Pd(ii)-Catalyzed atroposelective C-H olefination: synthesis of enantioenriched N-aryl peptoid atropisomers

Herein, we reported the synthesis of enantioenriched N-aryl peptoid atropisomers via Pd(ii)-catalyzed atroposelective C-H olefination using the easily accessible l-pyroglutamic acid (l-pGlu-OH) as the chiral ligand. A series of optically active N-aryl peptoid atropisomers were obtained in synthetically useful yields with high enantioselectivities.

Automated summary

In this study, enantioenriched N-aryl peptoid atropisomers were synthesized via Pd(ii)-catalyzed atroposelective C-H olefination using easily accessible l-pyroglutamic acid as the chiral ligand. The obtained optically active N-aryl peptoid atropisomers exhibited high enantioselectivities and useful yields.