Biophysical reviews top five: voltage-dependent charge movement in nerve and muscle

The discovery of gating currents and asymmetric charge movement in the early 1970s represented a remarkable leap forward in our understanding of the biophysical basis of voltage-dependent events that underlie electrical signalling that is vital for nerve and muscle function. Gating currents and charge movement reflect a fundamental process in which charged amino acid residues in an ion channel protein move in response to a change in the membrane electrical field and therefore activate the specific voltage-dependent response of that protein. The detection of gating currents and asymmetric charge movement over the past 50 years has been pivotal in unraveling the multiple molecular and intra-molecular processes which lead to action potentials in excitable tissues and excitation-contraction (EC) coupling in skeletal muscle. The recording of gating currents and asymmetric charge movement remains an essential component of investigations into the basic molecular mechanisms of neuronal conduction and muscle contraction.

Automated summary

The discovery of gating currents and asymmetric charge movement in the early 1970s has greatly advanced our understanding of the biophysical basis of voltage-dependent events in nerve and muscle function. The detection of these currents and charge movement has been crucial in unraveling the molecular and intra-molecular processes underlying action potentials and excitation-contraction coupling in excitable tissues.