Related references
Note: Only part of the references are listed.Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers
Mason W. Freeman et al.
HYPERTENSION RESEARCH (2023)
HIGHLY EFFECTIVE BLOOD PRESSURE LOWERING WITH MLS-101, A NEW ALDOSTERONE SYNTHASE INHIBITOR, IN INDIVIDUALS WITH OBESITY AND RAAS DYSREGULATION
David Rodman et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)
Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension The Target-HTN Randomized Clinical Trial
Luke J. Laffin et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)
Parallel targeted and non-targeted quantitative analysis of steroids in human serum and peritoneal fluid by liquid chromatography high-resolution mass spectrometry
Thomas Andrieu et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)
Randomized Trial of Osilodrostat for the Treatment of Cushing Disease
Monica Gadelha et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)
Origin of circulating 18-oxocortisol in the normal human adrenal
Celso E. Gomez-Sanchez et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2022)
Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone
Michael J. Reddish et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors
Steven M. Sparks et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design
Simone Brixius-Anderko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
A steady state system for in vitro evaluation of steroidogenic pathway dynamics: Application for CYP11B1, CYP11B2 and CYP17 inhibitors
Anastasios Mangelis et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)
A comprehensive urinary steroid analysis strategy using two-dimensional gas chromatography - time of flight mass spectrometry
Andrea Bileck et al.
ANALYST (2018)
LY3045697: Results from two randomized clinical trials of a novel inhibitor of aldosterone synthase
Joanne Sloan-Lancaster et al.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2017)
Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition
Natallia Strushkevich et al.
MOLECULAR ENDOCRINOLOGY (2013)
Novel Aromatase Inhibitors by Structure-Guided Design
Debashis Ghosh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Acute and chronic regulation of aldosterone production
Namita G. Hattangady et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Walter L. Miller et al.
ENDOCRINE REVIEWS (2011)
Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
Paul C. D. Hawkins et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)