4.7 Review

Construction and application of adenoviral vectors

Related references

Note: Only part of the references are listed.
Article Immunology

Developing a multiepitope vaccine for the prevention of SARS-CoV-2 and monkeypox virus co-infection: A reverse vaccinology analysis

Fan Jiang et al.

Summary: The researchers have developed a new multiepitope vaccine, S7M8, which can prevent infections of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and monkeypox virus (MPXV). The vaccine has good antigenicity, immunogenicity, and non-toxicity, and can activate the production of high levels of Th1 cytokines and antibodies.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

Editorial Material Urology & Nephrology

Adenovirus in a Kidney Transplant Recipient

Erik L. Lum et al.

KIDNEY MEDICINE (2023)

Review Infectious Diseases

Human adenovirus lung disease: outbreaks, models of immune-response-driven acute lung injury and pandemic potential

Jay R. Radke et al.

Summary: The purpose of this review is to provide an overview of epidemic human adenovirus lung infections and propose studies on the viral/host immune response interface for better understanding of immunopathogenesis mechanisms and development of improved responses to potential HAdV pandemics.

CURRENT OPINION IN INFECTIOUS DISEASES (2023)

Article Immunology

Risk assessment of retinal vascular occlusion after COVID-19 vaccination

Jing-Xing Li et al.

Summary: COVID-19 vaccines are associated with a higher risk of retinal vascular occlusion, according to a large multicenter study. The risk is increased immediately after vaccination and persists for 12 weeks. Both the BNT162b2 and mRNA-1273 vaccines are associated with this risk.

NPJ VACCINES (2023)

Article Immunology

Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs

Eleni Vatzia et al.

Summary: The study found that immunization with chimpanzee adenovirus and modified vaccinia Ankara vaccines expressing conserved influenza virus proteins can provide enhanced immune responses against H3N2 influenza and reduce viral shedding and lung pathology. The results are significant for the development of a broadly protective influenza vaccine and will contribute to future vaccine and clinical trial design.

NPJ VACCINES (2023)

Article Veterinary Sciences

Molecular epidemiology analysis of fowl adenovirus detected from apparently healthy birds in eastern China

Qingye Zhuang et al.

Summary: A survey in eastern China found that Fowl adenovirus is circulating in a variety of fowl species in living bird markets. Out of 1920 clinical samples, 8.65% tested positive for Fowl adenovirus, with all 12 serotypes detected. Phylogenetic analysis revealed the presence of 5 new Fowl adenovirus species.

BMC VETERINARY RESEARCH (2023)

Review Biochemistry & Molecular Biology

Oncolytic virotherapy: basic principles, recent advances and future directions

Danni Lin et al.

Summary: Oncolytic viruses (OVs) have gained attention for their potential in inducing direct tumor cell lysis and cancer immune effects. Recent studies have demonstrated promising clinical outcomes and advances in modifying OVs to enhance their targeting and therapeutic efficacy. Combination therapies with other agents have also shown encouraging antitumor effects.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Review Medicine, Research & Experimental

COVID-19 Vaccines: Adenoviral Vectors

Catherine Jacob-Dolan et al.

Summary: This review evaluates the use of adenovirus vector platforms in response to the COVID-19 pandemic. Ad vectors have been used in the past for vaccines against other viruses, but never on such a large scale. Several different serotypes of Ad encoding SARS-CoV-2 Spike have been tested and found to be effective against COVID-19. As vaccine rollouts continue, we will continue to learn about this vaccine platform.

ANNUAL REVIEW OF MEDICINE (2022)

Article Medicine, General & Internal

What Is Cystic Fibrosis?

Tori M. Endres et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Virology

Human Papillomavirus E6/E7 oncogene transcripts as biomarkers for the early detection of cervical cancer

Sadhana M. Gupta et al.

Summary: This study aimed to evaluate HPV E6/E7 oncogene expression as markers for early identification of cervical cancer risk in women with minor cytological abnormalities and negative cytology. The results showed that E6 and E7 transcripts could serve as sensitive early predictors of cervical cancer risk.

