Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease

Article Immunology

Identification of Distinct Immune Cell Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 Patients

Xiaorui Wang et al.

Summary: This study identified distinct cell subsets associated with different clinical presentations of COVID-19, providing insights into the immunopathogenesis of the disease. Classical monocytes and pDC were found to be correlated with disease severity and viral persistence.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

David J. Ahern et al.

Summary: The study presents a comprehensive blood atlas for patients with varying severity of COVID-19, compared to influenza, sepsis patients, and healthy volunteers. The results identify immune signatures and correlates of host response, including cells, inflammatory mediators, immune repertoire, and metabolic and coagulation features. The study also reveals that persistent immune activation is a specific feature of COVID-19. Plasma proteomic analysis enables sub-phenotyping and prediction of severity and outcome. Integrative analyses show feature groupings linked with severity and specificity compared to influenza and sepsis.

CELL (2022)

Add to Collection

Review Immunology

Monocytes and Macrophages in COVID-19

Rainer Knoll et al.

Summary: COVID-19 is a contagious viral disease caused by SARS-CoV-2, characterized primarily by respiratory symptoms of varying severity. Macrophages play crucial roles in host defense, and understanding their phenotypes is essential for unraveling the disease's pathological mechanisms.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Cell Biology

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

Martina Rossi et al.

Summary: Senetherapeutics are emerging to suppress the detrimental effects of senescence by targeting either senomorphics or senolytics. The main goal is to suppress the proinflammatory senescence-associated secretory phenotype and promote immune recognition and elimination of senescent cells. One attractive approach is targeting specific molecules or proteins on the surface of senescent cells for senolysis.

CELLS (2021)

Add to Collection

Editorial Material Multidisciplinary Sciences