstrated the gut-liver chip's potential as a novel and physiologically realistic in vitro model for studying fatty liver disease.

BIOTECHNOLOGY PROGRESS (2021)

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Article Engineering, Environmental

Engineering microcapsules to construct vascularized human brain organoids

Yujuan Zhu et al.

Summary: Our multidisciplinary strategy involves engineering vascularized human induced pluripotent stem cells (hiPSCs)-derived brain organoids system with biomimetic features using microfluidic hydrogel microcapsules. The precise fluids control of microfluidic electrospray technology enables the efficient encapsulation of hiPSCs-derived neural cells and formation of uniform human brain organoids. The resulting vascularized brain organoids exhibit structured organization, reasonable tissue size, in vivo-like neural identity, brain region, layered cortex, and complex vascular networks.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Copper peptide-incorporated 3D-printed silk-based scaffolds promote vascularized bone regeneration

Mingliang Zhou et al.

Summary: The incorporation of copper peptide into silk-based scaffolds promotes M2 macrophage polarization, assisting bone tissue repair, and offers a new approach for bioactive ion-based biomaterial design.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Ophthalmology

Organoids and organ chips in ophthalmology

Navid Manafi et al.

Summary: Recent advances in stem cell-derived, self-organizing, three-dimensional miniature organs, such as organoids and organ chips, have shown potential in simulating the complexity of native organ structure and function. They may enhance our understanding of the physiology of different eye structures, explore unknown aspects of ophthalmic disease pathogenesis, and serve as clinically-relevant tools for evaluating ocular therapeutics.

OCULAR SURFACE (2021)

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Review Biochemistry & Molecular Biology

A Review of the Use of Microparticles for Cartilage Tissue Engineering

Rachel J. Kulchar et al.

Summary: Tissue and organ failure present major concerns worldwide, leading to the emergence of tissue engineering as an alternative approach to organ transplantation. Advancements in microparticle technology have the potential to revolutionize cartilage tissue regeneration through drug delivery, controlled release systems, cell expansion, and scaffold formation. Further research is required to optimize clinical translation of these technologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Multidisciplinary

Nano-imprinted anisotropic structural color graphene films for cardiomyocytes dynamic displaying

Changmin Shao et al.

Summary: This study introduced a novel anisotropic structural color graphene film that can dynamically display cardiomyocyte processes through microgroove and photonic crystal structures, and has potential value in real-time monitoring and drug screening through integration with microfluidic channels.

MATERIALS TODAY (2021)

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Article Biochemical Research Methods

Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip

Linda Gijzen et al.

Summary: The study focuses on establishing tubuloid cultures from tissue and urine, generating three-dimensional tubular structures in a perfused microfluidic multi-chip platform. Advanced in vitro kidney models are crucial for studying renal physiology and diseases, with tubuloids providing a realistic recapitulation of tubular function for various disease studies. Integrating tubuloids into an organ-on-a-chip system allows for a more physiological representation of the kidney tubule, enhancing the complexity of the in vitro model with donor-specific properties.

NATURE PROTOCOLS (2021)

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Review Biotechnology & Applied Microbiology

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

Nathalie Picollet-D'hahan et al.

Summary: Multiorgan-on-a-chip platforms have the potential to redefine human health research by providing comprehensive and personalized models for understanding and treating multisystem diseases. These models offer unique information that is not accessible with single-organ-on-a-chip models, but there are still challenges to overcome in realizing and adopting these platforms worldwide.

TRENDS IN BIOTECHNOLOGY (2021)

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Editorial Material Biotechnology & Applied Microbiology

Human Blood-Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology

Song Ih Ahn et al.

Summary: Advancements in stem cell engineering have facilitated the development of human BBB-on-a-chip technologies, enabling more accurate modeling of the human blood-brain barrier. The use of human brain cells is crucial for better modeling human brain pathophysiology.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

Micro-electrode channel guide (μECG) technology: an online method for continuous electrical recording in a human beating heart-on-chip

Roberta Visone et al.

