Piceatannol alleviates liver ischaemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 in hepatic macrophages

Article Gastroenterology & Hepatology

Apolipoprotein A-1 protected hepatic ischaemia-reperfusion injury through suppressing macrophage pyroptosis via TLR4-NF-κB pathway

Rui-Xiang Chen et al.

Summary: This study identified the protective role of ApoA-1 in hepatic I/R injury by inhibiting pyroptosis in macrophages via the TLR4-NF-kappaB pathway. ApoA-1 may offer a novel therapeutic approach for hepatic I/R injury.

LIVER INTERNATIONAL (2023)

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Article Gastroenterology & Hepatology

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Naroa Goikoetxea-Usandizaga et al.

Summary: Boosting mitochondrial activity by silencing MCJ could be a protective approach, especially in metabolically compromised organs susceptible to IRI, promoting liver regeneration and reducing cell death.

HEPATOLOGY (2022)

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Article Critical Care Medicine

Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury

Konrad Peukert et al.

Summary: The study found that tetracycline may be effective in treating direct ARDS patients by reducing lung injury and inflammation through inhibiting the production of IL-1β and IL-18, thereby improving survival rates.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

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Review Immunology

An update on the regulatory mechanisms of NLRP3 inflammasome activation

Seungwha Paik et al.

Summary: This review article discusses the molecular details of NLRP3 inflammasome activation, focusing on priming/licensing and assembly steps, as well as protein-protein interactions, posttranslational modifications, and spatiotemporal regulation of the NLRP3 inflammasome machinery. Multiple positive and/or negative regulatory pathways providing upstream signals for NLRP3 inflammasome complex assembly are also summarized, with the ultimate goal of developing methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia et al.

Summary: Inflammasomes activate caspase-1 to cleave GSDMD and generate mature cytokines like IL-1 beta and IL-18, which are released through pores formed by GSDMD. The GSDMD pore mediates IL-1 release by electrostatic filtering, favoring the passage of mature cytokines over their precursors.

NATURE (2021)

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Article Cell Biology

SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization

Longcheng Shang et al.

Summary: The study discovered that SS-31 can effectively alleviate liver ischemia-reperfusion injury by scavenging reactive oxygen species and regulating macrophage polarization. The protective effects of SS-31 against hepatic IRI suggest it may be a suitable treatment in clinical settings.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Correction Biochemistry & Molecular Biology

Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice (vol 12, pg 11229, 2021)

Wei-Lun Hung et al.

FOOD & FUNCTION (2021)

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Article Critical Care Medicine

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Yang Jiao et al.

Summary: The study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-kappa B signaling. These findings suggest a novel mechanism of PMN-M phi interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.

CRITICAL CARE (2021)

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Review Immunology