Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy

Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state (PLQYs = 4.92%). DTPABT-MC-R-based nanoparticles also display excellent photo-stability, and impressive photosensitive characteristics (ROS efficiency = 10.74%), finally leading to applications in cellular imaging and photodynamic therapy (PDT). Multifunctional metallacycles with solid-state emission are highly important in cancer therapy.

Automated summary

Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state. DTPABT-MC-R-based nanoparticles also display excellent photo-stability, and impressive photosensitive characteristics, finally leading to applications in cellular imaging and photodynamic therapy (PDT).