Summary: Cardiac toxicity is a common adverse outcome in drug development that can lead to withdrawal of drugs from the market. Recent advancements in developing in vitro models resembling the human heart have allowed for more accurate detection of drug-induced cardiac toxicity early in the drug development process. Organs-on-chip are considered promising tools to replicate key aspects of in vivo cardiac physiology and provide a means for direct analysis of functional outputs.

BIOFABRICATION (2021)

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Article Multidisciplinary Sciences

Coculture with hiPS-derived intestinal cells enhanced human hepatocyte functions in a pneumatic-pressure-driven two-organ microphysiological system

Marie Shinohara et al.

Summary: Coculturing normal cells on the multi-organ MPS can effectively evaluate the intestine-liver interactions, enhancing the metabolic activity and gene expression of cells. This research approach helps to understand the physiological mechanisms of inter-organ interactions in vitro and explore the physiological response of new drugs.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Cell and tissue system capable of automated culture, stimulation, and monitor with the aim of feedback control of organs-on-a-chip

Satoshi Konishi et al.

Summary: This paper introduces advances in cell and tissue system automation, with a focus on in situ feedback control of organs-on-a-chip. The system combines automated culture, stimulation, and monitoring to achieve feedback control, with the highlight being the application to lipid droplet size control. The results demonstrate the potential for PC-controllable cell and tissue systems in maintaining desired cellular functions.

SCIENTIFIC REPORTS (2021)

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Review Engineering, Biomedical

2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges

Yuanyuan Zheng et al.

Summary: This review discusses the latest advances in the application of 2D nanomaterials in regenerative medicine, particularly in repairing skin, bone, and cartilage tissues. It also provides reviews on other applications, including cardiac muscle regeneration, skeletal muscle repair, nerve regeneration, etc. The challenges and prospects of using 2D nanomaterials in regenerative medicine are also discussed in the review.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Analytical

Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing

Leslie Donoghue et al.

Summary: This review discusses tissue chips and microphysiological systems, highlighting their basic definitions, major organs/tissues, critical parameters, and microfluidic approaches. It addresses current shortcomings and future directions of these technologies.

MICROMACHINES (2021)

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Article Materials Science, Biomaterials

Collagen I Based Enzymatically Degradable Membranes for Organ-on-a-Chip Barrier Models

Yusuf B. Arik et al.

Summary: This study focuses on a microfluidic device integrated with a vitrified membrane made of collagen-I hydrogel for organ-on-chip applications. The biocompatibility of the membrane was confirmed by growing endothelial cells and retinal pigment epithelium on it, and the effects of biochemical degradation were characterized by changes in permeability and topography. Overall, this research presents a bioresponsive membrane for studying disease-related extracellular matrix remodeling in organ-on-chip devices.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Multidisciplinary Sciences

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Iosif Pediaditakis et al.

Summary: The authors have developed a human brain-chip model using Organs-on-Chips technology, which recapitulates key features of Parkinson's disease. This model could be used to study the dynamics of cell-cell interactions in human synucleinopathies.

NATURE COMMUNICATIONS (2021)

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Article Nanoscience & Nanotechnology

Impact of Lipid/Magnesium Hydroxide Hybrid Nanoparticles on the Stability of Vascular Endothelial Growth Factor-Loaded PLGA Microspheres

Meisam Omidi et al.

Summary: This study characterizes PLGA composite microcarriers for VEGF delivery, utilizing reverse micelle nanoparticles to encapsulate VEGF and MNSs to suppress inflammation from PLGA acidic byproducts. The results show that MNSs can buffer pH values and improve the stability of encapsulated VEGF, reducing initial burst release, making these microcarriers suitable for tissue engineering and therapeutic applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Pharmaceutical electrospinning and 3D printing scaffold design for bone regeneration

Zhen Wang et al.

Summary: Bone regenerative engineering encompasses scaffold design and applications based on electrospinning and 3D bioprinting technologies, aiming to achieve bone tissue regeneration. Electrospun nanofibrous scaffolds and 3D bioprinted scaffolds play crucial roles in bone regeneration, with promising prospects for future development.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Engineering, Biomedical

Engineering Vascularized Organoid-on-a-Chip Models

Venktesh S. Shirure et al.