JOURNAL OF MEDICAL VIROLOGY (2022)

Article Oncology

A novel oncolytic virus induces a regional cytokine storm and safely eliminates malignant ascites of colon cancer

Shuang Dong et al.

Summary: The study focused on oncolytic virotherapy for malignant ascites and found that OH2 could safely eliminate ascites and significantly prolong the survival of mice with colon cancer. Treatment with OH2 caused a regional cytokine storm, increased secretion of the pro-inflammatory cytokine IL-6, and enhanced infiltration of CD4+ and CD8+ T cells. Blocking of the IL-6 pathway could suppress the antitumor immune responses driven by OH2. Additionally, single-cell RNA sequencing revealed upregulation of immune checkpoint genes.

CANCER MEDICINE (2022)

Article Oncology

Intravesical immunotherapy with a GM-CSF armed oncolytic vesicular stomatitis virus improves outcome in bladder cancer

Coby Rangsitratkul et al.

Summary: A significant proportion of non-muscle invasive bladder cancer cases will progress to muscle invasive disease. Currently, there are no effective treatments for Bacillus Calmette Guerin refractory disease. New research shows that a novel oncolytic vesicular stomatitis virus containing the human GM-CSF transgene could be a promising viro/immunotherapy for aggressive bladder cancer, enhancing release of danger signals and immunogenic factors and improving anti-tumor immunity.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Article Multidisciplinary Sciences

Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus

Ryosuke Ono et al.

Summary: This study examined the impact of anti-Ad5 neutralizing antibodies on the anticancer effects and transgene expression mediated by OAd5. The results showed that high titers of anti-Ad5 neutralizing antibodies attenuated the transgene expression and potential antitumor effects of OAd5.

SCIENTIFIC REPORTS (2022)

Article Immunology

Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy

John C. Flickinger et al.

Summary: Strategies to enhance immunity to self/neoantigens expressed by cancers are urgently needed. This study explored a prime-boost strategy combining a chimeric adenoviral vector and recombinant Listeria monocytogenes to amplify GI cancer antigen GUCY2C-specific immunity. The combination enhanced the efficacy of effector CD8(+) T cells without toxicity and resistance to pre-existing immunity.

NPJ VACCINES (2022)

Review Microbiology

Viral Vector Vaccine Development and Application during the COVID-19 Pandemic

Shaofeng Deng et al.

Summary: Viral vector vaccines have played an important role in combating the COVID-19 pandemic and have unique advantages compared to other vaccine platforms. The development of intranasal viral vector vaccines has become more urgent with the emergence of the Omicron variant.

MICROORGANISMS (2022)

Article Infectious Diseases

Safety and immunogenicity of a simian-adenovirus-vectored rabies vaccine: an open-label, non-randomised, dose-escalation, first-in-human, single-centre, phase 1 clinical trial

Daniel Jenkin et al.

Summary: This study evaluated the safety and immunogenicity of a novel simian adenovirus-vectored rabies vaccine in healthy adults. The results showed that the vaccine had an acceptable safety profile and induced antibody response, supporting further clinical evaluation.

LANCET MICROBE (2022)

Article Hematology

Adenovirus disease after hematopoietic cell transplantation: A Japanese transplant registry analysis

Yoshihiro Inamoto et al.

Summary: This study analyzed a Japanese registry database to investigate the incidence, risk factors, and outcomes of adenovirus (AdV) disease after autologous and allogeneic hematopoietic cell transplantation (HCT). The study found that the incidence of AdV disease was higher in adults compared to children, and higher in allogeneic HCT compared to autologous HCT. Renourinary infection was the most common manifestation of AdV disease, and viremia or disseminated disease occurred more frequently in allogeneic HCT. Age, gender, and lymphoma were associated with AdV disease after HCT. The study also found an increased risk of mortality after both autologous and allogeneic HCT regardless of the AdV disease burden. Currently available antiviral agents showed suboptimal improvement and survival rates. Better antiviral modalities are needed to address the challenge of AdV disease after HCT.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Review Biochemistry & Molecular Biology

Heparan Sulfate and Sialic Acid in Viral Attachment: Two Sides of the Same Coin?

Ivan Emmanuel Ramos-Martinez et al.

