4.4 Article

Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life

Related references

Note: Only part of the references are listed.
Review Neurosciences

Immunological Markers for Central Nervous System Glia

Hao Huang et al.

Summary: Glial cells in the CNS, including oligodendrocytes, astrocytes, and microglia, are vital for neural development and functioning. Proper use of cell- or stage-specific molecular markers is crucial for studying their fate specification, differentiation, and functional diversification. This article provides an updated overview of immunological markers for labeling central glia and discusses their cell-type specificity and stage dependency.

NEUROSCIENCE BULLETIN (2023)

Review Biochemistry & Molecular Biology

Caspase-3: Structure, function, and biotechnological aspects

Marzieh Asadi et al.

Summary: Caspase-3, a crucial enzyme in cell apoptosis, has shown promising therapeutic potentials in treating diseases like cancer, heart failure, and neurodegenerative disorders. Its biotechnological aspects, such as production of recombinant enzymes and protein engineering, are increasingly considered as emerging therapeutic strategies.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

Review Anatomy & Morphology

Apoptosis and its therapeutic implications in neurodegenerative diseases

Nour S. Erekat

Summary: Neurodegenerative disorders involve the progressive loss of specific populations of neurons, with apoptosis playing a role in diseases such as Parkinson's, Alzheimer's, Huntington's, and ALS. This review examines the morphological features, mediators, and regulators of cellular apoptosis, highlighting evidence of neuronal apoptotic death in these diseases. The potential for therapeutic agents to modify the apoptotic pathway and delay disease progression is also discussed.

CLINICAL ANATOMY (2022)

Article Mathematical & Computational Biology

Triad1 Promotes the Inflammatory Response and Neuronal Apoptosis to Aggravate Acute Spinal Cord Injury in Rats

Xiang Shen et al.

Summary: The study shows that knockdown of Triad1 improves inflammatory response and apoptosis in rats with acute SCI, thus reducing the severity of SCI.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2022)

Article Clinical Neurology

Neuroprotective Effects of Dexpanthenol on Rabbit Spinal Cord Ischemia/Reperfusion Injury Model

Ahmet Gulmez et al.

Summary: This study demonstrated the antioxidative, anti-inflammatory, antiapoptotic, and neuroprotective effects of Dexpanthenol on spinal cord ischemia/reperfusion injury in rabbits. Dexpanthenol treatment was associated with lower oxidative stress levels and improved neurological outcomes, indicating its potential as a new approach for SCIRI treatment.

WORLD NEUROSURGERY (2022)

Article Biochemistry & Molecular Biology

The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis

Masato Mashimo et al.

Summary: PARP1 is a nuclear protein that plays a role in DNA repair, but can also induce cell death when excessive DNA damage occurs. During cell death, PARP1 can be cleaved into 24kDa and 89kDa fragments, each with different localization and functions in the cell.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Clinical Neurology

Regulatory effect of neuroglobin in the recovery of spinal cord injury

Ji-Lin Dai et al.

JOURNAL OF SPINAL CORD MEDICINE (2019)

Review Cell Biology

Flipping the dogma - phosphatidylserine in non-apoptotic cell death

Inbar Shlomovitz et al.

CELL COMMUNICATION AND SIGNALING (2019)

Review Biochemistry & Molecular Biology

Caspases in metabolic disease and their therapeutic potential

Claire H. Wilson et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Neurosciences

High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes

Stephan J. Guyenet et al.

BRAIN RESEARCH (2013)

Review Biochemistry & Molecular Biology

Inhibitors of Apoptotic Proteins: New Targets for Anticancer Therapy

Mohammad Saleem et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2013)

Article Neurosciences

Adenomatous Polyposis Coli Regulates Oligodendroglial Development

Jordan Lang et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Neurosciences

Caspase activation contributes to astrogliosis

Radha Aras et al.

BRAIN RESEARCH (2012)

Article Biochemistry & Molecular Biology

Quantification of Gene Expression after Painful Nerve Injury: Validation of Optimal Reference Genes

Madhavi Latha Yadav Bangaru et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2012)

Review Biochemistry & Molecular Biology

Neuronal caspase-3 signaling: not only cell death

M. D'Amelio et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Multidisciplinary Sciences

AIF: Not Just an Apoptosis-Inducing Factor

Nicholas Joza et al.

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS (2009)

Article Cell & Tissue Engineering

Caspase activity mediates the differentiation of embryonic stem cells

Jun Fujita et al.

CELL STEM CELL (2008)

Article Biotechnology & Applied Microbiology

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman et al.

NATURE BIOTECHNOLOGY (2008)

Article Multidisciplinary Sciences

Executioner caspase-3 and caspase-7 are functionally distinct proteases

John G. Walsh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

Morphological and cytochemical determination of cell death by apoptosis

Douglas J. Taatjes et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

Article Neurosciences

Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia-induced apoptosis

Albert Cheung Hoi Yu et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2007)

Article Cell Biology

Active caspase-3 is required for osteoclast differentiation

K. H. Szymczyk et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2006)

Article Neurosciences

Bergmann glia utilize active caspase-3 for differentiation

S Oomman et al.

BRAIN RESEARCH (2006)

Article Multidisciplinary Sciences

Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis

SA Lakhani et al.

SCIENCE (2006)

Article Neurosciences

Caspase-like activity is essential for long-term synaptic plasticity in the terrestrial snail Helix

NI Bravarenko et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Neural stem cell differentiation is dependent upon endogenous caspase-3 activity

P Fernando et al.

FASEB JOURNAL (2005)

Article Medicine, Research & Experimental

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

M Miura et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Physiology

Morphological features of cell death

U Ziegler et al.

NEWS IN PHYSIOLOGICAL SCIENCES (2004)

Review Neurosciences

Caspase activity is essential for long-term potentiation

NV Gulyaeva et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

Review Biochemistry & Molecular Biology

Many cuts to ruin: a comprehensive update of caspase substrates

U Fischer et al.

CELL DEATH AND DIFFERENTIATION (2003)

Article Multidisciplinary Sciences

Caspase 3 activity is required for skeletal muscle differentiation

P Fernando et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Critical Care Medicine

IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury

O Nesic et al.

JOURNAL OF NEUROTRAUMA (2001)

Article Multidisciplinary Sciences

Endonuclease G is an apoptotic DNase when released from mitochondria

LY Li et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms

CA Belmokhtar et al.

ONCOGENE (2001)

Article Biochemistry & Molecular Biology

Structural basis for the inhibition of caspase-3 by XIAP

SJ Riedl et al.

Article Biochemistry & Molecular Biology

An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7

S Shin et al.

BIOCHEMISTRY (2001)

Review Multidisciplinary Sciences

Apoptosis in the nervous system

JY Yuan et al.

NATURE (2000)

Article Clinical Neurology

Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies

JP Rossiter et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2000)