Summary: The technology of vascularized organoids is rapidly advancing, with the key goal of reproducing specific organ functions and simulating tumor progression. Vascularization is not only a critical component of individual organ function, but also responsible for linking the fate of all organs and their functions.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021 (2021)

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Article Engineering, Biomedical

Engineered cardiac tissue microsphere production through direct differentiation of hydrogel-encapsulated human pluripotent stem cells

Ferdous B. Finklea et al.

Summary: The study demonstrates successful production of functional cardiac tissue microspheres through direct differentiation of hydrogel encapsulated hiPSCs, with high reproducibility and cell viability. These microspheres support efficient cardiac differentiation and have potential applications in biomanufacturing, drug screening, and regenerative therapies.

BIOMATERIALS (2021)

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Article Chemistry, Analytical

Design and Fabrication of Organ-on-Chips: Promises and Challenges

Alireza Tajeddin et al.

Summary: The advancement of miniaturization techniques has had a significant impact on various research fields, including bioengineering. The development of 3D cell culture environments and organ-on-chip technologies has provided new possibilities for cell and tissue culture, disease modeling, and drug discovery. While these technologies offer potential alternatives to traditional methods, they also present challenges that require interdisciplinary studies for further development.

MICROMACHINES (2021)

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Review Chemistry, Analytical

Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions

Sirjana Pun et al.

Summary: Traditional animal experiments have limitations in predicting the effectiveness of drug treatments in the clinic, while OOC technology and bioengineered tissues offer promising alternatives. Recent breakthroughs in stem cell and organoid biology, OOC technology, and 3D bioprinting have significantly improved the design of biomimetic systems for better predictions of human responses to drugs and environmental stimuli.

MICROMACHINES (2021)

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Article Biochemistry & Molecular Biology

Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model

Vivek V. Thacker et al.

Summary: Severe cases of SARS-CoV-2 infection are characterized by hypercoagulopathies and systemic endotheliitis of the lung microvasculature. The viral infection leads to endothelial damage independently of cytokine storm, resulting in a pro-coagulatory microenvironment.

EMBO REPORTS (2021)

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Review Immunology

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction

Fatina Siwczak et al.

Summary: The article discusses the anatomical structure and biological functions of the gut, introduces the method of using organ-on-chip technology for research, and discusses the latest developments and future research directions on intestinal stem cell differentiation, tissue formation, and the interaction of the gut with the microbiota.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction

Luyao Zhu et al.

Summary: Inspired by the microstructures of hepatic lobules, researchers developed a hierarchical hydrogel system for liver cancer-on-a-chip construction and drug screening, achieving precise control of cell spheroid size and adequate nutrient supply. This technology shows great potential in the field of personalized medicine.

RESEARCH (2021)

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Review Chemistry, Physical

Microfluidics on Standard Petri Dishes for Bioscientists

Cyril Deroy et al.

Summary: The article discusses an open microfluidic approach that creates aqueous circuits with almost any 2D shape on standard polystyrene Petri dishes, allowing for easy cell growth and observation. This fluid-shaping technology aims to provide a simple, accessible, and affordable entrance into microfluidics for bioscientists.

SMALL METHODS (2021)

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Article Multidisciplinary Sciences

Reversed-engineered human alveolar lung-on-a-chip model

Di Huang et al.

Summary: This study introduces a physiologically relevant model of human pulmonary alveoli, utilizing a lung-on-a-chip platform with an inverse opal hydrogel structure and primary human alveolar epithelial cells. The integration of cyclic strain allows for biomimetic breathing events and investigation into pathological effects like smoking and SARS-CoV-2 pseudoviral infection. This unique method for reconstituting functional human pulmonary alveoli in vitro has the potential to advance research on physiological and pathological events in the distal lung.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Pharmacology & Pharmacy

Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction

Felipe T. Lee-Montiel et al.