Summary: This article introduces the role of glycoconjugates in viral entry and discusses therapeutic strategies focused on inhibiting the interaction between viruses and glycoconjugates. It also emphasizes the importance of jointly evaluating and designing strategies to inhibit the interactions of both heparan sulfates and sialic acids, and expresses the expectation for a deeper understanding of interspecies transmission.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Medicine, General & Internal

Covid-19 Vaccines - Immunity, Variants, Boosters

Dan H. Barouch

Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Immunology

Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer

Mathieu J. F. Crupi et al.

Summary: This study proposes a novel combination strategy for the treatment of colorectal cancers using oncolytic vaccinia virus to enhance immune-payload delivery and boost T cell responses within tumors. TCEs targeting CEACAM5 and CD3 stimulate robust activation of CD4 and CD8-positive T cells in in vitro co-culture models with colorectal cancer cells, and lead to regression of colorectal tumors in syngeneic and xenograft mouse models.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy

Xiaofei Li et al.

Summary: In this study, a recombinant oncolytic adenovirus encoding CXCL10 was successfully constructed to recruit more T cells in the tumor microenvironment and enhance the antitumor effect of anti-PD-1 therapy.

ONCOIMMUNOLOGY (2022)

Article Microbiology

Study on the Canine Adenovirus Type 1 (CAdV-1) Infection in Domestic Dogs in Southern Italy

Francesco Mira et al.

Summary: A study conducted in southern Italy analyzed samples collected from dogs suspected of infectious gastrointestinal disease. Canine adenovirus type 1 (CAdV-1) was detected in dead stray dogs, either alone or in mixed infections with other viruses, and was found to involve the central nervous system tissues. Sequence analysis revealed genetic heterogeneity of CAdV-1 in Italy and a closer relation to older strains collected from other countries. These findings provide important insights into the epidemiology and evolution of CAdV-1 genomic variants.

PATHOGENS (2022)

Review Biochemical Research Methods

Adenovirus vector system: construction, history and therapeutic applications

Anum Syyam et al.

Summary: The article introduces the use of adenovirus as vectors in gene therapy, vaccine development, and delivery of the CRISPR-Cas9 system, as well as various modifications introduced to enhance the efficacy of AdV vectors for genome editing and cancer therapy.

BIOTECHNIQUES (2022)

Review Biochemistry & Molecular Biology

Engineering strategies to enhance oncolytic viruses in cancer immunotherapy

Yaomei Tian et al.

Summary: Oncolytic viruses (OVs) are a potentially useful treatment method for tumors, as they can selectively kill tumor cells without harming healthy cells and enhance antitumor immunity through inducing innate and adaptive immune responses. Genetic engineering of OVs to express immune regulators, as well as their combination with other immunotherapies, has shown promising progress in cancer treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Biotechnology & Applied Microbiology

Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes

Sadia Zafar et al.

Summary: The chimeric Ad5/3 adenovirus can reach non-injected tumors in the presence of neutralizing antibodies by reversibly binding to lymphocytes and erythrocytes, demonstrating good oncolytic efficacy.

CANCER GENE THERAPY (2021)

Article Biochemistry & Molecular Biology

Adenovirus Vectors Expressing Eight Multiplex Guide RNAs of CRISPR/Cas9 Efficiently Disrupted Diverse Hepatitis B Virus Gene Derived from Heterogeneous Patient

Yuya Kato et al.

Summary: Hepatitis B virus infects over 240 million people globally, leading to chronic diseases such as cirrhosis and liver cancer. The diversity of HBV genome sequences poses a challenge in developing genome editing therapies. An adenovirus vector carrying multiple gRNA expression units offers a potential solution to target diverse HBV genomes for effective editing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Oncolytic Adenoviruses for Cancer Therapy

Lorella Tripodi et al.

Summary: Oncolytic adenoviruses (Onc.Ads) play an interesting role in immunotherapy due to their tumor selectivity, safety, and transgene-delivery capability. Their exceptional immunogenicity leads to a strong T-cell response, potentially making them more effective than current strategies. Various strategies can enhance Onc.Ads' antitumoral efficacy, including tumor microenvironment modulation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Critical Care Medicine

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Joseph P. Lynch et al.