Summary: The study focuses on the integration of hiPSC-based liver and cardiac MPSs to study drug-drug interaction, using cisapride and ketoconazole as an example. The results demonstrate how ketoconazole inhibits the metabolic conversion of cisapride in the liver MPS, leading to arrhythmia in the cardiac MPS, highlighting the potential of this integrated approach for screening drug interactions and assessing drug efficacy and toxicity in the same genetic background.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Nanoscience & Nanotechnology

On-Chip Construction of Liver Lobules with Self-Assembled Perfusable Hepatic Sinusoid Networks

Shengnan Ya et al.

Summary: This study develops a lifelike bionic liver lobule chip with perfusable hepatic sinusoid networks achieved using microflow-guided angiogenesis methodology and regulated oxygen concentration. The design produces more bionic liver microstructures, higher metabolic abilities, and longer lasting hepatocyte function than other liver-on-a-chip techniques. The unique micropillar design and oxygen concentration play key roles in guiding the assembly of hepatic sinusoid and prolonging hepatocyte function, demonstrating a broad range of applications for chronic and acute hepatotoxicity testing and tumor growth replication.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply

Kun Du et al.

Summary: This study develops a biomimetic liver lobule chip and establishes a more accurate on-chip NAFLD model, demonstrating for the first time the changes in lipid zonation in a liver lobule with the progression of NAFLD on a microfluidic chip. The application of the induced NAFLD model has shown promise in the prevention and reversibility of drug treatments, providing a platform for understanding NAFLD progression and identifying potential drug therapies.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Organ-on-a-chip technology for the study of the female reproductive system

Rachel E. Young et al.

Summary: Organs-on-a-chip and microphysiological systems have emerged as disruptive in vitro technologies, offering new capabilities to engineer physiological living tissues and organ units. Recent progress in the development of microengineered female reproductive organ models has relevance to drug delivery and discovery, with applications in the study of pregnancy, infertility, and reproductive diseases.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Microfluidic Platforms for Programming Cell-Based Living Materials

Pengchao Zhang et al.

Summary: Cell-based living materials, including single cells, cell-laden fibers, cell sheets, organoids, and organs, have attracted intensive interests for their broad applications such as cancer therapy, regenerative medicine, and drug development. Recent advances in microfluidic platforms have enabled high-throughput, scalable, and efficient programming of these materials. This review highlights the progress of novel microfluidic platforms in programming cell-based living materials, providing insights into the future development in collaboration between materials scientists, engineers, biologists, and physicians for healthcare applications.

ADVANCED MATERIALS (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Organs-on-chip models for cardiovascular drug development

Wolfram-Hubertus Zimmermann

CARDIOVASCULAR RESEARCH (2021)

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Article Engineering, Environmental

Induced cardiomyocytes-integrated conductive microneedle patch for treating myocardial infarction

Lingyu Sun et al.

Summary: A novel cardiac patch integrating conductive microneedles and iPSC-derived CMs is proposed for MI treatment, featuring anisotropic structure and conductive elements. This patch shows potential as an ideal therapy strategy for cardiac diseases.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Drug Evaluation Based on a Multi-Channel Cell Chip with a Horizontal Co-Culture

Gyeong-Ji Kim et al.

Summary: The study developed a new multi-channel cell chip for horizontal co-culture and drug toxicity screening in multiple organs. Utilizing a 3D scaffold and avoiding the need for pumps or syringes, the chip demonstrated feasibility through experiments with different cell lines.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Engineering, Biomedical

Decellularized kidney extracellular matrix bioinks recapitulate renal 3D microenvironment in vitro

Rita Sobreiro-Almeida et al.

Summary: Decellularized kidney ECM-derived bioink shows great potential for bioprinting renal tissue analogs with high cell viability and structural integrity. The tissue-specific matrix can also influence cellular growth and differentiation over time, demonstrating promising translational applications and implications for bioengineering substitutes using decellularized matrices from other tissues.

BIOFABRICATION (2021)

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Article Engineering, Biomedical

Electrostatic Flocking of Insulative and Biodegradable Polymer Microfibers for Biomedical Applications

Alec McCarthy et al.

Summary: This study introduces a novel method to make electrically insulative polymer microfibers flockable, expanding the application of electrostatic flocking in engineering fields. By incorporating mixed conductive materials and fabricating biphasic, biodegradable scaffolds, antimicrobial activity and favorable in vitro cell response are achieved.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Cell Biology

Modeling alcohol-associated liver disease in a human Liver-Chip

Janna C. Nawroth et al.

Summary: This study utilized a human Liver-Chip to model ALD, successfully recapitulating relevant markers of alcohol-induced liver injury and supporting research on secondary insults. Remodeling of the bile canalicular network provided an in vitro quantitative readout of alcoholic liver toxicity.

CELL REPORTS (2021)

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Article Chemistry, Analytical

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Yasmin Roye et al.

Summary: This study engineered a personalized glomerulus chip system using human induced pluripotent stem cells, successfully mimicking the structure and some functions of the glomerular filtration barrier, and modeling glomerular injury and proteinuria. The research has the potential to advance studies of kidney disease mechanisms and the discovery of personalized therapies, and could serve as a blueprint for the development of more personalized organ chip and 'body-on-a-chip' models in the future.

MICROMACHINES (2021)

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Review Chemistry, Analytical

Physiological and Disease Models of Respiratory System Based on Organ-on-a-Chip Technology

Di Wang et al.

Summary: Microfluidic chip technology provides a platform for better research on respiratory diseases by simulating cell growth space and analyzing specific pathophysiological changes. Organ-on-a-chip enables co-cultivation of multiple cells and control of fluidic conditions, widely used in scientific research.

MICROMACHINES (2021)

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Article Chemistry, Analytical

Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

Yoel Goldstein et al.

Summary: This study introduces two 3D-printing based fabrication methods for a multi-organ-on-a-chip device, aiming to bridge the gap between in vitro models and in vivo conditions. By designing separate compartments for different tissues and integrating individual pairs of inlets and outlets, tissue-specific perfusion rates were achieved, facilitating the generation of tissue-adapted perfusion profiles.

MICROMACHINES (2021)

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Review Biochemistry & Molecular Biology

Gelatin-Polyvinyl Alcohol Film for Tissue Engineering: A Concise Review

Izzat Zulkiflee et al.

Summary: The field of biomaterials is rapidly expanding, with hybrid gelatin-PVA thin film showing promise as an effective tool for treating various biomedical and clinical applications. Research shows that this combination of materials has high potential for use in these areas.

BIOMEDICINES (2021)

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Review Biotechnology & Applied Microbiology

A Review of Biomaterials and Scaffold Fabrication for Organ-on-a-Chip (OOAC) Systems

Luana A. Osorio et al.

Summary: Organ-on-a-Chip (OOAC) systems are engineered microfluidic systems that mimic the physiological environment of specific organs and have the potential to replace animal models. The success of cell cultures within these systems depends on the choice of scaffold, highlighting the critical role of scaffolds in OOAC research.

BIOENGINEERING-BASEL (2021)

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Article Chemistry, Multidisciplinary

Black Phosphorus in Biological Applications: Evolutionary Journey from Monoelemental Materials to Composite Materials

Jiang Ouyang et al.

Summary: Understanding the evolution of monoelemental black phosphorus (BP) into BP-based composites is crucial for expanding its biological applications. Incorporating BP with specific materials to obtain high-performance composite materials is challenging, but promising for broadening its bioapplications.

ACCOUNTS OF MATERIALS RESEARCH (2021)

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Article Materials Science, Multidisciplinary

Multi-compartment Organ-on-a-Chip Based on Electrospun Nanofiber Membrane as In Vitro Jaundice Disease Model

Fan Lei et al.

Summary: Organ-on-a-chip (OOC) is a potential alternative to traditional preclinical animal models, reconstituting specific human tissues/organs in vitro. However, there is a need to explore new biomaterials and fabrication strategies to enable easy expansion from single-organ OOC to multi-organ configurations.

ADVANCED FIBER MATERIALS (2021)

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Article Biochemical Research Methods

Tubular human brain organoids to model microglia-mediated neuroinflammation

Zheng Ao et al.