Summary: Adenoviruses typically cause mild infections but can lead to severe complications in patients with compromised immune systems. Epidemics often occur in closed or crowded settings, with different virus types displaying varying tissue tropisms and transmission patterns. Treatment with antiviral drugs such as cidofovir may be necessary for severe cases, but live oral vaccines are effective in preventing respiratory AdV infections.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Review Virology

Adenovirus Core Proteins: Structure and Function

Shermila Kulanayake et al.

Summary: Adenoviruses have been used as a model for investigating viral-cell interactions and discovering cellular processes, as well as for the development of viral vectors for vaccination and gene therapy. There has been increased interest in elucidating the structure and function of adenovirus core proteins in recent years.

VIRUSES-BASEL (2021)

Article Microbiology

The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and-3 infection

Manuela Bieri et al.

Summary: This study identified alpha v beta 6/alpha v beta 8 integrins as receptors for M1 and M3 fiber knobs in mouse adenovirus infections. The findings have implications for understanding viral pathogenesis and developing therapeutic adenoviral vectors in autologous model systems.

PLOS PATHOGENS (2021)

Review Oncology

Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy

Masmudur M. Rahman et al.

Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.

CANCERS (2021)

Review Medicine, Research & Experimental

Therapeutic potential of interleukin-15 in cancer (Review)

Gheorghita Isvoranu et al.

Summary: IL-15 is a promising candidate for cancer immunotherapy, as it enhances antitumor responses by promoting the activation of T cells, B cells, and NK cells.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Review Oncology

The Mechanisms of HBV-Induced Hepatocellular Carcinoma

Yu Jiang et al.

Summary: Hepatocellular carcinoma (HCC) is a common malignancy in which hepatitis B virus (HBV) plays a major role in promoting disease progression and malignant transformation of liver cells. Research on HBV-associated HCC (HBV-HCC) has identified various mechanisms, including HBV gene integration, genomic instability, and activation of cancer-promoting signaling pathways. As research progresses, new mechanisms such as epigenetics, exosomes, autophagy, metabolic regulation, and immune suppression are also being explored for their roles in the occurrence and development of HBV-HCC.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

Article Biotechnology & Applied Microbiology

Fiber modifications enable fowl adenovirus 4 vectors to transduce human cells

Wenfeng Zhang et al.

Summary: By modifying the fibers of FAdV-4 vectors, the gene transduction efficiency to human cells can be significantly enhanced. Specifically, inserting exogenous peptides into the fiber knob proteins can promote the transduction of the vectors to different types of human cells.

JOURNAL OF GENE MEDICINE (2021)

Article Oncology

Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing

Tomoyoshi Inoue et al.

Summary: This study compared the antitumor activity of five vaccinia virus variants in mice with pancreatic neuroendocrine tumors and found that virus VV-A34/IL2v exhibited significantly greater antitumor activity. Viral expression of GM-CSF or IL2v combined with additional genetic modifications similarly increased antitumor activity.

MOLECULAR CANCER THERAPEUTICS (2021)

Review Virology

Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector-Host Interactions

Denice Weklak et al.

Summary: Adenovirus-based vectors are important for combating COVID-19 and have potential for oncolytic therapy and gene therapy. However, interactions between vectors and hosts, including immune responses, must be modulated for safety and efficacy. Strategies and techniques are needed to evade pre-existing immunity induced by Ad vectors used as vaccines.

VIRUSES-BASEL (2021)

Article Immunology

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1

Victor Cervera-Carrascon et al.

Summary: Immune checkpoint inhibitors have revolutionized oncology, but most patients do not benefit from them. Using virotherapy to enhance T-cell activity could improve the efficacy of immune checkpoint inhibitors, even in resistant tumors. The combination of virotherapy with anti-PD-1 therapy led to increased survival in resistant tumors, showing promise in overcoming resistance to immunotherapies.

FRONTIERS IN IMMUNOLOGY (2021)

Review Medicine, Research & Experimental

Nasally inhaled therapeutics and vaccination for COVID-19: Developments and challenges

Jinxiang Xi et al.