Summary: The study developed tubular organoid-on-a-chip devices to improve the generation of human brain organoids and model neuroinflammation. This device enables perfusion of nutrients and oxygen to minimize organoid necrosis, incorporates immune cells for modeling neuro-immune interactions, and increases neural progenitor proliferation while reducing organoid heterogeneity. The technology is simple, versatile, inexpensive, easy-to-use, and compatible with multiwell-plates, making it suitable for research and clinical applications in various inflammatory diseases.

LAB ON A CHIP (2021)

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Article Biochemical Research Methods

Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions

Marine Verhulsel et al.

Summary: A new gut on chip model has been developed for co-culture of primary epithelial and stromal cells, mimicking the structure and topography of the mouse gut. The collagen scaffold is rigidified by threose-based post-polymerization treatment to maintain its structure and cytocompatibility. Mouse organoids deposited into crypts are able to epithelialize the scaffold and form a polarized epithelial monolayer, demonstrating proper cell segregation along the crypt-villus axis. Fluid shear stress application allows long-term culture of the intestinal epithelium in this biomimetic tool.

LAB ON A CHIP (2021)

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Article Medicine, Research & Experimental

A SCID mouse-human lung xenograft model of SARS-CoV-2 infection

Wenkun Fu et al.

Summary: This study utilized a humanized mouse model with human lung xenografts to investigate SARS-CoV-2 infection. The results showed that the human lung xenografts closely resembled normal human lung structure, supported efficient replication and spread of SARS-CoV-2, caused severe lung damage, and induced a strong pro-inflammatory response. Treatment with IFN-alpha effectively inhibited viral replication in the lung xenografts. This model proves to be a valuable tool for studying SARS-CoV-2 lung infection pathogenesis and evaluating potential antiviral therapies.

THERANOSTICS (2021)

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Article Engineering, Environmental

3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration

Weiming Chen et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Review Pharmacology & Pharmacy

Silk fibroin for skin injury repair: Where do things stand?

Mazaher Gholipourmalekabadi et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Soft Robotic Caterpillar with Cardiomyocyte Drivers

Lingyu Sun et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Biomimetic Elastomeric Bioactive Siloxane-Based Hybrid Nanofibrous Scaffolds with miRNA Activation: A Joint Physico-Chemical-Biological Strategy for Promoting Bone Regeneration

Meng Yu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Graphene Hybrid Anisotropic Structural Color Film for Cardiomyocytes' Monitoring

Linjie Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies

David Chimene et al.

ADVANCED MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

Paula G. Miller et al.

BIOTECHNOLOGY AND BIOENGINEERING (2020)

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Review Dentistry, Oral Surgery & Medicine

Polymeric scaffolds for dental pulp tissue engineering: A review

Hossein E. Jazayeri et al.

DENTAL MATERIALS (2020)

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Article Engineering, Biomedical

A heart-on-a-chip platform for online monitoring of contractile behavior via digital image processing and piezoelectric sensing technique

Mutsuhito Sakamiya et al.

MEDICAL ENGINEERING & PHYSICS (2020)

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Review Engineering, Biomedical

Progress in 3D bioprinting technology for tissue/organ regenerative engineering

Ishita Matai et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Digital light processing 3D printed silk fibroin hydrogel for cartilage tissue engineering

Heesun Hong et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

Olya Mastikhina et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

SH-SY5Y and LUHMES cells display differential sensitivity to MPP plus , tunicamycin, and epoxomicin in 2D and 3D cell culture

Kristin Robin Ko et al.

BIOTECHNOLOGY PROGRESS (2020)

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Review Biotechnology & Applied Microbiology

Bioengineering strategies for nephrologists: kidney was not built in a day

Anna Julie Peired et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

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Article Medicine, General & Internal

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018

Olivier J. Wouters et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Medicine, Research & Experimental

Tumor microenvironment differences between primary tumor and brain metastases

Bernardo Cacho-Diaz et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

A developmental landscape of 3D-cultured human pre-gastrulation embryos

Lifeng Xiang et al.

NATURE (2020)

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Review Cardiac & Cardiovascular Systems

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

Elaheh Karbassi et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Multidisciplinary Sciences

Bioinspired programmable wettability arrays for droplets manipulation

Lingyu Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell & Tissue Engineering

Global Trends of Organoid and Organ-On-a-Chip in the Past Decade: A Bibliometric and Comparative Study

Zhen Wang et al.

TISSUE ENGINEERING PART A (2020)

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Review Behavioral Sciences

Linking Structure and Function in Macroscale Brain Networks

Laura E. Suarez et al.

TRENDS IN COGNITIVE SCIENCES (2020)

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Article Neurosciences

Optimization of a Method to Isolate and Culture Adult Porcine, Rats and Mice Muller Glia in Order to Study Retinal Diseases

Xandra Pereiro et al.

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Anisotropic structural color particles from colloidal phase separation

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Robotic fluidic coupling and interrogation of multiple vascularized organ chips

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Bioinspired Helical Micromotors as Dynamic Cell Microcarriers

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Fiber Lithography: A Facile Lithography Platform Based on Electromagnetic Phase Modulation Using a Highly Birefringent Electrospun Fiber

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Biomaterials and Culture Systems for Development of Organoid and Organ-on-a-Chip Models

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Thermoresponsive Inverted Colloidal Crystal Hydrogel Scaffolds for Lymphoid Tissue Engineering

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Advanced Biomaterials and Processing Methods for Liver Regeneration: State-of-the-Art and Future Trends

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Repeated dose multi-drug testing using a microfluidic chip-based coculture of human liver and kidney proximal tubules equivalents

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Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

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Programmed axon degeneration: from mouse to mechanism to medicine

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Decellularized Extracellular Matrix-based Bioinks for Engineering Tissue- and Organ-specific Microenvironments

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Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells

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Materials design for bone-tissue engineering

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Composite Hydrogels in Three-Dimensionalin vitroModels

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3D Immunocompetent Organ-on-a-Chip Models

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Toward Brain-on-a-Chip: Human Induced Pluripotent Stem Cell-Derived Guided Neuronal Networks in Tailor-Made 3D Nanoprinted Microscaffolds

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Microfluidic organ-on-a-chip models of human liver tissue

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Printability and Shape Fidelity of Bioinks in 3D Bioprinting

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Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

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Artificial intelligence in drug discovery and development

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Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

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Human intestinal models to study interactions between intestine and microbes

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Jet-Printing Microfluidic Devices on Demand

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Microfluidics for Medical Additive Manufacturing

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Combined Effects of Electric Stimulation and Microgrooves in Cardiac Tissue-on-a-Chip for Drug Screening

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Development of a pancreas-liver organ-on-chip coculture model for organ-to-organ interaction studies

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Biodegradable poly (lactic acid-co-trimethylene carbonate)/chitosan microsphere scaffold with shape-memory effect for bone tissue engineering

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A simple three-dimensional gut model constructed in a restricted ductal microspace induces intestinal epithelial cell integrity and facilitates absorption assays

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A miniaturized hydrogel-based in vitro model for dynamic culturing of human cells overexpressing beta-amyloid precursor protein

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Emerging aqueous two-phase systems: from fundamentals of interfaces to biomedical applications

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Cigarette smoke-induced malignant transformation via STAT3 signalling in pulmonary epithelial cells in a lung-on-a-chip model

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Microphysiological heart-liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery

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Tomorrow today: organ-on-a-chip advances towards clinically relevant pharmaceutical and medical in vitro models

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Flow-enhanced vascularization and maturation of kidney organoids in vitro

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A Photo-Crosslinkable Kidney ECM-Derived Bioink Accelerates Renal Tissue Formation

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Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells

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Brain-on-a-chip: A history of development and future perspective

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Nanogroove-Enhanced Hydrogel Scaffolds for 3D Neuronal Cell Culture: An Easy Access Brain-on-Chip Model

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A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

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An isogenic hiPSC-derived BBB-on-a-chip

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Cardiomyocyte-Driven Structural Color Actuation in Anisotropic Inverse Opals