Summary: The nose plays a critical role in viral infection, replication, and transmission in the human body, making nasally inhaled vaccines a promising alternative for managing COVID-19. Nasal vaccines based on traditional medicines are under active investigation. Effective delivery of nasal sprays to ACE2-rich regions is urgently needed.

MEDCOMM (2021)

Review Chemistry, Multidisciplinary

Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery

Liwang Shi et al.

Summary: This review discusses the impact of PEG coverage density and thickness on the biophysical and chemical properties of nanoparticles, as well as the related techniques used to detect these coverages.

NANOSCALE (2021)

Review Oncology

Oncolytic Viruses and Hematological Malignancies: A New Class of Immunotherapy Drugs

Vanessa Innao et al.

Summary: The use of oncolytic viruses for tumor treatment shows potential by not only directly destroying tumor cells, but also by operating through multiple systems to change the tumor environment towards an anti-tumoral state. Current research focuses on evaluating the effectiveness of using oncolytic viruses in treating hematologic malignancies and finding the most efficient virus or treatment combinations.

CURRENT ONCOLOGY (2021)

Review Virology

Epidemiology of human adenovirus associated with respiratory infection in southern Brazil

Veridiane Maria Pscheidt et al.

Summary: The study found that the infection rate of HAdV in respiratory infection patients in Rio Grande do Sul, Brazil was 2.8%, with a mortality rate of 3%. HAdV cases were mainly concentrated in winter and early spring, more common in male patients, and mostly in children. Patients with heart diseases and immunocompromised conditions were at higher risk of mortality.

REVIEWS IN MEDICAL VIROLOGY (2021)

Review Immunology

Adenovirus Vectors: Excellent Tools for Vaccine Development

Jun Chang

Summary: Adenovirus, originally used for gene therapy, has seen increased utility as a vaccine vector in recent years with higher safety and immunogenicity. It is being tested for preventing infectious diseases and as cancer vaccines, with ongoing research to overcome limitations for improved vaccine development using adenovirus vectors.

IMMUNE NETWORK (2021)

Review Immunology

Human adenovirus binding to host cell receptors: a structural view

Aleksandra Cecylia Stasiak et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells

Nikita Mokhashi et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

A Single All-in-One Helper-Dependent Adenovirus to Deliver Donor DNA and CRISPR/Cas9 for Efficient Homology-Directed Repair

Donna J. Palmer et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Article Biotechnology & Applied Microbiology

An Oncolytic Vaccinia Virus Armed with GM-CSF and IL-24 Double Genes for Cancer Targeted Therapy

Lili Deng et al.

ONCOTARGETS AND THERAPY (2020)

Article Biotechnology & Applied Microbiology

Extracellular Vesicles-Mimetic Encapsulation Improves Oncolytic Viro-Immunotherapy in Tumors With Low Coxsackie and Adenovirus Receptor

Yonghui Zhang et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Helper virus-free gutless adenovirus (HF-GLAd): a new platform for gene therapy

Jida Liu et al.

BMB REPORTS (2020)

Review Biotechnology & Applied Microbiology

Interferons α and β in cancer: therapeutic opportunities from new insights

Ernest C. Borden

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Biochemistry & Molecular Biology

An estimate of the total number of true human miRNAs

Julia Alles et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Oncology

Oncolytic viruses: how lytic must they be for therapeutic efficacy?

Maria Eugenia Davola et al.

ONCOIMMUNOLOGY (2019)

Review Oncology

Oncolytic Virus-Based Cytokine Expression to Improve Immune Activity in Brain and Solid Tumors

Taylor M. Pearl et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

Article Medicine, Research & Experimental

Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses

Donna J. Palmer et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

Article Multidisciplinary Sciences

Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor

Alexander T. Baker et al.

SCIENCE ADVANCES (2019)

Review Biochemistry & Molecular Biology

Intracellular sensing of viral genomes and viral evasion

Hyun-Cheol Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Review Biochemistry & Molecular Biology

Adenoviruses across the animal kingdom: a walk in the zoo

Balazs Harrach et al.