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Engineered Liver-On-A-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

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Vascularized 3D printed scaffolds for promoting bone regeneration

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Responsive Inverse Opal Scaffolds with Biomimetic Enrichment Capability for Cell Culture

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Animal Models in the Pathophysiology of Cystic Fibrosis

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Autologous induced pluripotent stem cell-derived four-organ-chip

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Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips

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A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography

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Design and Structure-Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering

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Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage

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Hydroxyapatite nanobelt/polylactic acid Janus membrane with osteoinduction/barrier dual functions for precise bone defect repair

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Three-dimensional electrical conductive scaffold from biomaterial-based carbon microfiber sponge with bioinspired coating for cell proliferation and differentiation

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A Three-Dimensional Arrayed Microfluidic Blood-Brain Barrier Model With Integrated Electrical Sensor Array

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Biomimetic Layer-by-Layer Self-Assembly of Nanofilms, Nanocoatings, and 3D Scaffolds for Tissue Engineering

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Silk fibroin/chitosan thin film promotes osteogenic and adipogenic differentiation of rat bone marrow-derived mesenchymal stem cells

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Environmental pollution and kidney diseases

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Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system

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Quantum-dot-encapsulated core-shell barcode particles from droplet microfluidics

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Self-Assembled Multimeric-Enzyme Nanoreactor for Robust and Efficient Biocatalysis

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Self-Assembled Multimeric-Enzyme Nanoreactor for Robust and Efficient Biocatalysis

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Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature

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Macroporous nanofibrous vascular scaffold with improved biodegradability and smooth muscle cells infiltration prepared by dual phase separation technique

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Design of capillary microfluidics for spinning cell-laden microfibers

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Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

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Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications

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Bottom-up biofabrication using microfluidic techniques

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Bioinspired living structural color hydrogels

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The blood-brain barrier in psychosis

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Raloxifene microsphere-embedded collagen/chitosan/β-tricalcium phosphate scaffold for effective bone tissue engineering

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Development of a novel alginate-polyvinyl alcohol-hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds

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A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

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Assessment of the toxicity and inflammatory effects of different-sized zinc oxide nanoparticles in 2D and 3D cell cultures

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Microfluidic generation of egg-derived protein microcarriers for 3D cell culture and drug delivery

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Microfluidic generation of Buddha beads-like microcarriers for cell culture

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Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

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Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

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Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures

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Emerging Droplet Microfluidics

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Organ-on-a-chip for assessing environmental toxicants

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Interwoven Aligned Conductive Nanofiber Yarn/Hydrogel Composite Scaffolds for Engineered 3D Cardiac Anisotropy

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Organoid and Organ-on-a-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease

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Bioinspired Helical Microfibers from Microfluidics

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Controlled Fabrication of Bioactive Microfibers for Creating Tissue Constructs Using Microfluidic Techniques

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Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

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Heart-on-a-chip based on stem cell biology

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Kidney bioengineering in regenerative medicine: An emerging therapy for kidney disease

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Droplet microfluidics for microbiology: techniques, applications and challenges

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Engineering a Brain Cancer Chip for High-throughput Drug Screening

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Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

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Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

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A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

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Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

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In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier

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Matrigel: From discovery and ECM mimicry to assays and models for cancer research

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Bioinspired Multicompartmental Microfibers from Microfluidics

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Droplet Microfluidics-A Tool for Single-Cell Analysis

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Truncations of Titin Causing Dilated Cardiomyopathy

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Microsphere-based scaffolds for cartilage tissue engineering: Using subcritical CO2 as a sintering agent

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Microfluidic synthesis of pure chitosan microfibers for bio-artificial liver chip

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Reconstituting Organ-Level Lung Functions on a Chip

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The use of chondrogenic differentiation drugs to induce stem cell differentiation using double bead microsphere structure

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Axonal outgrowth on nano-imprinted patterns

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Extracellular proteases of Acanthamoeba castellanii (encephalitis isolate belonging to T1 genotype) contribute to increased permeability in an in vitro model of the human blood-brain barrier

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