FEBS LETTERS (2019)

Article Medicine, Research & Experimental

Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses

Donna J. Palmer et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

Review Biochemistry & Molecular Biology

Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy

Brennetta J. Crenshaw et al.

BIOMEDICINES (2019)

Letter Immunology

Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease

Shuping Jing et al.

EMERGING INFECTIOUS DISEASES (2019)

Article Virology

Molecular epidemiology of human adenovirus infections in Denmark, 2011-2016

Celine Barnadas et al.

JOURNAL OF CLINICAL VIROLOGY (2018)

Article Multidisciplinary Sciences

Polysialic acid is a cellular receptor for human adenovirus 52

Annasara Lenman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemical Research Methods

Generation of infectious clone of bovine adenovirus type I expressing a visible marker gene

Jingjing Ren et al.

JOURNAL OF VIROLOGICAL METHODS (2018)

Article Pharmacology & Pharmacy

Gene Therapy for Cystic Fibrosis Lung Disease: Overcoming the Barriers to Translation to the Clinic

Martin Donnelley et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Gastroenterology & Hepatology

Hepatitis C virus: Morphogenesis, infection and therapy

Vladimir Alexei Morozov et al.

WORLD JOURNAL OF HEPATOLOGY (2018)

Article Medicine, General & Internal

Chimpanzee Adenovirus Vector Ebola Vaccine

Julie E. Ledgerwood et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Oncology

Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies

Sachin R. Jhawar et al.

FRONTIERS IN ONCOLOGY (2017)

Article Oncology

The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma

Naiara Martinez-Velez et al.

CLINICAL CANCER RESEARCH (2016)

Review Biotechnology & Applied Microbiology

Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs

Julio Alonso-Padilla et al.

MOLECULAR THERAPY (2016)

Correction Biotechnology & Applied Microbiology

Oncolytic viruses: a new class of immunotherapy drugs (vol 14, pg 642, 2015)

Howard L. Kaufman et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Chemistry, Medicinal

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma

Chunhua Yang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2016)

Review Microbiology

Components of Adenovirus Genome Packaging

Yadvinder S. Ahi et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Medicine, Research & Experimental

CRISPR-Cas9 System as a Versatile Tool for Genome Engineering in Human Cells

Xuelian Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2016)

Article Medicine, Research & Experimental

Hemagglutinin-targeting Artificial MicroRNAs Expressed by Adenovirus Protect Mice From Different Clades of H5N1 Infection

Xinying Tang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2016)

Review Chemistry, Multidisciplinary

CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering

Marion Kirchner et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Biotechnology & Applied Microbiology

Progress on adenovirus-vectored universal influenza vaccines

Kui Xiang et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer

J. C. Morris et al.

GENE THERAPY (2014)

Article Biotechnology & Applied Microbiology

Adenovirus: The First Effective In Vivo Gene Delivery Vector

Ronald G. Crystal

HUMAN GENE THERAPY (2014)

Article Biotechnology & Applied Microbiology

Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus

Elizabeth Ilett et al.

MOLECULAR THERAPY (2014)

Review Biotechnology & Applied Microbiology

Pre-existing immunity against Ad vectors Humoral, cellular, and innate response, what's important?

Hugues Fausther-Bovendo et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Article Biochemistry & Molecular Biology

Interferon--armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells

Hongling Huang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2012)

Article Biochemistry & Molecular Biology

A Siglec-like sialic-acid-binding motif revealed in an adenovirus capsid protein

Christoph Rademacher et al.

GLYCOBIOLOGY (2012)

Article Chemistry, Multidisciplinary

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors

Yukari Motegi et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Medicine, General & Internal

Ebola haemorrhagic fever

Heinz Feldmann et al.

LANCET (2011)

Article Multidisciplinary Sciences

Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation

William C. Adams et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Oncology

RNA interference in the clinic: challenges and future directions

Chad V. Pecot et al.

NATURE REVIEWS CANCER (2011)

Review Biochemistry & Molecular Biology

Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy

Kathryn Hall et al.

BIOCHEMICAL JOURNAL (2010)

Review Pharmacology & Pharmacy

Therapeutic potential of adenoviral vectors for delivery of expressed RNAi activators

Mohube Betty Mowa et al.

EXPERT OPINION ON DRUG DELIVERY (2010)

Article Biochemical Research Methods

An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector

Dongming Zhou et al.

NATURE PROTOCOLS (2010)

Article Multidisciplinary Sciences

Crystal Structure of Human Adenovirus at 3.5 Å Resolution

Vijay S. Reddy et al.

SCIENCE (2010)

Article Biotechnology & Applied Microbiology

Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters

Sergia Bortolanza et al.

MOLECULAR THERAPY (2009)

Review Biotechnology & Applied Microbiology

New Insights on Adenovirus as Vaccine Vectors

Marcio O. Lasaro et al.

MOLECULAR THERAPY (2009)

Review Virology

Adenovirus receptors: implications for tropism, treatment and targeting

Niklas Arnberg

REVIEWS IN MEDICAL VIROLOGY (2009)

Review Virology

Adenovirus receptors and their implications in gene delivery

Anurag Sharma et al.

VIRUS RESEARCH (2009)

Article Gastroenterology & Hepatology

An Effective vaccine against colon cancer in mice: Use of recombinant adenoviruses interleukin-12 transduced dendritic cells

Xiao-Zhou He et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

Article Biochemical Research Methods

A protocol for rapid generation of recombinant adenoviruses using the AdEasy system

Jinyong Luo et al.

NATURE PROTOCOLS (2007)

Review Oncology

Oncolytic viruses driven by tumor-specific promoters

Jayson Hardcastle et al.

CURRENT CANCER DRUG TARGETS (2007)

Article Immunology

Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa

Zhiquan Xiang et al.

EMERGING INFECTIOUS DISEASES (2006)

Article Biochemistry & Molecular Biology

Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

F. Sakurai et al.

GENE THERAPY (2006)

Article Biochemistry & Molecular Biology

Chimpanzee-origin adenovirus vectors as vaccine carriers

N Tatsis et al.

GENE THERAPY (2006)

Review Virology

Adenovirus receptors

YM Zhang et al.

JOURNAL OF VIROLOGY (2005)

Article Biochemistry & Molecular Biology

Gutless adenovirus: last-generation adenovirus for gene therapy

R Alba et al.

GENE THERAPY (2005)

Review Immunology

Functions and mechanisms of action of the adenovirus E3 proteins

DL Lichtenstein et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2004)

Review Biotechnology & Applied Microbiology

Adenoviruses as vaccine vectors

N Tatsis et al.

MOLECULAR THERAPY (2004)

Article Virology

Adenovirus type 11 uses CD46 as a cellular receptor

A Segerman et al.

JOURNAL OF VIROLOGY (2003)

Article Biochemistry & Molecular Biology

Adenovirus-mediated interleukin-2 gene therapy of nociception

MZ Yao et al.

GENE THERAPY (2003)

Article Biochemistry & Molecular Biology

CD46 is a cellular receptor for group B adenoviruses

A Gaggar et al.

NATURE MEDICINE (2003)

Review Oncology

Oncolytic viruses

EA Chiocca

NATURE REVIEWS CANCER (2002)

Article Biotechnology & Applied Microbiology

New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication

R Hernandez-Alcoceba et al.

HUMAN GENE THERAPY (2002)

Article Biochemistry & Molecular Biology

Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies

KD Fisher et al.

GENE THERAPY (2001)

Review Biochemistry & Molecular Biology

Production of first generation adenovirus vectors: a review

X Danthinne et al.

GENE THERAPY (2000)

Review Virology

Cell receptors involved in adenovirus entry

GR Nemerow

VIROLOGY (2000)

Article Veterinary Sciences

Avian adenoviruses

JB McFerran et al.

REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES (2000)

Article Biochemistry & Molecular Biology

Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

SP Cregan et al.

GENE THERAPY (2000)

Review Veterinary Sciences

Detection and differentiation of avian adenoviruses: a review

M Hess

AVIAN PATHOLOGY (2000)

Article Virology

Adenovirus type 37 uses sialic acid as a cellular receptor

N Arnberg et al.

JOURNAL OF VIROLOGY (2000)